IES20180251U1 - Nicotinamide-n-oxide drug intermediates synthesis method - Google Patents
Nicotinamide-n-oxide drug intermediates synthesis methodInfo
- Publication number
- IES20180251U1 IES20180251U1 IES20180251A IES20180251A IES20180251U1 IE S20180251 U1 IES20180251 U1 IE S20180251U1 IE S20180251 A IES20180251 A IE S20180251A IE S20180251 A IES20180251 A IE S20180251A IE S20180251 U1 IES20180251 U1 IE S20180251U1
- Authority
- IE
- Ireland
- Prior art keywords
- solution
- added
- nicotinamide
- controlled
- drug intermediates
- Prior art date
Links
- USSFUVKEHXDAPM-UHFFFAOYSA-N Nicotinamide N-oxide Chemical compound NC(=O)C1=CC=C[N+]([O-])=C1 USSFUVKEHXDAPM-UHFFFAOYSA-N 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 3
- 239000000543 intermediate Substances 0.000 title abstract 3
- 238000001308 synthesis method Methods 0.000 title abstract 2
- ITQTTZVARXURQS-UHFFFAOYSA-N 3-methylpyridine Chemical compound CC1=CC=CN=C1 ITQTTZVARXURQS-UHFFFAOYSA-N 0.000 abstract 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 abstract 2
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 abstract 2
- 238000003756 stirring Methods 0.000 abstract 2
- XFNJVJPLKCPIBV-UHFFFAOYSA-N trimethylenediamine Chemical compound NCCCN XFNJVJPLKCPIBV-UHFFFAOYSA-N 0.000 abstract 2
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 abstract 1
- 229910021380 Manganese Chloride Inorganic materials 0.000 abstract 1
- GLFNIEUTAYBVOC-UHFFFAOYSA-L Manganese chloride Chemical compound Cl[Mn]Cl GLFNIEUTAYBVOC-UHFFFAOYSA-L 0.000 abstract 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- YACLQRRMGMJLJV-UHFFFAOYSA-N chloroprene Chemical compound ClC(=C)C=C YACLQRRMGMJLJV-UHFFFAOYSA-N 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- IEPRKVQEAMIZSS-AATRIKPKSA-N diethyl fumarate Chemical compound CCOC(=O)\C=C\C(=O)OCC IEPRKVQEAMIZSS-AATRIKPKSA-N 0.000 abstract 1
- 235000002867 manganese chloride Nutrition 0.000 abstract 1
- 239000011565 manganese chloride Substances 0.000 abstract 1
- 229940099607 manganese chloride Drugs 0.000 abstract 1
- HSPSCWZIJWKZKD-UHFFFAOYSA-N n-chloroacetamide Chemical compound CC(=O)NCl HSPSCWZIJWKZKD-UHFFFAOYSA-N 0.000 abstract 1
- 235000011164 potassium chloride Nutrition 0.000 abstract 1
- 239000001103 potassium chloride Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 229910052938 sodium sulfate Inorganic materials 0.000 abstract 1
- 235000011152 sodium sulphate Nutrition 0.000 abstract 1
Landscapes
- Pyridine Compounds (AREA)
Abstract
The present invention discloses drug intermediates nicotinamide-N-oxide drug intermediates synthesis method, comprises the following steps: 3-methylpyridine and potassium chloride solution were added to the reaction vessel, controlled the stirring speed, controlled the temperature of the solution, added diethyl fumarate solution and 1,3 -propanediamine solution, added N-chloroacetamide in batches, continued to react; then added manganese chloride powder, controlled the stirring speed, continued to react, added sodium sulfate solution, until the solution was stratified, separated the reservoir, washed with potassium bromide solution, washed with chlorobutadiene solution, recrystallized in ethylene glycol monomethyl ether solution, dehydrated with dehydration, got the finished product nicotinamide-N-oxide. <Figure 1>
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IES20180251A IES20180251U1 (en) | 2018-08-16 | 2018-08-16 | Nicotinamide-n-oxide drug intermediates synthesis method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IES20180251A IES20180251U1 (en) | 2018-08-16 | 2018-08-16 | Nicotinamide-n-oxide drug intermediates synthesis method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IES20180251U1 true IES20180251U1 (en) | 2020-02-19 |
Family
ID=69528043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IES20180251A IES20180251U1 (en) | 2018-08-16 | 2018-08-16 | Nicotinamide-n-oxide drug intermediates synthesis method |
Country Status (1)
| Country | Link |
|---|---|
| IE (1) | IES20180251U1 (en) |
-
2018
- 2018-08-16 IE IES20180251A patent/IES20180251U1/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM9A | Patent lapsed through non-payment of renewal fee |