IL112557A - Peptides that are VIP antagonists and pharmaceutical compositions comprising them - Google Patents

Peptides that are VIP antagonists and pharmaceutical compositions comprising them

Info

Publication number: IL112557A
Authority: IL; Israel
Prior art keywords: vip; peptides; pharmaceutical compositions; relates; vip antagonists
Prior art date: 1994-02-07

Application number

IL11255795A

Other languages

English (en)

Other versions

IL112557A0 (en

Inventor

Illana Gozes

Douglas E Brenneman

Terry W Moody

Original Assignee

Univ Ramot

Yeda Res & Dev

Secretary Of The Dept Of Healt

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-02-07

Filing date

1995-02-06

Publication date

2000-02-17

1995-02-06 Application filed by Univ Ramot, Yeda Res & Dev, Secretary Of The Dept Of Healt filed Critical Univ Ramot

1995-05-26 Publication of IL112557A0 publication Critical patent/IL112557A0/xx

2000-02-17 Publication of IL112557A publication Critical patent/IL112557A/xx

Links

102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
239000005557 antagonist Substances 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
108010003205 Vasoactive Intestinal Peptide Proteins 0.000 abstract 5
102400000015 Vasoactive intestinal peptide Human genes 0.000 abstract 5
VBUWHHLIZKOSMS-RIWXPGAOSA-N invicorp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 VBUWHHLIZKOSMS-RIWXPGAOSA-N 0.000 abstract 5
230000000694 effects Effects 0.000 abstract 2
230000032823 cell division Effects 0.000 abstract 1
230000005062 synaptic transmission Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/083—Neurotensin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Toxicology (AREA)
Bioinformatics & Cheminformatics (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL11255795A 1994-02-07 1995-02-06 Peptides that are VIP antagonists and pharmaceutical compositions comprising them IL112557A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/194,591 US5565424A (en)	1994-02-07	1994-02-07	Superactive VIP antagonists

Publications (2)

Publication Number	Publication Date
IL112557A0 IL112557A0 (en)	1995-05-26
IL112557A true IL112557A (en)	2000-02-17

Family

ID=22718168

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11255795A IL112557A (en)	1994-02-07	1995-02-06	Peptides that are VIP antagonists and pharmaceutical compositions comprising them

Country Status (11)

Country	Link
US (1)	US5565424A (de)
EP (1)	EP0738280B1 (de)
JP (1)	JP3588119B2 (de)
AT (1)	ATE199160T1 (de)
AU (1)	AU697829B2 (de)
CA (1)	CA2182795C (de)
DE (1)	DE69520092T2 (de)
DK (1)	DK0738280T3 (de)
ES (1)	ES2155886T3 (de)
IL (1)	IL112557A (de)
WO (1)	WO1995021194A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5849261A (en) *	1991-02-08	1998-12-15	Diatide, Inc.	Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US6492330B1 (en) *	1996-08-16	2002-12-10	National Institute Of Immunology	Antiangiogenic drugs
US6156725A (en) *	1996-08-16	2000-12-05	National Institute Of Immunology	Drug for the treatment of cancer
EP0835662B1 (de) *	1996-10-08	2001-11-14	National Institute of Immunology	Arzneimittel zur Behandlung von Krebs
US20020099003A1 (en) *	1997-10-28	2002-07-25	Wilson Leland F.	Treatment of female sexual dysfunction with vasoactive agents, particularly vasoactive intestinal polypeptide and agonists thereof
JP2003530297A (ja) *	1998-10-16	2003-10-14	ザガバメントオブザユナイテッドステイツオブアメリカ，リプリゼンテッドバイザセクレタリーオブザデパートメントオブヘルスアンドヒューマンサービシーズ	Ｖｉｐアンタゴニストを用いる併用療法
DE60033697D1 (de)	2000-02-18	2007-04-12	Dabur Res Foundation Sahibabad	Radiomarkierte vip-analoge zur diagnose und therapie
AU2000265051A1 (en) *	2000-02-18	2001-08-27	Dabur Research Foundation	Vasoactive intestinal peptide analogs
US6828304B1 (en)	2000-07-31	2004-12-07	Dabur Research Foundation	Peptides for treatment of cancer
WO2002010193A1 (en) *	2000-07-31	2002-02-07	Dabur Research Foundation	Lipid-peptide conjugates for treatment of cancer
US20060075968A1 (en) *	2004-10-12	2006-04-13	Applied Materials, Inc.	Leak detector and process gas monitor
US9669092B2 (en)	2011-02-02	2017-06-06	Emory University	Antagonism of the VIP signaling pathway
US9458217B2 (en) *	2013-12-05	2016-10-04	Emory University	Methods of managing graft versus host disease
EP3439685B1 (de)	2016-04-08	2023-07-05	Emory University	Verfahren zur behandlung von krebs und infektionskrankheiten mit zellbasierten therapien
WO2019094817A1 (en)	2017-11-10	2019-05-16	Emory University	Nanoparticles conjugated with vasoactive intestinal peptide antagonists
WO2019209952A2 (en)	2018-04-23	2019-10-31	Emory University	Vip antagonists and uses in treating cancer
AU2019381809B2 (en) *	2018-11-15	2025-09-11	Emory University	Compositions and uses of vasoactive intestinal peptide (VIP) antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4605641A (en) *	1984-10-09	1986-08-12	Hoffmann-La Roche Inc.	Synthetic vasoactive intestinal peptide analogs
US4734400A (en) *	1984-10-09	1988-03-29	Hoffmann-La Roche Inc.	Synthetic vasoactive intestinal peptide analogs
US5196315A (en) *	1990-05-01	1993-03-23	The Johns Hopkins University	Human neuronal cell line
DK0463450T3 (da) *	1990-06-26	1994-06-27	Sanwa Kagaku Kenkyusho Co	Vasoaktive intestinale polypeptid-analoger og udnyttelsen heraf
US5217953A (en) *	1990-11-30	1993-06-08	The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services	Vasoactive intestinal peptide antagonist
US5273963A (en) *	1991-03-29	1993-12-28	The George Washington University	Compositions and methods for treating small cell and nonsmall cell lung cancers
IL99924A (en) *	1991-10-31	1995-12-31	Yeda Res & Dev	Derivatives of structurally modified vip and pharmaceutical compositions containing them

1994
- 1994-02-07 US US08/194,591 patent/US5565424A/en not_active Expired - Lifetime
1995
- 1995-02-06 IL IL11255795A patent/IL112557A/xx not_active IP Right Cessation
- 1995-02-06 WO PCT/US1995/001496 patent/WO1995021194A1/en not_active Ceased
- 1995-02-06 JP JP52080495A patent/JP3588119B2/ja not_active Expired - Fee Related
- 1995-02-06 ES ES95909489T patent/ES2155886T3/es not_active Expired - Lifetime
- 1995-02-06 AU AU17438/95A patent/AU697829B2/en not_active Ceased
- 1995-02-06 DE DE69520092T patent/DE69520092T2/de not_active Expired - Fee Related
- 1995-02-06 CA CA002182795A patent/CA2182795C/en not_active Expired - Fee Related
- 1995-02-06 EP EP95909489A patent/EP0738280B1/de not_active Expired - Lifetime
- 1995-02-06 AT AT95909489T patent/ATE199160T1/de not_active IP Right Cessation
- 1995-02-06 DK DK95909489T patent/DK0738280T3/da active

Also Published As

Publication number	Publication date
WO1995021194A1 (en)	1995-08-10
DK0738280T3 (da)	2001-09-17
JP3588119B2 (ja)	2004-11-10
CA2182795C (en)	2007-11-06
ES2155886T3 (es)	2001-06-01
ATE199160T1 (de)	2001-02-15
DE69520092D1 (de)	2001-03-22
JPH09511494A (ja)	1997-11-18
AU1743895A (en)	1995-08-21
US5565424A (en)	1996-10-15
CA2182795A1 (en)	1995-08-10
IL112557A0 (en)	1995-05-26
EP0738280B1 (de)	2001-02-14
EP0738280A1 (de)	1996-10-23
AU697829B2 (en)	1998-10-15
DE69520092T2 (de)	2001-08-02

Legal Events

Date	Code	Title
2000-06-29	FF	Patent granted
2000-10-31	KB	Patent renewed
2001-07-24	KB	Patent renewed
2006-01-15	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL112557A0 (en)	1995-05-26	Peptides that are vip antagonists and pharmaceutical compositions comprising them
ZA988585B (en)	2000-03-13	Pharmaceutical compositions containing plasma protein.
SI0984982T1 (en)	2002-02-28	Lh-rh peptide analogues, their uses and pharmaceutical compositions containing them
ZA975533B (en)	1998-01-29	Cyclosporin-containing pharmaceutical composition.
PH31059A (en)	1998-02-05	Pharmaceutical compositions comprising cyclosporins.
IL70944A (en)	1990-11-29	Octapeptide vasopressin antagonists,their preparation and pharmaceutical compositions comprising them
ZA967451B (en)	1997-03-10	Antagonists of the oncogenic activity of the mdm2 protein and their use in the treatment of cancers
AU5186799A (en)	2000-02-07	Peptides of il-2 and derivatives thereof and their use as therapeutic agents
AUPP589598A0 (en)	1998-10-08	Novel peptides
NZ305735A (en)	1999-01-28	Cyclic peptide antifungal agents, preparation and pharmaceutical compositions thereof
HRP950612B1 (en)	2003-12-31	PEPTIDE p277 ANALOGS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
MXPA03001468A (es)	2004-05-04	Polipeptidos de claudia.
EP0644769A4 (de)	1995-08-09	Biologisch aktive peptide mit n-terminalen substitutionen.
FI954986L (fi)	1995-10-19	Uudet, suun kautta annettavat, syklosporiinia sisältävät farmaseuttiset valmisteet
IL139604A0 (en)	2002-02-10	Novel peptides
ZA9710254B (en)	1998-05-28	LH-RH peptide analogues, their uses and pharmaceutical composition containing them.
BG101849A (en)	1998-04-30	Bicyclic tachyquinine antagonists, their preparation and use in pharmaceutical compositions
BG102514A (en)	1999-04-30	New lh-rh-antagonists of improved effect
DE69434151D1 (de)	2004-12-30	Therapeutische inhaltsstoffe
IL92441A0 (en)	1990-07-26	Imidazole containing peptides,their preparation and pharmaceutical compositions containing them
EP0778833A4 (de)	1998-12-16	Endothelin-rezeptor-antagonisten
WO1999025732A3 (en)	1999-09-02	Design of coiled-coil dimer derived antagonists of 4-helix bundle cytokine specific receptors
EP0154544A3 (de)	1988-10-05	Antagonisten von Des-Proline Vasopressin
IL127565A0 (en)	1999-10-28	Virginiamycin mixture
ZA9711158B (en)	1998-06-15	Structurally modified peptides that are resistant to peptidase degradation.