IES20180086A2 - Drug intermediates isovaleric acid synthesis method - Google Patents
Drug intermediates isovaleric acid synthesis methodInfo
- Publication number
- IES20180086A2 IES20180086A2 IES20180086A IES20180086A IES20180086A2 IE S20180086 A2 IES20180086 A2 IE S20180086A2 IE S20180086 A IES20180086 A IE S20180086A IE S20180086 A IES20180086 A IE S20180086A IE S20180086 A2 IES20180086 A2 IE S20180086A2
- Authority
- IE
- Ireland
- Prior art keywords
- solution
- added
- isovaleric acid
- mol
- synthesis method
- Prior art date
Links
- XYHKNCXZYYTLRG-UHFFFAOYSA-N 1h-imidazole-2-carbaldehyde Chemical compound O=CC1=NC=CN1 XYHKNCXZYYTLRG-UHFFFAOYSA-N 0.000 title abstract 3
- GWYFCOCPABKNJV-UHFFFAOYSA-M 3-Methylbutanoic acid Natural products CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 title abstract 3
- GWYFCOCPABKNJV-UHFFFAOYSA-N beta-methyl-butyric acid Natural products CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000001308 synthesis method Methods 0.000 title abstract 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 abstract 2
- QVMRSFQXWJGXRL-UHFFFAOYSA-N 1-chloro-4-methylpentan-2-one Chemical compound CC(C)CC(=O)CCl QVMRSFQXWJGXRL-UHFFFAOYSA-N 0.000 abstract 1
- SBASXUCJHJRPEV-UHFFFAOYSA-N 2-(2-methoxyethoxy)ethanol Chemical compound COCCOCCO SBASXUCJHJRPEV-UHFFFAOYSA-N 0.000 abstract 1
- 229910021380 Manganese Chloride Inorganic materials 0.000 abstract 1
- GLFNIEUTAYBVOC-UHFFFAOYSA-L Manganese chloride Chemical compound Cl[Mn]Cl GLFNIEUTAYBVOC-UHFFFAOYSA-L 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000012024 dehydrating agents Substances 0.000 abstract 1
- IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 abstract 1
- 235000002867 manganese chloride Nutrition 0.000 abstract 1
- 239000011565 manganese chloride Substances 0.000 abstract 1
- 229940099607 manganese chloride Drugs 0.000 abstract 1
- HDZGCSFEDULWCS-UHFFFAOYSA-N monomethylhydrazine Chemical compound CNN HDZGCSFEDULWCS-UHFFFAOYSA-N 0.000 abstract 1
- CHKVPAROMQMJNQ-UHFFFAOYSA-M potassium bisulfate Chemical compound [K+].OS([O-])(=O)=O CHKVPAROMQMJNQ-UHFFFAOYSA-M 0.000 abstract 1
- 229910000343 potassium bisulfate Inorganic materials 0.000 abstract 1
- 235000011164 potassium chloride Nutrition 0.000 abstract 1
- 239000001103 potassium chloride Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Drug intermediates isovaleric acid synthesis method, comprises the following steps: 2 mol 1-chloro-3-isopropylacetone and 4-5 mol dimethyl carbonate solution were added to the reaction vessel, control the stirring speed at 110-140 rpm, the solution temperature was raised to 30-40 t, and then added 3-4 mol manganese chloride, reacted for 70-90 min, added 900 ml potassium chloride solution, reduced the temperature of the solution to 20-25 °C, added potassium hydrogen sulfate solution to adjust the pH to 4-5, standing for 50-70 mm, the solution was layered, washed with a methyl carbitol solution, washed with a methyl hydrazine solution, recrystallized from 1-methylpiazepine solution, and dehydrated with the dehydrating agent, finally obtained the product isovaleric acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710216243.2A CN108238893A (en) | 2017-04-05 | 2017-04-05 | A kind of synthetic method of pharmaceutical intermediate isovaleric acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IES20180086A2 true IES20180086A2 (en) | 2019-04-03 |
| IES86991B2 IES86991B2 (en) | 2019-05-01 |
Family
ID=59220686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IES20180086A IES86991B2 (en) | 2017-04-05 | 2018-04-03 | Drug intermediates isovaleric acid synthesis method |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN108238893A (en) |
| AU (1) | AU2018100421A4 (en) |
| GB (1) | GB201708117D0 (en) |
| IE (1) | IES86991B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110776412B (en) * | 2019-11-12 | 2022-04-22 | 万华化学集团股份有限公司 | Method for preparing isovaleric acid, ligand, complex and application thereof in catalytic system |
-
2017
- 2017-04-05 CN CN201710216243.2A patent/CN108238893A/en active Pending
- 2017-05-22 GB GBGB1708117.5A patent/GB201708117D0/en not_active Ceased
-
2018
- 2018-04-01 AU AU2018100421A patent/AU2018100421A4/en not_active Ceased
- 2018-04-03 IE IES20180086A patent/IES86991B2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018100421A4 (en) | 2018-05-10 |
| GB201708117D0 (en) | 2017-07-05 |
| IES86991B2 (en) | 2019-05-01 |
| CN108238893A (en) | 2018-07-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Gogoi et al. | Copper–Schiff base complex catalyzed oxidation of sulfides with hydrogen peroxide | |
| NZ603268A (en) | Process for synthesizing oxidized lactam compounds | |
| PH12016502334A1 (en) | Method for producing fused heterocyclic compound | |
| IES20180086A2 (en) | Drug intermediates isovaleric acid synthesis method | |
| MX2020003162A (en) | A process for the production of alkylaromatics. | |
| Brondani et al. | A new and efficient N-alkylation procedure for semicarbazides/semicarbazones derivatives | |
| IES20180088A2 (en) | Drugs intermediates 2-ethylhexanoic acid synthesis method | |
| IES20180096A2 (en) | Organic synthesis intermediates m-aminobenzenesulfonic acid synthesis method | |
| CN103254268A (en) | Process for preparing dutasteride | |
| IES20180085A2 (en) | Drugs intermediates 1,4-dibromo-2,3-butanediol synthesis method | |
| IES20180198A2 (en) | Pharmaceutical intermediates 2-acetamido-5-sulfonyl chloride-1,3,4-thiadiazole synthesis method | |
| IE20180280U1 (en) | Methylchloroperoxybenzoic acid drug intermediates synthesis method | |
| IES20180107A2 (en) | Drug intermediates parachlorobenzoic-acid synthesis method | |
| IES20180203A2 (en) | Chlormadinone drug intermediates o-tetrachlorobenzoquinone synthesis method | |
| IE20180281U1 (en) | Benzoyl peroxide organic intermediates synthesis method | |
| IES20180187A2 (en) | Drug intermediates 4-benzyloxy-3-methoxy-4'-methylbenzophenone synthesis method | |
| CN101824003B (en) | Preparation method of isothiazolinone biocide mildewcide | |
| IES20180082A2 (en) | Organic intermediates dimethylacetic acid syntesis method | |
| IE20180290U1 (en) | P-aminobenzaldehyde drug intermediates synthesis method | |
| Zhang et al. | Hydrated nickel (II) halides mediated ring opening reaction with N-tosylaziridines | |
| IE20180282U1 (en) | Dodecanoyl peroxide organic intermediates synthesis method | |
| IES20180243U1 (en) | Dibenzyl sulfoxide organic intermediates synthesis method | |
| CN102351793B (en) | Direct synthesis method of 4-[3-(4- methylphenyl)-5-(trifluoromethyl)-1-hydrogen-pyrazole-1-yl] benzene sulfonamide | |
| IES20180263A2 (en) | Drug intermediates 3-methoxy-2-thiophenecarboxaldehyde synthesis method | |
| IES20180270U1 (en) | Organic analytical reagent diphenylcarbazone synthesis method |