IL121240A - (1-methylcyclohexanecarboxy-methyl (1,3) -1] --2 [R, 5S, 6S-thiazoline - 2yl) azetidine - 3yl) theo] - 6 (R-hydroxyethyl] - 1 methyl-carbene - 2m - 3 crystalline carboxylate - Google Patents

(1-methylcyclohexanecarboxy-methyl (1,3) -1] --2 [R, 5S, 6S-thiazoline - 2yl) azetidine - 3yl) theo] - 6 (R-hydroxyethyl] - 1 methyl-carbene - 2m - 3 crystalline carboxylate

Info

Publication number
IL121240A
IL121240A IL12124096A IL12124096A IL121240A IL 121240 A IL121240 A IL 121240A IL 12124096 A IL12124096 A IL 12124096A IL 12124096 A IL12124096 A IL 12124096A IL 121240 A IL121240 A IL 121240A
Authority
IL
Israel
Prior art keywords
compound
methyl
acid
thio
azetidin
Prior art date
Application number
IL12124096A
Other languages
English (en)
Hebrew (he)
Other versions
IL121240A0 (en
Original Assignee
Wyeth Lederle Japan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Lederle Japan Ltd filed Critical Wyeth Lederle Japan Ltd
Publication of IL121240A0 publication Critical patent/IL121240A0/xx
Publication of IL121240A publication Critical patent/IL121240A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL12124096A 1995-12-08 1996-12-04 (1-methylcyclohexanecarboxy-methyl (1,3) -1] --2 [R, 5S, 6S-thiazoline - 2yl) azetidine - 3yl) theo] - 6 (R-hydroxyethyl] - 1 methyl-carbene - 2m - 3 crystalline carboxylate IL121240A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP34507695 1995-12-08
PCT/JP1996/003540 WO1997021712A1 (en) 1995-12-08 1996-12-04 Carbapenem-3-carboxylic acid ester derivatives

Publications (2)

Publication Number Publication Date
IL121240A0 IL121240A0 (en) 1998-01-04
IL121240A true IL121240A (en) 2001-08-08

Family

ID=18374125

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12124096A IL121240A (en) 1995-12-08 1996-12-04 (1-methylcyclohexanecarboxy-methyl (1,3) -1] --2 [R, 5S, 6S-thiazoline - 2yl) azetidine - 3yl) theo] - 6 (R-hydroxyethyl] - 1 methyl-carbene - 2m - 3 crystalline carboxylate

Country Status (14)

Country Link
US (1) US5886172A (de)
EP (1) EP0808315B1 (de)
JP (1) JP4667542B2 (de)
KR (1) KR19980702089A (de)
AT (1) ATE200289T1 (de)
AU (1) AU705408B2 (de)
CA (1) CA2211075A1 (de)
DE (1) DE69612374T2 (de)
ES (1) ES2156303T3 (de)
HU (1) HUP9801156A3 (de)
IL (1) IL121240A (de)
NO (1) NO973625L (de)
TW (1) TW420681B (de)
WO (1) WO1997021712A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100345468B1 (ko) * 2000-07-10 2002-07-26 한국과학기술연구원 신규 1-베타메틸카바페넴 유도체 및 그의 제조방법
KR100446432B1 (ko) * 2001-08-13 2004-08-30 한국화학연구원 2-벤조티아졸 카바페넴 유도체 및 그의 제조방법
KR100451670B1 (ko) * 2001-09-14 2004-10-08 한국화학연구원 내성균에 대해 항생작용을 갖는 카바페넴 유도체 및 이의제조방법
WO2004035539A1 (ja) * 2002-10-18 2004-04-29 Meiji Seika Kaisha, Ltd. カルバペネム類の製造方法およびその製造に用いられる中間体
KR100599876B1 (ko) * 2004-08-31 2006-07-13 한국화학연구원 2-아릴메틸아제티딘 카바페넴 유도체 및 그의 제조방법
US20110118229A1 (en) * 2007-11-23 2011-05-19 Kukje Pharm. Ind. Co., Ltd. 2-arylmethylazetidine-carbapenem-3-carboxylic acid ester derivative or its salt, process for the preparation thereof and pharmaceutical composition comprising the same
US8394922B2 (en) 2009-08-03 2013-03-12 Medarex, Inc. Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
CN102532139A (zh) * 2010-12-07 2012-07-04 重庆医药工业研究院有限责任公司 一种替比培南的制备方法
CN102558181B (zh) * 2010-12-15 2015-04-22 石药集团中奇制药技术（石家庄）有限公司 一种碳青霉烯抗生素的制备方法
CN102731507B (zh) * 2011-04-13 2015-04-01 石药集团中奇制药技术（石家庄）有限公司 泰比培南晶型、其制备方法及其在制备药物中的应用
CN102757430B (zh) * 2011-04-29 2016-04-13 上海医药工业研究院 一种替比培南的制备方法
CN102775409B (zh) * 2011-05-10 2016-08-03 上海医药工业研究院 一种替比培南匹伏酯的中间体的制备方法
CN102584812B (zh) * 2011-11-18 2014-03-12 深圳万乐药业有限公司 一种泰比培南酯杂质的制备方法
CN102503940B (zh) * 2011-11-22 2013-12-25 深圳万乐药业有限公司 制备泰比培南酯开环杂质的方法
LT2956173T (lt) 2013-02-14 2017-06-26 Bristol-Myers Squibb Company Tubulizino junginiai, gavimo ir panaudojimo būdai
US10077287B2 (en) 2014-11-10 2018-09-18 Bristol-Myers Squibb Company Tubulysin analogs and methods of making and use
ES3037252T3 (en) 2016-12-15 2025-09-30 Spero Therapeutics Inc Novel tebipenem pivoxil immediate and modified release oral dosage forms
WO2018145089A1 (en) 2017-02-06 2018-08-09 Spero Therapeutics, Inc. Tebipenem pivoxil crystalline forms, compositions including the same, methods of manufacture, and methods of use
CA3201497A1 (en) 2020-11-11 2022-05-19 Spero Therapeutics, Inc. High dosage tebipenem pivoxil tablet formulation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60202886A (ja) * 1984-03-27 1985-10-14 Sankyo Co Ltd １―置換カルバペネム―３―カルボン酸誘導体
DE68919508T2 (de) * 1988-04-01 1995-07-20 Sankyo Co 2-(Heterocyclylthio)carbapenemderivate, deren Herstellung und deren Verwendung als Antibiotika.
JPH06157532A (ja) * 1992-11-17 1994-06-03 Sankyo Co Ltd 結晶性カルバペネム化合物
AU682510B2 (en) * 1993-07-01 1997-10-09 Pfizer Japan Inc. 2-(1-(1,3-thiazolin-2-yl)azetidin-3-yl)thio-carbapenem derivatives
JP3317604B2 (ja) * 1994-12-28 2002-08-26 日本ワイスレダリー株式会社 結晶形態のカルバペネム化合物

Also Published As

Publication number Publication date
AU1039997A (en) 1997-07-03
IL121240A0 (en) 1998-01-04
JP4667542B2 (ja) 2011-04-13
ES2156303T3 (es) 2001-06-16
WO1997021712A1 (en) 1997-06-19
KR19980702089A (ko) 1998-07-15
JPH11504039A (ja) 1999-04-06
TW420681B (en) 2001-02-01
DE69612374T2 (de) 2001-07-12
HUP9801156A3 (en) 1999-03-01
CA2211075A1 (en) 1997-06-19
US5886172A (en) 1999-03-23
AU705408B2 (en) 1999-05-20
EP0808315A1 (de) 1997-11-26
ATE200289T1 (de) 2001-04-15
HUP9801156A2 (hu) 1998-09-28
DE69612374D1 (de) 2001-05-10
NO973625D0 (no) 1997-08-06
EP0808315B1 (de) 2001-04-04
NO973625L (no) 1997-08-06

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