IES20180262A2 - Drug intermediates 3,5-dimethoxybenzaldehyde synthesis method - Google Patents
Drug intermediates 3,5-dimethoxybenzaldehyde synthesis methodInfo
- Publication number
- IES20180262A2 IES20180262A2 IES20180262A IES20180262A2 IE S20180262 A2 IES20180262 A2 IE S20180262A2 IE S20180262 A IES20180262 A IE S20180262A IE S20180262 A2 IES20180262 A2 IE S20180262A2
- Authority
- IE
- Ireland
- Prior art keywords
- solution
- dimethoxybenzaldehyde
- added
- temperature
- synthesis method
- Prior art date
Links
- VFZRZRDOXPRTSC-UHFFFAOYSA-N 3,5-Dimethoxybenzaldehyde Chemical compound COC1=CC(OC)=CC(C=O)=C1 VFZRZRDOXPRTSC-UHFFFAOYSA-N 0.000 title abstract 6
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000001308 synthesis method Methods 0.000 title abstract 2
- 239000000243 solution Substances 0.000 abstract 8
- PFEOZHBOMNWTJB-UHFFFAOYSA-N 3-methylpentane Chemical compound CCC(C)CC PFEOZHBOMNWTJB-UHFFFAOYSA-N 0.000 abstract 2
- RDOXTESZEPMUJZ-UHFFFAOYSA-N anisole Chemical compound COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 abstract 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- -1 2-bromo-3,5-dimethoxybenzyl Chemical group 0.000 abstract 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- USWJSZNKYVUTIE-UHFFFAOYSA-N bis(sulfanylidene)rhenium Chemical compound S=[Re]=S USWJSZNKYVUTIE-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 abstract 1
- JEHCHYAKAXDFKV-UHFFFAOYSA-J lead tetraacetate Chemical compound CC(=O)O[Pb](OC(C)=O)(OC(C)=O)OC(C)=O JEHCHYAKAXDFKV-UHFFFAOYSA-J 0.000 abstract 1
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 abstract 1
- 235000010333 potassium nitrate Nutrition 0.000 abstract 1
- 239000004323 potassium nitrate Substances 0.000 abstract 1
- 229910052938 sodium sulfate Inorganic materials 0.000 abstract 1
- 235000011152 sodium sulphate Nutrition 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention discloses drug intermediates 3,5-dimethoxybenzaldehyde synthesis method, comprises the following steps: 2-bromo-3,5-dimethoxybenzyl alcohol and potassium nitrate solution are added to the reaction vessel, controls the stirring speed, raises the temperature of the solution, and then adds lead tetraacetate powder and aqueous solution, reacts; then 3-methyl pentane solution and rhenium disulfide powder is added, raises the temperature, continues to react, reduces the solution temperature to, sodium sulfate solution is added, put it aside, the solution is stratified, washed with anisole solution, recrystallized from dipropylene glycol solution and dehydrated with dehydration, obtains the finished product 3,5-dimethoxybenzaldehyde. <Figure 1>
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710781785.4A CN108264453A (en) | 2017-09-07 | 2017-09-07 | The synthetic method of pharmaceutical intermediate 3,5- dimethoxy benzaldehydes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IES20180262A2 true IES20180262A2 (en) | 2019-11-13 |
Family
ID=60117383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IES20180262 IES20180262A2 (en) | 2017-09-07 | 2018-08-23 | Drug intermediates 3,5-dimethoxybenzaldehyde synthesis method |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN108264453A (en) |
| AU (1) | AU2018101125A4 (en) |
| GB (1) | GB201714447D0 (en) |
| IE (1) | IES20180262A2 (en) |
-
2017
- 2017-09-07 CN CN201710781785.4A patent/CN108264453A/en active Pending
- 2017-09-08 GB GBGB1714447.8A patent/GB201714447D0/en not_active Ceased
-
2018
- 2018-08-11 AU AU2018101125A patent/AU2018101125A4/en not_active Ceased
- 2018-08-23 IE IES20180262 patent/IES20180262A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GB201714447D0 (en) | 2017-10-25 |
| AU2018101125A4 (en) | 2018-09-13 |
| CN108264453A (en) | 2018-07-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FJ9A | Application deemed to be withdrawn section 31(3) |