IL116696A - Production of enzymatically active recombinant carboxypeptidase b - Google Patents

Production of enzymatically active recombinant carboxypeptidase b

Info

Publication number
IL116696A
IL116696A IL11669696A IL11669696A IL116696A IL 116696 A IL116696 A IL 116696A IL 11669696 A IL11669696 A IL 11669696A IL 11669696 A IL11669696 A IL 11669696A IL 116696 A IL116696 A IL 116696A
Authority
IL
Israel
Prior art keywords
procpb
enzymatically active
production
active recombinant
active cpb
Prior art date
Application number
IL11669696A
Other languages
English (en)
Other versions
IL116696A0 (en
Original Assignee
Bio Technology General Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Technology General Corp filed Critical Bio Technology General Corp
Publication of IL116696A0 publication Critical patent/IL116696A0/xx
Publication of IL116696A publication Critical patent/IL116696A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL11669696A 1995-01-25 1996-01-08 Production of enzymatically active recombinant carboxypeptidase b IL116696A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37823395A 1995-01-25 1995-01-25

Publications (2)

Publication Number Publication Date
IL116696A0 IL116696A0 (en) 1996-05-14
IL116696A true IL116696A (en) 1999-08-17

Family

ID=23492292

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11669696A IL116696A (en) 1995-01-25 1996-01-08 Production of enzymatically active recombinant carboxypeptidase b

Country Status (21)

Country Link
US (1) US5948668A (pl)
EP (1) EP0871718B1 (pl)
JP (1) JP4250716B2 (pl)
KR (1) KR100566136B1 (pl)
CN (1) CN1144874C (pl)
AT (1) ATE358717T1 (pl)
AU (1) AU698889B2 (pl)
BR (1) BR9606795A (pl)
CA (1) CA2210242C (pl)
CZ (1) CZ292541B6 (pl)
DE (1) DE69637011T2 (pl)
DK (1) DK0871718T3 (pl)
ES (1) ES2284167T3 (pl)
HU (1) HU225673B1 (pl)
IL (1) IL116696A (pl)
MX (1) MX9705279A (pl)
NZ (1) NZ302874A (pl)
PL (1) PL183228B1 (pl)
PT (1) PT871718E (pl)
WO (1) WO1996023064A1 (pl)
ZA (1) ZA96515B (pl)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU707689B2 (en) 1995-08-16 1999-07-15 Astrazeneca Ab Mutated Carboxypeptidase B enzyme conjugated to a tumour targeted antibody for use in Antibody Directed Enzyme Prodrug Therapy
EP2158923B1 (en) 1998-08-06 2013-02-27 Mountain View Pharmaceuticals, Inc. Peg-urate oxidase conjugates and use thereof
US20040117863A1 (en) * 1998-09-18 2004-06-17 Edge Michael D. Transgenically produced fusion proteins
DE19915938A1 (de) * 1999-04-09 2000-10-19 Aventis Pharma Gmbh Herstellung von pankreatischer Procarboxypeptidase B, Isoformen und Muteinen davon und ihre Verwendung
US6441153B1 (en) 1999-09-29 2002-08-27 Lexicon Genetics Incorporated Human carboxypeptidases and polynucleotides encoding the same
KR20020073127A (ko) * 1999-09-17 2002-09-19 겐자임 트랜스제닉스 코포레이션 형질전환에 의하여 생성된 융합 단백질
EP1632575B1 (en) * 1999-09-29 2009-01-28 Lexicon Pharmaceuticals, Inc. Human carboxypeptidases and polynucleotides encoding the same
AU2001229253A1 (en) * 2000-01-12 2001-07-24 Eli Lilly And Company Carboxypeptidase b free of animal products and contaminating enyzme activity
EP1538203B1 (en) * 2003-12-05 2010-01-20 Roche Diagnostics GmbH Recombinantly expressed carboxypeptidase B and purification thereof
ES2337684T3 (es) * 2003-12-05 2010-04-28 F. Hoffmann-La Roche Ag Carboxipeptidasa b recombinante y su purificacion.
EP1794294B1 (de) * 2004-09-27 2011-07-20 Sanofi-Aventis Deutschland GmbH Rekombinante carboxypeptidase b
WO2008051178A2 (en) 2006-04-12 2008-05-02 Savient Pharmaceuticals, Inc. Purification of proteins with cationic surfactant
DK3321359T3 (da) 2005-04-11 2021-03-08 Horizon Pharma Rheumatology Llc Variante former af uratoxidase og anvendelse deraf
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
CN102807973A (zh) 2005-04-11 2012-12-05 萨文特医药公司 尿酸氧化酶的变体形式及其用途
US20080159976A1 (en) * 2005-04-11 2008-07-03 Jacob Hartman Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
JP2008545665A (ja) * 2005-05-23 2008-12-18 ユニベルシテ ドゥ ジュネーブ 高体温による処置のための注入可能な超常磁性ナノ粒子および高体温インプラントを形成するための使用
CN101058805B (zh) * 2007-03-21 2011-09-07 北京贯虹科技有限公司 突变羧肽酶原b及突变羧肽酶b的生产方法
US8993714B2 (en) * 2007-10-26 2015-03-31 Imiplex Llc Streptavidin macromolecular adaptor and complexes thereof
US9102526B2 (en) 2008-08-12 2015-08-11 Imiplex Llc Node polypeptides for nanostructure assembly
WO2010132363A1 (en) 2009-05-11 2010-11-18 Imiplex Llc Method of protein nanostructure fabrication
RU2535038C2 (ru) 2009-06-25 2014-12-10 Криэлта Фармасьютикалз ЭлЭлСи Способы и наборы для прогнозирования риска инфузионных реакций и опосредованной антителами потери ответа при терапии пэгилированной уриказой с помощью мониторинга содержания мочевой кислоты в сыворотке крови
CN101967467B (zh) * 2009-07-28 2012-11-14 上海雅心生物技术有限公司 一种高稳定性的重组羧肽酶b的生产及应用
US20200237881A1 (en) 2019-01-30 2020-07-30 Horizon Pharma Rheumatology Llc Reducing immunogenicity to pegloticase
EP3538135A4 (en) 2016-11-11 2020-07-29 Horizon Pharma Rheumatology LLC POLYTHERAPIES OF PREDNISONE AND URICASE MOLECULES AND THEIR USES
US12121566B2 (en) 2019-01-30 2024-10-22 Horizon Therapeutics Usa, Inc. Methods for treating gout
US11918624B2 (en) * 2020-06-10 2024-03-05 Kelsius Laboratories LLC Therapeutic composition for use in the treatment of COVID-19 and other cytokine storm associated disorders
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3625829A (en) * 1967-12-04 1971-12-07 Bayer Ag Purification of carboxypeptidase b
US4511503A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
HU190129B (en) * 1983-07-11 1986-08-28 Reanal Finomvegyszergyar,Hu Process for the isolation of carboxypeptidase b enzyme from mammal pancreas
US5206161A (en) * 1991-02-01 1993-04-27 Genentech, Inc. Human plasma carboxypeptidase B
FR2692907B1 (fr) * 1992-06-25 1995-06-30 Rhone Poulenc Rorer Sa Levures kluyveromyces modifiees, preparation et utilisation.
JP3472587B2 (ja) * 1992-08-28 2003-12-02 アベンティス ファーマ株式会社 骨関連カルボキシペプチダーゼ様タンパク質およびその製造法
FI962044L (fi) * 1993-11-16 1996-05-14 Lilly Co Eli DNA-sekvenssejä, jotka koodittavat sian haiman karboksipeptidaasi-B:tä

Also Published As

Publication number Publication date
CN1177377A (zh) 1998-03-25
KR19980701652A (ko) 1998-06-25
EP0871718B1 (en) 2007-04-04
BR9606795A (pt) 1997-12-30
JP4250716B2 (ja) 2009-04-08
CA2210242C (en) 2010-04-27
US5948668A (en) 1999-09-07
CZ225897A3 (cs) 1998-10-14
CA2210242A1 (en) 1996-08-01
CZ292541B6 (cs) 2003-10-15
JPH11503002A (ja) 1999-03-23
HUP9800091A3 (en) 2004-03-29
KR100566136B1 (ko) 2006-11-10
ATE358717T1 (de) 2007-04-15
HK1014986A1 (en) 1999-10-08
WO1996023064A1 (en) 1996-08-01
CN1144874C (zh) 2004-04-07
ZA96515B (en) 1996-08-15
PL321499A1 (en) 1997-12-08
MX9705279A (es) 1998-06-30
HU225673B1 (en) 2007-06-28
ES2284167T3 (es) 2007-11-01
EP0871718A1 (en) 1998-10-21
AU4903496A (en) 1996-08-14
DE69637011T2 (de) 2007-12-13
EP0871718A4 (en) 2000-06-07
AU698889B2 (en) 1998-11-12
HUP9800091A2 (hu) 1998-05-28
PT871718E (pt) 2007-06-26
NZ302874A (en) 1998-11-25
IL116696A0 (en) 1996-05-14
DK0871718T3 (da) 2007-07-02
DE69637011D1 (de) 2007-05-16
PL183228B1 (pl) 2002-06-28

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Legal Events

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FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees
NE Application for restoration - patent lapsed through non-payment of renewal fees (section 60, patents law, 5727-1967)
EXP Patent expired