HRP20100560T1 - Minimalna dnk sekvenca koja djeluje kao izolator kromatina i njena upotreba u ekspresiji proteina - Google Patents

Minimalna dnk sekvenca koja djeluje kao izolator kromatina i njena upotreba u ekspresiji proteina Download PDF

Info

Publication number
HRP20100560T1
HRP20100560T1 HR20100560T HRP20100560T HRP20100560T1 HR P20100560 T1 HRP20100560 T1 HR P20100560T1 HR 20100560 T HR20100560 T HR 20100560T HR P20100560 T HRP20100560 T HR P20100560T HR P20100560 T1 HRP20100560 T1 HR P20100560T1
Authority
HR
Croatia
Prior art keywords
use according
interest
polypeptide
human
subunit
Prior art date
Application number
HR20100560T
Other languages
English (en)
Croatian (hr)
Inventor
Chatellard Philippe
Imhof Markus
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Publication of HRP20100560T1 publication Critical patent/HRP20100560T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HR20100560T 2003-10-21 2004-10-20 Minimalna dnk sekvenca koja djeluje kao izolator kromatina i njena upotreba u ekspresiji proteina HRP20100560T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03103890 2003-10-21
PCT/EP2004/052591 WO2005040384A1 (en) 2003-10-21 2004-10-20 Minimal dna sequence acting as a chromatin insulator and its use in protein expression

Publications (1)

Publication Number Publication Date
HRP20100560T1 true HRP20100560T1 (hr) 2010-11-30

Family

ID=34486337

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20100560T HRP20100560T1 (hr) 2003-10-21 2004-10-20 Minimalna dnk sekvenca koja djeluje kao izolator kromatina i njena upotreba u ekspresiji proteina

Country Status (17)

Country Link
US (1) US8133699B2 (de)
EP (1) EP1675956B1 (de)
JP (1) JP4745972B2 (de)
AT (1) ATE484591T1 (de)
AU (1) AU2004284243B2 (de)
CA (1) CA2541523A1 (de)
CY (1) CY1110868T1 (de)
DE (1) DE602004029598D1 (de)
DK (1) DK1675956T3 (de)
ES (1) ES2354160T3 (de)
HR (1) HRP20100560T1 (de)
IL (1) IL175021A (de)
NO (1) NO338767B1 (de)
PL (1) PL1675956T3 (de)
PT (1) PT1675956E (de)
SI (1) SI1675956T1 (de)
WO (1) WO2005040384A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1395669T3 (da) 2001-01-26 2009-11-16 Selexis Sa Matriks bindingsregioner og fremgangsmåder til anvendelse af disse
US7824907B2 (en) 2003-03-11 2010-11-02 Merck Serono Sa Expression vectors comprising the mCMV IE2 promoter
US20080076708A1 (en) * 2003-05-13 2008-03-27 Valter Altarocca Active Variants of the Il-18 Binding Protein and Medical Uses Thereof
KR101269656B1 (ko) 2003-10-24 2013-05-30 셀렉시스 에스. 에이. Ｍａｒ 서열의 복합 트랜스펙션 방법에 의한 포유동물 세포에서의 고효율 유전자 전달 및 발현
DK1689777T3 (da) * 2003-11-05 2007-06-11 Ares Trading Sa Fremgangsmåde til oprensning af il18-bindende protein
ES2292127T3 (es) 2004-03-01 2008-03-01 Ares Trading S.A. Uso de un medio de cultivo celular exento de suero para la produccion de il-18bp en celulas de mamiferos.
JP5043654B2 (ja) * 2004-06-29 2012-10-10 アレス トレーディング ソシエテ アノニム Ｉｌ−１８結合タンパク質の精製のための方法
AU2006254103B2 (en) * 2005-06-03 2012-09-06 Ares Trading S.A. Production of recombinant IL-18 binding protein
AU2006256763B2 (en) 2005-06-10 2012-08-02 Ares Trading S.A. Process for the purification of IL-18 binding protein
EP1760092A1 (de) * 2005-08-26 2007-03-07 Applied Research Systems ARS Holding N.V. System für Screening von Zellen mit hoher Expression von einem interessierenden Protein
FR2919616A1 (fr) * 2007-08-02 2009-02-06 Ecole Norm Superieure Lyon Polynucleotides insulateurs derives de l'element d4z4 et leurs utilisations en transgenese
WO2012139195A1 (en) 2011-04-13 2012-10-18 National Research Council Of Canada EXPRESSION SYSTEM WITH SAR ELEMENT FROM IFNα2
WO2013096056A1 (en) * 2011-12-21 2013-06-27 Danisco Us Inc. Improving fungal gene expression using insulator dna sequences
SG11201500799YA (en) 2012-07-31 2015-03-30 Basil M Hantash Hla g-modified cells and methods
KR101591823B1 (ko) 2013-12-27 2016-02-04 재단법인 목암생명공학연구소 증가된 유전자 발현능을 갖는 발현벡터
US11246896B2 (en) 2015-10-28 2022-02-15 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Tumor-specific adenovirus vectors and therapeutic uses
MY189674A (en) 2015-10-28 2022-02-24 Sangamo Therapeutics Inc Liver-specific constructs, factor viii expression cassettes and methods of use thereof
CA3029627A1 (en) 2016-07-01 2018-01-04 Resolve Therapeutics, Llc Optimized binuclease fusions and methods
CN106754817B (zh) * 2016-11-03 2021-02-05 山西省生物研究院有限公司 一种重组自分泌运动因子的表达方法
CA3073537A1 (en) 2017-08-22 2019-02-28 Sanabio, Llc Soluble interferon receptors and uses thereof
CA3100946A1 (en) 2018-05-22 2019-11-28 The Brigham And Women's Hospital, Inc. Gene therapy for alzheimer's disease
US12497632B2 (en) 2018-08-03 2025-12-16 Sangamo Therapeutics, Inc. Clinical parameters by expression of factor VIII
JP7686573B6 (ja) 2019-05-24 2025-07-04 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド アルツハイマー病のための遺伝子治療
BR112022010373A2 (pt) * 2019-11-29 2022-08-16 Paros Bio Inc Terapia genética para doenças neurodegenerativas

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US6113898A (en) * 1995-06-07 2000-09-05 Idec Pharmaceuticals Corporation Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies
US6432700B1 (en) * 1997-03-03 2002-08-13 Cell Genesys, Inc. Adenovirus vectors containing heterologous transcription regulatory elements and methods of using same
US6194152B1 (en) * 1997-08-20 2001-02-27 Dendreon Corporation Prostate tumor polynucleotide compositions and methods of detection thereof
WO2000023606A1 (en) * 1998-10-22 2000-04-27 Medical College Of Georgia Institute, Inc. Long terminal repeat, enhancer, and insulator sequences for use in recombinant vectors
CA2377929A1 (en) * 1999-06-30 2001-01-11 Adam C. Bell Dna binding protein and sequence as insulators having specific enhancer blocking activity for regulation of gene expression
US7824907B2 (en) * 2003-03-11 2010-11-02 Merck Serono Sa Expression vectors comprising the mCMV IE2 promoter
US20080076708A1 (en) 2003-05-13 2008-03-27 Valter Altarocca Active Variants of the Il-18 Binding Protein and Medical Uses Thereof
DK1689777T3 (da) 2003-11-05 2007-06-11 Ares Trading Sa Fremgangsmåde til oprensning af il18-bindende protein
ES2292127T3 (es) 2004-03-01 2008-03-01 Ares Trading S.A. Uso de un medio de cultivo celular exento de suero para la produccion de il-18bp en celulas de mamiferos.
JP5043654B2 (ja) * 2004-06-29 2012-10-10 アレス トレーディング ソシエテ アノニム Ｉｌ−１８結合タンパク質の精製のための方法
AU2006254103B2 (en) 2005-06-03 2012-09-06 Ares Trading S.A. Production of recombinant IL-18 binding protein
AU2006256763B2 (en) 2005-06-10 2012-08-02 Ares Trading S.A. Process for the purification of IL-18 binding protein

Also Published As

Publication number Publication date
US20070134761A1 (en) 2007-06-14
IL175021A0 (en) 2006-08-20
ES2354160T3 (es) 2011-03-10
WO2005040384A1 (en) 2005-05-06
JP2007508833A (ja) 2007-04-12
ATE484591T1 (de) 2010-10-15
DK1675956T3 (da) 2010-11-22
IL175021A (en) 2011-07-31
CY1110868T1 (el) 2015-06-10
SI1675956T1 (sl) 2010-12-31
NO338767B1 (no) 2016-10-17
PT1675956E (pt) 2010-11-04
EP1675956A1 (de) 2006-07-05
DE602004029598D1 (de) 2010-11-25
US8133699B2 (en) 2012-03-13
AU2004284243A1 (en) 2005-05-06
NO20062315L (no) 2006-07-18
AU2004284243B2 (en) 2010-11-04
JP4745972B2 (ja) 2011-08-10
EP1675956B1 (de) 2010-10-13
CA2541523A1 (en) 2005-05-06
PL1675956T3 (pl) 2011-06-30

Similar Documents

Publication Publication Date Title
HRP20100560T1 (hr) Minimalna dnk sekvenca koja djeluje kao izolator kromatina i njena upotreba u ekspresiji proteina
CA2516157A1 (en) Expression vectors comprising the mcmv ie2 promoter
Suematsu et al. IgG1 plasmacytosis in interleukin 6 transgenic mice.
ES2356620T3 (es) Reducción de la inmunogenicidad de las proteínas de fusión.
ES8407329A1 (es) "metodo para construir una secuencia de adn".
JPH07313170A (ja) 共有結合した細胞調節ポリペプチド
ES2564227T3 (es) Elemento de ADN que tiene actividad de aumento de expresión de un gen exógeno
WO2011065935A1 (en) Methods for monoclonal antibody production
KR101955366B1 (ko) 인터페론 베타-엘라스틴 재조합 단백질 및 이의 생산방법
US20110287454A1 (en) Methods for monoclonal antibody production
RU2336279C2 (ru) БЕЛОК IFNAB-BPI, ЕГО ПРЕДШЕСТВЕННИК, МОЛЕКУЛА ДНК, ЭКСПРЕССИРУЮЩИЙ ВЕКТОР, СПОСОБ ПРОДУЦИРОВАНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ ДЛЯ ИНГИБИРОВАНИЯ АКТИВНОСТИ IFN-α ИЛИ IFN-β
Lu et al. Rational design of an EGF-IL18 fusion protein: implication for developing tumor therapeutics
US20090111146A1 (en) Antibody Drug
US9085627B2 (en) Expression system with SAR element from IFNα2
CN104694568B (zh) 动物细胞用表达载体、其制备方法及应用
Li et al. A bifunctional vector suitable for both site-directed mutagenesis and recombinant expression of interferon-τ in Escherichia coli
KR20210081989A (ko) 동물세포 발현벡터
US7498150B2 (en) Materials and methods to increase peptide chain expression
CA2459013A1 (en) Proteins having effects of controlling cell migration and cell death