HUE041714T2 - Kompozíció, amely tartalmaz alfa tokotrienolkinont és annak intermediereit - Google Patents

Kompozíció, amely tartalmaz alfa tokotrienolkinont és annak intermediereit

Info

Publication number: HUE041714T2
Authority: HU; Hungary
Prior art keywords: intermediates; composition containing; containing alpha; tocotrienol quinone; tocotrienol
Prior art date: 2008-10-28

Application number

HUE15175938A

Other languages

English (en)

Hungarian (hu)

Inventor

Kieron Wesson

Andrew Hinman

Orion Jankowski

Original Assignee

Bioelectron Tech Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-10-28

Filing date

2009-10-27

Publication date

2019-05-28

2009-10-27 Application filed by Bioelectron Tech Corp filed Critical Bioelectron Tech Corp

2019-05-28 Publication of HUE041714T2 publication Critical patent/HUE041714T2/hu

Links

LNOVHERIIMJMDG-KTWAZNHYSA-N 2-[(6e,10e)-3-hydroxy-3,7,11,15-tetramethylhexadeca-6,10,14-trienyl]-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CCC(C)(O)CCC1=C(C)C(=O)C(C)=C(C)C1=O LNOVHERIIMJMDG-KTWAZNHYSA-N 0.000 title 1
239000000543 intermediate Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
- C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pyrane Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

HUE15175938A 2008-10-28 2009-10-27 Kompozíció, amely tartalmaz alfa tokotrienolkinont és annak intermediereit HUE041714T2 (hu)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US19758508P	2008-10-28	2008-10-28

Publications (1)

Publication Number	Publication Date
HUE041714T2 true HUE041714T2 (hu)	2019-05-28

Family

ID=42118126

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HUE15175938A HUE041714T2 (hu)	2008-10-28	2009-10-27	Kompozíció, amely tartalmaz alfa tokotrienolkinont és annak intermediereit

Country Status (17)

Country	Link
US (6)	US8106223B2 (2)
EP (3)	EP2362875B1 (2)
JP (7)	JP5775459B2 (2)
CN (2)	CN102264730B (2)
BR (1)	BRPI0920414B1 (2)
CA (2)	CA2741767C (2)
DK (2)	DK2963006T3 (2)
EA (2)	EA201692046A1 (2)
ES (2)	ES2553557T3 (2)
HU (1)	HUE041714T2 (2)
MX (1)	MX2011004440A (2)
MY (2)	MY157119A (2)
PL (2)	PL2362875T3 (2)
PT (2)	PT2362875E (2)
SI (1)	SI2963006T1 (2)
TR (1)	TR201819154T4 (2)
WO (1)	WO2010051277A1 (2)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005033093A1 (en)	2003-09-19	2005-04-14	Galileo Pharmaceuticals, Inc.	7,8-bicycloalkyl-chroman derivatives
ES2619303T3 (es) *	2005-06-01	2017-06-26	Edison Pharmaceuticals, Inc.	Productos terapéuticos redox activos para el tratamiento de enfermedades mitocondriales y otras afecciones y modulación de biomarcadores energéticos
WO2007100652A2 (en)	2006-02-22	2007-09-07	Edison Pharmaceuticals, Inc.	Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
EA038941B1 (ru)	2007-11-06	2021-11-12	ПиТиСи ТЕРАПЬЮТИКС, ИНК.	ПРОИЗВОДНЫЕ 4-(п-ХИНОНИЛ)-2-ГИДРОКСИБУТАНАМИДА ДЛЯ ЛЕЧЕНИЯ МИТОХОНДРИАЛЬНЫХ ЗАБОЛЕВАНИЙ
US8952071B2 (en) *	2008-01-08	2015-02-10	Edison Pharmaceuticals, Inc.	(Het)aryl-p-quinone derivatives for treatment of mitochondrial diseases
WO2009111576A2 (en)	2008-03-05	2009-09-11	Edison Pharmaceuticals, Inc.	2-SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES
JP5798481B2 (ja) *	2008-06-25	2015-10-21	エジソンファーマシューティカルズ，インコーポレイテッド	酸化ストレス疾患を治療するための２−ヘテロシクリルアミノアルキル−（ｐ−キノン）誘導体
MX363223B (es)	2008-09-10	2019-03-15	Bioelectron Tech Corp	Tratamiento de trastornos generalizados del desarrollo con terapeuticos con actividad redox.
EP2362726B1 (en)	2008-10-14	2018-08-08	Bioelectron Technology Corporation	Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells
ES2553557T3 (es) *	2008-10-28	2015-12-10	Edison Pharmaceuticals, Inc.	Proceso para la producción de alfa-tocotrienol y derivados
CA2777479C (en)	2009-04-28	2017-10-17	Ptc Therapeutics, Inc.	Treatment of leber's hereditary optic neuropathy and dominant optic atrophy with tocotrienol quinones
NO2470168T3 (2) *	2009-08-26	2018-06-30
WO2012154613A1 (en) *	2011-05-06	2012-11-15	Edison Pharmaceuticals, Inc.	Improved process for the preparation of d-alpha-tocotrienol from natural extracts
WO2012174286A1 (en)	2011-06-14	2012-12-20	Edison Pharmaceuticals, Inc.	Catechol derivatives for treatment of oxidative stress diseases
EP2734512B1 (en)	2011-07-19	2019-11-20	Bioelectron Technology Corporation	Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols
MY162508A (en) *	2011-07-21	2017-06-15	Sime Darby Malaysia Berhad	External preparation for skin
CA2883882A1 (en)	2012-09-07	2014-03-13	Ptc Therapeutics, Inc.	Benzoquinone derivatives for treating oxidative stress disorders
US8937191B2 (en) *	2012-12-20	2015-01-20	Orochem Technologies, Inc.	Recovery of highly pure alpha-tocotrienol from crude palm oil extract
US9670170B2 (en)	2013-03-15	2017-06-06	Bioelectron Technology Corporation	Resorufin derivatives for treatment of oxidative stress disorders
US10189830B2 (en)	2013-03-15	2019-01-29	Bioelectron Technology Corporation	Alkyl-heteroaryl substituted quinone derivatives for treatment of oxidative stress disorders
US9868711B2 (en)	2013-03-15	2018-01-16	Bioelectron Technology Corporation	Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
US9296712B2 (en)	2013-03-15	2016-03-29	Edison Pharmaceuticals, Inc.	Resorufin derivatives for treatment of oxidative stress disorders
US20170029597A1 (en) *	2013-11-29	2017-02-02	Saudi Basic Industries Corporation	Stabilised polyolefin composition
US9512098B1 (en)	2014-02-03	2016-12-06	Board Of Trustees Of The University Of Arkansas	Process of producing purified gamma- and delta-tocotrienols from tocol-rich oils or distillates
CN104262315A (zh) *	2014-09-05	2015-01-07	宁波大红鹰生物工程股份有限公司	一种生育三烯酚的分离提纯方法
DK3233786T3 (da)	2014-12-16	2022-05-09	Ptc Therapeutics Inc	Polymorfe og amorfe former af (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6- dioxocyclohexa-1,4-dienyl)butanamid
JP2018502127A (ja)	2015-01-12	2018-01-25	バイオエレクトロンテクノロジーコーポレイション	放射線被曝に対する防護のためのキノン
WO2017106786A1 (en) *	2015-12-16	2017-06-22	Bioelectron Technology Corporation	Improved methods for enriching alpha-tocotrienol from mixed tocol compositions
US10703701B2 (en)	2015-12-17	2020-07-07	Ptc Therapeutics, Inc.	Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
CA3011293A1 (en)	2016-01-12	2017-07-20	Ptc Therapeutics, Inc.	Tocopherol and tocotrienol quinone derivatives for increasing thiosulfate levels or decreasing hydrogen sulfide levels
JP2018083799A (ja)	2016-11-15	2018-05-31	バイオエレクトロンテクノロジーコーポレイション	２−置換アミノ−ナフト［１，２−ｄ］イミダゾール−５−オン化合物またはその製薬学上許容される塩
WO2018191732A1 (en)	2017-04-14	2018-10-18	Bioelectron Technology Corporation	Methods and compositions for treatment of inflammation and oxidative stress
TN2021000075A1 (en)	2018-10-17	2023-01-05	Ptc Therapeutics Inc	2,3,5-TRIMETHYL-6-NONYLCYCLOHEXA-2,5-DIENE-1,4-DIONE FOR SUPPRESSING AND TREATING α-SYNUCLEINOPATHIES, TAUOPATHIES, AND OTHER DISORDERS
CN121949079A (zh)	2019-10-04	2026-05-01	康德生物医疗有限公司	治疗线粒体异常疾病的伐替苯醌的醌、氢醌和萘醌类似物
CN115996916B (zh)	2020-04-03	2025-09-23	康德生物医疗有限公司	用于预防和/或治疗包括弗里德赖希共济失调的线粒体疾病的组合物和方法
MX2024000445A (es)	2021-07-08	2024-04-05	Ptc Therapeutics Inc	Composiciones farmaceuticas que comprenden 2,3,5-trimetil-6-nonilc iclohexa-2,5-dieno-1,4-diona.

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2519863A (en)	1949-05-14	1950-08-22	Eastman Kodak Co	Conversion of beta-, gamma-, and delta-tocopherol to alpha-tocopherol by aminoalkylation and reduction
US4977282A (en) *	1984-04-17	1990-12-11	Henkel Corporation	Production of d-alpha-tocopherol from natural plant sources
EP0159018A3 (en) *	1984-04-17	1986-10-01	HENKEL CORPORATION (a Delaware corp.)	Production of d-alpha-tocopherol from natural plant sources
US4603142A (en)	1984-06-01	1986-07-29	Wisconsin Alumni Research Foundation	Cholesterol lowering method of use
JPS636186A (ja)	1986-06-23	1988-01-12	タツタ電線株式会社	点滴監視装置
JPH0788376B2 (ja)	1986-09-02	1995-09-27	エーザイ株式会社	光学活性α−トコトリエノ−ルの製造方法
JP2685785B2 (ja)	1988-03-11	1997-12-03	エーザイ株式会社	光学活性α−トコトリエノールの製造方法
JPH029875A (ja)	1988-03-16	1990-01-12	Bio Ind Kyokai	トコフェロール及びトコトリエノールの製造方法
US5157132A (en) *	1990-05-18	1992-10-20	Carotech Associates	Integrated process for recovery of carotenoids and tocotrienols from oil
SG48108A1 (en)	1991-11-22	1998-04-17	Lipogenenics Inc	Tocotrienols and tocotrienol-like compounds and methods for their use
DK0735033T3 (da) *	1995-03-28	2000-10-23	Hoffmann La Roche	Aminomethylering af tocopheroler
US5660691A (en)	1995-11-13	1997-08-26	Eastman Chemical Company	Process for the production of tocotrienol/tocopherol blend concentrates
US6232060B1 (en)	1996-01-19	2001-05-15	Galileo Laboratories, Inc.	Assay system for anti-stress agents
US5801159A (en)	1996-02-23	1998-09-01	Galileo Laboratories, Inc.	Method and composition for inhibiting cellular irreversible changes due to stress
US5932748A (en)	1997-06-06	1999-08-03	Roche Vitamins Inc.	Process for permethylating non-α-tocopherols to produce α-tocopherol
CN1137077C (zh) *	1997-10-29	2004-02-04	弗莱克斯塞思美国有限合伙公司	使用过氧化氢和催化剂由苯二胺制备醌二亚胺的方法
EP1051412B1 (en)	1998-01-29	2003-09-24	Eastman Chemical Company	Methods for separating a tocotrienol from a tocol-containing mixture and compositions thereof
MY125803A (en) *	1998-11-06	2006-08-30	Fuji Chem Ind Co Ltd	A tocotrienol-containing powder, a process for preparing it and a tablet comprising compressed said powder into a tablet form
US6395915B1 (en)	1999-09-10	2002-05-28	Technikrom, Inc.	Method for producing purified tocotrienols and tocopherols using liquid chromatography
MY127451A (en)	1999-11-04	2006-12-29	Malaysian Palm Oil Board	A method of chromatographic isolation for vitamin e isomers
DE10034233A1 (de) *	2000-07-14	2002-01-24	Basf Ag	Tocotrienolchinon-Cyclisierungsprodukte
US7034054B2 (en)	2000-12-15	2006-04-25	Galileo Pharmaceuticals, Inc.	Methods for the prevention and treatment of cerebral ischemia using non-alpha tocopherols
US6838104B2 (en)	2000-12-20	2005-01-04	Archer Daniels Midland Company	Process for the production of tocotrienols
US6608196B2 (en)	2001-05-03	2003-08-19	Galileo Pharmaceuticals, Inc.	Process for solid supported synthesis of pyruvate-derived compounds
JP4842455B2 (ja)	2001-06-13	2011-12-21	コマツＮｔｃ株式会社	半導体単結晶引上げ装置及びそのライン構成
JP2003171376A (ja)	2001-09-27	2003-06-20	Lion Corp	トコフェロール類及びトコトリエノール類濃縮物、その製造方法
US6667330B2 (en)	2002-01-31	2003-12-23	Galileo Pharmaceuticals, Inc.	Furanone derivatives
US6653346B1 (en)	2002-02-07	2003-11-25	Galileo Pharmaceuticals, Inc.	Cytoprotective benzofuran derivatives
US6590113B1 (en)	2002-03-26	2003-07-08	Ronald T. Sleeter	Process for treating oils containing antioxidant compounds
AU2003287250B9 (en)	2002-10-30	2010-01-28	Ptc Therapeutics, Inc.	Identifying therapeutic compounds based on their physical-chemical properties
MY130618A (en)	2002-11-27	2007-07-31	Malaysian Palm Oil Board	A method of extracting and isolating minor components from vegetable oil
WO2005033093A1 (en)	2003-09-19	2005-04-14	Galileo Pharmaceuticals, Inc.	7,8-bicycloalkyl-chroman derivatives
WO2005035490A2 (en)	2003-10-10	2005-04-21	Yasoo Health, Inc.	PROCESS FOR SYNTHESIZING d-TOCOTRIENOLS
MY173044A (en)	2003-11-19	2019-12-20	Carotech Bhd	Recovery of phytonutriens from oils
US7393662B2 (en)	2004-09-03	2008-07-01	Centocor, Inc.	Human EPO mimetic hinge core mimetibodies, compositions, methods and uses
ES2619303T3 (es) *	2005-06-01	2017-06-26	Edison Pharmaceuticals, Inc.	Productos terapéuticos redox activos para el tratamiento de enfermedades mitocondriales y otras afecciones y modulación de biomarcadores energéticos
SI1933821T1 (sl)	2005-09-15	2020-11-30	Ptc Therapeutics, Inc.	Repne variante redoks-aktivnih terapevtikov za zdravljenje mitohondrijskih bolezni in drugih bolezni ter modulacijo energijskih biooznačevalcev
WO2007100652A2 (en)	2006-02-22	2007-09-07	Edison Pharmaceuticals, Inc.	Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
WO2007105297A1 (ja) *	2006-03-13	2007-09-20	Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo	メチン系色素とその用途
WO2008086025A2 (en)	2007-01-10	2008-07-17	Edison Pharmaceuticals, Inc.	Treatment of respiratory chain disorders using compounds having erythropoietin or thrombopoietin activity
WO2008142433A1 (en)	2007-05-24	2008-11-27	Loders Croklaan B.V.	Process for producing compositions comprising tocoherols and tocotrienols
EA038941B1 (ru)	2007-11-06	2021-11-12	ПиТиСи ТЕРАПЬЮТИКС, ИНК.	ПРОИЗВОДНЫЕ 4-(п-ХИНОНИЛ)-2-ГИДРОКСИБУТАНАМИДА ДЛЯ ЛЕЧЕНИЯ МИТОХОНДРИАЛЬНЫХ ЗАБОЛЕВАНИЙ
EP2242506A4 (en)	2008-01-07	2011-12-28	Janssen Biotech Inc	METHOD FOR THE TREATMENT OF ERYTHROPOIETIN HYPORESPONSE ANIMALS
US8952071B2 (en)	2008-01-08	2015-02-10	Edison Pharmaceuticals, Inc.	(Het)aryl-p-quinone derivatives for treatment of mitochondrial diseases
WO2009111576A2 (en)	2008-03-05	2009-09-11	Edison Pharmaceuticals, Inc.	2-SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES
EP2262519A4 (en) *	2008-03-05	2011-03-23	Edison Pharmaceuticals Inc	TREATMENT OF HEARING AND BALANCING DISORDERS WITH REDOXACTIVE THERAPEUTICS
US20110142834A1 (en)	2008-05-15	2011-06-16	Edison Pharmaceuticals, Inc.	Treatment of hearing and balance impairments using compounds having erythropoietin activity
US20090291092A1 (en)	2008-05-22	2009-11-26	Miller Guy M	Treatment of mitochondrial diseases with an erythropoietin mimetic
JP5798481B2 (ja)	2008-06-25	2015-10-21	エジソンファーマシューティカルズ，インコーポレイテッド	酸化ストレス疾患を治療するための２−ヘテロシクリルアミノアルキル−（ｐ−キノン）誘導体
WO2010005989A1 (en)	2008-07-09	2010-01-14	Edison Pharmaceuticals, Inc.	Dermatological compositions with anti-aging and skin even-toning properties
US20100029784A1 (en)	2008-07-30	2010-02-04	Hinman Andrew W	Naphthoquinone compositions with anti-aging, anti-inflammatory and skin even-toning properties
WO2010014758A1 (en)	2008-07-30	2010-02-04	Edison Pharmaceuticals, Inc.	Use of hydrogenated pyrido[4,3-b] indoles for the treatment of oxidative stress
MX363223B (es)	2008-09-10	2019-03-15	Bioelectron Tech Corp	Tratamiento de trastornos generalizados del desarrollo con terapeuticos con actividad redox.
EP2362726B1 (en)	2008-10-14	2018-08-08	Bioelectron Technology Corporation	Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells
ES2553557T3 (es) *	2008-10-28	2015-12-10	Edison Pharmaceuticals, Inc.	Proceso para la producción de alfa-tocotrienol y derivados
US20120136048A1 (en)	2009-04-28	2012-05-31	Miller Guy M	Topical, periocular, or intraocular use of tocotrienols for the treatment of ophthalmic diseases
CA2777479C (en)	2009-04-28	2017-10-17	Ptc Therapeutics, Inc.	Treatment of leber's hereditary optic neuropathy and dominant optic atrophy with tocotrienol quinones
EA201101576A1 (ru)	2009-04-28	2012-04-30	Эдисон Фармасьютикалз, Инк.	Лекарственная форма токотриенол хинонов для лечения офтальмических (глазных) заболеваний
EP2445519A4 (en)	2009-06-25	2012-12-26	Ampere Life Sciences Inc	TREATMENT OF PERVASIVE DEVELOPMENT DISORDERS USING TOCOTRIENOLS OR TOCOTRIENOLS ENRICHED EXTRACTS
NO2470168T3 (2)	2009-08-26	2018-06-30
US20110172312A1 (en)	2009-12-31	2011-07-14	Miller Guy M	Treatment of leigh syndrome and leigh-like syndrome with tocotrienol quinones
BR112012022634A2 (pt)	2010-03-09	2019-09-24	Edison Pharmaceuticals Inc	síntese de derivados de alto-tocoferolquinona e métodos de utilização dos mesmos
WO2011113018A1 (en)	2010-03-12	2011-09-15	Ampere Life Sciences, Inc.	Measurement and control of biological time
CA2795726A1 (en)	2010-04-06	2011-10-13	Edison Pharmaceuticals, Inc.	Treatment of ataxia telangiectasia
JP5902673B2 (ja)	2010-04-27	2016-04-13	エジソンファーマシューティカルズ，インコーポレイテッド	眼疾患の処置のためのキノンの製剤
US20120101169A1 (en)	2010-07-14	2012-04-26	Penwest Pharmaceuticals Co.	Methods of providing anticoagulation effects in subjects
SG187744A1 (en)	2010-08-06	2013-03-28	Edison Pharmaceuticals Inc	Treatment of mitochondrial diseases with naphthoquinones
US20120295985A1 (en)	2010-11-19	2012-11-22	Miller Guy M	Methods for improving blood glucose control
WO2012154613A1 (en)	2011-05-06	2012-11-15	Edison Pharmaceuticals, Inc.	Improved process for the preparation of d-alpha-tocotrienol from natural extracts
WO2012170773A1 (en)	2011-06-08	2012-12-13	Edison Pharmaceuticals, Inc.	Adjunctive therapy for the treatment of mitochondrial disorders with quinones and naphthoquinones
WO2012174286A1 (en)	2011-06-14	2012-12-20	Edison Pharmaceuticals, Inc.	Catechol derivatives for treatment of oxidative stress diseases
WO2013006736A1 (en)	2011-07-06	2013-01-10	Edison Pharmaceuticals, Inc	Treatment of leigh syndrome and leigh-like syndrome, including complications of sucla2 mutations, with tocotrienol quinones
ES2795798T3 (es)	2011-07-06	2020-11-24	Ptc Therapeutics Inc	Tratamiento de aciduria metilmalónica, aciduria isovalérica, y otras acidurias orgánicas con tocotrienol quinonas
EP2734512B1 (en)	2011-07-19	2019-11-20	Bioelectron Technology Corporation	Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols
CA2883882A1 (en)	2012-09-07	2014-03-13	Ptc Therapeutics, Inc.	Benzoquinone derivatives for treating oxidative stress disorders
US8937191B2 (en)	2012-12-20	2015-01-20	Orochem Technologies, Inc.	Recovery of highly pure alpha-tocotrienol from crude palm oil extract
CN105142603B (zh)	2013-03-08	2018-10-19	荷兰联合利华有限公司	用于皮肤病用途的间苯二酚化合物
US9868711B2 (en)	2013-03-15	2018-01-16	Bioelectron Technology Corporation	Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
US20140275045A1 (en)	2013-03-15	2014-09-18	Edison Pharmaceuticals, Inc.	Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
US9670170B2 (en)	2013-03-15	2017-06-06	Bioelectron Technology Corporation	Resorufin derivatives for treatment of oxidative stress disorders
US9296712B2 (en)	2013-03-15	2016-03-29	Edison Pharmaceuticals, Inc.	Resorufin derivatives for treatment of oxidative stress disorders
US10189830B2 (en)	2013-03-15	2019-01-29	Bioelectron Technology Corporation	Alkyl-heteroaryl substituted quinone derivatives for treatment of oxidative stress disorders
EP3004071A1 (en)	2013-05-31	2016-04-13	Edison Pharmaceuticals, Inc.	Carboxylic acid derivatives for treatment of oxidative stress disorders
EP3233819A1 (en)	2014-12-16	2017-10-25	Bioelectron Technology Corporation	Methods for chiral resolution of trolox
DK3233786T3 (da)	2014-12-16	2022-05-09	Ptc Therapeutics Inc	Polymorfe og amorfe former af (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6- dioxocyclohexa-1,4-dienyl)butanamid
JP2018502127A (ja)	2015-01-12	2018-01-25	バイオエレクトロンテクノロジーコーポレイション	放射線被曝に対する防護のためのキノン
WO2017106786A1 (en)	2015-12-16	2017-06-22	Bioelectron Technology Corporation	Improved methods for enriching alpha-tocotrienol from mixed tocol compositions
US10703701B2 (en)	2015-12-17	2020-07-07	Ptc Therapeutics, Inc.	Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
CA3011293A1 (en)	2016-01-12	2017-07-20	Ptc Therapeutics, Inc.	Tocopherol and tocotrienol quinone derivatives for increasing thiosulfate levels or decreasing hydrogen sulfide levels
WO2017123823A1 (en)	2016-01-12	2017-07-20	Bioelectron Technology Corporation	Alkyl-, acyl-, urea-, and aza-uracil sulfide:quinone oxidoreductase inhibitors
WO2018081644A1 (en)	2016-10-28	2018-05-03	Bioelectron Technology Corporation	Methods of analyzing p-hydroquinone levels and ratios
WO2018093957A1 (en)	2016-11-15	2018-05-24	Bioelectron Technology Corporation	2-substituted amino-naphth[1,2-d]imidazol-5-one compounds or pharmaceutically acceptable salts thereof cross reference to related applications
WO2018129411A1 (en)	2017-01-06	2018-07-12	Bioelectron Technology Corporation	Aryl- and heteroaryl-resorufin derivatives for treatment of oxidative stress disorders and liver and kidney disorders
WO2018191732A1 (en)	2017-04-14	2018-10-18	Bioelectron Technology Corporation	Methods and compositions for treatment of inflammation and oxidative stress

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Publication number	Publication date
MX2011004440A (es)	2011-06-20
US20140221674A1 (en)	2014-08-07
PL2362875T3 (pl)	2016-01-29
EP2362875B1 (en)	2015-08-19
JP2015187169A (ja)	2015-10-29
EA201100699A1 (ru)	2011-12-30
EP2362875A4 (en)	2012-06-27
US11312697B2 (en)	2022-04-26
CN105753829A (zh)	2016-07-13
BRPI0920414A2 (pt)	2015-08-04
DK2963006T3 (en)	2019-01-14
JP2012506910A (ja)	2012-03-22
US20190002428A1 (en)	2019-01-03
DK2362875T3 (en)	2015-11-30
CN102264730A (zh)	2011-11-30
WO2010051277A8 (en)	2011-01-27
MY157119A (en)	2016-05-13
EP2963006A1 (en)	2016-01-06
JP6001025B2 (ja)	2016-10-05
ES2553557T3 (es)	2015-12-10
JP2018135394A (ja)	2018-08-30
CA2974482A1 (en)	2010-05-06
CA2741767A1 (en)	2010-05-06
US20220204469A1 (en)	2022-06-30
CN105753829B (zh)	2019-02-01
EP3450431A1 (en)	2019-03-06
JP2023073469A (ja)	2023-05-25
EP2362875A1 (en)	2011-09-07
EP2963006B1 (en)	2018-10-17
JP2014221842A (ja)	2014-11-27
HK1161876A1 (en)	2012-08-10
CA2974482C (en)	2019-10-29
US10071978B2 (en)	2018-09-11
EP3450431B1 (en)	2023-09-13
US8575369B2 (en)	2013-11-05
SI2963006T1 (sl)	2019-01-31
EA026417B1 (ru)	2017-04-28
JP2021066745A (ja)	2021-04-30
HK1219718A1 (en)	2017-04-13
JP2019065041A (ja)	2019-04-25
TR201819154T4 (tr)	2019-01-21
MY185183A (en)	2021-04-30
CN102264730B (zh)	2016-04-13
PT2963006T (pt)	2018-12-14
ES2701260T3 (es)	2019-02-21
JP5775459B2 (ja)	2015-09-09
JP7181708B2 (ja)	2022-12-01
WO2010051277A1 (en)	2010-05-06
US20120130093A1 (en)	2012-05-24
US8106223B2 (en)	2012-01-31
PT2362875E (pt)	2015-11-03
US20170037023A1 (en)	2017-02-09
CA2741767C (en)	2017-09-12
EA201692046A1 (ru)	2017-06-30
US20100105930A1 (en)	2010-04-29
PL2963006T3 (pl)	2019-01-31
BRPI0920414B1 (pt)	2018-05-22

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