DK0892796T3 - Isatinderivater som acetylcholinesteraseinhibitorer og analgetika - Google Patents

Isatinderivater som acetylcholinesteraseinhibitorer og analgetika

Info

Publication number
DK0892796T3
DK0892796T3 DK97908942T DK97908942T DK0892796T3 DK 0892796 T3 DK0892796 T3 DK 0892796T3 DK 97908942 T DK97908942 T DK 97908942T DK 97908942 T DK97908942 T DK 97908942T DK 0892796 T3 DK0892796 T3 DK 0892796T3
Authority
DK
Denmark
Prior art keywords
analgesics
acetylcholinesterase inhibitors
isatin derivatives
isatin
derivatives
Prior art date
Application number
DK97908942T
Other languages
English (en)
Inventor
Stephen J Shimshock
Abdul E Mutlib
Susan M Chesson
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of DK0892796T3 publication Critical patent/DK0892796T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DK97908942T 1996-04-12 1997-03-07 Isatinderivater som acetylcholinesteraseinhibitorer og analgetika DK0892796T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63187096A 1996-04-12 1996-04-12
PCT/US1997/003598 WO1997038993A1 (en) 1996-04-12 1997-03-07 Isatin derivatives as acetylcholinesterase inhibitors and analgesics

Publications (1)

Publication Number Publication Date
DK0892796T3 true DK0892796T3 (da) 2001-11-19

Family

ID=24533114

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97908942T DK0892796T3 (da) 1996-04-12 1997-03-07 Isatinderivater som acetylcholinesteraseinhibitorer og analgetika

Country Status (19)

Country Link
EP (1) EP0892796B1 (da)
JP (1) JP4109718B2 (da)
KR (1) KR20000005379A (da)
CN (1) CN1215399A (da)
AR (1) AR006606A1 (da)
AT (1) ATE207483T1 (da)
BR (1) BR9708655A (da)
CA (1) CA2252039C (da)
DE (1) DE69707659T2 (da)
DK (1) DK0892796T3 (da)
ES (1) ES2165586T3 (da)
GR (1) GR3037006T3 (da)
HU (1) HUP9903473A3 (da)
IL (1) IL126308A0 (da)
NO (1) NO984740D0 (da)
PT (1) PT892796E (da)
TW (1) TW426678B (da)
WO (1) WO1997038993A1 (da)
ZA (1) ZA972990B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
US8278345B2 (en) 2006-11-09 2012-10-02 Probiodrug Ag Inhibitors of glutaminyl cyclase
ATE554085T1 (de) 2006-11-30 2012-05-15 Probiodrug Ag Neue inhibitoren von glutaminylcyclase
JP5930573B2 (ja) 2007-03-01 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤の新規使用
EP2142514B1 (en) 2007-04-18 2014-12-24 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
JP5934645B2 (ja) 2009-09-11 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
AU2011215870B2 (en) 2010-02-09 2016-01-28 The Johns Hopkins University Methods and compositions for improving cognitive function
CA2788656A1 (en) 2010-02-16 2011-08-25 Pfizer Inc. (r)-4-((4-((4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2h-pyran-4-ol, a partial agonist of 5-ht4 receptors
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
NZ602312A (en) 2010-03-10 2014-02-28 Probiodrug Ag Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
PL2931276T3 (pl) 2012-12-13 2018-06-29 H. Lundbeck A/S Kompozycje zawierające wortioksetynę i donepezil
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
JP6433482B2 (ja) 2013-03-15 2018-12-05 エージンバイオ， インコーポレイテッド 認知機能を改善するための方法および組成物
US10537552B2 (en) 2015-05-05 2020-01-21 Carafe Drug Innovation, Llc Substituted 5-hydroxyoxindoles and their use as analgesics and fever reducers
WO2016191288A1 (en) 2015-05-22 2016-12-01 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa
WO2023081800A1 (en) * 2021-11-05 2023-05-11 The Regents Of The University Of California Alpha-2a adrenergic receptor modulators and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5296488A (en) * 1989-08-02 1994-03-22 Hoechst-Roussel Pharmaceuticals Inc. Method of using 2,3-dihydro-1-(pyridinylamino)-indoles as anticonvulsants and for the enhancement of memory
US5006537A (en) * 1989-08-02 1991-04-09 Hoechst-Roussel Pharmaceuticals, Inc. 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
US4994472A (en) * 1989-08-02 1991-02-19 Hoechst-Roussel Pharmaceuticals Incorporated 1-(pyridinylamino)-2-pyrrolidinones as pain relievers

Also Published As

Publication number Publication date
WO1997038993A1 (en) 1997-10-23
DE69707659T2 (de) 2002-05-08
CA2252039A1 (en) 1997-10-23
IL126308A0 (en) 1999-05-09
AU716997B2 (en) 2000-03-16
ZA972990B (en) 1997-11-03
NO984740L (no) 1998-10-09
EP0892796A1 (en) 1999-01-27
HUP9903473A3 (en) 2000-09-28
PT892796E (pt) 2002-03-28
JP2001508400A (ja) 2001-06-26
GR3037006T3 (en) 2002-01-31
AU2072597A (en) 1997-11-07
ES2165586T3 (es) 2002-03-16
EP0892796B1 (en) 2001-10-24
KR20000005379A (en) 2000-01-25
ATE207483T1 (de) 2001-11-15
DE69707659D1 (de) 2001-11-29
TW426678B (en) 2001-03-21
JP4109718B2 (ja) 2008-07-02
BR9708655A (pt) 1999-08-03
AR006606A1 (es) 1999-09-08
HUP9903473A2 (hu) 2000-05-28
CA2252039C (en) 2002-12-24
CN1215399A (zh) 1999-04-28
NO984740D0 (no) 1998-10-09

Similar Documents

Publication Publication Date Title
DK0892796T3 (da) Isatinderivater som acetylcholinesteraseinhibitorer og analgetika
NO955074D0 (no) 1-substituerte istain- og oksindolderivater som inhibitorer til acetylkolinesterase
NO992725D0 (no) 6-Fenylpyridyl-2-amin-derivater anvendelige som NOS-inhibitorer
NO990965D0 (no) Terapeutiske fremgangsmÕter og blandinger som inneholder isoflavoner
NO20003096D0 (no) Sammensetninger og fremgangsmÕter for behandling av ADD
DK1454907T3 (da) Quninazolin og pyridopyrmidin-derivativer
NO991922L (no) Heteroarylsuccinamider og deres anvendelse som metalloproteinaseinhibitorer
NO993217D0 (no) Br°nntetningssammensetninger og fremgangsmÕter
NO985977D0 (no) Spiro-piperidinderivater og deres anvendelse som terapeutiske midler
NO992512L (no) Aminoguanidiner og alkoksyguanidiner som proteaseinhibitorer
DK0900225T3 (da) Alkyl-4-silyl-phenoler og estere deraf som antiatherosklerosemidler
PT956294E (pt) Inibidores da trombina
NO980718D0 (no) Bicykliske 4-aralkylaminopyrimidinderivater og tyrosinkinaseinhibitorer
FI955795A7 (fi) Aromaattisia asetyylikoliiniesteraasin inhibiittoreita
PT934280E (pt) Derivados 2-cianoiminoimidazolo inibidores da pde iv
PT948483E (pt) Inibidores da farnesil-transferase
FI953851L (fi) Silybidut asetyylikoliiniesteraase-inhibiittorit
NO985621D0 (no) FremgangsmÕte og system for boring under anvendelse av skum - skumsammensetning
FI960730A7 (fi) Indolijohdannaiset 5alfa-reduktaasi-1-inhibiittoreina
NO307727B1 (no) Fremgangsmåte og system for seriefeilvern
DK1042286T3 (da) Gamme-glutamyl- og beta-aspartyl-holdige immunmodulerende forbindelser og tilhørense fremgangsmåder
DE69720957T2 (de) Ace-hemmer
SI0892796T1 (en) Isatin derivatives as acetylcholinesterase inhibitors and analgesics
DE59708546D1 (de) Löschgerät
ATE226465T1 (de) Löschgerät