HUP9903473A3 - Isatin derivatives as acetylcholinesterase inhibitors and analgesics - Google Patents

Isatin derivatives as acetylcholinesterase inhibitors and analgesics

Info

Publication number: HUP9903473A3
Authority: HU; Hungary
Prior art keywords: analgesics; acetylcholinesterase inhibitors; isatin derivatives; isatin; derivatives
Prior art date: 1996-04-12

Application number

HU9903473A

Other languages

English (en)

Original Assignee

Hoechst Marion Roussel Inc Cin

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-12

Filing date

1997-03-07

Publication date

2000-09-28

1997-03-07 Application filed by Hoechst Marion Roussel Inc Cin filed Critical Hoechst Marion Roussel Inc Cin

2000-05-28 Publication of HUP9903473A2 publication Critical patent/HUP9903473A2/hu

2000-09-28 Publication of HUP9903473A3 publication Critical patent/HUP9903473A3/hu

Links

229940035676 analgesics Drugs 0.000 title 1
239000000730 antalgic agent Substances 0.000 title 1
239000000544 cholinesterase inhibitor Substances 0.000 title 1
JXDYKVIHCLTXOP-UHFFFAOYSA-N isatin Chemical class C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

HU9903473A 1996-04-12 1997-03-07 Isatin derivatives as acetylcholinesterase inhibitors and analgesics HUP9903473A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US63187096A	1996-04-12	1996-04-12

Publications (2)

Publication Number	Publication Date
HUP9903473A2 HUP9903473A2 (hu)	2000-05-28
HUP9903473A3 true HUP9903473A3 (en)	2000-09-28

Family

ID=24533114

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU9903473A HUP9903473A3 (en)	1996-04-12	1997-03-07	Isatin derivatives as acetylcholinesterase inhibitors and analgesics

Country Status (19)

Country	Link
EP (1)	EP0892796B1 (hu)
JP (1)	JP4109718B2 (hu)
KR (1)	KR20000005379A (hu)
CN (1)	CN1215399A (hu)
AR (1)	AR006606A1 (hu)
AT (1)	ATE207483T1 (hu)
BR (1)	BR9708655A (hu)
CA (1)	CA2252039C (hu)
DE (1)	DE69707659T2 (hu)
DK (1)	DK0892796T3 (hu)
ES (1)	ES2165586T3 (hu)
GR (1)	GR3037006T3 (hu)
HU (1)	HUP9903473A3 (hu)
IL (1)	IL126308A0 (hu)
NO (1)	NO984740D0 (hu)
PT (1)	PT892796E (hu)
TW (1)	TW426678B (hu)
WO (1)	WO1997038993A1 (hu)
ZA (1)	ZA972990B (hu)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6218383B1 (en)	1998-08-07	2001-04-17	Targacept, Inc.	Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
US8278345B2 (en)	2006-11-09	2012-10-02	Probiodrug Ag	Inhibitors of glutaminyl cyclase
ATE554085T1 (de)	2006-11-30	2012-05-15	Probiodrug Ag	Neue inhibitoren von glutaminylcyclase
JP5930573B2 (ja)	2007-03-01	2016-06-15	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤の新規使用
EP2142514B1 (en)	2007-04-18	2014-12-24	Probiodrug AG	Thiourea derivatives as glutaminyl cyclase inhibitors
JP5934645B2 (ja)	2009-09-11	2016-06-15	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
AU2011215870B2 (en)	2010-02-09	2016-01-28	The Johns Hopkins University	Methods and compositions for improving cognitive function
CA2788656A1 (en)	2010-02-16	2011-08-25	Pfizer Inc.	(r)-4-((4-((4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2h-pyran-4-ol, a partial agonist of 5-ht4 receptors
JP6026284B2 (ja)	2010-03-03	2016-11-16	プロビオドルグエージー	グルタミニルシクラーゼの阻害剤
NZ602312A (en)	2010-03-10	2014-02-28	Probiodrug Ag	Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
WO2011131748A2 (en)	2010-04-21	2011-10-27	Probiodrug Ag	Novel inhibitors
EP2686313B1 (en)	2011-03-16	2016-02-03	Probiodrug AG	Benzimidazole derivatives as inhibitors of glutaminyl cyclase
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
PL2931276T3 (pl)	2012-12-13	2018-06-29	H. Lundbeck A/S	Kompozycje zawierające wortioksetynę i donepezil
WO2014144663A1 (en)	2013-03-15	2014-09-18	The Johns Hopkins University	Methods and compositions for improving cognitive function
JP6433482B2 (ja)	2013-03-15	2018-12-05	エージンバイオ，インコーポレイテッド	認知機能を改善するための方法および組成物
US10537552B2 (en)	2015-05-05	2020-01-21	Carafe Drug Innovation, Llc	Substituted 5-hydroxyoxindoles and their use as analgesics and fever reducers
WO2016191288A1 (en)	2015-05-22	2016-12-01	Agenebio, Inc.	Extended release pharmaceutical compositions of levetiracetam
ES2812698T3 (es)	2017-09-29	2021-03-18	Probiodrug Ag	Inhibidores de glutaminil ciclasa
WO2023081800A1 (en) *	2021-11-05	2023-05-11	The Regents Of The University Of California	Alpha-2a adrenergic receptor modulators and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5296488A (en) *	1989-08-02	1994-03-22	Hoechst-Roussel Pharmaceuticals Inc.	Method of using 2,3-dihydro-1-(pyridinylamino)-indoles as anticonvulsants and for the enhancement of memory
US5006537A (en) *	1989-08-02	1991-04-09	Hoechst-Roussel Pharmaceuticals, Inc.	1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
US4994472A (en) *	1989-08-02	1991-02-19	Hoechst-Roussel Pharmaceuticals Incorporated	1-(pyridinylamino)-2-pyrrolidinones as pain relievers

1997
- 1997-03-07 JP JP53708497A patent/JP4109718B2/ja not_active Expired - Fee Related
- 1997-03-07 EP EP97908942A patent/EP0892796B1/en not_active Expired - Lifetime
- 1997-03-07 AT AT97908942T patent/ATE207483T1/de not_active IP Right Cessation
- 1997-03-07 BR BR9708655A patent/BR9708655A/pt not_active Application Discontinuation
- 1997-03-07 ES ES97908942T patent/ES2165586T3/es not_active Expired - Lifetime
- 1997-03-07 CN CN97193728A patent/CN1215399A/zh active Pending
- 1997-03-07 DE DE69707659T patent/DE69707659T2/de not_active Expired - Fee Related
- 1997-03-07 CA CA002252039A patent/CA2252039C/en not_active Expired - Fee Related
- 1997-03-07 IL IL12630897A patent/IL126308A0/xx unknown
- 1997-03-07 PT PT97908942T patent/PT892796E/pt unknown
- 1997-03-07 HU HU9903473A patent/HUP9903473A3/hu unknown
- 1997-03-07 DK DK97908942T patent/DK0892796T3/da active
- 1997-03-07 WO PCT/US1997/003598 patent/WO1997038993A1/en not_active Ceased
- 1997-04-07 TW TW086104363A patent/TW426678B/zh active
- 1997-04-08 ZA ZA9702990A patent/ZA972990B/xx unknown
- 1997-04-11 AR ARP970101447A patent/AR006606A1/es unknown
1998
- 1998-10-09 NO NO984740A patent/NO984740D0/no unknown
- 1998-10-12 KR KR1019980708105A patent/KR20000005379A/ko not_active Abandoned
2001
- 2001-10-25 GR GR20010401584T patent/GR3037006T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO1997038993A1 (en)	1997-10-23
DE69707659T2 (de)	2002-05-08
CA2252039A1 (en)	1997-10-23
IL126308A0 (en)	1999-05-09
AU716997B2 (en)	2000-03-16
ZA972990B (en)	1997-11-03
NO984740L (no)	1998-10-09
EP0892796A1 (en)	1999-01-27
PT892796E (pt)	2002-03-28
JP2001508400A (ja)	2001-06-26
GR3037006T3 (en)	2002-01-31
AU2072597A (en)	1997-11-07
ES2165586T3 (es)	2002-03-16
EP0892796B1 (en)	2001-10-24
KR20000005379A (en)	2000-01-25
ATE207483T1 (de)	2001-11-15
DE69707659D1 (de)	2001-11-29
DK0892796T3 (da)	2001-11-19
TW426678B (en)	2001-03-21
JP4109718B2 (ja)	2008-07-02
BR9708655A (pt)	1999-08-03
AR006606A1 (es)	1999-09-08
HUP9903473A2 (hu)	2000-05-28
CA2252039C (en)	2002-12-24
CN1215399A (zh)	1999-04-28
NO984740D0 (no)	1998-10-09

Publication	Publication Date	Title
GR3037006T3 (en)	2002-01-31	Isatin derivatives as acetylcholinesterase inhibitors and analgesics
HRP970249A2 (en)	1998-06-30	Indole derivatives useful in therapy
ZA9711376B (en)	1998-07-21	Indole or dihydroindole derivatives
PL331338A1 (en)	1999-07-05	Thiosulphonamidic metaloprotease inhibitors
HUP9903974A3 (en)	2001-12-28	Substituted pyridine derivatives as selective cyclooxigenase-2 inhibitors and use thereof
HUP9903560A3 (en)	2000-07-28	Quinoline and quinazoline derivatives
FI956074A0 (fi)	1995-12-18	Asetyylikolinesteraasin inhibiittoreina toimivia 1-asemasta substituoituja isatiini- ja oksindolijohdannaisia
IL130111A0 (en)	2000-06-01	6-phenylpyridyl-2-amine derivatives useful as nos inhibitors
GB9607729D0 (en)	1996-06-19	Quinazoline derivatives
PL329875A1 (en)	1999-04-12	Derivatives of carbolin
PL329195A1 (en)	1999-03-15	Derivatives of 6-phenylpyridol-2-amine
AP9801175A0 (en)	1998-01-31	Quinoline and quinoline compounds useful in therapy
HUP0001110A3 (en)	2002-04-29	3-pyridyl enantiomers and their use as analgesics
IL121299A0 (en)	1998-01-04	4-hydroxy-piperidine derivatives and their uses
PL331920A1 (en)	1999-08-16	Spirocyclic inhibitors of metaloproteases
PL331803A1 (en)	1999-08-02	Bidonoric metaloprotease inhibitors
EP0876157A4 (en)	2001-04-11	METHODS AND COMPOSITIONS FOR PASSIVE IMMUNOTHERAPY
PL341318A1 (en)	2001-04-09	Derivatives of indole useful in treating oesteoporosis
PL333323A1 (en)	1999-12-06	Derivatives of piperidine
IL120488A (en)	2000-07-16	Modifiers for water-setting inorganic compositions and modified water-setting inorganic compositions
SI0892796T1 (en)	2002-04-30	Isatin derivatives as acetylcholinesterase inhibitors and analgesics
GB9616563D0 (en)	1996-09-25	Compounds and methods
HU9700273D0 (en)	1997-03-28	Tetrahydroisoquinoline derivatives
EP0934345A4 (en)	1999-12-22	CONNECTIONS AND PROCEDURE
GB9617346D0 (en)	1996-10-02	Therapeutic methods and compositions for use therein