HK80596A - Amphotericin b/cholesterol sulfate composition and method - Google Patents

Amphotericin b/cholesterol sulfate composition and method Download PDF

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Publication number
HK80596A
HK80596A HK80596A HK80596A HK80596A HK 80596 A HK80596 A HK 80596A HK 80596 A HK80596 A HK 80596A HK 80596 A HK80596 A HK 80596A HK 80596 A HK80596 A HK 80596A
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HK
Hong Kong
Prior art keywords
amb
cholesterol sulfate
particles
amphotericin
cholesterol
Prior art date
Application number
HK80596A
Other languages
English (en)
French (fr)
Inventor
Abra Robert
Original Assignee
Intermune, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intermune, Inc. filed Critical Intermune, Inc.
Publication of HK80596A publication Critical patent/HK80596A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nanotechnology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Claims (7)

  1. Amphotericin B-Zusammensetzung, umfassend Partikel von Amphotericin B, die Cholesterinsulfat in einem Molverhältnis von Amphotericin B zu Cholesterinsulfat von 1:1 bis 1:4 enthalten.
  2. Zusammensetzung nach Anspruch 1, worin die Partikel in einem wäßrigen Medium suspendiert sind und eine Partikelgröße zwischen 100-400 nm aufweisen.
  3. Zusammensetzung nach Anspruch 2, die durch die Verfahrensschritte erhalten wurde:
    (a) Dispergieren einer wäßrigen Suspension von Amphotericin B und Cholesterinsulfat in einem Molverhältnis von 1:1 bis 1:4 bis zur optischen Klärung,
    (b) Lyophilisieren der Suspension in Gegenwart eines Kälteschutzmittels, ehe die Partikelgröße in der Suspension wesentlich zunimmt und
    (c) Rekonstituieren des lyophilisierten Materials mit einem wäßrigen Medium.
  4. Zusammensetzung nach Anspruch 1, worin das Molverhältnis von Amphotericin B und Cholesterinsulfat etwa 1:1 beträgt.
  5. Zusammensetzung nach einem der Ansprüche 1 bis 4 zur Verwendung bei der Behandlung von Pilzinfektionen.
  6. Verfahren zur Herstellung von Amphotericin B in einer Form, die einen LD₅₀-Wert von größer als 15 mg/kg aufweist, und die mit einem wäßrigen Medium zu Partikeln mit einer Große zwischen 100-400 nm rekonstituiert werden kann, umfassend
    (a) Dispergieren einer wäßrigen Suspension von Amphotericin B und Cholesterinsulfat in einem Molverhältnis zwischen 1:1 bis 1:4, bis zur optischen Klärung und
    (b) Lyophilisieren der Suspension in Gegenwart eines Kälteschutzmittels, ehe die Größe der Partikel in der Suspension wesentlich zunimmt.
  7. Verfahren nach Anspruch 6, in dem das Molverhältnis von Amphotericin B zu Cholesterin in der Suspension etwa 1:1 beträgt.
HK80596A 1987-02-27 1996-05-09 Amphotericin b/cholesterol sulfate composition and method HK80596A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/019,575 US4822777A (en) 1987-02-27 1987-02-27 Amphotericin B/cholesterol sulfate composition

Publications (1)

Publication Number Publication Date
HK80596A true HK80596A (en) 1996-05-17

Family

ID=21793937

Family Applications (1)

Application Number Title Priority Date Filing Date
HK80596A HK80596A (en) 1987-02-27 1996-05-09 Amphotericin b/cholesterol sulfate composition and method

Country Status (12)

Country Link
US (1) US4822777A (de)
EP (1) EP0303683B1 (de)
JP (1) JPH0610134B2 (de)
AT (1) ATE88348T1 (de)
AU (1) AU599779B2 (de)
CA (1) CA1336890C (de)
DE (1) DE3880397T2 (de)
DK (1) DK174871B1 (de)
FI (1) FI884889A0 (de)
HK (1) HK80596A (de)
NO (1) NO884741D0 (de)
WO (1) WO1988006450A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0825869B2 (ja) * 1987-02-09 1996-03-13 株式会社ビタミン研究所 抗腫瘍剤包埋リポソ−ム製剤
US5032582A (en) * 1987-02-27 1991-07-16 Liposome Technology, Inc. Method for treating fungal infections with amphotericin B/cholesterol sulfate composition
US6406713B1 (en) 1987-03-05 2002-06-18 The Liposome Company, Inc. Methods of preparing low-toxicity drug-lipid complexes
US5616334A (en) * 1987-03-05 1997-04-01 The Liposome Company, Inc. Low toxicity drug-lipid systems
US5194266A (en) * 1989-08-08 1993-03-16 Liposome Technology, Inc. Amphotericin B/cholesterol sulfate composition and method
ATE176155T1 (de) * 1990-11-16 1999-02-15 Nippon Shinyaku Co Ltd Injizierbare amphotericin b enthaltende dispersion
AU664857B2 (en) * 1991-08-14 1995-12-07 Sequus Pharmaceuticals, Inc. HIV-treatment method with low-toxicity amphotericin B
US5264220A (en) * 1991-11-12 1993-11-23 Long David M Jr Method of extending the vascular dwell-time of particulate therapeutic and particulate diagnostic agents
AU5171293A (en) * 1992-10-14 1994-05-09 Regents Of The University Of Colorado, The Ion-pairing of drugs for improved efficacy and delivery
IT1283149B1 (it) * 1996-07-12 1998-04-07 Prodotti Antibiotici Spa Complessi di n'-dimetilaminoacetilpartricina a dimetilaminoetilamide, o suoi sali, e colesterol 3-solfato
US6613352B2 (en) 1999-04-13 2003-09-02 Universite De Montreal Low-rigidity liposomal formulation
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
KR100743404B1 (ko) 2000-12-21 2007-07-30 넥타르 테라퓨틱스 폴리엔 항균제의 폐 전달
TWI297335B (en) 2001-07-10 2008-06-01 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI252847B (en) * 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
TWI332943B (en) * 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI330079B (en) * 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
TWI249408B (en) * 2003-12-10 2006-02-21 Ind Tech Res Inst New antifungal formulation and manufacturing method thereof
PL1781604T3 (pl) * 2004-06-23 2014-01-31 Synta Pharmaceuticals Corp Sole bis(tiohydrazydoamidu) do leczenia nowotworów
MX2007012688A (es) * 2005-04-15 2008-03-14 Synta Pharmaceuticals Corp Terapia de combinacion para el cancer con compuestos de bis(tiohidrazida) amida.
US7678832B2 (en) * 2005-08-16 2010-03-16 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amide) formulation
RU2475478C2 (ru) 2006-08-21 2013-02-20 Синта Фармасьютиклз Корп. Соединения для лечения пролиферативных расстройств
JP2010502616A (ja) * 2006-08-31 2010-01-28 シンタ ファーマシューティカルズ コーポレーション 癌を治療するためのビス（チオヒドラジドアミド）の組み合わせ
WO2008033494A2 (en) * 2006-09-15 2008-03-20 Synta Pharmaceuticals Corp. Purification of bis(thiohydrazide amides)
US20100068251A1 (en) * 2006-10-10 2010-03-18 Jina Pharmaceuticals, Inc. Aqueous Systems For The Preparation Of Lipid Based Pharmaceutical Compounds; Compositions, Methods, And Uses Thereof
DE102015102210A1 (de) 2015-02-16 2016-08-18 Heraeus Medical Gmbh Antimykotischer polymerisierbarer Knochenzement und ein Verfahren zu seiner Herstellung
EP3585397A4 (de) * 2017-02-21 2020-11-25 iCo Therapeutics Inc. Feste orale formulierungen von amphotericin b
CN110305926B (zh) * 2019-05-27 2021-02-26 浙江工业大学 一种基于两性霉素b代谢途径的发酵方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4002741A (en) * 1974-04-24 1977-01-11 Valter Osvaldovich Kulbakh Meglumine complex fungicidal polyene macrolide antibiotic compositions and treatment method
US4468513A (en) * 1980-09-22 1984-08-28 Eli Lilly And Company 2'-N-Acylated and 2'-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides
PT78628B (en) * 1984-05-02 1986-06-18 Liposome Co Inc Pharmaceutical composition with reduced toxicity
US4707470A (en) * 1985-05-17 1987-11-17 Smithkline Beckman Corporation Polyene antibiotic emulsion formulation

Also Published As

Publication number Publication date
DE3880397D1 (de) 1993-05-27
ATE88348T1 (de) 1993-05-15
DE3880397T2 (de) 1993-07-29
DK598388A (da) 1988-10-27
JPH01502270A (ja) 1989-08-10
EP0303683B1 (de) 1993-04-21
DK174871B1 (da) 2004-01-12
FI884889L (fi) 1988-10-21
FI884889A7 (fi) 1988-10-21
NO884741L (no) 1988-10-25
WO1988006450A1 (en) 1988-09-07
NO884741D0 (no) 1988-10-25
FI884889A0 (fi) 1988-10-21
AU1482688A (en) 1988-09-26
DK598388D0 (da) 1988-10-27
EP0303683A1 (de) 1989-02-22
JPH0610134B2 (ja) 1994-02-09
CA1336890C (en) 1995-09-05
AU599779B2 (en) 1990-07-26
EP0303683A4 (de) 1989-12-28
US4822777A (en) 1989-04-18

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PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20060226