ID22763A - Komposisi penstabil tibolon - Google Patents

Komposisi penstabil tibolon

Info

Publication number: ID22763A
Authority: ID; Indonesia
Prior art keywords: tibolon; stabilizer composition; dosage unit; tibolone; contained
Prior art date: 1997-04-22

Application number

IDW991204A

Other languages

English (en)

Indonesian (id)

Inventor

Pieter Haan De

Adrianus Cornelis Petru Rovers

Theodora Antonia Maria La Hurk

Jocorminus Antonius M Zwinkels

Ryoichi Morita

Original Assignee

Akzo Nobel Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-22

Filing date

1998-04-20

Publication date

1999-12-09

1998-04-20 Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv

1999-12-09 Publication of ID22763A publication Critical patent/ID22763A/id

Links

239000003381 stabilizer Substances 0.000 title 1
239000003937 drug carrier Substances 0.000 abstract 1
WZDGZWOAQTVYBX-XOINTXKNSA-N tibolone Chemical compound C([C@@H]12)C[C@]3(C)[C@@](C#C)(O)CC[C@H]3[C@@H]1[C@H](C)CC1=C2CCC(=O)C1 WZDGZWOAQTVYBX-XOINTXKNSA-N 0.000 abstract 1
229960001023 tibolone Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IDW991204A 1997-04-22 1998-04-20 Komposisi penstabil tibolon ID22763A (id)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP97201180		1997-04-22

Publications (1)

Publication Number	Publication Date
ID22763A true ID22763A (id)	1999-12-09

Family

ID=8228228

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IDW991204A ID22763A (id)	1997-04-22	1998-04-20	Komposisi penstabil tibolon

Country Status (25)

Country	Link
US (6)	US6399594B2 (fr)
EP (1)	EP0975348B1 (fr)
JP (1)	JPH10316573A (fr)
KR (1)	KR100580855B1 (fr)
CN (2)	CN1146424C (fr)
AR (1)	AR012480A1 (fr)
AT (1)	ATE281836T1 (fr)
AU (1)	AU742037B2 (fr)
BR (1)	BR9809268A (fr)
CA (1)	CA2288070A1 (fr)
DE (1)	DE69827484T2 (fr)
DK (1)	DK0975348T3 (fr)
ES (1)	ES2232949T3 (fr)
HU (1)	HUP0001780A3 (fr)
ID (1)	ID22763A (fr)
IL (1)	IL123984A (fr)
NO (1)	NO995127D0 (fr)
NZ (1)	NZ338028A (fr)
PL (1)	PL190227B1 (fr)
PT (1)	PT975348E (fr)
RU (1)	RU2207133C2 (fr)
TR (1)	TR199902530T2 (fr)
TW (1)	TW570798B (fr)
WO (1)	WO1998047517A1 (fr)
ZA (1)	ZA983169B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CZ298703B6 (cs) *	1998-10-16	2007-12-27	N.V. Organon	Vysoce cistý (7alfa, 17alfa)-17-hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn-3-on se zvýšenou stabilitou
US7763276B1 (en) *	1999-02-26	2010-07-27	Shionogi & Co., Ltd.	Chewable soft capsules having improved administration properties and process for producing the same
US20040229854A1 (en) *	2000-11-28	2004-11-18	Pieter Haan De	Immediate release dosage form for HRT
US20070098784A1 (en)	2001-09-28	2007-05-03	Nutraceutix, Inc.	Delivery system for biological component
EP1429802B1 (fr) *	2001-09-28	2012-11-07	TNTGamble, Inc.	Systeme de distribution de composant biologique
GB0125061D0 (en) *	2001-10-18	2001-12-12	Norton Healthcare Ltd	Pharmaceutical composition
TW200418525A (en) *	2002-11-20	2004-10-01	Akzo Nobel Nv	Coated pharmaceutical tablets containing Tibolone
CN1324041C (zh) *	2003-04-01	2007-07-04	上海迪赛诺医药科技开发有限公司	替勃龙晶型i的制备方法
CN100434133C (zh) *	2003-04-29	2008-11-19	欧加农股份有限公司	反溶剂凝固方法
MXPA05000824A (es) *	2003-05-23	2005-04-28	Akzo Nobel Nv	Forma de dosis farmaceutica de liberacion inmediata que contiene tibolona polimorfa.
WO2005105278A2 (fr) *	2004-05-05	2005-11-10	Akzo Nobel N.V.	Procede de solidification d'emulsion antisolvante
WO2005117899A1 (fr) *	2004-06-02	2005-12-15	Cipla Limited	Composition pharmaceutique comprenant de la tibolone et son procede de production
WO2005120517A1 (fr) *	2004-06-07	2005-12-22	Strides Arcolab Limited	Preparation de suspension liquide stable comprenant des steroides synthetiques et leur procede de production
CZ300465B6 (cs) *	2007-07-25	2009-05-27	Zentiva, A. S.	Zpusob výroby komprimované farmaceutické formulace s obsahem tibolonu
CN102085193B (zh) *	2009-12-08	2013-11-06	北京以岭生物工程技术有限公司	一种替勃龙口腔崩解片及其制备方法
CN104345098B (zh) *	2013-08-05	2016-04-13	华润紫竹药业有限公司	一种测定替勃龙片剂中抗氧剂含量的方法
HUE055164T2 (hu)	2016-05-04	2021-11-29	Novalon S A	Cukoralkoholok alkalmazása Tobolon tartalmú készítményekben

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4701450A (en) *	1984-03-21	1987-10-20	Akzo N.V.	Steroids for use as immunomodulators
CH676470A5 (fr) *	1988-02-03	1991-01-31	Nestle Sa
IE63051B1 (en) *	1989-03-18	1995-03-22	Akzo Nv	Pharmaceutical composition which contains a pharmaceutically suitable carrier and the compound having the structure (7alpha, 17alpha)-17-Hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn- 3-one
EP0613687B1 (fr)	1993-03-05	1999-06-02	Akzo Nobel N.V.	Utilisation des dérivés de pregnane pour le traitement des tumeurs
US5882681A (en) *	1993-09-03	1999-03-16	Smithkline Beecham Corporation	Stabilized tablet formulation
CA2159419C (fr) *	1994-10-17	2006-07-04	Pieter De Haan	Composition pharmaceutique solide renfermant un excipient pouvant fixer l'eau

1998
- 1998-04-07 IL IL12398498A patent/IL123984A/en active IP Right Grant
- 1998-04-15 ZA ZA983169A patent/ZA983169B/xx unknown
- 1998-04-20 TR TR1999/02530T patent/TR199902530T2/xx unknown
- 1998-04-20 HU HU0001780A patent/HUP0001780A3/hu unknown
- 1998-04-20 DE DE69827484T patent/DE69827484T2/de not_active Expired - Fee Related
- 1998-04-20 PL PL98336658A patent/PL190227B1/pl not_active IP Right Cessation
- 1998-04-20 WO PCT/EP1998/002361 patent/WO1998047517A1/fr not_active Ceased
- 1998-04-20 CN CNB988044579A patent/CN1146424C/zh not_active Expired - Fee Related
- 1998-04-20 CN CNA2003101026335A patent/CN1494908A/zh active Pending
- 1998-04-20 DK DK98928214T patent/DK0975348T3/da active
- 1998-04-20 NZ NZ338028A patent/NZ338028A/en unknown
- 1998-04-20 US US09/403,139 patent/US6399594B2/en not_active Expired - Fee Related
- 1998-04-20 CA CA002288070A patent/CA2288070A1/fr not_active Abandoned
- 1998-04-20 KR KR1019997009726A patent/KR100580855B1/ko not_active Expired - Fee Related
- 1998-04-20 RU RU99121407/14A patent/RU2207133C2/ru not_active IP Right Cessation
- 1998-04-20 AT AT98928214T patent/ATE281836T1/de not_active IP Right Cessation
- 1998-04-20 BR BR9809268-5A patent/BR9809268A/pt not_active Application Discontinuation
- 1998-04-20 PT PT98928214T patent/PT975348E/pt unknown
- 1998-04-20 EP EP98928214A patent/EP0975348B1/fr not_active Expired - Lifetime
- 1998-04-20 AU AU80146/98A patent/AU742037B2/en not_active Ceased
- 1998-04-20 ID IDW991204A patent/ID22763A/id unknown
- 1998-04-20 ES ES98928214T patent/ES2232949T3/es not_active Expired - Lifetime
- 1998-04-21 AR ARP980101819A patent/AR012480A1/es not_active Application Discontinuation
- 1998-04-22 JP JP10112312A patent/JPH10316573A/ja active Pending
- 1998-05-11 TW TW087107211A patent/TW570798B/zh not_active IP Right Cessation
1999
- 1999-10-21 NO NO995127A patent/NO995127D0/no unknown
2002
- 2002-04-08 US US10/117,899 patent/US6514958B1/en not_active Expired - Fee Related
- 2002-11-25 US US10/303,494 patent/US20030119801A1/en not_active Abandoned
2004
- 2004-01-08 US US10/754,685 patent/US20040142030A1/en not_active Abandoned
- 2004-01-08 US US10/754,733 patent/US20040142031A1/en not_active Abandoned
- 2004-01-08 US US10/754,732 patent/US20040142028A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP0975348B1 (fr)	2004-11-10
DE69827484T2 (de)	2005-03-17
AR012480A1 (es)	2000-10-18
RU2207133C2 (ru)	2003-06-27
KR20010020163A (ko)	2001-03-15
US20040142031A1 (en)	2004-07-22
PL190227B1 (pl)	2005-11-30
ATE281836T1 (de)	2004-11-15
ZA983169B (en)	1998-10-20
CN1146424C (zh)	2004-04-21
CN1253503A (zh)	2000-05-17
ES2232949T3 (es)	2005-06-01
US20030119801A1 (en)	2003-06-26
KR100580855B1 (ko)	2006-05-17
DK0975348T3 (da)	2005-03-07
IL123984A (en)	2004-09-27
DE69827484D1 (de)	2004-12-16
US6514958B1 (en)	2003-02-04
BR9809268A (pt)	2000-06-27
NZ338028A (en)	2001-10-26
US20040142030A1 (en)	2004-07-22
HK1023508A1 (en)	2000-09-15
CA2288070A1 (fr)	1998-10-29
CN1494908A (zh)	2004-05-12
PT975348E (pt)	2005-01-31
JPH10316573A (ja)	1998-12-02
TR199902530T2 (xx)	2000-05-22
HUP0001780A2 (hu)	2000-12-28
NO995127L (no)	1999-10-21
HUP0001780A3 (en)	2001-02-28
AU742037B2 (en)	2001-12-13
WO1998047517A1 (fr)	1998-10-29
US6399594B2 (en)	2002-06-04
US20010005513A1 (en)	2001-06-28
TW570798B (en)	2004-01-11
EP0975348A1 (fr)	2000-02-02
AU8014698A (en)	1998-11-13
PL336658A1 (en)	2000-07-03
NO995127D0 (no)	1999-10-21
US20040142028A1 (en)	2004-07-22

Publication	Publication Date	Title
ID22763A (id)	1999-12-09	Komposisi penstabil tibolon
SE9700135D0 (sv)	1997-01-20	New formulation
DE69940557D1 (de)	2009-04-23	Ein hydrokolloid und einen celluloseether enthaltende tablette mit verzögerter freisetzung
MY118371A (en)	2004-10-30	Tetrahydrolipstatin containing compositions
ATE240344T1 (de)	2003-05-15	Nor-pregnane zur induzierung hypothalamischer effekte
FI964583L (fi)	1996-11-15	Tokoferolikoostumuksia biologisesti aktiivisten aineiden antamiseksi
FI973518A7 (fi)	1997-08-27	Piperidinoalkanoliyhdistettä tai sen farmaseuttisesti hyväksyttävää suolaa sisltävä farmaseuttinen koostumus kiinteässä yksikköannosmuodossa
BR9810495A (pt)	2000-09-12	Composição farmacêutica
ATE329608T1 (de)	2006-07-15	Formulierungen von copolymer 1 (glatirameracetat) zur oralen, nasalen und pulmonalen verabreichung
ATE165971T1 (de)	1998-05-15	Ein definiertes lipidsystem enthaltende pharmazeutische zusammensetzung
ATE202931T1 (de)	2001-07-15	Taxanderivate enthaltende arzneizubereitungen
IL101056A (en)	1997-03-18	Composition for nasal treatment
FI870457A0 (fi)	1987-02-03	Farmaceutiska preparatformer foer stabilisering av interferon- .
IE891414L (en)	1989-11-04	Pharmaceutical compositions
PL348202A1 (en)	2002-05-06	Pharmaceutically active composition and dispensing device
SE9403389D0 (sv)	1994-10-06	Pharmaceutical composition containing derivattves of sex hormones
BG94934A (bg)	1993-12-24	Твърди лекарствени форми за орално приложение,съдържащи ифосфамид като активно вещество
MXPA02006034A (es)	2004-08-23	Formas de dosis mucosaloral de apomorfina.
GB2258397A (en)	1993-02-10	Pharmaceutical compositions containing amethocaine
BG102638A (bg)	1999-07-30	Таблети с високо съдържание на фамцикловир
EP0761209A3 (fr)	1998-02-04	Formulations de la ranitidine à libération commandée
ATE224716T1 (de)	2002-10-15	Pharmazeutische zusammensetzungen von cinchonin dihydrochlorid
NZ241309A (en)	1993-08-26	Heterocyclic amido prostaglandin analogues, preparation and pharmaceutical compositions thereof
KR970058720A (ko)	1997-08-12	향균 및 항진균 활성을 갖는 펩타이드
ITRM910038A1 (it)	1992-07-18	Composizioni farmaceutiche aventi come principio attivo calcitonina da somministrarsi per via intranasale.