ID22984A - Proses epoksidasi selektif untuk pembuatan senyawa farmasi - Google Patents

Proses epoksidasi selektif untuk pembuatan senyawa farmasi

Info

Publication number
ID22984A
ID22984A IDW990901A ID990901A ID22984A ID 22984 A ID22984 A ID 22984A ID W990901 A IDW990901 A ID W990901A ID 990901 A ID990901 A ID 990901A ID 22984 A ID22984 A ID 22984A
Authority
ID
Indonesia
Prior art keywords
pharmaceutical compounds
epoxidation process
making pharmaceutical
selective epoxidation
selective
Prior art date
Application number
IDW990901A
Other languages
English (en)
Indonesian (id)
Inventor
Vinod Francis Patel
David Warren Hoard
Eric David Moher
Bryan Hurst Norman
Original Assignee
Eli Lilly And Company Cs
Univ Hawaii
Univ Wayne State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company Cs, Univ Hawaii, Univ Wayne State filed Critical Eli Lilly And Company Cs
Publication of ID22984A publication Critical patent/ID22984A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/46—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by amide or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
IDW990901A 1997-02-26 1998-02-25 Proses epoksidasi selektif untuk pembuatan senyawa farmasi ID22984A (id)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3911497P 1997-02-26 1997-02-26
US3911697P 1997-02-26 1997-02-26

Publications (1)

Publication Number Publication Date
ID22984A true ID22984A (id) 1999-12-23

Family

ID=26715826

Family Applications (2)

Application Number Title Priority Date Filing Date
IDW990901A ID22984A (id) 1997-02-26 1998-02-25 Proses epoksidasi selektif untuk pembuatan senyawa farmasi
IDW990900D ID24527A (id) 1997-02-26 1998-02-25 Proses pembuatan senyawa-senyawa farmasi

Family Applications After (1)

Application Number Title Priority Date Filing Date
IDW990900D ID24527A (id) 1997-02-26 1998-02-25 Proses pembuatan senyawa-senyawa farmasi

Country Status (17)

Country Link
US (1) US6143909A (de)
EP (2) EP0861838A3 (de)
JP (2) JP2002513403A (de)
KR (2) KR20000075623A (de)
CN (2) CN1255121A (de)
AU (2) AU738999B2 (de)
BR (2) BR9811252A (de)
CA (2) CA2281108A1 (de)
CZ (1) CZ9902998A3 (de)
EA (2) EA002547B1 (de)
ID (2) ID22984A (de)
IL (2) IL131162A0 (de)
NO (2) NO994049D0 (de)
NZ (1) NZ336918A (de)
PL (2) PL335478A1 (de)
TR (2) TR199902064T2 (de)
WO (2) WO1998038158A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4233997A (en) * 1996-08-30 1998-03-19 Eli Lilly And Company Process for preparing pharmaceutical compounds
WO1998009974A1 (en) * 1996-09-06 1998-03-12 Eli Lilly And Company Process and novel intermediates
JP2002527509A (ja) * 1998-10-16 2002-08-27 イーライ・リリー・アンド・カンパニー 抗腫瘍剤を製造するための立体選択的な方法
WO2000034252A2 (en) * 1998-12-07 2000-06-15 Eli Lilly And Company Process for the preparation of cryptophycin derivatives
WO2000034253A2 (en) * 1998-12-07 2000-06-15 Eli Lilly And Company Intermediates and reaction sequence to produce said intermediates useful for the preparation of antineoplastic and antifungal cryptophycin derivatives
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
US7229814B2 (en) * 2004-05-05 2007-06-12 Regents Of The University Of Minnesota Nucleic acids and polypeptides involved in the production of cryptophycin
CN101962323B (zh) * 2010-07-16 2013-06-05 中国人民解放军第二军医大学 2-丙烯酰x基-3-取代苯基丙酸类化合物及其用途
CN111333560B (zh) * 2020-04-13 2024-01-23 合肥工业大学 一种制备螺环β-内酰胺的方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946835A (en) * 1988-07-15 1990-08-07 Merck & Co., Inc. Antifungal fermentation product and method
US4868208A (en) * 1988-07-15 1989-09-19 Merck & Co., Inc. Antifungal agent and method
US4845086A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
US4845085A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
DE69020143T2 (de) * 1989-02-17 1996-01-25 Chiron Mimotopes Pty Ltd Verfahren zur verwendung und herstellung von peptiden.
US5256802A (en) * 1990-04-03 1993-10-26 Miles Inc. Process for the production of oxiranes
NZ257077A (en) * 1992-11-06 1997-05-26 Chiron Mimotopes Pty Ltd Support for synthesis of modular polymers
GB2282384B8 (en) * 1993-08-18 1997-09-04 Europ Economic Community Drug delivery agents incorporating mitomycin
US5952298A (en) * 1993-12-21 1999-09-14 The University Of Hawaii Cryptophycins
ATE203016T1 (de) * 1993-12-21 2001-07-15 Univ Hawaii Cryptophycine
EP0785941B1 (de) * 1994-10-14 2000-04-19 Stratagene Porphyrin-markierung von polynukleotiden
DE69633667T2 (de) * 1995-03-07 2006-03-02 University Of Hawaii, Honolulu Neue synthetische cryptophycine
AU716620B2 (en) * 1995-03-31 2000-03-02 Nippon Chemiphar Co. Ltd. Epoxysuccinic acid derivatives
US5700826A (en) * 1995-06-07 1997-12-23 Ontogen Corporation 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance
EP0850057A4 (de) * 1995-08-30 2001-04-11 Lilly Co Eli Pharmazeutische zusammensetzungen
DE69626544T2 (de) * 1995-12-22 2004-01-15 Lilly Co Eli Arzneistoffe
CN1105496C (zh) * 1996-02-07 2003-04-16 巴科曼实验室国际公司 含一种紫罗烯聚合物及十二烷胺盐的协同抗微生物组合物及其使用方法
ATE201018T1 (de) * 1996-02-27 2001-05-15 Lilly Co Eli Cryptophycinderivate und ihre verwendung als antimikrotubuli mittel
WO1998008505A1 (en) * 1996-08-30 1998-03-05 Eli Lilly And Company Pharmaceutical compounds
EP0957912A1 (de) * 1996-08-30 1999-11-24 Eli Lilly And Company Pharmazeutische zusammensetzungen
JP2001500853A (ja) * 1996-08-30 2001-01-23 イーライ・リリー・アンド・カンパニー 医薬化合物
US6025506A (en) * 1997-02-21 2000-02-15 Dsm N.V. Process for preparing an optically active phenylglycidyl acid derivative
TW438787B (en) * 1997-02-27 2001-06-07 Tanabe Seiyaku Co Process for preparing optically active trans-3-substituted glycidic acid ester

Also Published As

Publication number Publication date
EP0861838A2 (de) 1998-09-02
NO994083D0 (no) 1999-08-24
CN1252788A (zh) 2000-05-10
KR20000075623A (ko) 2000-12-26
WO1998038158A1 (en) 1998-09-03
AU6667198A (en) 1998-09-18
EA199900772A1 (ru) 2000-04-24
WO1998038164A1 (en) 1998-09-03
TR199902064T2 (xx) 2001-10-22
NO994049L (no) 1999-08-23
CA2281104A1 (en) 1998-09-03
CN1255121A (zh) 2000-05-31
NO994083L (no) 1999-10-25
CA2281108A1 (en) 1998-09-03
IL131162A0 (en) 2001-01-28
CZ9902998A3 (cs) 2002-10-16
KR20000075671A (ko) 2000-12-26
IL131205A0 (en) 2001-01-28
BR9807265A (pt) 2000-05-23
AU6667298A (en) 1998-09-18
EA199900770A1 (ru) 2000-04-24
JP2002513403A (ja) 2002-05-08
ID24527A (id) 2000-07-20
PL335478A1 (en) 2000-04-25
EA002547B1 (ru) 2002-06-27
NO994049D0 (no) 1999-08-23
PL335347A1 (en) 2000-04-25
BR9811252A (pt) 2000-09-26
US6143909A (en) 2000-11-07
TR199902065T2 (xx) 2000-02-21
EP0861838A3 (de) 1998-12-09
EP0861839A1 (de) 1998-09-02
AU738999B2 (en) 2001-10-04
JP2002512603A (ja) 2002-04-23
NZ336918A (en) 2001-11-30

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