ATE207483T1 - Isatinderivate als acetylcholinesterase- inhibitoren und analgetika - Google Patents

Isatinderivate als acetylcholinesterase- inhibitoren und analgetika

Info

Publication number: ATE207483T1
Authority: AT; Austria
Prior art keywords: analgesics; acetylcholinesterase inhibitors; isatin derivatives; isatin; derivatives
Prior art date: 1996-04-12

Application number

AT97908942T

Other languages

English (en)

Inventor

Stephen J Shimshock

Abdul E Mutlib

Susan M Chesson

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-12

Filing date

1997-03-07

Publication date

2001-11-15

1997-03-07 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2001-11-15 Application granted granted Critical

2001-11-15 Publication of ATE207483T1 publication Critical patent/ATE207483T1/de

Links

229940035676 analgesics Drugs 0.000 title 1
239000000730 antalgic agent Substances 0.000 title 1
239000000544 cholinesterase inhibitor Substances 0.000 title 1
JXDYKVIHCLTXOP-UHFFFAOYSA-N isatin Chemical class C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

AT97908942T 1996-04-12 1997-03-07 Isatinderivate als acetylcholinesterase- inhibitoren und analgetika ATE207483T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US63187096A	1996-04-12	1996-04-12
PCT/US1997/003598 WO1997038993A1 (en)	1996-04-12	1997-03-07	Isatin derivatives as acetylcholinesterase inhibitors and analgesics

Publications (1)

Publication Number	Publication Date
ATE207483T1 true ATE207483T1 (de)	2001-11-15

Family

ID=24533114

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97908942T ATE207483T1 (de)	1996-04-12	1997-03-07	Isatinderivate als acetylcholinesterase- inhibitoren und analgetika

Country Status (19)

Country	Link
EP (1)	EP0892796B1 (de)
JP (1)	JP4109718B2 (de)
KR (1)	KR20000005379A (de)
CN (1)	CN1215399A (de)
AR (1)	AR006606A1 (de)
AT (1)	ATE207483T1 (de)
BR (1)	BR9708655A (de)
CA (1)	CA2252039C (de)
DE (1)	DE69707659T2 (de)
DK (1)	DK0892796T3 (de)
ES (1)	ES2165586T3 (de)
GR (1)	GR3037006T3 (de)
HU (1)	HUP9903473A3 (de)
IL (1)	IL126308A0 (de)
NO (1)	NO984740L (de)
PT (1)	PT892796E (de)
TW (1)	TW426678B (de)
WO (1)	WO1997038993A1 (de)
ZA (1)	ZA972990B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6218383B1 (en)	1998-08-07	2001-04-17	Targacept, Inc.	Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
JP5379692B2 (ja)	2006-11-09	2013-12-25	プロビオドルグエージー	潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
EP2091948B1 (de)	2006-11-30	2012-04-18	Probiodrug AG	Neue inhibitoren von glutaminylcyclase
CA2679446C (en)	2007-03-01	2016-05-17	Probiodrug Ag	New use of glutaminyl cyclase inhibitors
US9656991B2 (en)	2007-04-18	2017-05-23	Probiodrug Ag	Inhibitors of glutaminyl cyclase
BR112012008346B1 (pt)	2009-09-11	2021-12-21	Vivoryon Therapeutics N.V.	Derivados heterocíclicos, seu processo de preparação, e composição farmacêutica
EP2533645B1 (de)	2010-02-09	2016-07-27	The Johns Hopkins University	Verfahren und zusammensetzungen zur verbesserung von kognitiven funktionen
JP2013519722A (ja)	2010-02-16	2013-05-30	ファイザー・インク	（ｒ）−４−（（４−（（４−（テトラヒドロフラン−３−イルオキシ）ベンゾ［ｄ］イソオキサゾール−３−イルオキシ）メチル）ピペリジン−１−イル）メチル）テトラヒドロ−２ｈ−ピラン−４−オール、５−ｈｔ４受容体の部分アゴニスト
WO2011107530A2 (en)	2010-03-03	2011-09-09	Probiodrug Ag	Novel inhibitors
DK2545047T3 (da)	2010-03-10	2014-07-28	Probiodrug Ag	Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5)
EP2560953B1 (de)	2010-04-21	2016-01-06	Probiodrug AG	Hemmer der glutaminylzyklase
WO2012123563A1 (en)	2011-03-16	2012-09-20	Probiodrug Ag	Benz imidazole derivatives as inhibitors of glutaminyl cyclase
JP6440625B2 (ja)	2012-11-14	2018-12-19	ザ・ジョンズ・ホプキンス・ユニバーシティー	精神分裂病を処置するための方法および組成物
CN104853755B (zh)	2012-12-13	2017-08-22	H.隆德贝克有限公司	包含沃替西汀和多奈哌齐的组合物
EP2968237A4 (de)	2013-03-15	2016-08-31	Univ Johns Hopkins	Verfahren und zusammensetzungen zur verbesserung der kognitiven funktion
EP2968220B1 (de)	2013-03-15	2021-05-05	Agenebio, Inc.	Verfahren und zusammensetzungen zur verbesserung von kognitiven funktionen
US10537552B2 (en)	2015-05-05	2020-01-21	Carafe Drug Innovation, Llc	Substituted 5-hydroxyoxindoles and their use as analgesics and fever reducers
MX384391B (es)	2015-05-22	2025-03-14	Agenebio Inc	Composiciones farmacéuticas de levetiracetam de liberación extendida.
PL3461819T3 (pl)	2017-09-29	2020-11-30	Probiodrug Ag	Inhibitory cyklazy glutaminylowej
EP4426287A4 (de) *	2021-11-05	2026-01-14	Univ California	Modulatoren des alpha-2a-adrenergen rezeptors und verwendungen davon

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4994472A (en) *	1989-08-02	1991-02-19	Hoechst-Roussel Pharmaceuticals Incorporated	1-(pyridinylamino)-2-pyrrolidinones as pain relievers
US5006537A (en) *	1989-08-02	1991-04-09	Hoechst-Roussel Pharmaceuticals, Inc.	1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
US5296488A (en) *	1989-08-02	1994-03-22	Hoechst-Roussel Pharmaceuticals Inc.	Method of using 2,3-dihydro-1-(pyridinylamino)-indoles as anticonvulsants and for the enhancement of memory

1997
- 1997-03-07 WO PCT/US1997/003598 patent/WO1997038993A1/en not_active Ceased
- 1997-03-07 EP EP97908942A patent/EP0892796B1/de not_active Expired - Lifetime
- 1997-03-07 ES ES97908942T patent/ES2165586T3/es not_active Expired - Lifetime
- 1997-03-07 HU HU9903473A patent/HUP9903473A3/hu unknown
- 1997-03-07 CA CA002252039A patent/CA2252039C/en not_active Expired - Fee Related
- 1997-03-07 DE DE69707659T patent/DE69707659T2/de not_active Expired - Fee Related
- 1997-03-07 AT AT97908942T patent/ATE207483T1/de not_active IP Right Cessation
- 1997-03-07 IL IL12630897A patent/IL126308A0/xx unknown
- 1997-03-07 JP JP53708497A patent/JP4109718B2/ja not_active Expired - Fee Related
- 1997-03-07 CN CN97193728A patent/CN1215399A/zh active Pending
- 1997-03-07 BR BR9708655A patent/BR9708655A/pt not_active Application Discontinuation
- 1997-03-07 DK DK97908942T patent/DK0892796T3/da active
- 1997-03-07 PT PT97908942T patent/PT892796E/pt unknown
- 1997-04-07 TW TW086104363A patent/TW426678B/zh active
- 1997-04-08 ZA ZA9702990A patent/ZA972990B/xx unknown
- 1997-04-11 AR ARP970101447A patent/AR006606A1/es unknown
1998
- 1998-10-09 NO NO984740A patent/NO984740L/no unknown
- 1998-10-12 KR KR1019980708105A patent/KR20000005379A/ko not_active Abandoned
2001
- 2001-10-25 GR GR20010401584T patent/GR3037006T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP4109718B2 (ja)	2008-07-02
AU2072597A (en)	1997-11-07
PT892796E (pt)	2002-03-28
NO984740D0 (no)	1998-10-09
NO984740L (no)	1998-10-09
CN1215399A (zh)	1999-04-28
DE69707659T2 (de)	2002-05-08
AU716997B2 (en)	2000-03-16
AR006606A1 (es)	1999-09-08
HUP9903473A3 (en)	2000-09-28
ES2165586T3 (es)	2002-03-16
EP0892796A1 (de)	1999-01-27
HUP9903473A2 (hu)	2000-05-28
GR3037006T3 (en)	2002-01-31
CA2252039A1 (en)	1997-10-23
ZA972990B (en)	1997-11-03
DK0892796T3 (da)	2001-11-19
KR20000005379A (en)	2000-01-25
CA2252039C (en)	2002-12-24
TW426678B (en)	2001-03-21
BR9708655A (pt)	1999-08-03
DE69707659D1 (de)	2001-11-29
JP2001508400A (ja)	2001-06-26
IL126308A0 (en)	1999-05-09
WO1997038993A1 (en)	1997-10-23
EP0892796B1 (de)	2001-10-24

Legal Events

Date	Code	Title	Description
2002-04-15	UEP	Publication of translation of european patent specification
2004-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE207483T1 (de)	2001-11-15	Isatinderivate als acetylcholinesterase- inhibitoren und analgetika
FI956074A0 (fi)	1995-12-18	Asetyylikolinesteraasin inhibiittoreina toimivia 1-asemasta substituoituja isatiini- ja oksindolijohdannaisia
DE69723711D1 (de)	2003-08-28	Aralkyl und aralkyliden heterocyclische lactame und imide
DE69731161D1 (de)	2004-11-18	Kontroller und erweiterungseinheit dafür
DE69725465D1 (de)	2003-11-13	6-phenylpyridyl-2-amin-derivate verwendbar als nos-inhibitoren
DE69732084D1 (de)	2005-02-03	Pulsladeverfahren und ladegerät
HUP9901155A3 (en)	2003-04-28	Quinazoline derivatives as vegf inhibitors
DE69723446D1 (de)	2003-08-14	Oxindole derivate
ATE449849T1 (de)	2009-12-15	Ob rezeptor-variante und liganden
BR9612263A (pt)	1999-07-13	Compostos quinolina e qinazolina úteis em terapia
BR9710606A (pt)	1999-08-17	Barreira acÚstica e conjunto de barreira acÚstica
DE69903143D1 (de)	2002-10-31	Chromanon und thiochromanon derivate
NO992104D0 (no)	1999-04-30	Isokinoloner
ATE240943T1 (de)	2003-06-15	Isochinolin derivate als urokinase inhibitoren
BR9708677A (pt)	1999-08-03	Piperidinas e pirrolidinas
DE50001834D1 (de)	2003-05-28	Vliesanlage und Betriebsverfahren
DE69708629D1 (de)	2002-01-10	Alkyloxyamin-substituierte fluorenonderivate und ihre verwendung als proteinkinase-c-inhibitoren
DE59914173D1 (de)	2007-03-15	Zündanlage und zündsteuerverfahren
DE69918625D1 (de)	2004-08-19	Wiedergabegerät und Wiedergabeverfahren
SG71062A1 (en)	2000-03-21	4-Hydroxy piperidine derivatives
ATE228372T1 (de)	2002-12-15	Hcg und derivate als matrixmetalloprotease- inhibitoren
DK0912553T3 (da)	2002-04-22	Benzo[g]quinolin-derivater
DE69715979D1 (de)	2002-11-07	Chinolinderivate und ihre Anwendung
SI0892796T1 (en)	2002-04-30	Isatin derivatives as acetylcholinesterase inhibitors and analgesics
ATA18796A (de)	1999-07-15	Sicherheitshaus