HRP20020005A2 - Process for the preparation of pure citalopram - Google Patents

Process for the preparation of pure citalopram Download PDF

Info

Publication number
HRP20020005A2
HRP20020005A2 HR20020005A HRP20020005A HRP20020005A2 HR P20020005 A2 HRP20020005 A2 HR P20020005A2 HR 20020005 A HR20020005 A HR 20020005A HR P20020005 A HRP20020005 A HR P20020005A HR P20020005 A2 HRP20020005 A2 HR P20020005A2
Authority
HR
Croatia
Prior art keywords
cyanide
citalopram
distillation
reaction
base
Prior art date
Application number
HR20020005A
Other languages
English (en)
Croatian (hr)
Inventor
Andrea Castellin
Giulio Volpe
Federico Sbrogio
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of HRP20020005A2 publication Critical patent/HRP20020005A2/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HR20020005A 2000-12-28 2001-03-07 Process for the preparation of pure citalopram HRP20020005A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001943 2000-12-28
PCT/DK2001/000148 WO2001047877A2 (en) 2000-12-28 2001-03-07 Process for the preparation of pure citalopram

Publications (1)

Publication Number Publication Date
HRP20020005A2 true HRP20020005A2 (en) 2003-04-30

Family

ID=8159933

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020005A HRP20020005A2 (en) 2000-12-28 2001-03-07 Process for the preparation of pure citalopram

Country Status (41)

Country Link
US (2) US6855834B2 (de)
EP (1) EP1181272B1 (de)
JP (1) JP2003519121A (de)
KR (1) KR100430746B1 (de)
CN (1) CN1366526A (de)
AR (1) AR029898A1 (de)
AT (2) ATE222899T1 (de)
AU (3) AU3920201A (de)
BE (2) BE1013417A6 (de)
BG (1) BG106219A (de)
BR (1) BR0106271A (de)
CA (1) CA2359810C (de)
CH (1) CH691536A5 (de)
CZ (1) CZ293140B6 (de)
DE (1) DE60100016T2 (de)
DK (1) DK1181272T3 (de)
EA (1) EA003459B1 (de)
ES (2) ES2181663T3 (de)
FI (2) FI108640B (de)
FR (1) FR2818977B1 (de)
GB (2) GB2356199B (de)
GR (1) GR20010100131A (de)
HK (1) HK1049332A1 (de)
HR (1) HRP20020005A2 (de)
HU (2) HU0101028D0 (de)
IE (2) IES20010253A2 (de)
IL (1) IL147162A0 (de)
IS (1) IS5884A (de)
IT (1) ITMI20010604A1 (de)
MX (1) MXPA01013336A (de)
NL (1) NL1017534C1 (de)
NO (1) NO313047B1 (de)
NZ (1) NZ516299A (de)
PL (1) PL353369A1 (de)
PT (1) PT1181272E (de)
SE (1) SE0103044L (de)
SK (1) SK284418B6 (de)
TR (1) TR200200018T1 (de)
UA (1) UA71635C2 (de)
WO (1) WO2001047877A2 (de)
ZA (1) ZA200110133B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
DK1173431T4 (da) 1999-04-14 2010-01-04 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
CH692421A5 (de) 1999-10-25 2002-06-14 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram.
DK1298124T3 (da) 1999-10-25 2007-07-09 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
JP2003519136A (ja) 1999-12-28 2003-06-17 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
DK1246813T3 (da) 1999-12-30 2004-03-01 Lundbeck & Co As H Fremgangsmåde til fremstilling af Citalopram
AU3033700A (en) 2000-01-14 2001-07-24 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
AU2001242298A1 (en) 2000-03-13 2001-09-24 H Lunbeck A/S Method for the preparation of citalopram
KR20020080485A (ko) 2000-03-13 2002-10-23 하. 룬트벡 아크티에 셀스카브 5-치환 1-(4-플루오로페닐)-1,3-디히드로이소벤조푸란의단계적 알킬화
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
ES2214400T3 (es) 2000-03-14 2004-09-16 H. Lundbeck A/S Metodo para la preparacion de citalopram.
DE10190485T1 (de) * 2000-03-16 2002-03-21 Lundbeck & Co As H Verfahren zur Herstellung von 5-Cyano-1-(4-fluorphenyl)-1,3-dihydroisobenzofuranen
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2354877C (en) 2000-08-18 2006-05-02 H. Lundbeck A/S Method for the preparation of citalopram
CA2360303C (en) 2000-12-22 2003-08-12 Marco Villa Process for the preparation of pure citalopram
SK284418B6 (sk) 2000-12-28 2005-04-01 H. Lundbeck A/S Spôsob výroby citalopramu
GB2376945A (en) * 2001-06-27 2002-12-31 Cipla Ltd Citalopram preparation
AU2003222435A1 (en) 2002-01-07 2003-07-24 Sun Pharmaceutical Industries Limited Process for the preparation of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
ES2194597B2 (es) * 2002-01-25 2004-08-01 Esteve Quimica, S.A. Procedimiento para la obtencion de citalopram.
GB2386119A (en) * 2002-02-27 2003-09-10 Cipla Ltd Purification of citalopram
GB0204607D0 (en) 2002-02-27 2002-04-10 Matrix Lab Ltd Process
EP1346989A1 (de) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Verbessertes Verfahren zur Herstellung von Citalopram und Citalopram Hydrobromid
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US7019153B2 (en) 2003-06-10 2006-03-28 Sun Pharmaceutical Industries Limited Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl

Family Cites Families (34)

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Publication number Priority date Publication date Assignee Title
NL135959C (de) 1964-12-23
GB1143703A (de) 1965-03-18
DE1619713A1 (de) * 1967-03-29 1970-12-17 Leybold Heraeus Gmbh & Co Kg Vorrichtung zur Vakuum- und Kurzwegdestillation
DE2135085C3 (de) 1971-07-14 1981-12-03 Basf Ag, 6700 Ludwigshafen Verfahren zur Wiedergewinnung von Caprolactam aus einem Gemisch, das Caprolactam und dessen Oligomere enthält
DE2442426C2 (de) 1974-09-05 1983-04-07 Bayer Ag, 5090 Leverkusen Diisocyanatodiketene, Verfahren zu deren Herstellung und deren Verwendung
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
IT8020902A0 (it) 1980-03-25 1980-03-25 Snia Viscosa Procedimento ed apparecchiatura per la separazione continua per via termica di miscele liquide dicomposti termolabili.
JPS6082101A (ja) 1983-10-13 1985-05-10 Mitsui Toatsu Chem Inc 高沸点重合性化合物の薄膜蒸留による精製方法
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
FR2656305B1 (fr) 1989-12-22 1992-04-10 Norsolor Sa Procede de purification du (meth)acrylate de glycidyle.
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
US5582692A (en) 1994-10-07 1996-12-10 Artisan Industries, Inc. Method for the purification of vitamin E
US6136991A (en) * 1996-05-21 2000-10-24 Exxon Chemical Patents Inc. Glycidyl ester adducts having increased glass transition temperatures
DE69725717T2 (de) 1996-05-21 2004-07-29 Exxonmobil Chemical Patents Inc., Baytown Reinigung von glycidylestern durch dünnschichtverdampfung
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
SK283309B6 (sk) 1997-07-08 2003-05-02 H. Lundbeck A/S Spôsob výroby citalopramu a medziprodukty
DE19734673A1 (de) 1997-08-11 1999-02-18 Rwe Dea Ag Verfahren zur Herstellung von metallfreien Guerbetalkoholen
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
DK1042310T3 (da) 1997-11-11 2002-12-02 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
EP0965593B2 (de) 1998-06-19 2008-12-03 Shin-Etsu Chemical Co., Ltd. Destillationsverfahren für (Meth)acryloxysilane
ES2189502T3 (es) * 1998-10-20 2003-07-01 Lundbeck & Co As H Metodo para la prevencion de citalopram.
IL143422A0 (en) 1998-12-23 2002-04-21 Lundbeck & Co As H Method for the preparation of 5-cyanophthalide
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
DK1173431T4 (da) 1999-04-14 2010-01-04 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
CH692421A5 (de) 1999-10-25 2002-06-14 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
CA2360303C (en) 2000-12-22 2003-08-12 Marco Villa Process for the preparation of pure citalopram
SK284418B6 (sk) 2000-12-28 2005-04-01 H. Lundbeck A/S Spôsob výroby citalopramu
US6781003B1 (en) * 2003-06-09 2004-08-24 Aurobindo Pharma Ltd. Preparation of pure citalopram

Also Published As

Publication number Publication date
GB2361697A (en) 2001-10-31
PL353369A1 (pl) 2003-11-17
US20030178295A1 (en) 2003-09-25
AU750006B1 (en) 2002-07-11
ITMI20010604A0 (it) 2001-03-22
ES2181663T3 (es) 2003-03-01
HU0101028D0 (en) 2001-05-28
ATE222899T1 (de) 2002-09-15
HUP0102818A3 (en) 2003-07-28
AR029898A1 (es) 2003-07-23
IL147162A0 (en) 2002-08-14
SE0103044D0 (sv) 2001-09-14
BG106219A (bg) 2002-08-30
WO2001047877A3 (en) 2001-12-27
KR20020073379A (ko) 2002-09-26
IS5884A (is) 2002-06-28
JP2003519121A (ja) 2003-06-17
ES2170733A1 (es) 2002-08-01
WO2001047877A2 (en) 2001-07-05
CN1366526A (zh) 2002-08-28
EA003459B1 (ru) 2003-06-26
ZA200110133B (en) 2003-01-13
CZ2001891A3 (cs) 2002-08-14
SK18472001A3 (sk) 2002-05-09
NO20011272D0 (no) 2001-03-13
UA71635C2 (uk) 2004-12-15
US20020087012A1 (en) 2002-07-04
AT4368U1 (de) 2001-06-25
GB0117095D0 (en) 2001-09-05
NL1017534C1 (nl) 2001-04-26
NO20011272L (no) 2002-07-01
BE1013316A6 (fr) 2001-11-06
TR200200018T1 (tr) 2002-06-21
FI20011578A0 (fi) 2001-07-26
CZ293140B6 (cs) 2004-02-18
AU2001100399A4 (en) 2001-11-01
CA2359810A1 (en) 2001-07-05
GB2356199B (en) 2001-10-03
BR0106271A (pt) 2002-05-21
NZ516299A (en) 2002-12-20
GB0105981D0 (en) 2001-05-02
FI109023B (fi) 2002-05-15
IES20010253A2 (en) 2002-03-06
AU2001100399B4 (en) 2002-03-21
FI108640B (fi) 2002-02-28
ES2170733B1 (es) 2003-12-16
HK1049332A1 (zh) 2003-05-09
DK1181272T3 (da) 2002-12-30
KR100430746B1 (ko) 2004-05-10
IES20010632A2 (en) 2002-03-06
AU3920201A (en) 2001-07-09
HUP0102818A2 (hu) 2001-12-28
EA200200016A1 (ru) 2002-04-25
CH691536A5 (de) 2001-08-15
SE0103044L (sv) 2002-06-29
NO313047B1 (no) 2002-08-05
FR2818977A1 (fr) 2002-07-05
ITMI20010604A1 (it) 2002-09-22
GR20010100131A (el) 2002-10-09
CA2359810C (en) 2002-11-05
DE60100016T2 (de) 2003-04-17
FI20010501A0 (fi) 2001-03-13
GB2356199A (en) 2001-05-16
DE60100016D1 (de) 2002-10-02
SK284418B6 (sk) 2005-04-01
FR2818977B1 (fr) 2003-12-05
PT1181272E (pt) 2003-01-31
EP1181272B1 (de) 2002-08-28
BE1013417A6 (fr) 2001-12-04
HU0102818D0 (en) 2001-09-28
MXPA01013336A (es) 2002-07-09
EP1181272A2 (de) 2002-02-27
US6855834B2 (en) 2005-02-15

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