IES20180195A2 - Pharmaceutical hormone intermediates 11-ketone-16α, 17α-epoxy progesterone synthesis method - Google Patents
Pharmaceutical hormone intermediates 11-ketone-16α, 17α-epoxy progesterone synthesis methodInfo
- Publication number
- IES20180195A2 IES20180195A2 IES20180195A IES20180195A2 IE S20180195 A2 IES20180195 A2 IE S20180195A2 IE S20180195 A IES20180195 A IE S20180195A IE S20180195 A2 IES20180195 A2 IE S20180195A2
- Authority
- IE
- Ireland
- Prior art keywords
- solution
- ketone
- epoxy progesterone
- washed
- several times
- Prior art date
Links
- 229940088597 hormone Drugs 0.000 title abstract 2
- 239000005556 hormone Substances 0.000 title abstract 2
- 238000001308 synthesis method Methods 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- OISVCGZHLKNMSJ-UHFFFAOYSA-N 2,6-dimethylpyridine Chemical compound CC1=CC=CC(C)=N1 OISVCGZHLKNMSJ-UHFFFAOYSA-N 0.000 abstract 3
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 abstract 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 abstract 2
- NHXSTXWKZVAVOQ-UHFFFAOYSA-N Ethyl furoate Chemical compound CCOC(=O)C1=CC=CO1 NHXSTXWKZVAVOQ-UHFFFAOYSA-N 0.000 abstract 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 abstract 1
- DAMJCWMGELCIMI-UHFFFAOYSA-N benzyl n-(2-oxopyrrolidin-3-yl)carbamate Chemical compound C=1C=CC=CC=1COC(=O)NC1CCNC1=O DAMJCWMGELCIMI-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 abstract 1
- 235000019404 dichlorodifluoromethane Nutrition 0.000 abstract 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 abstract 1
- 235000011164 potassium chloride Nutrition 0.000 abstract 1
- 239000001103 potassium chloride Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 235000010344 sodium nitrate Nutrition 0.000 abstract 1
- 239000004317 sodium nitrate Substances 0.000 abstract 1
- 229910052938 sodium sulfate Inorganic materials 0.000 abstract 1
- 235000011152 sodium sulphate Nutrition 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention discloses pharmaceutical hormone intermediates11-ketone-16α,17α-epoxy progesterone synthesis method, comprises the following steps: 2-bromine-llα-hydroxy-14-amino-16α,17α-epoxy progesterone, sodium sulfate solution were added to the reaction vessel, controlled the stirring speed, controlled the temperature of the solution, reacted; added furan carboxylic acid ethyl ester solution and antimony trichloride powder, raised the temperature of the solution, reacted, added potassium chloride solution, lay up, got crystal, filter, washed with the sodium nitrate solution for several times, washed with the 2,6-dimethyl pyridine solution for several times, washed with the difluorodichloromethane solution for several times, re-crystallized in the diethylene glycol ether solution, dehydrated with dehydration, got the finished product 11-ketone-16α,17α-epoxy progesterone.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710527156.9A CN108239137A (en) | 2017-07-01 | 2017-07-01 | Medical -16 α of hormone intermediate 11- ketone, the synthetic method of 17 α-epoxy progesterone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IES20180195A2 true IES20180195A2 (en) | 2019-11-13 |
Family
ID=59996619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IES20180195 IES20180195A2 (en) | 2017-07-01 | 2018-06-26 | Pharmaceutical hormone intermediates 11-ketone-16α, 17α-epoxy progesterone synthesis method |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN108239137A (en) |
| AU (1) | AU2018100819A4 (en) |
| GB (1) | GB201713391D0 (en) |
| IE (1) | IES20180195A2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019037743A1 (en) * | 2017-08-22 | 2019-02-28 | 中国石油化工股份有限公司 | Starch-containing microsphere and preparation method therefor and application thereof |
-
2017
- 2017-07-01 CN CN201710527156.9A patent/CN108239137A/en active Pending
- 2017-08-21 GB GBGB1713391.9A patent/GB201713391D0/en not_active Ceased
-
2018
- 2018-06-19 AU AU2018100819A patent/AU2018100819A4/en not_active Ceased
- 2018-06-26 IE IES20180195 patent/IES20180195A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN108239137A (en) | 2018-07-03 |
| GB201713391D0 (en) | 2017-10-04 |
| AU2018100819A4 (en) | 2018-08-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FJ9A | Application deemed to be withdrawn section 31(3) |