ATE101619T1 - Vip-analogen und ihre verwendung. - Google Patents

Vip-analogen und ihre verwendung.

Info

Publication number: ATE101619T1
Authority: AT; Austria
Prior art keywords: homoserine; vip; analogues; amidized; lactone
Prior art date: 1990-06-26

Application number

AT91109490T

Other languages

English (en)

Inventor

Masayasu Kurono

Takahiko Mitani

Haruo Takahashi

Kiichi Sawai

Original Assignee

Sanwa Kagaku Kenkyusho Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-26

Filing date

1991-06-10

Publication date

1994-03-15

1990-06-26 Priority claimed from JP2165739A external-priority patent/JPH0459794A/ja

1990-12-27 Priority claimed from JP2408425A external-priority patent/JPH04230400A/ja

1991-06-10 Application filed by Sanwa Kagaku Kenkyusho Co filed Critical Sanwa Kagaku Kenkyusho Co

1994-03-15 Application granted granted Critical

1994-03-15 Publication of ATE101619T1 publication Critical patent/ATE101619T1/de

Links

108010003205 Vasoactive Intestinal Peptide Proteins 0.000 abstract 4
102400000015 Vasoactive intestinal peptide Human genes 0.000 abstract 4
UKAUYVFTDYCKQA-UHFFFAOYSA-N -2-Amino-4-hydroxybutanoic acid Natural products OC(=O)C(N)CCO UKAUYVFTDYCKQA-UHFFFAOYSA-N 0.000 abstract 3
UKAUYVFTDYCKQA-VKHMYHEASA-N L-homoserine Chemical group OC(=O)[C@@H](N)CCO UKAUYVFTDYCKQA-VKHMYHEASA-N 0.000 abstract 3
QJPWUUJVYOJNMH-VKHMYHEASA-N L-homoserine lactone Chemical group N[C@H]1CCOC1=O QJPWUUJVYOJNMH-VKHMYHEASA-N 0.000 abstract 2
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
150000003973 alkyl amines Chemical class 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
210000004899 c-terminal region Anatomy 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
201000001881 impotence Diseases 0.000 abstract 1
239000004615 ingredient Substances 0.000 abstract 1
229930182817 methionine Natural products 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
230000001256 tonic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Toxicology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Vascular Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)

AT91109490T 1990-06-26 1991-06-10 Vip-analogen und ihre verwendung. ATE101619T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2165739A JPH0459794A (ja)	1990-06-26	1990-06-26	Ｖｉｐ様活性を有するポリペプチド誘導体及びその用途
JP2408425A JPH04230400A (ja)	1990-12-27	1990-12-27	Ｖｉｐ様活性を有するポリペプチド誘導体及びその用途

Publications (1)

Publication Number	Publication Date
ATE101619T1 true ATE101619T1 (de)	1994-03-15

Family

ID=26490358

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91109490T ATE101619T1 (de)	1990-06-26	1991-06-10	Vip-analogen und ihre verwendung.

Country Status (6)

Country	Link
US (1)	US5428015A (de)
EP (1)	EP0463450B1 (de)
AT (1)	ATE101619T1 (de)
DE (1)	DE69101187T2 (de)
DK (1)	DK0463450T3 (de)
ES (1)	ES2063406T3 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5849261A (en) *	1991-02-08	1998-12-15	Diatide, Inc.	Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
IL99924A (en) *	1991-10-31	1995-12-31	Yeda Res & Dev	Derivatives of structurally modified vip and pharmaceutical compositions containing them
US5998368A (en) *	1991-10-31	1999-12-07	Yeda Research And Development Co. Ltd.	Derivatives of structurally modified VIP and pharmaceutical compositions containing them
JPH06220090A (ja) *	1993-01-22	1994-08-09	Sanwa Kagaku Kenkyusho Co Ltd	ポリペプチド
JPH06306100A (ja) *	1993-04-26	1994-11-01	Sanwa Kagaku Kenkyusho Co Ltd	Ｖｉｐアナログ調製用融合蛋白、ｖｉｐアナログの製法並びにそのための遺伝子組換えプラスミド及び形質転換微生物
JPH07173197A (ja) *	1993-12-20	1995-07-11	Sanwa Kagaku Kenkyusho Co Ltd	ポリペプチド修飾化合物及びその用途
US5565424A (en) *	1994-02-07	1996-10-15	Ramot - University Authority For Applied Research And Industrial Development Ltd.	Superactive VIP antagonists
US20020032160A1 (en) *	1995-02-24	2002-03-14	Nyce Jonathan W.	Compositions & formulations with an epiandrosterone or a ubiquinone & kits & their use for treatment of asthma symptoms & for reducing adenosine/adenosine receptor levels
US5660835A (en) *	1995-02-24	1997-08-26	East Carolina University	Method of treating adenosine depletion
EP0796867B1 (de) *	1995-06-09	2003-11-05	Itoham Foods Inc.	Peptide, bronchodilator und den blutstrom verbesserndes mittel
IL118003A0 (en) *	1996-04-23	1996-08-04	Yeda Res & Dev	Novel vip fragments and pharmaceutical compositions comprising them
US20020099003A1 (en) *	1997-10-28	2002-07-25	Wilson Leland F.	Treatment of female sexual dysfunction with vasoactive agents, particularly vasoactive intestinal polypeptide and agonists thereof
US6303575B1 (en)	1998-05-12	2001-10-16	The Regents Of The University Of California	Indolicidin analogs and methods of using same
EP1233811A2 (de) *	1999-11-12	2002-08-28	Leo Rubin	Verfahren zur behandlung von herzstillstand oder pulmonarer hypertension und substanzen zur verwendung dafür mit vasoaktivem intestinalen polypeptid und kardiales gerät zur elektrischen und chemischen regulation sowie verwendungsverfahren dafür
US6489297B1 (en) *	2000-02-18	2002-12-03	Dabur Research Foundation	Vasoactive intestinal peptide analogs
WO2001060863A1 (en)	2000-02-18	2001-08-23	Dabur Research Foundation	Radiolabeled vasoactive intestinal peptide analogs for diagnosis and radiotherapy
WO2001090144A2 (en) *	2000-05-22	2001-11-29	Ramot At Tel-Aviv University Ltd.	Vip-related peptides for the treatment of sexual disorders in women
GB0016441D0 (en) *	2000-07-04	2000-08-23	Pharmagene Lab Limited	Therapeutic method
US6828304B1 (en)	2000-07-31	2004-12-07	Dabur Research Foundation	Peptides for treatment of cancer
AU2072002A (en)	2000-11-28	2002-06-11	Mondobiotech Sa	Compounds with the biological activity of vasoactive intestinal peptide for the treatment of pulmonary and arteriolar hypertension
GB0118383D0 (en) *	2001-07-27	2001-09-19	Pharmagene Lab Ltd	Therapeutic methods
AU2003236072B2 (en)	2002-06-10	2008-10-23	Mondobiotech Ag	Use of compounds having the biological activity of vasoactive intestinal peptide for the treatment of sarcoidosis
US20040086566A1 (en) *	2002-11-04	2004-05-06	Alpharma, Inc.	Waxy matrix dosage forms
ES2363738T3 (es) *	2005-03-07	2011-08-12	Mondobiotech Ag	Formulación de aviptadil.
US20080051413A1 (en) *	2006-08-25	2008-02-28	Kaohsiung Medical University	Nitrophenylpiperazine derivative of xanthine which relaxes tracheal airway and increases respiratory performance
US9029505B2 (en) *	2009-08-14	2015-05-12	Phasebio Pharmaceuticals, Inc.	Modified vasoactive intestinal peptides
CA2873553C (en)	2011-06-06	2020-01-28	Phasebio Pharmaceuticals, Inc.	Use of modified vasoactive intestinal peptides in the treatment of hypertension
US11052132B2 (en)	2014-05-08	2021-07-06	Phasebio Pharmaceuticals, Inc.	Methods and compositions for treating cystic fibrosis
CN114652817B (zh)	2015-02-09	2026-04-17	费斯生物制药公司	用于治疗肌肉疾病和病症的方法和组合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3880826A (en) *	1971-09-17	1975-04-29	Sami I Said	Vasoactive intestinal peptide
JPS56128721A (en) *	1980-03-12	1981-10-08	Eisai Co Ltd	Antiallergic agent
JPS6216429A (ja) *	1985-05-14	1987-01-24	アイ・リサ−チ・インステイテユ−ト・オブ・ザ・レテイナ・フアウンデイシヨン	涙液分秘の刺激
GB8525852D0 (en) *	1985-10-19	1985-11-20	Beecham Group Plc	Compounds
JPS62246595A (ja) *	1986-04-17	1987-10-27	Eisai Co Ltd	気菅支拡張作用・降圧作用ペプタイド
JP2862870B2 (ja) *	1986-09-12	1999-03-03	協和醗酵工業株式会社	新規ペプチド
JPS63179892A (ja) *	1987-01-19	1988-07-23	Daicel Chem Ind Ltd	Ｖｉｐ塩酸塩及びその製造法
JPS6483012A (en) *	1987-09-22	1989-03-28	Eisai Co Ltd	Hair growth agent
JPH01296996A (ja) *	1988-05-26	1989-11-30	Akira Kaji	新規ペプチド
IL87055A (en) *	1988-07-08	1994-06-24	Illana Gozes	Conjugates of vasoactive intestinal peptide (vip) and of fragments thereof and pharmaceutical compositions comprising them
EP0378078A1 (de) *	1989-01-06	1990-07-18	Sanwa Kagaku Kenkyusho Co., Ltd.	Dem Motilin ähnliches Polypeptid und seine Verwendung

1991
- 1991-06-10 DE DE69101187T patent/DE69101187T2/de not_active Expired - Fee Related
- 1991-06-10 EP EP91109490A patent/EP0463450B1/de not_active Expired - Lifetime
- 1991-06-10 ES ES91109490T patent/ES2063406T3/es not_active Expired - Lifetime
- 1991-06-10 AT AT91109490T patent/ATE101619T1/de not_active IP Right Cessation
- 1991-06-10 DK DK91109490.2T patent/DK0463450T3/da active
1994
- 1994-02-24 US US08/201,092 patent/US5428015A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK0463450T3 (da)	1994-06-27
DE69101187T2 (de)	1994-09-29
US5428015A (en)	1995-06-27
DE69101187D1 (de)	1994-03-24
EP0463450B1 (de)	1994-02-16
ES2063406T3 (es)	1995-01-01
EP0463450A1 (de)	1992-01-02

Legal Events

Date	Code	Title	Description
1994-11-15	UEP	Publication of translation of european patent specification
1997-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE101619T1 (de)	1994-03-15	Vip-analogen und ihre verwendung.
ATE123296T1 (de)	1995-06-15	Gip-analoge und deren verwendung.
DK0535346T3 (da)	1995-12-04	3-Amino-7-substitueret-6-demethyl-6-deoxytetracyclin
DE68927861D1 (de)	1997-04-17	11 beta-substituierte progesteron-analoge
EP0152820A3 (en)	1987-04-22	Carbamate compounds, compositions and method of making the same
DE69232302D1 (de)	2002-01-31	7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline
ATE138652T1 (de)	1996-06-15	Aminoalkohole
DE69521615D1 (de)	2001-08-09	Streptogramine in gereinigter form, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen
MX22239A (es)	1993-11-01	Derivados de n-fenilpirazol.
EP0379483A4 (en)	1991-10-09	1,2,3,4,10,14b-hexahydrodibenzo c,f¨pyrazino- 1,2-a¨azepino derivatives and 10-aza, 10-oxa and 10-thia analogues
ES2001697A6 (es)	1988-06-01	Procedimiento para preparar 2-aminopurinas sustituidas en posiciones 6 y 9
ES2108016T3 (es)	1997-12-16	Triazolopiridazinas substituidas.
ES8705853A1 (es)	1987-05-16	Un procedimiento para la produccion de derivados de benzoilurea
EP0637958A1 (de)	1995-02-15	Wirkstoffe gegen fettleibigkeit.
BR8208033A (pt)	1983-11-22	Processo quimico
DK0411313T3 (da)	1994-02-28	N,N-Disubstituerede og N,N,N-/N,N,N-trisubstituerede thiourinstoffer og fremgangsmåde til deres fremstilling (II)
DE3680725D1 (en)	1991-09-12	Propanolabkoemmlinge.
YU44164B (en)	1990-02-28	New industrial process for synthesis of n-/(1\|alyl-2\|-pyrolidinyle) methyl/-2-metoxy-4,5-azimido-benzamide
CA1270833C (en)	1990-06-26	2,5-PYRROLIDINEDIONE DERIVATIVES USEFUL AS ANTI-ARHYTMIZING AGENTS
BR8706887A (pt)	1988-07-26	Processo para a preparacao de compostos
ATE59040T1 (de)	1990-12-15	Verfahren zur herstellung von ergolinylthioharnstoffen.