IES20180203A2 - Chlormadinone drug intermediates o-tetrachlorobenzoquinone synthesis method - Google Patents
Chlormadinone drug intermediates o-tetrachlorobenzoquinone synthesis methodInfo
- Publication number
- IES20180203A2 IES20180203A2 IES20180203A IES20180203A2 IE S20180203 A2 IES20180203 A2 IE S20180203A2 IE S20180203 A IES20180203 A IE S20180203A IE S20180203 A2 IES20180203 A2 IE S20180203A2
- Authority
- IE
- Ireland
- Prior art keywords
- solution
- temperature
- tetrachlorobenzoquinone
- several times
- chlormadinone
- Prior art date
Links
- VUHJZBBCZGVNDZ-TTYLFXKOSA-N chlormadinone Chemical compound C1=C(Cl)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 VUHJZBBCZGVNDZ-TTYLFXKOSA-N 0.000 title abstract 2
- 229960003996 chlormadinone Drugs 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000001308 synthesis method Methods 0.000 title abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- PGEVTVXEERFABN-UHFFFAOYSA-N 1,1-dichloropentane Chemical compound CCCCC(Cl)Cl PGEVTVXEERFABN-UHFFFAOYSA-N 0.000 abstract 1
- KJDRSWPQXHESDQ-UHFFFAOYSA-N 1,4-dichlorobutane Chemical compound ClCCCCCl KJDRSWPQXHESDQ-UHFFFAOYSA-N 0.000 abstract 1
- FALCMQXTWHPRIH-UHFFFAOYSA-N 2,3-dichloroprop-1-ene Chemical compound ClCC(Cl)=C FALCMQXTWHPRIH-UHFFFAOYSA-N 0.000 abstract 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 abstract 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 239000012024 dehydrating agents‎ Substances 0.000 abstract 1
- 229910052748 manganese Inorganic materials 0.000 abstract 1
- 239000011572 manganese Substances 0.000 abstract 1
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 abstract 1
- 229910052939 potassium sulfate Inorganic materials 0.000 abstract 1
- 235000011151 potassium sulphates Nutrition 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
The present invention discloses chlormadinone drug intermediates o-tetrachlorobenzoquinone synthesis method, comprises the following steps:2,3-dihydroxy-4,5,6-trichloro-aniline, cyclohexane solution is added to the reaction vessel, slowly raising the temperature, raising the temperature, then adds potassium sulfate solution, reacts; continues to add the 2,3-dichloropropene solution,reduces the temperature, adds tricarbonyl menthyl manganese in batches, controls the stirring speed, continues to react, then the solution layers, the temperature is decreased, washed several times with sodium chloride solution, several times with ethylene oxide solution, several times with 1,4-dichlorobutane solution, recrystallized in dichloropentane solution, dehydrated with dehydrating agent, got the finished producto-tetrachlorobenzoquinone. <Figure 1>
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710706464.8A CN108238886A (en) | 2017-08-19 | 2017-08-19 | The synthetic method of chlormadinone pharmaceutical intermediate neighbour's tetrachloroquinone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IES20180203A2 true IES20180203A2 (en) | 2019-11-13 |
Family
ID=60037134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IES20180203 IES20180203A2 (en) | 2017-08-19 | 2018-06-26 | Chlormadinone drug intermediates o-tetrachlorobenzoquinone synthesis method |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN108238886A (en) |
| AU (1) | AU2018100844A4 (en) |
| GB (1) | GB201713868D0 (en) |
| IE (1) | IES20180203A2 (en) |
-
2017
- 2017-08-19 CN CN201710706464.8A patent/CN108238886A/en active Pending
- 2017-08-30 GB GBGB1713868.6A patent/GB201713868D0/en not_active Ceased
-
2018
- 2018-06-20 AU AU2018100844A patent/AU2018100844A4/en not_active Ceased
- 2018-06-26 IE IES20180203 patent/IES20180203A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN108238886A (en) | 2018-07-03 |
| AU2018100844A4 (en) | 2018-08-09 |
| GB201713868D0 (en) | 2017-10-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12016502334A1 (en) | Method for producing fused heterocyclic compound | |
| MX2016004940A (en) | Processes for the preparation of pesticidal compounds. | |
| AU2016237099B2 (en) | Method for producing novel nitrogen-containing compound or salt thereof, and production intermediate of same | |
| MX2016004946A (en) | Processes for the preparation of pesticidal compounds. | |
| EA201591236A1 (en) | CATALYST FOR LOW-TEMPERATURE SYNTHESIS OF FISHER TRIPS WITH SUSPENSION LAYER | |
| IES20180203A2 (en) | Chlormadinone drug intermediates o-tetrachlorobenzoquinone synthesis method | |
| AU2016102168A4 (en) | Antibacterial disinfectants phenyl salicylate synthesis method | |
| IE20180281U1 (en) | Benzoyl peroxide organic intermediates synthesis method | |
| IE20180280U1 (en) | Methylchloroperoxybenzoic acid drug intermediates synthesis method | |
| IES20180243U1 (en) | Dibenzyl sulfoxide organic intermediates synthesis method | |
| IES20180086A2 (en) | Drug intermediates isovaleric acid synthesis method | |
| IES20180113A2 (en) | Drug intermediates p-benzoylbenzoic acid synthesis method | |
| IE20180282U1 (en) | Dodecanoyl peroxide organic intermediates synthesis method | |
| IE20180288U1 (en) | P-methoxphenylacetic acid drug intermediates synthesis method | |
| IES20180242U1 (en) | Broad spectrum antimicrobial agents thiamphenicol synthesis method | |
| IE20180290U1 (en) | P-aminobenzaldehyde drug intermediates synthesis method | |
| IES20180267U1 (en) | Aminoquinone drug intermediates tetrachlorobenzoquinone synthesis method | |
| IES20180251U1 (en) | Nicotinamide-n-oxide drug intermediates synthesis method | |
| IES20180107A2 (en) | Drug intermediates parachlorobenzoic-acid synthesis method | |
| IES20180187A2 (en) | Drug intermediates 4-benzyloxy-3-methoxy-4'-methylbenzophenone synthesis method | |
| IE20180284U1 (en) | 2,3-dihydroxy-succinic acid drug intermediates synthesis method | |
| IE20180292U1 (en) | 7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenyl heptanoic acid synthesis method | |
| IES20180293A2 (en) | 1,2-naphthoquinone drug intermediates synthesis method | |
| IES20180200A2 (en) | Anti-clavicular spirochete drugs ethyl imidazole synthesis method | |
| IES20180250A2 (en) | Butyraldehyde oxime drug itermediates synthesis method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FJ9A | Application deemed to be withdrawn section 31(3) |