MA30407B1 - Composes a base de benzoxazole et de benzothiazole 6-0 substitues et procedes d'inhibition de signalisation csf-1r - Google Patents

Composes a base de benzoxazole et de benzothiazole 6-0 substitues et procedes d'inhibition de signalisation csf-1r

Info

Publication number
MA30407B1
MA30407B1 MA31372A MA31372A MA30407B1 MA 30407 B1 MA30407 B1 MA 30407B1 MA 31372 A MA31372 A MA 31372A MA 31372 A MA31372 A MA 31372A MA 30407 B1 MA30407 B1 MA 30407B1
Authority
MA
Morocco
Prior art keywords
benzoxazole
compounds
inhibition
signaling
substituted
Prior art date
Application number
MA31372A
Other languages
English (en)
Inventor
James C Sutton
Marion Wiesmann
Weibo Wang
Mika K Lindvall
Jiong Lan
Savithri Ramurthy
Anu Sharma
Elizabeth J Mieuli
Liana M Klivansky
William P Lenahan
Susan Kaufman
Hong Yang
Simon C Ng
Keith Pfister
Allan Wagman
Victoria Sung
Martin Sendzik
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA30407B1 publication Critical patent/MA30407B1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)

Abstract

ON DÉCRIT LES COMPOSÉS À BASE DE BENZOXAZOLE ET DE BENZOTHIAZOLE ET LES STÉRÉOISOMÈRES, LES TAUTOMÈRES, LES SOLVATES, LES OXYDES, LES ESTERS ET LEURS PROMÉDICAMENTS AINSI QUE LEURS SELS ACCEPTABLES SUR LE PLAN PHARMACEUTIQUE. ON DÉCRIT AUSSI LES COMPOSITIONS DES COMPOSÉS, SOIT SEULS SOIT EN COMBINAISON AVEC AU MOINS UN AGENT THÉRAPEUTIQUE SUPPLÉMENTAIRE, AVEC UN EXCIPIENT ACCEPTABLE SUR LE PLAN PHARMACEUTIQUE, ET LES UTILISATIONS DES COMPOSÉS, SOIT SEULS SOIT EN COMBINAISON AVEC AU MOINS UN AUTRE AGENT THÉRAPEUTIQUE SUPPLÉMENTAIRE. LES MODES DE RÉALISATION SONT UTILES POUR L'INHIBITION DE LA PROLIFÉRATION CELLULAIRE, L'INHIBITION DE LA CROISSANCE ET/OU DE LA MÉTASTASE DE TUMEURS, LE TRAITEMENT OU LA PRÉVENTION DU CANCER, LE TRAITEMENT OU LA PRÉVENTION DE MALADIES OSSEUSES DÉGÉNÉRATIVES TELLES QUE L'ARTHRITE RHUMATOÏDE ET/OU L'INHIBITION DE MOLÉCULES TELLES QUE LA CSF-1R.
MA31372A 2006-04-19 2008-11-10 Composes a base de benzoxazole et de benzothiazole 6-0 substitues et procedes d'inhibition de signalisation csf-1r MA30407B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79351706P 2006-04-19 2006-04-19
US89385707P 2007-03-08 2007-03-08

Publications (1)

Publication Number Publication Date
MA30407B1 true MA30407B1 (fr) 2009-05-04

Family

ID=38610468

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31372A MA30407B1 (fr) 2006-04-19 2008-11-10 Composes a base de benzoxazole et de benzothiazole 6-0 substitues et procedes d'inhibition de signalisation csf-1r

Country Status (30)

Country Link
US (3) US7553854B2 (fr)
EP (1) EP2010528B1 (fr)
JP (1) JP5328640B2 (fr)
KR (1) KR101464385B1 (fr)
AR (1) AR060545A1 (fr)
AU (1) AU2007237904B2 (fr)
BR (1) BRPI0710540B1 (fr)
CA (1) CA2649288C (fr)
CR (1) CR10365A (fr)
CY (1) CY1119679T1 (fr)
DK (1) DK2010528T3 (fr)
EA (1) EA018917B1 (fr)
EC (1) ECSP088830A (fr)
ES (1) ES2654847T3 (fr)
HR (1) HRP20171924T1 (fr)
HU (1) HUE035654T2 (fr)
IL (1) IL194662A0 (fr)
LT (1) LT2010528T (fr)
MA (1) MA30407B1 (fr)
MX (1) MX2008013427A (fr)
NO (1) NO20084800L (fr)
PE (1) PE20080359A1 (fr)
PL (1) PL2010528T3 (fr)
PT (1) PT2010528T (fr)
RS (1) RS56600B1 (fr)
SI (1) SI2010528T1 (fr)
SM (1) SMP200800063B (fr)
TN (1) TNSN08406A1 (fr)
TW (1) TW200813039A (fr)
WO (1) WO2007121484A2 (fr)

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US20080045528A1 (en) 2008-02-21
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US20120225861A1 (en) 2012-09-06
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