IES20180187A2 - Drug intermediates 4-benzyloxy-3-methoxy-4'-methylbenzophenone synthesis method - Google Patents
Drug intermediates 4-benzyloxy-3-methoxy-4'-methylbenzophenone synthesis methodInfo
- Publication number
- IES20180187A2 IES20180187A2 IES20180187A IES20180187A2 IE S20180187 A2 IES20180187 A2 IE S20180187A2 IE S20180187 A IES20180187 A IE S20180187A IE S20180187 A2 IES20180187 A2 IE S20180187A2
- Authority
- IE
- Ireland
- Prior art keywords
- solution
- benzyloxy
- methoxy
- methylbenzophenone
- washed
- Prior art date
Links
- VJZQUDKKOLPJHF-UHFFFAOYSA-N (3-methoxy-4-phenylmethoxyphenyl)-(4-methylphenyl)methanone Chemical compound COC1=CC(C(=O)C=2C=CC(C)=CC=2)=CC=C1OCC1=CC=CC=C1 VJZQUDKKOLPJHF-UHFFFAOYSA-N 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000001308 synthesis method Methods 0.000 title abstract 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 abstract 2
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 abstract 2
- HHOSMYBYIHNXNO-UHFFFAOYSA-N 2,2,5-trimethylhexane Chemical compound CC(C)CCC(C)(C)C HHOSMYBYIHNXNO-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000012024 dehydrating agents Substances 0.000 abstract 1
- UCVPKAZCQPRWAY-UHFFFAOYSA-N dibenzyl benzene-1,2-dicarboxylate Chemical compound C=1C=CC=C(C(=O)OCC=2C=CC=CC=2)C=1C(=O)OCC1=CC=CC=C1 UCVPKAZCQPRWAY-UHFFFAOYSA-N 0.000 abstract 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 abstract 1
- 229940075557 diethylene glycol monoethyl ether Drugs 0.000 abstract 1
- PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical compound Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 abstract 1
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 abstract 1
- 229910052939 potassium sulfate Inorganic materials 0.000 abstract 1
- 235000011151 potassium sulphates Nutrition 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention discloses drug intermediates 4-benzyloxy-3-methoxy-4'-methylbenzophenone synthesis method, comprises the following steps: 2-bromo-3-methoxy-4-benzyloxy-4'-methyl diphenyl ether, sodium bromide solution were added to the reaction vessel, controlled the stirring rate, raised the solution temperature, reacted; then added the benzyl phthalate solution, added palladium chloride powder in batches, reacted, standing still, washed with potassium sulfate solution for several times, washed with 2,2,5-trimethylhexane solution for several times, washed with the dodecane solution for several times, recrystallized in a diethylene glycol monoethyl ether solution, dehydrated with dehydrating agent, got the finished product 4-benzyloxy-3-methoxy-4'-methylbenzophenone.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710528992.9A CN108238869A (en) | 2017-07-01 | 2017-07-01 | - 4 ＇ of pharmaceutical intermediate 4- benzyloxy -3- methoxyl groups-methyldiphenyl ketone synthetic method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IES20180187A2 true IES20180187A2 (en) | 2019-11-13 |
Family
ID=59996716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IES20180187 IES20180187A2 (en) | 2017-07-01 | 2018-06-26 | Drug intermediates 4-benzyloxy-3-methoxy-4'-methylbenzophenone synthesis method |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN108238869A (en) |
| AU (1) | AU2018100827A4 (en) |
| GB (1) | GB201713409D0 (en) |
| IE (1) | IES20180187A2 (en) |
-
2017
- 2017-07-01 CN CN201710528992.9A patent/CN108238869A/en active Pending
- 2017-08-21 GB GBGB1713409.9A patent/GB201713409D0/en not_active Ceased
-
2018
- 2018-06-19 AU AU2018100827A patent/AU2018100827A4/en not_active Ceased
- 2018-06-26 IE IES20180187 patent/IES20180187A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN108238869A (en) | 2018-07-03 |
| AU2018100827A4 (en) | 2018-08-02 |
| GB201713409D0 (en) | 2017-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FJ9A | Application deemed to be withdrawn section 31(3) |