HU215258B - Eljárás rekombináns, humán epesó által stimulált lipázszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására - Google Patents

Eljárás rekombináns, humán epesó által stimulált lipázszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására Download PDF

Info

Publication number: HU215258B
Authority: HU; Hungary
Prior art keywords: protein; amino acid; sequence; bssl; acid sequence
Prior art date: 1990-06-01

Application number

HU9203774A

Other languages

English (en)

Hungarian (hu)

Other versions

HU9203774D0 (en

HUT63184A (en

Inventor

Gunnar Bjursell

Lars Bläckberg

Peter Carlsson

Sven Enerbäck

Olle Hernell

Jeanette Nilsson

Thomas Olivecrona

Original Assignee

Aktiebolaget Astra

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-01

Filing date

1991-05-30

Publication date

1998-11-30

1991-05-30 Application filed by Aktiebolaget Astra filed Critical Aktiebolaget Astra

1993-03-29 Publication of HU9203774D0 publication Critical patent/HU9203774D0/hu

1993-07-28 Publication of HUT63184A publication Critical patent/HUT63184A/hu

1998-11-30 Publication of HU215258B publication Critical patent/HU215258B/hu

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239000000499 gel Substances 0.000 description 1
208000016361 genetic disease Diseases 0.000 description 1
PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 1
ZJYYHGLJYGJLLN-UHFFFAOYSA-N guanidinium thiocyanate Chemical compound SC#N.NC(N)=N ZJYYHGLJYGJLLN-UHFFFAOYSA-N 0.000 description 1
230000036541 health Effects 0.000 description 1
229920000669 heparin Polymers 0.000 description 1
229960002897 heparin Drugs 0.000 description 1
239000002628 heparin derivative Substances 0.000 description 1
102000047688 human TG Human genes 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
230000008105 immune reaction Effects 0.000 description 1
230000016784 immunoglobulin production Effects 0.000 description 1
238000010874 in vitro model Methods 0.000 description 1
230000002779 inactivation Effects 0.000 description 1
239000012678 infectious agent Substances 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
230000002452 interceptive effect Effects 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
JDNTWHVOXJZDSN-UHFFFAOYSA-N iodoacetic acid Chemical compound OC(=O)CI JDNTWHVOXJZDSN-UHFFFAOYSA-N 0.000 description 1
230000020958 lipid digestion Effects 0.000 description 1
230000004130 lipolysis Effects 0.000 description 1
230000002366 lipolytic effect Effects 0.000 description 1
239000007791 liquid phase Substances 0.000 description 1
230000003908 liver function Effects 0.000 description 1
230000001071 malnutrition Effects 0.000 description 1
235000000824 malnutrition Nutrition 0.000 description 1
210000004962 mammalian cell Anatomy 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
KRZWEBVPFGCYMY-UHFFFAOYSA-M methylmercury(1+);hydroxide Chemical compound [OH-].[Hg+]C KRZWEBVPFGCYMY-UHFFFAOYSA-M 0.000 description 1
239000000693 micelle Substances 0.000 description 1
235000021239 milk protein Nutrition 0.000 description 1
238000010369 molecular cloning Methods 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
238000007899 nucleic acid hybridization Methods 0.000 description 1
208000015380 nutritional deficiency disease Diseases 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
208000024691 pancreas disease Diseases 0.000 description 1
230000004203 pancreatic function Effects 0.000 description 1
229940116369 pancreatic lipase Drugs 0.000 description 1
238000009928 pasteurization Methods 0.000 description 1
230000009984 peri-natal effect Effects 0.000 description 1
210000001322 periplasm Anatomy 0.000 description 1
239000012071 phase Substances 0.000 description 1
239000006187 pill Substances 0.000 description 1
230000008488 polyadenylation Effects 0.000 description 1
235000020777 polyunsaturated fatty acids Nutrition 0.000 description 1
230000002028 premature Effects 0.000 description 1
238000012545 processing Methods 0.000 description 1
235000019833 protease Nutrition 0.000 description 1
230000006337 proteolytic cleavage Effects 0.000 description 1
238000000746 purification Methods 0.000 description 1
238000009256 replacement therapy Methods 0.000 description 1
125000000946 retinyl group Chemical group [H]C([*])([H])/C([H])=C(C([H])([H])[H])/C([H])=C([H])/C([H])=C(C([H])([H])[H])/C([H])=C([H])/C1=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
230000007017 scission Effects 0.000 description 1
238000012216 screening Methods 0.000 description 1
230000028327 secretion Effects 0.000 description 1
108020002447 serine esterase Proteins 0.000 description 1
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210000002966 serum Anatomy 0.000 description 1
238000000527 sonication Methods 0.000 description 1
238000010186 staining Methods 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000012086 standard solution Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
235000003702 sterols Nutrition 0.000 description 1
238000003860 storage Methods 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
238000013518 transcription Methods 0.000 description 1
230000035897 transcription Effects 0.000 description 1
238000013519 translation Methods 0.000 description 1
125000003203 triacylglycerol group Chemical group 0.000 description 1
241000701447 unidentified baculovirus Species 0.000 description 1
235000021122 unsaturated fatty acids Nutrition 0.000 description 1
150000004670 unsaturated fatty acids Chemical class 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Birds (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Obesity (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Zoology (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Microbiology (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

HU9203774A 1990-06-01 1991-05-30 Eljárás rekombináns, humán epesó által stimulált lipázszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására HU215258B (hu)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE9001985A SE9001985D0 (sv)	1990-06-01	1990-06-01	New chemical products

Publications (3)

Publication Number	Publication Date
HU9203774D0 HU9203774D0 (en)	1993-03-29
HUT63184A HUT63184A (en)	1993-07-28
HU215258B true HU215258B (hu)	1998-11-30

Family

ID=20379662

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU9203774A HU215258B (hu)	1990-06-01	1991-05-30	Eljárás rekombináns, humán epesó által stimulált lipázszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására

Country Status (44)

Country	Link
EP (1)	EP0535048B1 (lt)
JP (1)	JPH05507201A (lt)
KR (1)	KR100212411B1 (lt)
CN (2)	CN1075113C (lt)
AP (1)	AP207A (lt)
AT (1)	ATE151077T1 (lt)
AU (1)	AU651979B2 (lt)
BG (1)	BG61165B1 (lt)
CA (1)	CA2083396C (lt)
CZ (1)	CZ287470B6 (lt)
DE (1)	DE69125489T2 (lt)
DK (1)	DK0535048T3 (lt)
DZ (1)	DZ1503A1 (lt)
EG (1)	EG19937A (lt)
ES (1)	ES2099159T3 (lt)
FI (1)	FI114639B (lt)
GR (1)	GR3023618T3 (lt)
HK (1)	HK62497A (lt)
HR (1)	HRP920771B1 (lt)
HU (1)	HU215258B (lt)
IE (1)	IE911844A1 (lt)
IL (1)	IL98273A (lt)
IS (1)	IS1751B (lt)
JO (1)	JO1694B1 (lt)
LT (1)	LT4020B (lt)
LV (1)	LV10292B (lt)
MA (1)	MA22166A1 (lt)
MY (1)	MY111245A (lt)
NO (1)	NO322962B1 (lt)
NZ (1)	NZ238223A (lt)
PH (1)	PH30761A (lt)
PL (1)	PL166534B1 (lt)
PT (1)	PT97836B (lt)
RO (1)	RO114793B1 (lt)
RU (1)	RU2140983C1 (lt)
SE (1)	SE9001985D0 (lt)
SG (1)	SG48078A1 (lt)
SK (1)	SK281089B6 (lt)
TN (1)	TNSN91041A1 (lt)
TW (1)	TW221712B (lt)
UA (1)	UA39165C2 (lt)
WO (1)	WO1991018923A1 (lt)
YU (1)	YU49138B (lt)
ZA (1)	ZA913778B (lt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP930935A2 (en) *	1992-06-11	1994-12-31	Astra Ab	New dna sequences
IS4130A (is) *	1993-03-01	1994-09-02	Ab Astra	Ný fjölpeptíð
SE9300686D0 (sv)	1993-03-01	1993-03-01	Astra Ab	Novel polypeptides
FR2754827B1 (fr) *	1996-10-17	1998-12-24	Biocem	Lipases pancreatiques et/ou colipases recombinantes et polypeptides dervies produits par les plantes, leurs procedes d'obtention et leurs utilisations
JP2000026311A (ja) *	1998-07-02	2000-01-25	Amano Pharmaceut Co Ltd	胃排出能亢進剤組成物
US20090226904A1 (en) *	2005-12-01	2009-09-10	University Of Bergen	Diagnosis and treatment of exocrine pancreatic dysfunction and diabetes
KR101742346B1 (ko)	2010-04-23	2017-06-15	시나게바 바이오파르마, 코포레이션	리소솜 축적병 효소
BR122019021757B1 (pt)	2010-09-09	2020-12-08	Alexion Pharmaceuticals, Inc	composição farmacêutica para tratamento de um paciente humano sofrendo de uma deficiência de lipase ácida lisossomal (lal)
JP5850940B2 (ja) *	2010-10-21	2016-02-03	スウェディッシュオーファンバイオビトラムパブリークアクチエボラグ	ヒト乳児の発育速度を増大させる方法
AU2010362575A1 (en)	2010-10-21	2013-04-11	Swedish Orphan Biovitrum Ab (Publ)	Method to increase the absorption of unsaturated fatty acids by human infants
BR112019025973A2 (pt)	2017-06-19	2020-07-07	Swedish Orphan Biovitrum Ab (Publ)	proteína de fusão com polipeptídeo de extensão de meia-vida
BR112022003705A2 (pt)	2019-08-30	2022-05-24	Codexis Inc	Lipase recombinante, composição, sequência de polinucleotídeo recombinante, vetor de expressão, composição farmacêutica para o tratamento de insuficiência pancreática, célula hospedeira, métodos para produzir uma lipase recombinante e para tratar e/ou prevenir os sintomas de insuficiência pancreática, e, uso

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60501758A (ja) *	1983-07-01	1985-10-17	セルテク　リミテツド	タンパク質、医薬構成物、遺伝子、ベクタ−宿主生物及びそれらの生産方法

1990
- 1990-06-01 SE SE9001985A patent/SE9001985D0/xx unknown
1991
- 1991-05-17 ZA ZA913778A patent/ZA913778B/xx unknown
- 1991-05-18 TW TW080103838A patent/TW221712B/zh not_active IP Right Cessation
- 1991-05-20 DZ DZ910064A patent/DZ1503A1/fr active
- 1991-05-22 NZ NZ238223A patent/NZ238223A/xx not_active IP Right Cessation
- 1991-05-23 MY MYPI91000877A patent/MY111245A/en unknown
- 1991-05-27 IL IL9827391A patent/IL98273A/xx not_active IP Right Cessation
- 1991-05-29 MA MA22438A patent/MA22166A1/fr unknown
- 1991-05-29 EG EG33391A patent/EG19937A/xx active
- 1991-05-29 YU YU95191A patent/YU49138B/sh unknown
- 1991-05-30 PL PL91296937A patent/PL166534B1/pl unknown
- 1991-05-30 UA UA93003780A patent/UA39165C2/uk unknown
- 1991-05-30 ES ES91911030T patent/ES2099159T3/es not_active Expired - Lifetime
- 1991-05-30 AU AU79645/91A patent/AU651979B2/en not_active Expired
- 1991-05-30 RU RU92016526/13A patent/RU2140983C1/ru active
- 1991-05-30 SG SG1996006887A patent/SG48078A1/en unknown
- 1991-05-30 HU HU9203774A patent/HU215258B/hu unknown
- 1991-05-30 IE IE184491A patent/IE911844A1/en not_active IP Right Cessation
- 1991-05-30 WO PCT/SE1991/000381 patent/WO1991018923A1/en not_active Ceased
- 1991-05-30 EP EP91911030A patent/EP0535048B1/en not_active Expired - Lifetime
- 1991-05-30 DK DK91911030.4T patent/DK0535048T3/da active
- 1991-05-30 DE DE69125489T patent/DE69125489T2/de not_active Expired - Lifetime
- 1991-05-30 RO RO92-01490A patent/RO114793B1/ro unknown
- 1991-05-30 CA CA002083396A patent/CA2083396C/en not_active Expired - Lifetime
- 1991-05-30 JP JP91510382A patent/JPH05507201A/ja active Pending
- 1991-05-30 AT AT91911030T patent/ATE151077T1/de not_active IP Right Cessation
- 1991-05-31 PT PT97836A patent/PT97836B/pt not_active IP Right Cessation
- 1991-05-31 TN TNTNSN91041A patent/TNSN91041A1/fr unknown
- 1991-05-31 SK SK1644-91A patent/SK281089B6/sk not_active IP Right Cessation
- 1991-05-31 IS IS3710A patent/IS1751B/is unknown
- 1991-05-31 CZ CS19911644A patent/CZ287470B6/cs not_active IP Right Cessation
- 1991-06-01 AP APAP/P/1991/000270A patent/AP207A/en active
- 1991-06-01 JO JO19911694A patent/JO1694B1/en active
- 1991-06-01 CN CN91104368A patent/CN1075113C/zh not_active Expired - Lifetime
- 1991-10-11 PH PH43285A patent/PH30761A/en unknown
1992
- 1992-10-01 HR HRP-951/91A patent/HRP920771B1/xx not_active IP Right Cessation
- 1992-11-24 NO NO19924528A patent/NO322962B1/no not_active IP Right Cessation
- 1992-11-26 BG BG97123A patent/BG61165B1/bg unknown
- 1992-11-30 FI FI925453A patent/FI114639B/fi active IP Right Grant
- 1992-11-30 KR KR1019920703049A patent/KR100212411B1/ko not_active Expired - Lifetime
1993
- 1993-07-30 LV LVP-93-1005A patent/LV10292B/en unknown
- 1993-12-30 LT LTIP1736A patent/LT4020B/lt not_active IP Right Cessation
1997
- 1997-05-08 HK HK62497A patent/HK62497A/en not_active IP Right Cessation
- 1997-05-30 GR GR970401262T patent/GR3023618T3/el unknown
2000
- 2000-11-20 CN CN00130975A patent/CN1326782A/zh active Pending

Also Published As

Publication number	Publication date
IE911844A1 (en)	1991-12-04
IL98273A (en)	2005-11-20
RU2140983C1 (ru)	1999-11-10
FI925453A0 (fi)	1992-11-30
HU9203774D0 (en)	1993-03-29
ES2099159T3 (es)	1997-05-16
SK164491A3 (en)	1995-07-11
SE9001985D0 (sv)	1990-06-01
WO1991018923A1 (en)	1991-12-12
IL98273A0 (en)	1992-06-21
FI925453L (fi)	1992-11-30
HRP920771A2 (en)	1997-04-30
CZ287470B6 (cs)	2000-12-13
IS1751B (is)	2000-07-21
EP0535048A1 (en)	1993-04-07
BG97123A (bg)	1993-12-24
JO1694B1 (en)	1992-08-09
AU651979B2 (en)	1994-08-11
IS3710A7 (is)	1991-12-02
SG48078A1 (en)	1998-04-17
LV10292B (en)	1995-08-20
CN1075113C (zh)	2001-11-21
DE69125489D1 (de)	1997-05-07
YU95191A (sh)	1994-06-10
TNSN91041A1 (fr)	1992-10-25
CN1326782A (zh)	2001-12-19
EP0535048B1 (en)	1997-04-02
DK0535048T3 (da)	1997-09-29
GR3023618T3 (en)	1997-08-29
JPH05507201A (ja)	1993-10-21
HUT63184A (en)	1993-07-28
NO924528D0 (no)	1992-11-24
RO114793B1 (ro)	1999-07-30
CN1064313A (zh)	1992-09-09
LT4020B (en)	1996-08-26
AP207A (en)	1992-08-18
KR100212411B1 (en)	1999-08-02
YU49138B (sh)	2004-03-12
PH30761A (en)	1997-10-17
BG61165B1 (bg)	1997-01-31
HK62497A (en)	1997-05-16
MA22166A1 (fr)	1991-12-31
AP9100270A0 (en)	1991-07-31
ZA913778B (en)	1992-02-26
AU7964591A (en)	1991-12-31
PT97836B (pt)	1998-11-30
PL166534B1 (pl)	1995-05-31
EG19937A (en)	2000-12-31
CZ164491A3 (cs)	1999-07-14
FI114639B (fi)	2004-11-30
NO924528L (no)	1992-11-24
PT97836A (pt)	1992-02-28
DE69125489T2 (de)	1997-08-14
LTIP1736A (en)	1995-08-25
TW221712B (lt)	1994-03-11
LV10292A (lv)	1994-10-20
CA2083396A1 (en)	1991-12-02
HRP920771B1 (en)	1999-10-31
UA39165C2 (uk)	2001-06-15
MY111245A (en)	1999-10-30
SK281089B6 (sk)	2000-11-07
CA2083396C (en)	2006-09-19
ATE151077T1 (de)	1997-04-15
NO322962B1 (no)	2006-12-18
DZ1503A1 (fr)	2004-09-13
NZ238223A (en)	1993-05-26

Publication	Publication Date	Title
Nilsson et al.	1990	cDNA cloning of human‐milk bile‐salt‐stimulated lipase and evidence for its identity to pancreatic carboxylic ester hydrolase
Morimoto et al.	1989	Saposin A: second cerebrosidase activator protein.
Lowe et al.	1989	Cloning and characterization of human pancreatic lipase cDNA
RU2128708C1 (ru)	1999-04-10	Молекула днк, вектор экспрессии
Reue et al.	1991	cDNA cloning of carboxyl ester lipase from human pancreas reveals a unique proline-rich repeat unit.
Anderson et al.	1991	Cloning and expression of cDNA encoding human lysosomal acid lipase/cholesteryl ester hydrolase. Similarities to gastric and lingual lipases.
JP3072853B2 (ja)	2000-08-07	治療用に、組換方法で生産されたリパーゼ
AU651979B2 (en)	1994-08-11	Derivatives of human bile-salt stimulated lipase, and pharmaceutical compositions containing them
ES2229252T3 (es)	2005-04-16	Aplicacion de fosfolipasas en la alimentacion del ganado.
CZ333595A3 (en)	1997-03-12	Recombinant stratum corneum chymotryptic enzyme (scce)
Poulose et al.	1985	Cloning and sequencing of the cDNA for S-acyl fatty acid synthase thioesterase from the uropygial gland of mallard duck.
JP2004331566A (ja)	2004-11-25	皮膚コラーゲン産生促進剤
EP0131418A1 (en)	1985-01-16	Proteins, pharmaceutical compositons, genes, vectors, host organisms and processes for their production
Knipping	1986	Isolation and properties of porcine lecithin: cholesterol acyltransferase
de Araújo et al.	1994	Purification of an acidic phospholipase A2 from Bothrops lanceolatus (fer de lance) venom: molecular and enzymatic properties
Hwang et al.	1993	Molecular cloning and sequencing of thioesterase B cDNA and stimulation of expression of the thioesterase B gene associated with hormonal induction of peroxisome proliferation
Rice	1995	Secretory type II phospholipase A2 and the generation of intrauterine signals
JP2004331565A (ja)	2004-11-25	皮膚コラーゲン産生促進剤
Timmermans	1996	Purification, mofecular cloning and expression of the cDNA of bovine pregastric esterase