NO984740L - Isatinderivater som acetylcholinesteraseinhibitorer og analgetiske midler - Google Patents

Isatinderivater som acetylcholinesteraseinhibitorer og analgetiske midler

Info

Publication number
NO984740L
NO984740L NO984740A NO984740A NO984740L NO 984740 L NO984740 L NO 984740L NO 984740 A NO984740 A NO 984740A NO 984740 A NO984740 A NO 984740A NO 984740 L NO984740 L NO 984740L
Authority
NO
Norway
Prior art keywords
analgesics
compounds
acetylcholinesterase inhibitors
isatin derivatives
isatin
Prior art date
Application number
NO984740A
Other languages
English (en)
Other versions
NO984740D0 (no
Inventor
Stephen James Shimshock
Abdul Ezaz Mutlib
Susan Marie Chesson
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of NO984740D0 publication Critical patent/NO984740D0/no
Publication of NO984740L publication Critical patent/NO984740L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Foreliggende søknad angår forbindelser av formel (I) (D hvori R, X og Y er som definert, hvilke forbindelser er anvendbare for behand- ling av hukommelsesdysfunksjon som er karakterisert ved redusert cholinerg funksjon, og for analgesi, farmasøyt- iske preparater inneholdende forbindel- sene og metoder for fremstilling og anvendelse av forbindelsene.
NO984740A 1996-04-12 1998-10-09 Isatinderivater som acetylcholinesteraseinhibitorer og analgetiske midler NO984740L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63187096A 1996-04-12 1996-04-12
PCT/US1997/003598 WO1997038993A1 (en) 1996-04-12 1997-03-07 Isatin derivatives as acetylcholinesterase inhibitors and analgesics

Publications (2)

Publication Number Publication Date
NO984740D0 NO984740D0 (no) 1998-10-09
NO984740L true NO984740L (no) 1998-10-09

Family

ID=24533114

Family Applications (1)

Application Number Title Priority Date Filing Date
NO984740A NO984740L (no) 1996-04-12 1998-10-09 Isatinderivater som acetylcholinesteraseinhibitorer og analgetiske midler

Country Status (19)

Country Link
EP (1) EP0892796B1 (no)
JP (1) JP4109718B2 (no)
KR (1) KR20000005379A (no)
CN (1) CN1215399A (no)
AR (1) AR006606A1 (no)
AT (1) ATE207483T1 (no)
BR (1) BR9708655A (no)
CA (1) CA2252039C (no)
DE (1) DE69707659T2 (no)
DK (1) DK0892796T3 (no)
ES (1) ES2165586T3 (no)
GR (1) GR3037006T3 (no)
HU (1) HUP9903473A3 (no)
IL (1) IL126308A0 (no)
NO (1) NO984740L (no)
PT (1) PT892796E (no)
TW (1) TW426678B (no)
WO (1) WO1997038993A1 (no)
ZA (1) ZA972990B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
US8278345B2 (en) 2006-11-09 2012-10-02 Probiodrug Ag Inhibitors of glutaminyl cyclase
JP5523107B2 (ja) 2006-11-30 2014-06-18 プロビオドルグ エージー グルタミニルシクラーゼの新規阻害剤
EP2481408A3 (en) 2007-03-01 2013-01-09 Probiodrug AG New use of glutaminyl cyclase inhibitors
WO2008128985A1 (en) 2007-04-18 2008-10-30 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
MX2012002993A (es) 2009-09-11 2012-04-19 Probiodrug Ag Derivados heterociclicos como inhibidores de ciclasa glutaminilo.
US20110212928A1 (en) 2010-02-09 2011-09-01 The Johns Hopkins University Methods and compositions for improving cognitive function
AU2011216950A1 (en) 2010-02-16 2012-08-23 Pfizer Inc. (R)-4-((4-((4-(tetrahydrofuran-3-yloxy) benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol, a partial agonist of 5-HT4 receptors
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
US8269019B2 (en) 2010-03-10 2012-09-18 Probiodrug Ag Inhibitors
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
ES2570167T3 (es) 2011-03-16 2016-05-17 Probiodrug Ag Derivados de benzimidazol como inhibidores de glutaminil ciclasa
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
MX362886B (es) 2012-12-13 2019-02-22 H Lundbeck As Composición sinérgica que comprende vortioxetina y donepezilo para incrementar los niveles de acetilcolina en el cerebro, y el uso de la misma en el tratamiento de una disfunción cognitiva.
EP2968220B1 (en) 2013-03-15 2021-05-05 Agenebio, Inc. Methods and compositions for improving cognitive function
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
US10537552B2 (en) 2015-05-05 2020-01-21 Carafe Drug Innovation, Llc Substituted 5-hydroxyoxindoles and their use as analgesics and fever reducers
NZ738682A (en) 2015-05-22 2022-01-28 Agenebio Inc Extended release pharmaceutical compositions of levetiracetam
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
AU2022380831A1 (en) * 2021-11-05 2024-06-06 Chinese University Of Hong Kong, Shenzhen Alpha-2a adrenergic receptor modulators and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4994472A (en) * 1989-08-02 1991-02-19 Hoechst-Roussel Pharmaceuticals Incorporated 1-(pyridinylamino)-2-pyrrolidinones as pain relievers
US5296488A (en) * 1989-08-02 1994-03-22 Hoechst-Roussel Pharmaceuticals Inc. Method of using 2,3-dihydro-1-(pyridinylamino)-indoles as anticonvulsants and for the enhancement of memory
US5006537A (en) * 1989-08-02 1991-04-09 Hoechst-Roussel Pharmaceuticals, Inc. 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones

Also Published As

Publication number Publication date
JP4109718B2 (ja) 2008-07-02
JP2001508400A (ja) 2001-06-26
GR3037006T3 (en) 2002-01-31
IL126308A0 (en) 1999-05-09
CA2252039C (en) 2002-12-24
DE69707659T2 (de) 2002-05-08
ATE207483T1 (de) 2001-11-15
ZA972990B (en) 1997-11-03
AR006606A1 (es) 1999-09-08
AU2072597A (en) 1997-11-07
NO984740D0 (no) 1998-10-09
PT892796E (pt) 2002-03-28
CN1215399A (zh) 1999-04-28
DE69707659D1 (de) 2001-11-29
EP0892796B1 (en) 2001-10-24
TW426678B (en) 2001-03-21
DK0892796T3 (da) 2001-11-19
KR20000005379A (en) 2000-01-25
HUP9903473A3 (en) 2000-09-28
AU716997B2 (en) 2000-03-16
ES2165586T3 (es) 2002-03-16
WO1997038993A1 (en) 1997-10-23
HUP9903473A2 (hu) 2000-05-28
EP0892796A1 (en) 1999-01-27
CA2252039A1 (en) 1997-10-23
BR9708655A (pt) 1999-08-03

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