HU196602B - Process for producing acid-addition salts of 7-square brackets open alpha-(aminothiazol-4-yl)-alpha-/z/-methoxy-imino-acetamido square brackets closed -3-square brackets open (1-methyl-1-pyrrolidino)-methyl square brackets closed -3-cefem-4-carboxilate, as well as dry mixtures thereof formed with bases and suitable for producing injectable solutions - Google Patents

Process for producing acid-addition salts of 7-square brackets open alpha-(aminothiazol-4-yl)-alpha-/z/-methoxy-imino-acetamido square brackets closed -3-square brackets open (1-methyl-1-pyrrolidino)-methyl square brackets closed -3-cefem-4-carboxilate, as well as dry mixtures thereof formed with bases and suitable for producing injectable solutions Download PDF

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Publication number
HU196602B
HU196602B HU863376A HU337686A HU196602B HU 196602 B HU196602 B HU 196602B HU 863376 A HU863376 A HU 863376A HU 337686 A HU337686 A HU 337686A HU 196602 B HU196602 B HU 196602B
Authority
HU
Hungary
Prior art keywords
salt
methyl
acid addition
square brackets
zwitterionic
Prior art date
Application number
HU863376A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT41802A (en
Inventor
Murray A Kaplan
Thomas W Hudyma
Robert A Lipper
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of HUT41802A publication Critical patent/HUT41802A/hu
Publication of HU196602B publication Critical patent/HU196602B/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Die Erfindung betrifft ein Verfahren zur Herstellung eines Gemisches aus bestimmten temperaturstabilen kristallinen Cephalosporinsalzen und einer pharmazeutisch vertraeglichen nicht-toxischen organischen oder anorganischen Base. Beim erfindungsgemaessen Verfahren vermengt man die genannten Bestandteile in solchen Anteilen, dass nach Verduennen des Gemisches mit Wasser bis zur injizierbaren Konzentration ein p H-Wert von etwa 3,5 bis etwa 7 erzielt wird. Die erfindungsgemaess erhaeltlichen physikalischen Gemische kann man ohne Schwierigkeiten lagern und in fester Form vertreiben. Man kann sie zudem ohne Schwierigkeiten in injizierbare Mittel ueberfuehren, indem man lediglich Wasser zugibt.
HU863376A 1985-08-05 1986-08-05 Process for producing acid-addition salts of 7-square brackets open alpha-(aminothiazol-4-yl)-alpha-/z/-methoxy-imino-acetamido square brackets closed -3-square brackets open (1-methyl-1-pyrrolidino)-methyl square brackets closed -3-cefem-4-carboxilate, as well as dry mixtures thereof formed with bases and suitable for producing injectable solutions HU196602B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76223585A 1985-08-05 1985-08-05

Publications (2)

Publication Number Publication Date
HUT41802A HUT41802A (en) 1987-05-28
HU196602B true HU196602B (en) 1988-12-28

Family

ID=25064475

Family Applications (1)

Application Number Title Priority Date Filing Date
HU863376A HU196602B (en) 1985-08-05 1986-08-05 Process for producing acid-addition salts of 7-square brackets open alpha-(aminothiazol-4-yl)-alpha-/z/-methoxy-imino-acetamido square brackets closed -3-square brackets open (1-methyl-1-pyrrolidino)-methyl square brackets closed -3-cefem-4-carboxilate, as well as dry mixtures thereof formed with bases and suitable for producing injectable solutions

Country Status (34)

Country Link
JP (1) JPH0615548B2 (de)
KR (1) KR930003121B1 (de)
AR (1) AR243894A1 (de)
AT (1) AT390957B (de)
AU (1) AU597262B2 (de)
BE (1) BE905219A (de)
CA (1) CA1284994C (de)
CH (1) CH675581A5 (de)
CS (2) CS276717B6 (de)
CY (1) CY1614A (de)
DD (2) DD254941A5 (de)
DE (1) DE3626375A1 (de)
DK (1) DK162053C (de)
EG (1) EG18003A (de)
ES (1) ES2002112A6 (de)
FI (1) FI84484C (de)
FR (1) FR2585705B1 (de)
GB (1) GB2179936B (de)
GR (1) GR862055B (de)
HK (1) HK99691A (de)
HU (1) HU196602B (de)
IE (1) IE59222B1 (de)
IL (1) IL79608A (de)
IT (1) IT1197067B (de)
LU (2) LU88574I2 (de)
MY (1) MY102212A (de)
NL (1) NL8601991A (de)
OA (1) OA08672A (de)
PT (1) PT83134B (de)
SE (1) SE469633B (de)
SG (1) SG79791G (de)
SU (1) SU1516013A3 (de)
YU (1) YU45793B (de)
ZA (1) ZA865842B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4883868A (en) * 1984-12-27 1989-11-28 Banyu Pharmaceutical Co., Ltd. 7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives
US4959469A (en) * 1984-12-27 1990-09-25 Banyu Pharmaceutical Company, Ltd. Crystalline cephalosporin compounds
US5244891A (en) * 1985-08-05 1993-09-14 Bristol-Myers Squibb Company Injectable compositions of cefepime dihydrochloride hydrate
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
US4808617A (en) * 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination
KR950010084B1 (ko) * 1987-06-25 1995-09-06 반유세이야꾸 가부시끼가이샤 결정성 세팔로스포린 화합물, 그의 제조법 및 그의 제조 중간체
JPH02101081A (ja) * 1988-10-08 1990-04-12 Meiji Seika Kaisha Ltd セファロスポリン誘導体結晶性二塩酸塩及びその製造法
CA2011116C (en) * 1989-03-06 1999-11-16 Murray A. Kaplan Lyophilized bmy-28142 dihydrochloride for parenteral use
CA2101571A1 (en) * 1992-09-08 1994-03-09 Elizabeth A. Garofalo Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof
ATE202109T1 (de) * 1993-03-12 2001-06-15 Upjohn Co Kristallines ceftiofur (freie säure)
EP0638573A1 (de) * 1993-08-10 1995-02-15 Lucky Ltd. Kristalline Hydrate eines Cephalosporins und Verfahren zu ihrer Herstellung
ES2298850T3 (es) 2003-12-23 2008-05-16 Sandoz Gmbh Proceso para la produccion de intermedios para utilizar en la sintesis de la cefalosporina.
WO2008056221A2 (en) * 2006-11-06 2008-05-15 Orchid Chemicals & Pharmaceuticals Limited Crystalline sulfate salt of cephalosporin antibiotic
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151588A (en) * 1979-05-14 1980-11-26 Takeda Chem Ind Ltd Preparation of cephalosporin salt crystal
CA1213882A (en) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporins
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
DE3419015A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von cephalosporinen
GB8424692D0 (en) * 1984-10-01 1984-11-07 Glaxo Group Ltd Chemical compounds
GB2165245B (en) * 1984-10-01 1988-05-25 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
AU6069486A (en) 1987-02-12
LU88574I2 (fr) 1995-03-01
ATA211086A (de) 1990-01-15
CA1284994C (en) 1991-06-18
FI863155A7 (fi) 1987-02-06
CS276717B6 (en) 1992-08-12
SU1516013A3 (ru) 1989-10-15
CY1614A (en) 1992-07-10
SE8603308D0 (sv) 1986-08-04
BE905219A (fr) 1987-02-04
IL79608A (en) 1991-07-18
CH675581A5 (de) 1990-10-15
LU86540A1 (fr) 1987-03-06
DK162053B (da) 1991-09-09
DD268395A5 (de) 1989-05-31
IE862078L (en) 1987-02-05
AR243894A1 (es) 1993-09-30
DE3626375A1 (de) 1987-02-12
IT1197067B (it) 1988-11-25
DK371886D0 (da) 1986-08-04
ZA865842B (en) 1987-04-29
AU597262B2 (en) 1990-05-31
FR2585705A1 (fr) 1987-02-06
PT83134A (en) 1986-09-01
FI84484C (fi) 1991-12-10
KR930003121B1 (ko) 1993-04-19
SE8603308L (sv) 1987-02-06
YU137186A (en) 1987-12-31
OA08672A (en) 1989-03-31
GB8618989D0 (en) 1986-09-17
YU45793B (sh) 1992-07-20
AT390957B (de) 1990-07-25
JPH0615548B2 (ja) 1994-03-02
KR880002530A (ko) 1988-05-09
JPS62103090A (ja) 1987-05-13
HUT41802A (en) 1987-05-28
SE469633B (sv) 1993-08-09
NL8601991A (nl) 1987-03-02
IL79608A0 (en) 1986-11-30
HK99691A (en) 1991-12-13
DK162053C (da) 1992-02-10
DK371886A (da) 1987-02-06
CS276849B6 (en) 1992-08-12
FI863155A0 (fi) 1986-08-01
GB2179936B (en) 1989-04-26
FR2585705B1 (fr) 1989-01-13
MY102212A (en) 1992-05-15
PT83134B (pt) 1989-07-31
FI84484B (fi) 1991-08-30
SG79791G (en) 1991-11-15
IT8621409A0 (it) 1986-08-04
GB2179936A (en) 1987-03-18
EG18003A (en) 1991-08-30
IT8621409A1 (it) 1988-02-04
DD254941A5 (de) 1988-03-16
ES2002112A6 (es) 1988-07-16
IE59222B1 (en) 1994-01-26
GR862055B (en) 1986-12-24

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Date Code Title Description
HU90 Patent valid on 900628