HRP20171924T1 - 6-o-supstituirani spojevi benzoksazola i benzotiazola te postupci inhibiranja signalizacije csf-1r - Google Patents
6-o-supstituirani spojevi benzoksazola i benzotiazola te postupci inhibiranja signalizacije csf-1r Download PDFInfo
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- HRP20171924T1 HRP20171924T1 HRP20171924TT HRP20171924T HRP20171924T1 HR P20171924 T1 HRP20171924 T1 HR P20171924T1 HR P20171924T T HRP20171924T T HR P20171924TT HR P20171924 T HRP20171924 T HR P20171924T HR P20171924 T1 HRP20171924 T1 HR P20171924T1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Claims (12)
1. Spoj, naznačen time, da je odabran iz skupine koja se sastoji od sljedećih:
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ili njihov stereoizomer, tautomer, solvat, ili oksid, ili njihova farmaceutski prihvatljiva sol.
2. Spoj prema zahtjevu 1, naznačen time, da je to:
[image]
ili njegov solvat, oksid, ili njegova farmaceutski prihvatljiva sol.
3. Spoj prema zahtjevu 1, naznačen time, da je to:
[image]
ili njegov solvat, oksid, ili njegova farmaceutski prihvatljiva sol.
4. Spoj prema zahtjevu 1, naznačen time, da je to:
[image]
ili njegov solvat, oksid, ili njegova farmaceutski prihvatljiva sol.
5. Farmaceutski sastav, naznačen time, da obuhvaća spoj, njegov stereoizomer, tautomer, solvat ili oksid, ili njegovu farmaceutski prihvatljivu sol u skladu s bilo kojim od zahtjeva 1 do 4, zajedno s farmaceutski prihvatljivim nosačima.
6. Uporaba spoja, njegovog stereoizomera, tautomera, solvata ili oksida, ili njegove farmaceutski prihvatljive soli, u skladu s bilo kojim od zahtjeva 1 do 4, naznačena time, da je za proizvodnju lijeka za liječenje raka, osteoporoze, artritisa, ateroskleroze, mijelocitne leukemije, idiopatske mijelofibroze, raka dojke, raka cerviksa, raka jajnika, endometrijskog raka, raka prostate, hepatocelularnog raka, višestrukog mijeloma, raka pluća, raka kostiju, te reumatoidnog artritisa.
7. Spoj, njegov stereoizomer, tautomer, solvat ili oksid, ili njegova farmaceutski prihvatljiva sol, u skladu s bilo kojim od zahtjeva 1 do 4, naznačen/a time, da se daje pojedincu u djelotvornoj količini za smanjivanje ili sprečavanje rasta tumora, u kombinaciji s najmanje jednim dodatnim sredstvom za liječenje raka.
8. Spoj, njegov stereoizomer, tautomer, solvat ili oksid, ili njegova farmaceutski prihvatljiva sol, prema zahtjevu 7, naznačen/a time, da je dodatno sredstvo za liječenje raka odabrano od sljedećih: modulatori receptora estrogena, modulatori receptora androgena, modulatori receptora retinoida, citotoksična/citostatična sredstva, antiproliferativna sredstva, inhibitori transferaze prenilproteina, inhibitori reduktaze HMG-CoA i ostali inhibitori angiogeneze, inhibitori stanične proliferacije i signalizacije preživljavanja, sredstva za izazivanje apoptoze i sredstva koja interferiraju s kontrolnim točkama staničnog ciklusa, inhibitori proteaze HIV-a i inhibitori reverzibilne transkriptaze.
9. Spoj prema bilo kojem od zahtjeva 1 do 4, ili njegov stereoizomer, tautomer, solvat ili oksid, ili njegova farmaceutski prihvatljiva sol, naznačen/a time, da se upotrebljava u liječenju raka, osteoporoze, artritisa, ateroskleroze, mijelocitne leukemije, idiopatske mijelofibroze, raka dojke, raka cerviksa, raka jajnika, endometrijskog raka, raka prostate, hepatocelularnog raka, višestrukog mijeloma, raka pluća, raka kostiju, te reumatoidnog artritisa.
10. Spoj prema bilo kojem od zahtjeva 1 do 4, ili njegov stereoizomer, tautomer, solvat ili oksid, ili njegova farmaceutski prihvatljiva sol, naznačen/a time, da se upotrebljava u zajedničkoj primjeni s radijacijskom terapijom.
11. Kombinacija, naznačena time, da obuhvaća spoj, njegov stereoizomer, tautomer, solvat ili oksid, ili njegovu farmaceutski prihvatljivu sol, u skladu s bilo kojim od zahtjeva 1 do 4, te jedno ili više sredstava koja se upotrebljavaju u liječenju raka.
12. Spoj, njegov stereoizomer, tautomer, solvat ili oksid, ili njegova farmaceutski prihvatljiva sol, u skladu s bilo kojim od zahtjeva 1 do 4, te najmanje jedno dodatno terapeutsko sredstvo, naznačen/a/o time, da se upotrebljava u liječenju raka.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79351706P | 2006-04-19 | 2006-04-19 | |
| US89385707P | 2007-03-08 | 2007-03-08 | |
| EP07797244.6A EP2010528B1 (en) | 2006-04-19 | 2007-04-18 | 6-o-substituted benzoxazole and benzothiazole compounds and methods of inhibiting csf-1r signaling |
| PCT/US2007/066898 WO2007121484A2 (en) | 2006-04-19 | 2007-04-18 | 6-o-substituted benzoxazole and benzothiazole compounds and methods of inhibiting csf-1r signaling |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20171924T1 true HRP20171924T1 (hr) | 2018-02-09 |
Family
ID=38610468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171924TT HRP20171924T1 (hr) | 2006-04-19 | 2007-04-18 | 6-o-supstituirani spojevi benzoksazola i benzotiazola te postupci inhibiranja signalizacije csf-1r |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US7553854B2 (hr) |
| EP (1) | EP2010528B1 (hr) |
| JP (1) | JP5328640B2 (hr) |
| KR (1) | KR101464385B1 (hr) |
| AR (1) | AR060545A1 (hr) |
| AU (1) | AU2007237904B2 (hr) |
| BR (1) | BRPI0710540B1 (hr) |
| CA (1) | CA2649288C (hr) |
| CR (1) | CR10365A (hr) |
| CY (1) | CY1119679T1 (hr) |
| DK (1) | DK2010528T3 (hr) |
| EA (1) | EA018917B1 (hr) |
| EC (1) | ECSP088830A (hr) |
| ES (1) | ES2654847T3 (hr) |
| HR (1) | HRP20171924T1 (hr) |
| HU (1) | HUE035654T2 (hr) |
| IL (1) | IL194662A0 (hr) |
| LT (1) | LT2010528T (hr) |
| MA (1) | MA30407B1 (hr) |
| MX (1) | MX2008013427A (hr) |
| NO (1) | NO20084800L (hr) |
| PE (1) | PE20080359A1 (hr) |
| PL (1) | PL2010528T3 (hr) |
| PT (1) | PT2010528T (hr) |
| RS (1) | RS56600B1 (hr) |
| SI (1) | SI2010528T1 (hr) |
| SM (1) | SMP200800063B (hr) |
| TN (1) | TNSN08406A1 (hr) |
| TW (1) | TW200813039A (hr) |
| WO (1) | WO2007121484A2 (hr) |
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