IL111925A - Preparation of agents containing virus-inactivated vitamin K-dependent plasma components protein C and protein S by membrane chromatography - Google Patents

Preparation of agents containing virus-inactivated vitamin K-dependent plasma components protein C and protein S by membrane chromatography

Info

Publication number: IL111925A
Authority: IL; Israel
Prior art keywords: protein; preparation; agents containing; plasma components; containing virus
Prior art date: 1993-12-10

Application number

IL11192594A

Other languages

English (en)

Other versions

IL111925A0 (en

Original Assignee

Octapharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-10

Filing date

1994-12-07

Publication date

2000-06-01

1994-12-07 Application filed by Octapharma Ag filed Critical Octapharma Ag

1995-03-15 Publication of IL111925A0 publication Critical patent/IL111925A0/xx

2000-06-01 Publication of IL111925A publication Critical patent/IL111925A/xx

Links

101800004937 Protein C Proteins 0.000 title abstract 2
102000017975 Protein C Human genes 0.000 title abstract 2
229940096437 Protein S Drugs 0.000 title abstract 2
102000029301 Protein S Human genes 0.000 title abstract 2
108010066124 Protein S Proteins 0.000 title abstract 2
101800001700 Saposin-D Proteins 0.000 title abstract 2
229930003448 Vitamin K Natural products 0.000 title abstract 2
239000003795 chemical substances by application Substances 0.000 title abstract 2
230000001419 dependent effect Effects 0.000 title abstract 2
SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
229960000856 protein c Drugs 0.000 title abstract 2
235000019168 vitamin K Nutrition 0.000 title abstract 2
239000011712 vitamin K Substances 0.000 title abstract 2
150000003721 vitamin K derivatives Chemical class 0.000 title abstract 2
229940046010 vitamin k Drugs 0.000 title abstract 2
238000011140 membrane chromatography Methods 0.000 title 1
238000004587 chromatography analysis Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
108010012557 prothrombin complex concentrates Proteins 0.000 abstract 1
238000000926 separation method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biotechnology (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Animal Behavior & Ethology (AREA)
Peptides Or Proteins (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

IL11192594A 1993-12-10 1994-12-07 Preparation of agents containing virus-inactivated vitamin K-dependent plasma components protein C and protein S by membrane chromatography IL111925A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4342132A DE4342132C1 (de)	1993-12-10	1993-12-10	Verfahren zur Herstellung virusinaktivierte Vitamin K abhängige Plasmakomponenten sowie Protein C und Protein S enthaltender Mittel durch Membran-Chromatographie

Publications (2)

Publication Number	Publication Date
IL111925A0 IL111925A0 (en)	1995-03-15
IL111925A true IL111925A (en)	2000-06-01

Family

ID=6504650

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11192594A IL111925A (en)	1993-12-10	1994-12-07	Preparation of agents containing virus-inactivated vitamin K-dependent plasma components protein C and protein S by membrane chromatography

Country Status (19)

Country	Link
US (2)	US20020045240A1 (de)
EP (1)	EP0733104B1 (de)
JP (1)	JPH09506256A (de)
KR (1)	KR100320394B1 (de)
CN (1)	CN1175105C (de)
AT (1)	ATE276357T1 (de)
AU (1)	AU682560B2 (de)
CA (1)	CA2178208C (de)
CZ (1)	CZ291708B6 (de)
DE (2)	DE4342132C1 (de)
DK (1)	DK0733104T3 (de)
ES (1)	ES2224119T3 (de)
HU (1)	HU222084B1 (de)
IL (1)	IL111925A (de)
PL (1)	PL180179B1 (de)
PT (1)	PT733104E (de)
UA (1)	UA44261C2 (de)
WO (1)	WO1995016030A1 (de)
ZA (1)	ZA949820B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT409334B (de) *	1997-09-19	2002-07-25	Immuno Ag	Pharmazeutisches präparat enthaltend vitamin k-abhängige einzelfaktoren
US7932365B2 (en)	2003-11-08	2011-04-26	Pro Thera Biologics, Llc	Preparation and composition of inter-alpha inhibitor proteins from human plasma for therapeutic use
JP2005315666A (ja) *	2004-04-28	2005-11-10	Toshihiko Hanai	糖結合充填剤およびその製造方法
CN101098883B (zh) *	2004-12-23	2013-01-23	诺和诺德医疗保健公司	减少含有目的维生素k依赖性蛋白质的组合物中的蛋白质污染物的含量
KR100667860B1 (ko)	2005-10-18	2007-01-11	주식회사 녹십자	고순도 사람 혈액응고 제9인자의 정제 방법
PT2563805T (pt) *	2010-04-29	2020-05-18	Baxalta Inc	Método de purificação de proteínas que se ligam a catiões divalentes em resina de permuta aniónica
AU2011343813B2 (en)	2010-12-15	2015-05-21	Takeda Pharmaceutical Company Limited	Eluate collection using conductivity gradient
CN103665098B (zh) *	2012-09-20	2015-08-05	中国科学院大连化学物理研究所	双相柱膜蛋白质微反应器及其应用
CN104447975A (zh) *	2014-11-18	2015-03-25	深圳市人口和计划生育科学研究所	一种提取人肿瘤细胞膜蛋白的方法
WO2019086463A1 (en)	2017-10-30	2019-05-09	Baxalta GmbH	Environmentally compatible detergents for inactivation of lipid-enveloped viruses
CN111378029B (zh) *	2018-12-29	2023-05-05	四川远大蜀阳药业有限责任公司	一种人凝血因子ix的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3173208D1 (en) *	1980-10-06	1986-01-23	Edward Shanbrom	Method of reducing undesirable activities of biological and pharmaceutical products
DE3045153A1 (de) *	1980-11-29	1982-07-08	Behringwerke Ag, 3550 Marburg	Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ix und x
US4820805A (en) *	1983-07-14	1989-04-11	New York Blood Center, Inc.	Undenatured virus-free trialkyl phosphate treated biologically active protein derivatives
US4540573A (en) *	1983-07-14	1985-09-10	New York Blood Center, Inc.	Undenatured virus-free biologically active protein derivatives
ATE130620T1 (de) *	1986-01-06	1995-12-15	Blood Systems Inc	Therapeutisches blutprodukt, mittel und verfahren zu dessen erzeugung.
ES2045167T5 (es) *	1987-10-23	1996-07-01	Centre Regional De Transfusion	Preparacion de concentrado de factor ix humano de elevada pureza y de otras proteinas plasmaticas.
CA2001720C (en) *	1988-10-31	2001-10-02	Randal A. Goffe	Membrane affinity apparatus and purification methods related thereto
DE3914869C1 (de) *	1989-05-05	1990-08-09	Biotest Pharma Gmbh, 6072 Dreieich, De
CA2073511A1 (en) *	1990-11-14	1992-05-29	Matthew R. Callstrom	Conjugates of poly(vinylsaccharide) with proteins for the stabilization of proteins
AT402261B (de) *	1991-01-25	1997-03-25	Immuno Ag	Komplex enthaltend den gerinnungsfaktor ix
AT402891B (de) *	1991-06-20	1997-09-25	Immuno Ag	Verfahren zur herstellung eines inaktivierten blutproduktes
DE4204694C3 (de) *	1992-02-01	1995-10-12	Octapharma Ag	Verfahren zur Gewinnung von hochreinem, virusinaktiviertem Faktor VIII mittels Anionenaustauscher-Chromatographie

1993
- 1993-12-10 DE DE4342132A patent/DE4342132C1/de not_active Expired - Lifetime
1994
- 1994-07-12 UA UA96062228A patent/UA44261C2/uk unknown
- 1994-12-07 AT AT95903324T patent/ATE276357T1/de active
- 1994-12-07 CZ CZ19961670A patent/CZ291708B6/cs not_active IP Right Cessation
- 1994-12-07 JP JP7515975A patent/JPH09506256A/ja active Pending
- 1994-12-07 CA CA002178208A patent/CA2178208C/en not_active Expired - Fee Related
- 1994-12-07 KR KR1019960703050A patent/KR100320394B1/ko not_active Expired - Fee Related
- 1994-12-07 DE DE69434001T patent/DE69434001T2/de not_active Expired - Lifetime
- 1994-12-07 DK DK95903324T patent/DK0733104T3/da active
- 1994-12-07 AU AU12425/95A patent/AU682560B2/en not_active Ceased
- 1994-12-07 CN CNB94194445XA patent/CN1175105C/zh not_active Expired - Fee Related
- 1994-12-07 HU HU9601594A patent/HU222084B1/hu not_active IP Right Cessation
- 1994-12-07 EP EP95903324A patent/EP0733104B1/de not_active Expired - Lifetime
- 1994-12-07 IL IL11192594A patent/IL111925A/xx not_active IP Right Cessation
- 1994-12-07 WO PCT/EP1994/004067 patent/WO1995016030A1/en not_active Ceased
- 1994-12-07 PL PL94314801A patent/PL180179B1/pl not_active IP Right Cessation
- 1994-12-07 US US08/646,331 patent/US20020045240A1/en not_active Abandoned
- 1994-12-07 ES ES95903324T patent/ES2224119T3/es not_active Expired - Lifetime
- 1994-12-07 PT PT95903324T patent/PT733104E/pt unknown
- 1994-12-09 ZA ZA949820A patent/ZA949820B/xx unknown
2002
- 2002-05-02 US US10/136,468 patent/US6893856B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO1995016030A1 (en)	1995-06-15
PT733104E (pt)	2004-12-31
EP0733104A1 (de)	1996-09-25
HU222084B1 (hu)	2003-04-28
CZ167096A3 (en)	1996-09-11
US6893856B2 (en)	2005-05-17
DK0733104T3 (da)	2005-01-17
KR100320394B1 (ko)	2002-07-31
PL314801A1 (en)	1996-09-30
AU1242595A (en)	1995-06-27
EP0733104B1 (de)	2004-09-15
US20020045240A1 (en)	2002-04-18
CN1137292A (zh)	1996-12-04
IL111925A0 (en)	1995-03-15
US20020182582A1 (en)	2002-12-05
CA2178208A1 (en)	1995-06-15
ATE276357T1 (de)	2004-10-15
CN1175105C (zh)	2004-11-10
DE4342132C1 (de)	1994-11-03
AU682560B2 (en)	1997-10-09
UA44261C2 (uk)	2002-02-15
ZA949820B (en)	1995-08-16
CZ291708B6 (cs)	2003-05-14
JPH09506256A (ja)	1997-06-24
CA2178208C (en)	2009-06-02
DE69434001D1 (de)	2004-10-21
PL180179B1 (pl)	2000-12-29
HU9601594D0 (en)	1996-07-29
DE69434001T2 (de)	2005-09-22
ES2224119T3 (es)	2005-03-01
HUT76881A (en)	1997-12-29

Legal Events

Date	Code	Title
2000-06-01	HE	Change of address of proprietor(s)
2000-11-21	FF	Patent granted
2001-07-24	KB	Patent renewed
2005-02-20	KB	Patent renewed
2009-06-15	KB	Patent renewed
2013-07-31	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
Loskutoff	1979	Effect of thrombin on the fibrinolytic activity of cultured bovine endothelial cells.
IL111925A0 (en)	1995-03-15	Preparation of agents containing virus - inactivated vitamin k-dependent plasma components, protein c and protein s by membrane chromatography
GR3021875T3 (en)	1997-03-31	Process for preparing an activated factor VII concentrate having a high purity
MY121543A (en)	2006-02-28	Preparation of 3,4,4-trisubstituted-piperidinyl-n- alkylcarboxylates and intermediates
ES8607732A1 (es)	1986-06-01	Procedimiento para producir un preparado implantable de un peptido regulador, uno de sus analogos o una de sus sales fisiologicamente compatibles.
HUT63863A (en)	1993-10-28	Complex comprising anticoagulant ix factor
EP0035202A3 (en)	1982-09-01	Fibronectin compositions and methods of isolation therefor
EP0378208A3 (de)	1991-01-30	Verfahren zur Herstellung einer Protein enthaltenden Zusammensetzung
UA18261A (uk)	1997-12-25	Спосіб одержаhhя простих перфторполіефірів
IE863279L (en)	1987-06-17	Plasminogen activator composition
CA2002540A1 (fr)	1990-05-09	Sequence d'adn codant pour le facteur ix humain ou une proteine analogue, vecteur d'expression, cellules transformees procede de preparation du facteur ix et produits obtenus correspondants
ES2000030A6 (es)	1987-10-01	Metodo de purificar factor sanguineo viii:c
GB9221163D0 (en)	1992-11-25	Dna compounds
MY106202A (en)	1995-03-31	Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof.
Seegers et al.	1965	Some activation characteristics of the prethrombin subunit of prothrombin
GB8914968D0 (en)	1989-08-23	Production of virus and purification of viral envelope proteins for vaccine use
Voellmy et al.	1981	ATP-stimulated endoprotease is associated with the cell membrane of E. coli
AU2997684A (en)	1985-01-03	Process for the dissolution of peptides and proteins
GR3025929T3 (en)	1998-04-30	Ein isolation and purification of lung surfactant prot
Legrand et al.	1975	Separation of human blood platelet elastase and proelastase by affinity chromatography
Kisiel et al.	1987	Isolation of a protein C activator from southern copperhead venom
ES8900018A1 (es)	1988-11-16	Procedimiento para la fabricacion de derivados aminoalcoholes peptidicos inhibidores de la renina y de las proteasas acidas
AU632526B2 (en)	1993-01-07	Novel peptides inhibiting the maturation of t-lymphocytes and the activity of macrophages, pharmaceutical compositions containing them and process for preparing same
Sakamoto et al.	1986	T-kinin is released from T-kininogen by consecutive cleavage by cathespin E-like proteinase and 72 kDa proteinase
EP0146929A3 (de)	1987-06-03	Mikroorganismus des Genus serratia ein hybrides Plasmid enthaltend und Verfahren zur Herstellung desselbes