HUP9903473A3 - Isatin derivatives as acetylcholinesterase inhibitors and analgesics - Google Patents

Isatin derivatives as acetylcholinesterase inhibitors and analgesics

Info

Publication number: HUP9903473A3
Authority: HU; Hungary
Prior art keywords: analgesics; acetylcholinesterase inhibitors; isatin derivatives; isatin; derivatives
Prior art date: 1996-04-12

Application number

HU9903473A

Other languages

English (en)

Original Assignee

Hoechst Marion Roussel Inc Cin

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-12

Filing date

1997-03-07

Publication date

2000-09-28

1997-03-07 Application filed by Hoechst Marion Roussel Inc Cin filed Critical Hoechst Marion Roussel Inc Cin

2000-05-28 Publication of HUP9903473A2 publication Critical patent/HUP9903473A2/hu

2000-09-28 Publication of HUP9903473A3 publication Critical patent/HUP9903473A3/hu

Links

229940035676 analgesics Drugs 0.000 title 1
239000000730 antalgic agent Substances 0.000 title 1
239000000544 cholinesterase inhibitor Substances 0.000 title 1
JXDYKVIHCLTXOP-UHFFFAOYSA-N isatin Chemical class C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

HU9903473A 1996-04-12 1997-03-07 Isatin derivatives as acetylcholinesterase inhibitors and analgesics HUP9903473A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US63187096A	1996-04-12	1996-04-12

Publications (2)

Publication Number	Publication Date
HUP9903473A2 HUP9903473A2 (hu)	2000-05-28
HUP9903473A3 true HUP9903473A3 (en)	2000-09-28

Family

ID=24533114

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU9903473A HUP9903473A3 (en)	1996-04-12	1997-03-07	Isatin derivatives as acetylcholinesterase inhibitors and analgesics

Country Status (19)

Country	Link
EP (1)	EP0892796B1 (hu)
JP (1)	JP4109718B2 (hu)
KR (1)	KR20000005379A (hu)
CN (1)	CN1215399A (hu)
AR (1)	AR006606A1 (hu)
AT (1)	ATE207483T1 (hu)
BR (1)	BR9708655A (hu)
CA (1)	CA2252039C (hu)
DE (1)	DE69707659T2 (hu)
DK (1)	DK0892796T3 (hu)
ES (1)	ES2165586T3 (hu)
GR (1)	GR3037006T3 (hu)
HU (1)	HUP9903473A3 (hu)
IL (1)	IL126308A0 (hu)
NO (1)	NO984740L (hu)
PT (1)	PT892796E (hu)
TW (1)	TW426678B (hu)
WO (1)	WO1997038993A1 (hu)
ZA (1)	ZA972990B (hu)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6218383B1 (en)	1998-08-07	2001-04-17	Targacept, Inc.	Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
JP5379692B2 (ja)	2006-11-09	2013-12-25	プロビオドルグエージー	潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
EP2091948B1 (en)	2006-11-30	2012-04-18	Probiodrug AG	Novel inhibitors of glutaminyl cyclase
CA2679446C (en)	2007-03-01	2016-05-17	Probiodrug Ag	New use of glutaminyl cyclase inhibitors
US9656991B2 (en)	2007-04-18	2017-05-23	Probiodrug Ag	Inhibitors of glutaminyl cyclase
BR112012008346B1 (pt)	2009-09-11	2021-12-21	Vivoryon Therapeutics N.V.	Derivados heterocíclicos, seu processo de preparação, e composição farmacêutica
EP2533645B1 (en)	2010-02-09	2016-07-27	The Johns Hopkins University	Methods and compositions for improving cognitive function
JP2013519722A (ja)	2010-02-16	2013-05-30	ファイザー・インク	（ｒ）−４−（（４−（（４−（テトラヒドロフラン−３−イルオキシ）ベンゾ［ｄ］イソオキサゾール−３−イルオキシ）メチル）ピペリジン−１−イル）メチル）テトラヒドロ−２ｈ−ピラン−４−オール、５−ｈｔ４受容体の部分アゴニスト
WO2011107530A2 (en)	2010-03-03	2011-09-09	Probiodrug Ag	Novel inhibitors
DK2545047T3 (da)	2010-03-10	2014-07-28	Probiodrug Ag	Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5)
EP2560953B1 (en)	2010-04-21	2016-01-06	Probiodrug AG	Inhibitors of glutaminyl cyclase
WO2012123563A1 (en)	2011-03-16	2012-09-20	Probiodrug Ag	Benz imidazole derivatives as inhibitors of glutaminyl cyclase
JP6440625B2 (ja)	2012-11-14	2018-12-19	ザ・ジョンズ・ホプキンス・ユニバーシティー	精神分裂病を処置するための方法および組成物
CN104853755B (zh)	2012-12-13	2017-08-22	H.隆德贝克有限公司	包含沃替西汀和多奈哌齐的组合物
EP2968237A4 (en)	2013-03-15	2016-08-31	Univ Johns Hopkins	METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
EP2968220B1 (en)	2013-03-15	2021-05-05	Agenebio, Inc.	Methods and compositions for improving cognitive function
US10537552B2 (en)	2015-05-05	2020-01-21	Carafe Drug Innovation, Llc	Substituted 5-hydroxyoxindoles and their use as analgesics and fever reducers
MX384391B (es)	2015-05-22	2025-03-14	Agenebio Inc	Composiciones farmacéuticas de levetiracetam de liberación extendida.
PL3461819T3 (pl)	2017-09-29	2020-11-30	Probiodrug Ag	Inhibitory cyklazy glutaminylowej
EP4426287A4 (en) *	2021-11-05	2026-01-14	Univ California	ALPHA-2A ADRENERGIC RECEIVER MODULATORS AND THEIR USES

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4994472A (en) *	1989-08-02	1991-02-19	Hoechst-Roussel Pharmaceuticals Incorporated	1-(pyridinylamino)-2-pyrrolidinones as pain relievers
US5006537A (en) *	1989-08-02	1991-04-09	Hoechst-Roussel Pharmaceuticals, Inc.	1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
US5296488A (en) *	1989-08-02	1994-03-22	Hoechst-Roussel Pharmaceuticals Inc.	Method of using 2,3-dihydro-1-(pyridinylamino)-indoles as anticonvulsants and for the enhancement of memory

1997
- 1997-03-07 WO PCT/US1997/003598 patent/WO1997038993A1/en not_active Ceased
- 1997-03-07 EP EP97908942A patent/EP0892796B1/en not_active Expired - Lifetime
- 1997-03-07 ES ES97908942T patent/ES2165586T3/es not_active Expired - Lifetime
- 1997-03-07 HU HU9903473A patent/HUP9903473A3/hu unknown
- 1997-03-07 CA CA002252039A patent/CA2252039C/en not_active Expired - Fee Related
- 1997-03-07 DE DE69707659T patent/DE69707659T2/de not_active Expired - Fee Related
- 1997-03-07 AT AT97908942T patent/ATE207483T1/de not_active IP Right Cessation
- 1997-03-07 IL IL12630897A patent/IL126308A0/xx unknown
- 1997-03-07 JP JP53708497A patent/JP4109718B2/ja not_active Expired - Fee Related
- 1997-03-07 CN CN97193728A patent/CN1215399A/zh active Pending
- 1997-03-07 BR BR9708655A patent/BR9708655A/pt not_active Application Discontinuation
- 1997-03-07 DK DK97908942T patent/DK0892796T3/da active
- 1997-03-07 PT PT97908942T patent/PT892796E/pt unknown
- 1997-04-07 TW TW086104363A patent/TW426678B/zh active
- 1997-04-08 ZA ZA9702990A patent/ZA972990B/xx unknown
- 1997-04-11 AR ARP970101447A patent/AR006606A1/es unknown
1998
- 1998-10-09 NO NO984740A patent/NO984740L/no unknown
- 1998-10-12 KR KR1019980708105A patent/KR20000005379A/ko not_active Abandoned
2001
- 2001-10-25 GR GR20010401584T patent/GR3037006T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP4109718B2 (ja)	2008-07-02
AU2072597A (en)	1997-11-07
PT892796E (pt)	2002-03-28
NO984740D0 (no)	1998-10-09
NO984740L (no)	1998-10-09
CN1215399A (zh)	1999-04-28
DE69707659T2 (de)	2002-05-08
AU716997B2 (en)	2000-03-16
AR006606A1 (es)	1999-09-08
ES2165586T3 (es)	2002-03-16
EP0892796A1 (en)	1999-01-27
HUP9903473A2 (hu)	2000-05-28
ATE207483T1 (de)	2001-11-15
GR3037006T3 (en)	2002-01-31
CA2252039A1 (en)	1997-10-23
ZA972990B (en)	1997-11-03
DK0892796T3 (da)	2001-11-19
KR20000005379A (en)	2000-01-25
CA2252039C (en)	2002-12-24
TW426678B (en)	2001-03-21
BR9708655A (pt)	1999-08-03
DE69707659D1 (de)	2001-11-29
JP2001508400A (ja)	2001-06-26
IL126308A0 (en)	1999-05-09
WO1997038993A1 (en)	1997-10-23
EP0892796B1 (en)	2001-10-24

Publication	Publication Date	Title
IL126308A0 (en)	1999-05-09	Isatin derivatives as acetylcholinesterase inhibitors and analgesics
AP9700982A0 (en)	1997-07-31	Indole derivatives useful in therapy
ZA9711376B (en)	1998-07-21	Indole or dihydroindole derivatives
PL331338A1 (en)	1999-07-05	Thiosulphonamidic metaloprotease inhibitors
HUP9903974A3 (en)	2001-12-28	Substituted pyridine derivatives as selective cyclooxigenase-2 inhibitors and use thereof
FI956074A0 (fi)	1995-12-18	Asetyylikolinesteraasin inhibiittoreina toimivia 1-asemasta substituoituja isatiini- ja oksindolijohdannaisia
HUP0001848A3 (en)	2002-03-28	6-phenylpyridyl-2-amine derivatives useful as nos inhibitors
HUP9903560A3 (en)	2000-07-28	Quinoline and quinazoline derivatives
GB9607729D0 (en)	1996-06-19	Quinazoline derivatives
PL329875A1 (en)	1999-04-12	Derivatives of carbolin
PL329195A1 (en)	1999-03-15	Derivatives of 6-phenylpyridol-2-amine
AP9801175A0 (en)	1998-01-31	Quinoline and quinoline compounds useful in therapy
HUP0001110A3 (en)	2002-04-29	3-pyridyl enantiomers and their use as analgesics
PL331920A1 (en)	1999-08-16	Spirocyclic inhibitors of metaloproteases
PL331803A1 (en)	1999-08-02	Bidonoric metaloprotease inhibitors
ZA977326B (en)	1999-02-15	Tetrahydroquinoline derivatives
PL329351A1 (en)	1999-03-29	Piperidines and pyrolydines
EP0876157A4 (en)	2001-04-11	METHODS AND COMPOSITIONS FOR PASSIVE IMMUNOTHERAPY
PL341318A1 (en)	2001-04-09	Derivatives of indole useful in treating oesteoporosis
PL333323A1 (en)	1999-12-06	Derivatives of piperidine
IL120488A (en)	2000-07-16	Modifiers for water-setting inorganic compositions and modified water-setting inorganic compositions
SI0892796T1 (en)	2002-04-30	Isatin derivatives as acetylcholinesterase inhibitors and analgesics
GB9616563D0 (en)	1996-09-25	Compounds and methods
GB9417969D0 (en)	1994-10-26	Alkaloids and derivatives thereof
EP0934345A4 (en)	1999-12-22	CONNECTIONS AND PROCEDURE