IES20180200A2 - Anti-clavicular spirochete drugs ethyl imidazole synthesis method - Google Patents
Anti-clavicular spirochete drugs ethyl imidazole synthesis methodInfo
- Publication number
- IES20180200A2 IES20180200A2 IES20180200A IES20180200A2 IE S20180200 A2 IES20180200 A2 IE S20180200A2 IE S20180200 A IES20180200 A IE S20180200A IE S20180200 A2 IES20180200 A2 IE S20180200A2
- Authority
- IE
- Ireland
- Prior art keywords
- solution
- ethyl imidazole
- clavicular
- spirochete
- drugs
- Prior art date
Links
- PQAMFDRRWURCFQ-UHFFFAOYSA-N 2-ethyl-1h-imidazole Chemical compound CCC1=NC=CN1 PQAMFDRRWURCFQ-UHFFFAOYSA-N 0.000 title abstract 3
- 241000589970 Spirochaetales Species 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 238000001308 synthesis method Methods 0.000 title abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 abstract 2
- WAEVWDZKMBQDEJ-UHFFFAOYSA-N 2-[2-(2-methoxypropoxy)propoxy]propan-1-ol Chemical compound COC(C)COC(C)COC(C)CO WAEVWDZKMBQDEJ-UHFFFAOYSA-N 0.000 abstract 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 abstract 1
- XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical compound C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 abstract 1
- LBFUKZWYPLNNJC-UHFFFAOYSA-N cobalt(ii,iii) oxide Chemical compound [Co]=O.O=[Co]O[Co]=O LBFUKZWYPLNNJC-UHFFFAOYSA-N 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 abstract 1
- 229910052939 potassium sulfate Inorganic materials 0.000 abstract 1
- 235000011151 potassium sulphates Nutrition 0.000 abstract 1
- 235000010344 sodium nitrate Nutrition 0.000 abstract 1
- 239000004317 sodium nitrate Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The present invention discloses anti-clavicular spirochete drugs ethyl imidazole synthesis method, comprises the following steps:2,5-dihydroxyimidazole-4-carboxylate, potassium sulfate solution were added to the reaction vessel, controlled the stirring speed, raised the temperature, continued the reaction;, increased the temperature, added dicyclohexylamine solution, added the octacarbonyl cobalt oxide powder in batches, continued to react, reduced the temperature, precipitated the solids, washed with sodium nitrate solution for several times, washed with cyclohexane solution for several times, recrystallized in the tripropylene glycol monomethyl ether solution, dehydrated with dehydration, got the finished product ethyl imidazole.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710715096.3A CN108239032A (en) | 2017-08-19 | 2017-08-19 | The anti-synthetic method for hooking Leptospiral drug imidazole carboxylate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IES20180200A2 true IES20180200A2 (en) | 2019-11-13 |
Family
ID=60037232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IES20180200 IES20180200A2 (en) | 2017-08-19 | 2018-06-26 | Anti-clavicular spirochete drugs ethyl imidazole synthesis method |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN108239032A (en) |
| AU (1) | AU2018100847A4 (en) |
| GB (1) | GB201713880D0 (en) |
| IE (1) | IES20180200A2 (en) |
-
2017
- 2017-08-19 CN CN201710715096.3A patent/CN108239032A/en active Pending
- 2017-08-30 GB GBGB1713880.1A patent/GB201713880D0/en not_active Ceased
-
2018
- 2018-06-21 AU AU2018100847A patent/AU2018100847A4/en not_active Ceased
- 2018-06-26 IE IES20180200 patent/IES20180200A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GB201713880D0 (en) | 2017-10-11 |
| AU2018100847A4 (en) | 2018-08-02 |
| CN108239032A (en) | 2018-07-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FJ9A | Application deemed to be withdrawn section 31(3) |