HRP20080100T3 - Hydroisoindoline tachykinin receptor antagonists - Google Patents

Hydroisoindoline tachykinin receptor antagonists

Info

Publication number
HRP20080100T3
HRP20080100T3 HR20080100T HRP20080100T HRP20080100T3 HR P20080100 T3 HRP20080100 T3 HR P20080100T3 HR 20080100 T HR20080100 T HR 20080100T HR P20080100 T HRP20080100 T HR P20080100T HR P20080100 T3 HRP20080100 T3 HR P20080100T3
Authority
HR
Croatia
Prior art keywords
6alkyl
receptor antagonists
tachykinin receptor
hydroisoindoline
unsubstituted
Prior art date
Application number
HR20080100T
Other languages
English (en)
Croatian (hr)
Inventor
Lynn Bunda Jaime
J. Devita Robert
Jiang Jinlong
G. Mills Sander
Original Assignee
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.
Publication of HRP20080100T3 publication Critical patent/HRP20080100T3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HR20080100T 2004-01-27 2005-01-26 Hydroisoindoline tachykinin receptor antagonists HRP20080100T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53991304P 2004-01-27 2004-01-27
US56122704P 2004-04-09 2004-04-09
PCT/US2005/002149 WO2005073191A1 (fr) 2004-01-27 2005-01-26 Antagonistes des recepteurs de l'hydroisoindoline tachykinine

Publications (1)

Publication Number Publication Date
HRP20080100T3 true HRP20080100T3 (en) 2008-04-30

Family

ID=34830494

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20080100T HRP20080100T3 (en) 2004-01-27 2005-01-26 Hydroisoindoline tachykinin receptor antagonists

Country Status (30)

Country Link
US (3) US7217731B2 (fr)
EP (1) EP1711465B1 (fr)
JP (1) JP3987100B2 (fr)
KR (1) KR20060127927A (fr)
AR (1) AR047439A1 (fr)
AT (1) ATE382034T1 (fr)
AU (1) AU2005207934B2 (fr)
BR (1) BRPI0507050A (fr)
CA (1) CA2554550C (fr)
CO (1) CO5700771A2 (fr)
CR (1) CR8522A (fr)
CY (1) CY1107167T1 (fr)
DE (1) DE602005004011T2 (fr)
DK (1) DK1711465T3 (fr)
EA (1) EA010598B1 (fr)
EC (1) ECSP066716A (fr)
ES (1) ES2297687T3 (fr)
GE (1) GEP20094691B (fr)
HR (1) HRP20080100T3 (fr)
IL (1) IL176879A0 (fr)
MA (1) MA28359A1 (fr)
NI (1) NI200600164A (fr)
NO (1) NO339041B1 (fr)
NZ (1) NZ548415A (fr)
PE (1) PE20050687A1 (fr)
PL (1) PL1711465T3 (fr)
PT (1) PT1711465E (fr)
TW (1) TWI341198B (fr)
UA (1) UA84192C2 (fr)
WO (1) WO2005073191A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR047439A1 (es) 2004-01-27 2006-01-18 Merck & Co Inc Antagonistas del receptor hidroisoindolina taquiquinina
WO2006065711A2 (fr) * 2004-12-14 2006-06-22 Merck & Co., Inc. Antagonistes du recepteur de tachykinine d'octahydropyrano[3,4-c]pyrrole
US7683068B2 (en) * 2005-06-27 2010-03-23 Merck Sharp & Dohme Corp. Hydroisoindoline tachykinin receptor antagonists
WO2007008564A1 (fr) 2005-07-11 2007-01-18 Merck & Co., Inc. Procede de fabrication d'antagonistes des recepteurs de l'hydroisoindoline tachykinine
US7893091B2 (en) 2005-10-04 2011-02-22 Merck Sharp & Dohme Corp. Combination therapy for the treatment of urinary frequency, urinary urgency and urinary incontinence
WO2007075528A2 (fr) * 2005-12-22 2007-07-05 Merck & Co., Inc. Antagonistes de recepteur d’octahydropyrano[3,4-c]pyrrole-tachykinine
US20090042854A1 (en) * 2006-01-24 2009-02-12 Jianming Bao Hexahydro-3H-Pyrrolizin-3-Ones Useful as Tachykinin Receptor Antagonists
AU2007293393A1 (en) * 2006-09-06 2008-03-13 Merck & Co., Inc. Liquid and semi-solid pharmaceutical formulations for oral administration of a substituted amide
WO2008054690A2 (fr) * 2006-11-02 2008-05-08 Merck & Co., Inc. Polymorphes d'un antagoniste des récepteurs de tachykinine hydro-iso-indolique
WO2008121268A1 (fr) * 2007-03-29 2008-10-09 Merck & Co., Inc. Polythérapie pour le traitement de troubles urinaires du bas appareil
CA2683584C (fr) * 2007-04-10 2015-07-07 Merck & Co., Inc. Antagonistes hydroisoindolines d'ether hydroxymethyle des recepteurs de tachykinine
AU2011245499B2 (en) 2010-04-30 2014-09-25 Merck Sharp & Dohme Corp. Novel beta 3 adrenergic receptor agonists
US8627816B2 (en) 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
ES2672099T3 (es) 2011-07-04 2018-06-12 Irbm - Science Park S.P.A. Antagonistas del receptor NK-1 para el tratamiento de la neovascularización corneal
US9198898B2 (en) 2013-06-24 2015-12-01 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
US8906951B1 (en) 2013-06-24 2014-12-09 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
KR20160023692A (ko) * 2013-06-24 2016-03-03 타이거캣 파마, 인크. 소양증에서의 nk-1 수용체 길항제 세를로피탄트의 용도
IL312486B2 (en) 2017-04-10 2025-05-01 Chase Therapeutics Corp NK1 antagonist combination and method for treating synucleinopathies
IL271464B2 (en) 2017-06-30 2024-08-01 Chase Therapeutics Corp NK-1 antagonist compositions and methods for use in the treatment of depression
EP3758688B1 (fr) 2018-02-26 2024-03-27 Ospedale San Raffaele S.r.l. Antagonistes nk-1 destinés à être utilisés dans le traitement de la douleur oculaire
EP4117673A1 (fr) 2020-03-11 2023-01-18 Ospedale San Raffaele S.r.l. Traitement d'une déficience en cellules souches
AU2021246889A1 (en) 2020-04-03 2022-10-13 Nerre Therapeutics Limited An NK-1 receptor antagonist for treating a disease selecting from sepsis, septic shock,, acute respiratory distress syndrome (ARDS) or multiple organ dysfunction syndrome (MODS)
CA3177477A1 (fr) 2020-06-02 2021-12-09 Nerre Therapeutics Limited Antagonistes du recepteur de la neurokinine (nk)-1 destines a etre utilises dans le traitement d'etats de fibrose pulmonaire favorises par une lesion mecanique des poumons

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650142A (en) * 1995-09-27 1997-07-22 Church & Dwight Co., Inc. Bicarbonate-containing deodorant cosmetic stick compositions
WO1997014671A1 (fr) * 1995-10-18 1997-04-24 Merck & Co., Inc. Antagonistes des recepteurs de la cyclopentyle-tachykinine
US7468437B2 (en) 2003-09-30 2008-12-23 Merck & Co., Inc. Phenyl pyrrolidine ether tachykinin receptor antagonists
AR047439A1 (es) 2004-01-27 2006-01-18 Merck & Co Inc Antagonistas del receptor hidroisoindolina taquiquinina

Also Published As

Publication number Publication date
CY1107167T1 (el) 2012-10-24
JP2007519728A (ja) 2007-07-19
JP3987100B2 (ja) 2007-10-03
KR20060127927A (ko) 2006-12-13
EA200601378A1 (ru) 2007-02-27
ES2297687T3 (es) 2008-05-01
EP1711465B1 (fr) 2007-12-26
US7645790B2 (en) 2010-01-12
US20080280966A1 (en) 2008-11-13
NO339041B1 (no) 2016-11-07
IL176879A0 (en) 2006-10-31
PT1711465E (pt) 2008-02-25
DK1711465T3 (da) 2008-03-31
MA28359A1 (fr) 2006-12-01
PE20050687A1 (es) 2005-09-27
HK1100937A1 (zh) 2007-10-05
TWI341198B (en) 2011-05-01
EP1711465A1 (fr) 2006-10-18
US20070161695A1 (en) 2007-07-12
US20050165083A1 (en) 2005-07-28
PL1711465T3 (pl) 2008-05-30
AU2005207934A1 (en) 2005-08-11
ATE382034T1 (de) 2008-01-15
US7345083B2 (en) 2008-03-18
CA2554550C (fr) 2011-05-03
TW200534850A (en) 2005-11-01
AU2005207934B2 (en) 2010-11-25
US7217731B2 (en) 2007-05-15
GEP20094691B (en) 2009-05-25
DE602005004011T2 (de) 2008-12-11
DE602005004011D1 (de) 2008-02-07
ECSP066716A (es) 2006-10-31
CA2554550A1 (fr) 2005-08-11
AR047439A1 (es) 2006-01-18
BRPI0507050A (pt) 2007-06-12
UA84192C2 (en) 2008-09-25
NZ548415A (en) 2009-11-27
EA010598B1 (ru) 2008-10-30
WO2005073191A1 (fr) 2005-08-11
NI200600164A (es) 2007-05-29
NO20063810L (no) 2006-10-26
CR8522A (es) 2007-06-06
CO5700771A2 (es) 2006-11-30

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