ID30401A - Turunan-turunan indol dan penggunaannya sebagai antagonis mcp-1 - Google Patents
Turunan-turunan indol dan penggunaannya sebagai antagonis mcp-1Info
- Publication number
- ID30401A ID30401A IDW00200101667A ID20011667A ID30401A ID 30401 A ID30401 A ID 30401A ID W00200101667 A IDW00200101667 A ID W00200101667A ID 20011667 A ID20011667 A ID 20011667A ID 30401 A ID30401 A ID 30401A
- Authority
- ID
- Indonesia
- Prior art keywords
- mcp
- indol
- antagonists
- drives
- indol drives
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 229940123313 MCP-1 antagonist Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9902461.4A GB9902461D0 (en) | 1999-02-05 | 1999-02-05 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ID30401A true ID30401A (id) | 2001-11-29 |
Family
ID=10847084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IDW00200101667A ID30401A (id) | 1999-02-05 | 2000-01-31 | Turunan-turunan indol dan penggunaannya sebagai antagonis mcp-1 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6737435B1 (id) |
| EP (1) | EP1150952B1 (id) |
| JP (1) | JP2002536359A (id) |
| KR (1) | KR20010094755A (id) |
| CN (1) | CN1339025A (id) |
| AR (1) | AR022461A1 (id) |
| AT (1) | ATE280757T1 (id) |
| AU (1) | AU770856B2 (id) |
| BR (1) | BR0007984A (id) |
| CA (1) | CA2356898A1 (id) |
| CZ (1) | CZ20012807A3 (id) |
| DE (1) | DE60015296T2 (id) |
| EE (1) | EE200100403A (id) |
| GB (1) | GB9902461D0 (id) |
| HU (1) | HUP0105079A3 (id) |
| ID (1) | ID30401A (id) |
| IL (1) | IL144611A0 (id) |
| IS (1) | IS5980A (id) |
| MY (1) | MY133209A (id) |
| NO (1) | NO20013809L (id) |
| NZ (1) | NZ512680A (id) |
| PL (1) | PL350184A1 (id) |
| RU (1) | RU2235090C2 (id) |
| SK (1) | SK11152001A3 (id) |
| TR (1) | TR200102233T2 (id) |
| WO (1) | WO2000046196A1 (id) |
| ZA (1) | ZA200105311B (id) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9716657D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB0000626D0 (en) * | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
| GB0000625D0 (en) * | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
| AU2002211901A1 (en) | 2000-10-10 | 2002-04-22 | Smithkline Beecham Corporation | Substituted indoles, pharmaceutical compositions containing such indoles and their use as PPAR-gamma binding agents |
| WO2002050019A2 (en) | 2000-12-20 | 2002-06-27 | Bristol-Myers Squibb Pharma Co. | Diamines as modulators of chemokine receptor activity |
| US6706712B2 (en) | 2000-12-20 | 2004-03-16 | Bristol-Myers Squibb Pharma Company | Cyclic derivatives as modulators of chemokine receptor activity |
| EP1531822B1 (en) | 2002-06-12 | 2009-08-05 | ChemoCentryx Inc | 1-aryl-4-substituted piperazine derivatives for use as ccr1 antagonists for the treatment of inflammation and immune disorders |
| US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
| US7842693B2 (en) | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
| TW200508224A (en) | 2003-02-12 | 2005-03-01 | Bristol Myers Squibb Co | Cyclic derivatives as modulators of chemokine receptor activity |
| RU2366655C2 (ru) | 2003-03-14 | 2009-09-10 | Оно Фармасьютикал Ко., Лтд. | Азотсодержащие гетероциклические производные и лекарственные средства, содержащие их в качестве активного ингредиента |
| WO2004092169A1 (ja) | 2003-04-18 | 2004-10-28 | Ono Pharmaceutical Co., Ltd. | スピロピペリジン化合物およびその医薬用途 |
| US7230133B2 (en) | 2003-05-01 | 2007-06-12 | Bristol-Myers Squibb Company | Malonamides and malonamide derivatives as modulators of chemokine receptor activity |
| US7291615B2 (en) | 2003-05-01 | 2007-11-06 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| US7288563B2 (en) | 2004-02-19 | 2007-10-30 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
| US7479496B2 (en) | 2004-02-19 | 2009-01-20 | Bristol-Myers Squibb Company | Substituted spiro azabicyclics as modulators of chemokine receptor activity |
| US7381738B2 (en) | 2004-02-19 | 2008-06-03 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
| US7230022B2 (en) | 2004-02-19 | 2007-06-12 | Bristol-Myers Squibb Company | Substituted fused bicyclic amines as modulators of chemokine receptor activity |
| US7435831B2 (en) | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| US7435830B2 (en) | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| US8481035B2 (en) | 2004-04-27 | 2013-07-09 | Northwestern University | Methods for treating chronic pelvic pain syndrome with antibodies that binds MCP-1 or MIP-1A |
| EP1802331A2 (en) * | 2004-09-08 | 2007-07-04 | Boys Town National Research Hospital | Treatment of glomerular basement membrane disease involving matrix metalloproteinase-12 |
| US8143404B2 (en) | 2004-09-13 | 2012-03-27 | Ono Pharmaceutical Co., Ltd | Nitrogenous heterocylic derivative and medicine containing the same as an active ingredient |
| EP1889622A4 (en) | 2005-05-31 | 2009-12-23 | Ono Pharmaceutical Co | SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF |
| FR2890071B1 (fr) | 2005-08-30 | 2007-11-09 | Fournier Sa Sa Lab | Nouveaux composes de l'indole |
| EP2657235A1 (en) | 2005-10-28 | 2013-10-30 | Ono Pharmaceutical Co., Ltd. | Compound containing basic group and use thereof |
| WO2007058322A1 (ja) | 2005-11-18 | 2007-05-24 | Ono Pharmaceutical Co., Ltd. | 塩基性基を含有する化合物およびその用途 |
| DE602006010433D1 (de) | 2005-12-09 | 2009-12-24 | Hoffmann La Roche | Für die behandlung von obesitas geeignete tricyclische amidderivate |
| KR20080114711A (ko) * | 2006-03-02 | 2008-12-31 | 아스텔라스세이야쿠 가부시키가이샤 | 17β ＨＳＤ 타입 5 저해제 |
| CA2644368A1 (en) | 2006-03-10 | 2007-09-20 | Ono Pharmaceutical Co., Ltd. | Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient |
| WO2007132846A1 (ja) | 2006-05-16 | 2007-11-22 | Ono Pharmaceutical Co., Ltd. | 保護されていてもよい酸性基を含有する化合物およびその用途 |
| DE102006033572A1 (de) | 2006-07-20 | 2008-01-24 | Bayer Cropscience Ag | N'-Cyano-N-halogenalkyl-imidamid Derivate |
| JP5245827B2 (ja) | 2006-07-31 | 2013-07-24 | 小野薬品工業株式会社 | スピロ結合した環状基を含有する化合物およびその用途 |
| US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
| US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| JP5930573B2 (ja) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
| EP2142514B1 (en) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| CA2712017C (en) * | 2008-01-18 | 2016-08-09 | Oxagen Limited | Compounds having crth2 antagonist activity |
| WO2010043396A1 (en) * | 2008-10-16 | 2010-04-22 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| WO2010129351A1 (en) | 2009-04-28 | 2010-11-11 | Schepens Eye Research Institute | Method to identify and treat age-related macular degeneration |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| FR2950053B1 (fr) | 2009-09-11 | 2014-08-01 | Fournier Lab Sa | Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| NZ602312A (en) | 2010-03-10 | 2014-02-28 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| KR101350077B1 (ko) * | 2010-12-13 | 2014-01-14 | 한국화학연구원 | 신규한 3-인돌리논 유도체 및 이를 포함하는 조성물 |
| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| WO2018106945A1 (en) | 2016-12-07 | 2018-06-14 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
| EP3554541B1 (en) | 2016-12-14 | 2023-06-07 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| EP3883635A1 (en) | 2018-11-19 | 2021-09-29 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
| CN115666704B (zh) | 2019-12-13 | 2025-09-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| EP4450494A1 (en) | 2023-04-20 | 2024-10-23 | Consejo Superior De Investigaciones Científicas | Indole derivatives as histone deacetylase (hdac) inhibitors for the treatment of cancer |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3196162A (en) * | 1961-03-13 | 1965-07-20 | Merck & Co Inc | Indolyl aliphatic acids |
| GB957990A (en) * | 1961-03-14 | 1964-05-13 | Merck & Co Inc | Salts of substituted indoles |
| US3557142A (en) | 1968-02-20 | 1971-01-19 | Sterling Drug Inc | 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters |
| US3776923A (en) | 1970-01-06 | 1973-12-04 | American Cyanamid Co | 2-nitro-4-oxo-4,5,6,7-tetrahydroindole |
| US3997557A (en) | 1974-04-23 | 1976-12-14 | American Hoechst Corporation | Substituted N-aminoalkylpyrroles |
| US4496742A (en) | 1981-10-13 | 1985-01-29 | The Upjohn Company | Analogs of 5,6-dihydro PGI2 |
| FR2537974A1 (fr) | 1982-12-16 | 1984-06-22 | Adir | Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| US4529724A (en) | 1983-10-11 | 1985-07-16 | Mcneilab, Inc. | 6H-indolo[2,1-c][1,4]benzodiazepines and 12-oxo derivatives useful as antihypertensives |
| FR2565981B1 (fr) | 1984-06-15 | 1986-09-19 | Adir | Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| CA1241660A (en) * | 1984-06-25 | 1988-09-06 | Yvan Guindon | Indole-2-alkanoic acids |
| JPS61502818A (ja) | 1984-07-30 | 1986-12-04 | シェリング・コ−ポレ−ション | シス、エンド−オクタヒドロシクロペンタ〔ｂ〕ピロ−ル−２−カルボキシレ−トの新規製造方法 |
| US4675332A (en) * | 1984-12-10 | 1987-06-23 | Warner-Lambert Company | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents |
| DE3568431D1 (en) | 1984-12-12 | 1989-04-06 | Merck & Co Inc | Substituted aromatic sulfonamides, their preparation and ophthalmic compositions containing them |
| US4721725A (en) | 1986-01-27 | 1988-01-26 | E. R. Squibb & Sons, Inc. | Aryl-cycloalkyl[b]pyrrole derivatives |
| NZ222878A (en) | 1986-12-17 | 1991-02-26 | Merck Frosst Canada Inc | 3-hetero-substituted-n-benzyl-indole derivatives, and pharmaceutical compositions |
| US4751231A (en) | 1987-09-16 | 1988-06-14 | Merck & Co., Inc. | Substituted thieno[2,3-b]pyrrole-5-sulfonamides as antiglaucoma agents |
| DE3907388A1 (de) | 1989-03-08 | 1990-09-13 | Kali Chemie Pharma Gmbh | Verfahren zur herstellung von indolcarbonsaeurederivaten |
| US5272145A (en) | 1989-08-22 | 1993-12-21 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
| NZ234883A (en) | 1989-08-22 | 1995-01-27 | Merck Frosst Canada Inc | Quinolin-2-ylmethoxy indole derivatives, preparation and pharmaceutical compositions thereof |
| DD298913A5 (de) | 1989-11-17 | 1992-03-19 | Arzneimittelwerk Dresden Gmbh,De | Verfahren zur herstellung von n-substituierten 3-aminopyrrolen |
| DE3943225A1 (de) | 1989-12-23 | 1991-06-27 | Schering Ag | Neue ss-carboline, verfahren zu deren herstellung und deren verwendung in arzneimitteln |
| US5081145A (en) * | 1990-02-01 | 1992-01-14 | Merck Frosst Canada, Inc. | Indole-2-alkanoic acids compositions of and anti allergic use thereof |
| FR2679903B1 (fr) * | 1991-08-02 | 1993-12-03 | Elf Sanofi | Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant. |
| US5260322A (en) | 1990-10-08 | 1993-11-09 | Merck & Co., Inc. | Angiotension II antagonists in the treatment of hyperuricemia |
| US5290798A (en) | 1991-09-30 | 1994-03-01 | Merck Frosst Canada, Inc. | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5190968A (en) | 1991-09-30 | 1993-03-02 | Merck Frosst Canada, Inc. | (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
| US5273980A (en) | 1991-09-30 | 1993-12-28 | Merck Frosst Canada Inc. | Bicyclic-azaarylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
| CA2079374C (en) | 1991-09-30 | 2003-08-05 | Merck Frosst Canada Incorporated | (bicyclic-azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5389650A (en) | 1991-09-30 | 1995-02-14 | Merck Frosst Canada, Inc. | (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5308850A (en) | 1991-09-30 | 1994-05-03 | Merck Frosst Canada, Inc. | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5318985A (en) | 1991-12-20 | 1994-06-07 | Merrell Dow Pharmaceuticals Inc. | Potentiation of NMDA antagonists |
| WO1993016069A1 (en) | 1992-02-13 | 1993-08-19 | Merck Frosst Canada Inc. | (azaaromaticalkoxy)indoles as inhibitors of leukotriene biosynthesis |
| ES2150941T3 (es) | 1992-04-03 | 2000-12-16 | Upjohn Co | Aminas biciclicas-heterociclicas eficaces farmaceuticamente. |
| US5334719A (en) | 1992-06-17 | 1994-08-02 | Merck Frosst Canada, Inc. | Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis |
| US5288743A (en) | 1992-11-20 | 1994-02-22 | Abbott Laboratories | Indole carboxylate derivatives which inhibit leukotriene biosynthesis |
| ZA939516B (en) | 1992-12-22 | 1994-06-06 | Smithkline Beecham Corp | Endothelin receptor antagonists |
| EP0639573A1 (de) | 1993-08-03 | 1995-02-22 | Hoechst Aktiengesellschaft | Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament |
| US5852046A (en) | 1993-08-03 | 1998-12-22 | Hoechst Aktiengesellschaft | Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them |
| US5399699A (en) | 1994-01-24 | 1995-03-21 | Abbott Laboratories | Indole iminooxy derivatives which inhibit leukotriene biosynthesis |
| HUT76923A (hu) | 1994-07-27 | 1998-01-28 | Sankyo Company Limited | Muszkarinreceptorokra alloszterikus hatást kifejtő heterociklusos vegyületek |
| US5482960A (en) * | 1994-11-14 | 1996-01-09 | Warner-Lambert Company | Nonpeptide endothelin antagonists |
| WO1996018393A1 (en) | 1994-12-13 | 1996-06-20 | Smithkline Beecham Corporation | Novel compounds |
| US5684032A (en) | 1994-12-13 | 1997-11-04 | Smithkline Beecham Corporation | Compounds |
| ATE243203T1 (de) | 1995-04-04 | 2003-07-15 | Texas Biotechnology Corp | Thienyl-, furyl-, pyrrolyl- und biphenylsulfonamide und derivate zur modulation der endothelin-aktivität |
| IT1282797B1 (it) | 1995-04-21 | 1998-03-31 | Colla Paolo | Pirril-(indolil)-aril-sulfoni e relativo processo di produzione ed impiego nella terapia delle infezioni da virus dell'aids |
| US5639780A (en) | 1995-05-22 | 1997-06-17 | Merck Frosst Canada, Inc. | N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors |
| US5604253A (en) * | 1995-05-22 | 1997-02-18 | Merck Frosst Canada, Inc. | N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors |
| AU6966696A (en) | 1995-10-05 | 1997-04-28 | Warner-Lambert Company | Method for treating and preventing inflammation and atherosclerosis |
| ES2199348T4 (es) | 1996-02-26 | 2010-10-19 | ADVANCED RESEARCH & TECHNOLOGY INSTITUTE | Uso de inhibidores de carbonico anhidrasa para el tratamiento del edema macular. |
| EP1021181A4 (en) | 1996-03-28 | 2002-06-26 | Smithkline Beecham Corp | INDOLCARBOXYLIC ACIDS AS CHEMOKIN INHIBITORS |
| EP0822185A1 (en) | 1996-07-31 | 1998-02-04 | Pfizer Inc. | B-3-adrenergic agonists as antidiabetic and antiobesity agents |
| WO1998006703A1 (en) * | 1996-08-14 | 1998-02-19 | Warner-Lambert Company | 2-phenyl benzimidazole derivatives as mcp-1 antagonists |
| GB9716656D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| GB9716657D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| DK1042287T3 (da) * | 1997-12-24 | 2005-08-15 | Aventis Pharma Gmbh | Indolderivater som inhibitorer af faktor Xa |
| GB9803228D0 (en) | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
| GB9803226D0 (en) | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
| GB9902459D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB9902453D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB9902455D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB9902452D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB0000626D0 (en) | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
| GB0000625D0 (en) | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
-
1999
- 1999-02-05 GB GBGB9902461.4A patent/GB9902461D0/en not_active Ceased
-
2000
- 2000-01-31 DE DE60015296T patent/DE60015296T2/de not_active Expired - Lifetime
- 2000-01-31 AR ARP000100407A patent/AR022461A1/es not_active Application Discontinuation
- 2000-01-31 SK SK1115-2001A patent/SK11152001A3/sk unknown
- 2000-01-31 PL PL00350184A patent/PL350184A1/xx not_active Application Discontinuation
- 2000-01-31 EP EP20000901259 patent/EP1150952B1/en not_active Expired - Lifetime
- 2000-01-31 CZ CZ20012807A patent/CZ20012807A3/cs unknown
- 2000-01-31 ID IDW00200101667A patent/ID30401A/id unknown
- 2000-01-31 CN CN00803463A patent/CN1339025A/zh active Pending
- 2000-01-31 WO PCT/GB2000/000265 patent/WO2000046196A1/en not_active Ceased
- 2000-01-31 BR BR0007984-7A patent/BR0007984A/pt not_active IP Right Cessation
- 2000-01-31 EE EEP200100403A patent/EE200100403A/xx unknown
- 2000-01-31 RU RU2001124567/04A patent/RU2235090C2/ru not_active IP Right Cessation
- 2000-01-31 JP JP2000597267A patent/JP2002536359A/ja active Pending
- 2000-01-31 US US09/889,599 patent/US6737435B1/en not_active Expired - Fee Related
- 2000-01-31 KR KR1020017009862A patent/KR20010094755A/ko not_active Withdrawn
- 2000-01-31 TR TR2001/02233T patent/TR200102233T2/xx unknown
- 2000-01-31 AU AU21213/00A patent/AU770856B2/en not_active Ceased
- 2000-01-31 IL IL14461100A patent/IL144611A0/xx unknown
- 2000-01-31 AT AT00901259T patent/ATE280757T1/de not_active IP Right Cessation
- 2000-01-31 NZ NZ512680A patent/NZ512680A/en unknown
- 2000-01-31 CA CA002356898A patent/CA2356898A1/en not_active Abandoned
- 2000-01-31 HU HU0105079A patent/HUP0105079A3/hu unknown
- 2000-02-04 MY MYPI20000404A patent/MY133209A/en unknown
-
2001
- 2001-06-26 IS IS5980A patent/IS5980A/is unknown
- 2001-06-27 ZA ZA200105311A patent/ZA200105311B/en unknown
- 2001-08-03 NO NO20013809A patent/NO20013809L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20012807A3 (cs) | 2001-10-17 |
| DE60015296T2 (de) | 2006-02-02 |
| MY133209A (en) | 2007-10-31 |
| BR0007984A (pt) | 2001-11-06 |
| GB9902461D0 (en) | 1999-03-24 |
| CA2356898A1 (en) | 2000-08-10 |
| HUP0105079A2 (hu) | 2002-04-29 |
| DE60015296D1 (de) | 2004-12-02 |
| NZ512680A (en) | 2003-11-28 |
| RU2235090C2 (ru) | 2004-08-27 |
| NO20013809L (no) | 2001-10-02 |
| SK11152001A3 (sk) | 2001-12-03 |
| EE200100403A (et) | 2002-10-15 |
| US6737435B1 (en) | 2004-05-18 |
| CN1339025A (zh) | 2002-03-06 |
| AU770856B2 (en) | 2004-03-04 |
| NO20013809D0 (no) | 2001-08-03 |
| IS5980A (is) | 2001-06-26 |
| RU2001124567A (ru) | 2004-01-10 |
| PL350184A1 (en) | 2002-11-18 |
| KR20010094755A (ko) | 2001-11-01 |
| AR022461A1 (es) | 2002-09-04 |
| EP1150952A1 (en) | 2001-11-07 |
| JP2002536359A (ja) | 2002-10-29 |
| TR200102233T2 (tr) | 2001-12-21 |
| WO2000046196A1 (en) | 2000-08-10 |
| EP1150952B1 (en) | 2004-10-27 |
| AU2121300A (en) | 2000-08-25 |
| ATE280757T1 (de) | 2004-11-15 |
| IL144611A0 (en) | 2002-05-23 |
| HUP0105079A3 (en) | 2002-11-28 |
| ZA200105311B (en) | 2002-09-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ID30401A (id) | Turunan-turunan indol dan penggunaannya sebagai antagonis mcp-1 | |
| ATE503487T1 (de) | Myostatin-antagonisten und verwendungen davon | |
| CY2015041I2 (el) | Παραγωγα 4- φαινυλπυριδινης και η χρηση αυτων ως ανταγωνιστες του υποδοχεα νκ-1 | |
| DE60026169D1 (de) | Selektive neurokinin-antagonisten | |
| NO20035530D0 (no) | Sementeringshode | |
| EE05169B1 (et) | Asendatud oksasolidinoonid ja nende kasutamine | |
| NO20021116D0 (no) | Ny sammensetning | |
| NO20043064L (no) | 1-alkyl-1-azoniabisyklo [2.2.2] oktankarbamatderivater og anvendelse av disse som muskarine reseptorantagonister | |
| FI991485A0 (fi) | Uusi farmaseuttinen koostumus | |
| DE60222647D1 (de) | Urea derivate als integrin alpha 4 antagonisten | |
| DE60024731D1 (de) | Ritzgerät | |
| AU6031001A (en) | Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists | |
| NO20021115D0 (no) | Ny sammensetning | |
| EP1361872A4 (en) | NOVEL LYSOPHOSPHATIDIC ACID RECEPTOR AGONISTS AND ANTAGONISTS | |
| IL152701A0 (en) | Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists | |
| NO20010804D0 (no) | Muskariniske agonister og antagonister | |
| NO20005375D0 (no) | Ultralyd-gjennomstrømningsmÕleinnretning | |
| EP1162876A4 (en) | REPLIABLE / DISMANTLING STRUCTURES | |
| ATE254621T1 (de) | Thienoisoxazolyl- und thienylpyrazolyl-phenoxy substituierte propyl derivate als d4 antagonisten | |
| ATE264301T1 (de) | Muscarin-antagonisten | |
| DK199901730A (da) | Ny Sammensætning | |
| ID27835A (id) | Piranti elektromagnit dan sirkuit untuk menggerakan piranti elektromagnit | |
| NO20015237L (no) | Integrinreseptor-antagonister | |
| EP1324763A4 (en) | AGONISTS AND ANTAGONISTS OF STAT3 AND THERAPEUTIC APPLICATIONS THEREOF | |
| ID29581A (id) | Metode dan peralatan untuk memproduksi sabuk-v bergerigi |