HRP20041233A2 - Selective estrogen receptor modulators containing a phenylsulfonyl group - Google Patents
Selective estrogen receptor modulators containing a phenylsulfonyl group Download PDFInfo
- Publication number
- HRP20041233A2 HRP20041233A2 HR20041233A HRP20041233A HRP20041233A2 HR P20041233 A2 HRP20041233 A2 HR P20041233A2 HR 20041233 A HR20041233 A HR 20041233A HR P20041233 A HRP20041233 A HR P20041233A HR P20041233 A2 HRP20041233 A2 HR P20041233A2
- Authority
- HR
- Croatia
- Prior art keywords
- mmol
- compound
- phenyl
- solution
- added
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39786902P | 2002-07-22 | 2002-07-22 | |
| US45023303P | 2003-02-25 | 2003-02-25 | |
| PCT/IB2003/003349 WO2004009086A1 (en) | 2002-07-22 | 2003-07-16 | Selective estrogen receptor modulators containing a phenylsulfonyl group |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20041233A2 true HRP20041233A2 (en) | 2005-02-28 |
Family
ID=30773044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20041233A HRP20041233A2 (en) | 2002-07-22 | 2003-07-16 | Selective estrogen receptor modulators containing a phenylsulfonyl group |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7399867B2 (es) |
| EP (1) | EP1530470B9 (es) |
| JP (2) | JP4656939B2 (es) |
| CN (1) | CN1668303B (es) |
| AT (1) | ATE433322T1 (es) |
| AU (1) | AU2003253129B2 (es) |
| BR (1) | BR0312675A (es) |
| CA (1) | CA2490580C (es) |
| CO (1) | CO5680445A2 (es) |
| CR (1) | CR7657A (es) |
| DE (1) | DE60327931D1 (es) |
| EA (1) | EA008024B1 (es) |
| EC (1) | ECSP055549A (es) |
| ES (1) | ES2326593T3 (es) |
| HR (1) | HRP20041233A2 (es) |
| IL (1) | IL165745A0 (es) |
| MX (1) | MXPA05000898A (es) |
| MY (1) | MY141879A (es) |
| NO (1) | NO20050832L (es) |
| NZ (1) | NZ537138A (es) |
| PE (1) | PE20040678A1 (es) |
| PL (1) | PL374845A1 (es) |
| TW (1) | TWI314860B (es) |
| WO (1) | WO2004009086A1 (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA008024B1 (ru) * | 2002-07-22 | 2007-02-27 | Эли Лилли Энд Компани | Селективные модуляторы эстрогенных рецепторов, содержащие фенилсульфонильную группу |
| PL377494A1 (pl) * | 2003-02-25 | 2006-02-06 | Eli Lilly And Company | Krystaliczny, niesolwatowany chlorowodorek 1-(4-(2-pipe-rydynyloetoksy) fenoksy)-2-(4-metanosulfonylofenylo)-6- hydroksynaftalenu |
| WO2004075894A1 (en) * | 2003-02-25 | 2004-09-10 | Eli Lilly And Company | Crystalline non-solvated 1-(4-(2-piperidinylethoxy)phenoxy)-2-(4-methanesulfonylphenyl)-6-hydroxynaphthalene hydrochloride |
| WO2005073206A1 (en) * | 2004-01-22 | 2005-08-11 | Eli Lilly And Company | Selective estrogen receptor modulators |
| KR100849559B1 (ko) * | 2004-01-22 | 2008-07-31 | 일라이 릴리 앤드 캄파니 | 혈관운동 증상의 치료를 위한 선택적 에스트로겐 수용체조절제 |
| CN1910167B (zh) * | 2004-01-22 | 2011-08-10 | 伊莱利利公司 | 用于治疗血管舒缩症状的选择性雌激素受体调节剂 |
| WO2005073190A1 (en) * | 2004-01-29 | 2005-08-11 | Eli Lilly And Company | Selective estrogen receptor modulators |
| CA2571309A1 (en) | 2004-06-22 | 2006-01-05 | Smithkline Beecham Corporation | Chemical compounds |
| US20080200507A1 (en) * | 2005-07-29 | 2008-08-21 | Jeanette Tower Dunlap | Crystalline Non-Solvated Methanesulfonic Acid Salt of 1-(4-(2-Piperidinylethoxy)Phenoxy)-2-(3-Hydroxyphenyl)-6-Hydroxynaphthalene |
| CA2738878C (en) * | 2008-09-29 | 2013-08-13 | Eli Lilly And Company | Selective estrogen receptor modulator for the treatment of osteoarthritis |
| DE102008057230A1 (de) | 2008-11-11 | 2010-05-12 | Bayer Schering Pharma Aktiengesellschaft | Synergistische pharmazeutische Kombination mit einem Estrogenrezeptorantagonisten und einem Progestin |
| CA2754685A1 (en) | 2009-03-11 | 2010-09-16 | Pfizer Inc. | Substituted indazole amides |
| EA026675B1 (ru) | 2010-06-16 | 2017-05-31 | Эндорешерш, Инк. | Способы лечения или предотвращения эстрогензависимых заболеваний |
| JP6292744B2 (ja) * | 2012-09-19 | 2018-03-14 | 富士カプセル株式会社 | 医薬品組成物 |
| ES2671516T3 (es) | 2013-02-19 | 2018-06-06 | Novartis Ag | Derivados de benzotiofeno y composiciones de los mismos como degradantes selectivos de los receptores de estrógeno |
| ES2953140T3 (es) | 2019-03-08 | 2023-11-08 | Syngenta Crop Protection Ag | Compuestos de azol-amida activos de manera plaguicida |
| CN113631552A (zh) | 2019-03-20 | 2021-11-09 | 先正达农作物保护股份公司 | 杀有害生物活性的唑酰胺化合物 |
| JP2022525809A (ja) | 2019-03-22 | 2022-05-19 | シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト | 殺虫剤としてのｎ－［１－（５－ブロモ－２－ピリミジン－２－イル－１，２，４－トリアゾール－３－イル）エチル］－２－シクロプロピル－６－（トリフルオロメチル）ピリジン－４－カルボキサミド誘導体及び関連化合物 |
| TWI853009B (zh) | 2019-03-29 | 2024-08-21 | 瑞士商先正達農作物保護公司 | 殺有害生物活性之二-醯胺化合物 |
| KR20210149113A (ko) | 2019-04-05 | 2021-12-08 | 신젠타 크롭 프로텍션 아게 | 살충 활성 디아진-아미드 화합물 |
| EP4017851A1 (en) | 2019-08-23 | 2022-06-29 | Syngenta Crop Protection AG | Pesticidally active pyrazine-amide compounds |
| CN110526881B (zh) * | 2019-08-27 | 2020-09-22 | 河南省锐达医药科技有限公司 | 一种萘胺类化合物及其生物学可接受的盐，其制备方法和应用 |
| JP2023515979A (ja) | 2020-02-27 | 2023-04-17 | シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト | 殺有害生物的に活性なジアジン－ビスアミド化合物 |
| EP4339181A4 (en) * | 2021-05-14 | 2025-06-04 | Jiangsu Yahong Meditech Co., Ltd. | Naphthalene ring-containing compound, pharmaceutical composition containing it and use thereof |
| US20240287047A1 (en) | 2021-06-09 | 2024-08-29 | Syngenta Crop Protection Ag | Pesticidally active diazine-amide compounds |
| WO2023283315A1 (en) * | 2021-07-07 | 2023-01-12 | South Dakota Board Of Regents | Compositions and methods for treatment of cervical and ovarian cancer |
| EP4577532A1 (en) | 2022-08-25 | 2025-07-02 | Sanofi | Novel substituted benzothiophene-6-carboxylic acid derivatives, processes for their preparation and therapeutic uses thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4418068A (en) | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| EP0639567A1 (en) | 1992-05-08 | 1995-02-22 | Otsuka Pharmaceutical Factory, Inc. | Indole derivative |
| US6756388B1 (en) | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
| US7501441B1 (en) | 1994-09-20 | 2009-03-10 | Eli Lilly And Company | Naphthyl compounds, intermediates, processes, compositions, and methods |
| US6399634B1 (en) * | 1994-09-20 | 2002-06-04 | Eli Lilly And Company | Benzothiophene compounds, compositions, and methods |
| US5552412A (en) | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
| US5998401A (en) * | 1995-02-28 | 1999-12-07 | Eli Lilly And Company | Naphthyl compounds, intermediates, compositions, and methods |
| SG64896A1 (en) | 1995-02-28 | 1999-05-25 | Lilly Co Eli | Benzothiophene compounds intermediates compositions and methods |
| US5599822A (en) | 1995-06-06 | 1997-02-04 | Eli Lilly And Company | Methods for minimizing bone loss |
| EP0863755B1 (en) * | 1995-10-31 | 2004-12-15 | Eli Lilly And Company | Antithrombotic diamines |
| WO1997030709A1 (en) * | 1996-02-22 | 1997-08-28 | Eli Lilly And Company | Benzothiophenes, formulations containing same, and methods |
| PT802183E (pt) | 1996-04-19 | 2002-03-28 | American Home Prod | Agentes estrogenicos |
| CA2213810C (en) | 1996-08-29 | 2006-06-06 | Lewis Dale Pennington | Benzo¬b|thiophene compounds, intermediates, processes, compositions and methods |
| CA2214070C (en) | 1996-08-29 | 2006-03-14 | Eli Lilly And Company | Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods |
| ID19392A (id) | 1996-08-29 | 1998-07-09 | Lilly Co Eli | Senyawa naftil dan bahan pertengahan serta komposisi dan metode penggunaan |
| CA2213814A1 (en) | 1996-08-29 | 1998-02-28 | Henry Uhlman Bryant | Naphthalene compounds, intermediates, formulations, and methods |
| CA2217810A1 (en) * | 1996-10-10 | 1998-04-10 | Eli Lilly And Company | 2-aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods |
| JPH10204082A (ja) | 1996-10-25 | 1998-08-04 | Eli Lilly & Co | 選択的エストロゲンレセプターモジュレーターとしての活性を有する置換されたベンゾ［ｂ］チオフェン化合物 |
| EA008024B1 (ru) * | 2002-07-22 | 2007-02-27 | Эли Лилли Энд Компани | Селективные модуляторы эстрогенных рецепторов, содержащие фенилсульфонильную группу |
-
2003
- 2003-07-16 EA EA200500248A patent/EA008024B1/ru not_active IP Right Cessation
- 2003-07-16 WO PCT/IB2003/003349 patent/WO2004009086A1/en not_active Ceased
- 2003-07-16 NZ NZ537138A patent/NZ537138A/en not_active IP Right Cessation
- 2003-07-16 BR BR0312675-7A patent/BR0312675A/pt not_active IP Right Cessation
- 2003-07-16 AT AT03765254T patent/ATE433322T1/de not_active IP Right Cessation
- 2003-07-16 HR HR20041233A patent/HRP20041233A2/hr not_active Application Discontinuation
- 2003-07-16 US US10/521,896 patent/US7399867B2/en not_active Expired - Fee Related
- 2003-07-16 MX MXPA05000898A patent/MXPA05000898A/es active IP Right Grant
- 2003-07-16 DE DE60327931T patent/DE60327931D1/de not_active Expired - Lifetime
- 2003-07-16 ES ES03765254T patent/ES2326593T3/es not_active Expired - Lifetime
- 2003-07-16 EP EP03765254A patent/EP1530470B9/en not_active Expired - Lifetime
- 2003-07-16 AU AU2003253129A patent/AU2003253129B2/en not_active Ceased
- 2003-07-16 CA CA2490580A patent/CA2490580C/en not_active Expired - Fee Related
- 2003-07-16 JP JP2004522648A patent/JP4656939B2/ja not_active Expired - Fee Related
- 2003-07-16 CN CN038172011A patent/CN1668303B/zh not_active Expired - Fee Related
- 2003-07-16 PL PL03374845A patent/PL374845A1/xx unknown
- 2003-07-18 MY MYPI20032711A patent/MY141879A/en unknown
- 2003-07-18 PE PE2003000717A patent/PE20040678A1/es not_active Application Discontinuation
- 2003-07-18 TW TW092119725A patent/TWI314860B/zh not_active IP Right Cessation
-
2004
- 2004-12-13 IL IL16574504A patent/IL165745A0/xx unknown
-
2005
- 2005-01-18 CR CR7657A patent/CR7657A/es unknown
- 2005-01-19 EC EC2005005549A patent/ECSP055549A/es unknown
- 2005-01-20 CO CO05004232A patent/CO5680445A2/es not_active Application Discontinuation
- 2005-02-16 NO NO20050832A patent/NO20050832L/no not_active Application Discontinuation
-
2008
- 2008-04-09 US US12/100,093 patent/US7585977B2/en not_active Expired - Fee Related
-
2010
- 2010-05-11 JP JP2010109009A patent/JP5220800B2/ja not_active Expired - Fee Related
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| A1OB | Publication of a patent application | ||
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