IL122649A - (1s, 2s) - 1- (4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol methanesulfonate trihydrate, its use in the preparation of medicaments and pharmaceutical compositions comprising same - Google Patents

(1s, 2s) - 1- (4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol methanesulfonate trihydrate, its use in the preparation of medicaments and pharmaceutical compositions comprising same

Info

Publication number: IL122649A
Authority: IL; Israel
Prior art keywords: phenylpiperidin; medicaments; hydroxyphenyl; hydroxy; preparation
Prior art date: 1995-08-11

Application number

IL12264996A

Other languages

English (en)

Other versions

IL122649A0 (en

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-08-11

Filing date

1996-06-20

Publication date

2001-08-26

1996-06-20 Application filed by Pfizer filed Critical Pfizer

1998-08-16 Publication of IL122649A0 publication Critical patent/IL122649A0/xx

2001-08-26 Publication of IL122649A publication Critical patent/IL122649A/xx

Links

LUILKELNVBKKTG-ZOZJKLBQSA-N 1-[(1s,2s)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]-4-phenylpiperidin-4-ol;methanesulfonic acid;trihydrate Chemical compound O.O.O.CS(O)(=O)=O.C1([C@H](O)[C@H](C)N2CCC(O)(CC2)C=2C=CC=CC=2)=CC=C(O)C=C1 LUILKELNVBKKTG-ZOZJKLBQSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Virology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)

IL12264996A 1995-08-11 1996-06-20 (1s, 2s) - 1- (4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol methanesulfonate trihydrate, its use in the preparation of medicaments and pharmaceutical compositions comprising same IL122649A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US223895P	1995-08-11	1995-08-11
PCT/IB1996/000592 WO1997007098A1 (en)	1995-08-11	1996-06-20	(1s,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanolmethanesulfonate trihydrate

Publications (2)

Publication Number	Publication Date
IL122649A0 IL122649A0 (en)	1998-08-16
IL122649A true IL122649A (en)	2001-08-26

Family

ID=21699847

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12264996A IL122649A (en)	1995-08-11	1996-06-20	(1s, 2s) - 1- (4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol methanesulfonate trihydrate, its use in the preparation of medicaments and pharmaceutical compositions comprising same

Country Status (41)

Country	Link
US (1)	US6008233A (cs)
EP (1)	EP0843661B1 (cs)
JP (1)	JP3099072B2 (cs)
KR (1)	KR100291882B1 (cs)
CN (2)	CN1615861A (cs)
AP (1)	AP755A (cs)
AR (1)	AR004676A1 (cs)
AT (1)	ATE215072T1 (cs)
AU (1)	AU710984B2 (cs)
BG (1)	BG63678B1 (cs)
BR (1)	BR9610766A (cs)
CA (1)	CA2228752C (cs)
CO (1)	CO4750830A1 (cs)
CZ (1)	CZ296236B6 (cs)
DE (1)	DE69620191T2 (cs)
DK (1)	DK0843661T3 (cs)
DZ (1)	DZ2083A1 (cs)
ES (1)	ES2170857T3 (cs)
GT (1)	GT199600051A (cs)
HR (1)	HRP960372B1 (cs)
HU (1)	HUP9802862A3 (cs)
IL (1)	IL122649A (cs)
IS (1)	IS1945B (cs)
MA (1)	MA23957A1 (cs)
NO (1)	NO310458B1 (cs)
NZ (1)	NZ309134A (cs)
OA (1)	OA10664A (cs)
PE (1)	PE4898A1 (cs)
PL (1)	PL185603B1 (cs)
PT (1)	PT843661E (cs)
RO (1)	RO120134B1 (cs)
RS (1)	RS49521B (cs)
RU (1)	RU2140910C1 (cs)
SA (1)	SA96170171B1 (cs)
SK (1)	SK284209B6 (cs)
TN (1)	TNSN96104A1 (cs)
TR (1)	TR199800208T1 (cs)
TW (1)	TW495502B (cs)
UA (1)	UA59341C2 (cs)
WO (1)	WO1997007098A1 (cs)
ZA (1)	ZA966760B (cs)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX9701282A (es) *	1994-08-18	1997-05-31	Pfizer	Fenoles neuroprotectores.
ATE215072T1 (de) *	1995-08-11	2002-04-15	Pfizer	(1s,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4- phenylpiperidin-1-yl)-1-propanol-methansulfonat trihydrat
GB9820405D0 (en) *	1998-09-18	1998-11-11	Smithkline Beecham Plc	Process
AU3676100A (en) *	1999-04-09	2000-11-14	Mochida Pharmaceutical Co., Ltd.	Remedies for neuropathic pain
GB9920917D0 (en)	1999-09-03	1999-11-10	Sb Pharmco Inc	Novel process
GB9920919D0 (en)	1999-09-03	1999-11-10	Sb Pharmco Inc	Novel compound
US6620830B2 (en) *	2000-04-21	2003-09-16	Pfizer, Inc.	Thyroid receptor ligands
YU27801A (sh) *	2000-04-28	2003-04-30	Pfizer Products Inc.	Postupak za dobijanje trihidrata mezilatne soli 1-(4- hidroksifenil)-2-(4-hidroksi-4-fenilpiperidin-1-il)-1-propanola i korisnih intermedijera
YU27701A (sh) *	2000-04-28	2003-04-30	Pfizer Products Inc.	Postupak za dobijanje trihidrata mezilatne soli 1-(4- hidroksifenil)-2-(4-hidroksi-4-fenilpiperidin-1-il)1-propanola
AU2001283393B2 (en)	2000-08-16	2005-09-22	Pharmacia & Upjohn Company	Compounds for the treatment of addictive disorders
EP1186303A3 (en) *	2000-09-06	2003-12-10	Pfizer Products Inc.	Pharmaceutical combinations, for the treatment of stroke and traumatic brain injury, containing a neutrophil inhibiting factor and an selective NMDA-NR2B receptor antagonist
EP1674087A1 (en)	2000-10-02	2006-06-28	Pfizer Products Inc.	Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists
IL145584A0 (en) *	2000-10-02	2002-06-30	Pfizer Prod Inc	Nmda nr2b antagonists for treatment
UA73619C2 (en) *	2000-12-13	2005-08-15	Pfizer Prod Inc	Stable pharmaceutical compositions of nmda receptor agonist (variants) and method of treatment
CN100500662C (zh)	2001-10-19	2009-06-17	富山化学工业株式会社	烷基醚衍生物或其盐
KR100517638B1 (ko)	2002-04-08	2005-09-28	주식회사 엘지생명과학	게미플록사신 산염의 새로운 제조방법
EP2612854B1 (en)	2005-10-25	2015-04-29	Shionogi&Co., Ltd.	Aminothiazolidine and aminotetrahydrothiazepine derivatives as BACE 1 inhibitors
TW200902526A (en)	2007-04-24	2009-01-16	Shionogi & Amp Co Ltd	Aminodihydrothiazin derivative substituted with a cyclic group
WO2008133273A1 (ja)	2007-04-24	2008-11-06	Shionogi & Co., Ltd.	アルツハイマー症治療用医薬組成物
WO2009151098A1 (ja)	2008-06-13	2009-12-17	塩野義製薬株式会社	βセクレターゼ阻害作用を有する含硫黄複素環誘導体
JPWO2010047372A1 (ja)	2008-10-22	2012-03-22	塩野義製薬株式会社	Ｂａｃｅ１阻害活性を有する２−アミノピリミジン−４−オンおよび２−アミノピリジン誘導体
UA110467C2 (uk)	2009-12-11	2016-01-12	Шионогі Енд Ко., Лтд.	Похідні оксазину
CN103261199A (zh)	2010-10-29	2013-08-21	盐野义制药株式会社	萘啶衍生物
EP2634188A4 (en)	2010-10-29	2014-05-07	Shionogi & Co	FUSIONED AMINODIHYDROPYRIMIDINE DERIVATIVE
WO2012147763A1 (ja)	2011-04-26	2012-11-01	塩野義製薬株式会社	オキサジン誘導体およびそれを含有するｂａｃｅ１阻害剤
EP2912035A4 (en)	2012-10-24	2016-06-15	Shionogi & Co	DERIVATIVES OF DIHYDROOXAZINE OR OXAZEPINE HAVING BACE1 INHIBITING ACTIVITY
CA2957898C (en)	2014-09-15	2023-02-21	Rugen Holdings (Cayman) Limited	Pyrrolopyrimidine derivatives as nr2b nmda receptor antagonists
WO2016049048A1 (en) *	2014-09-22	2016-03-31	Rugen Holdings (Cayman) Limited	Treatment of anxiety disorders and autism spectrum disorders
US10221182B2 (en)	2015-02-04	2019-03-05	Rugen Holdings (Cayman) Limited	3,3-difluoro-piperidine derivatives as NR2B NMDA receptor antagonists
US10584127B2 (en)	2015-06-01	2020-03-10	Rugen Holdings (Cayman) Limited	3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists
WO2018098128A1 (en)	2016-11-22	2018-05-31	Rugen Holdings (Cayman) Limited	Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5272160A (en) *	1989-05-17	1993-12-21	Pfizer Inc	2-piperidino-1-alkanol derivatives as antiischemic agents
WO1990014087A1 (en) *	1989-05-17	1990-11-29	Pfizer Inc.	2-piperidino-1-alkanol derivatives as antiischemic agents
MX9701282A (es) *	1994-08-18	1997-05-31	Pfizer	Fenoles neuroprotectores.
ATE215072T1 (de) *	1995-08-11	2002-04-15	Pfizer	(1s,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4- phenylpiperidin-1-yl)-1-propanol-methansulfonat trihydrat

1996
- 1996-06-20 AT AT96916266T patent/ATE215072T1/de not_active IP Right Cessation
- 1996-06-20 NZ NZ309134A patent/NZ309134A/en unknown
- 1996-06-20 IL IL12264996A patent/IL122649A/xx not_active IP Right Cessation
- 1996-06-20 KR KR1019980700989A patent/KR100291882B1/ko not_active Expired - Fee Related
- 1996-06-20 CA CA002228752A patent/CA2228752C/en not_active Expired - Fee Related
- 1996-06-20 US US09/011,426 patent/US6008233A/en not_active Expired - Fee Related
- 1996-06-20 PL PL96325050A patent/PL185603B1/pl not_active IP Right Cessation
- 1996-06-20 CZ CZ0039098A patent/CZ296236B6/cs not_active IP Right Cessation
- 1996-06-20 JP JP09509083A patent/JP3099072B2/ja not_active Expired - Fee Related
- 1996-06-20 AU AU59084/96A patent/AU710984B2/en not_active Ceased
- 1996-06-20 DE DE69620191T patent/DE69620191T2/de not_active Expired - Fee Related
- 1996-06-20 RU RU98102116A patent/RU2140910C1/ru not_active IP Right Cessation
- 1996-06-20 BR BR9610766A patent/BR9610766A/pt not_active Application Discontinuation
- 1996-06-20 PT PT96916266T patent/PT843661E/pt unknown
- 1996-06-20 UA UA98020673A patent/UA59341C2/uk unknown
- 1996-06-20 EP EP96916266A patent/EP0843661B1/en not_active Expired - Lifetime
- 1996-06-20 CN CNA031584969A patent/CN1615861A/zh active Pending
- 1996-06-20 HU HU9802862A patent/HUP9802862A3/hu unknown
- 1996-06-20 RO RO98-00231A patent/RO120134B1/ro unknown
- 1996-06-20 ES ES96916266T patent/ES2170857T3/es not_active Expired - Lifetime
- 1996-06-20 WO PCT/IB1996/000592 patent/WO1997007098A1/en not_active Ceased
- 1996-06-20 CN CN96195649A patent/CN1198739A/zh active Pending
- 1996-06-20 SK SK166-98A patent/SK284209B6/sk unknown
- 1996-06-20 DK DK96916266T patent/DK0843661T3/da active
- 1996-06-20 TR TR1998/00208T patent/TR199800208T1/xx unknown
- 1996-06-24 TW TW085107571A patent/TW495502B/zh not_active IP Right Cessation
- 1996-07-04 GT GT199600051A patent/GT199600051A/es unknown
- 1996-07-23 SA SA96170171A patent/SA96170171B1/ar unknown
- 1996-08-06 PE PE1996000587A patent/PE4898A1/es not_active Application Discontinuation
- 1996-08-07 DZ DZ960127A patent/DZ2083A1/fr active
- 1996-08-07 MA MA24335A patent/MA23957A1/fr unknown
- 1996-08-07 AR ARP960103904A patent/AR004676A1/es unknown
- 1996-08-07 TN TNTNSN96104A patent/TNSN96104A1/fr unknown
- 1996-08-08 ZA ZA9606760A patent/ZA966760B/xx unknown
- 1996-08-08 AP APAP/P/1996/000856A patent/AP755A/en active
- 1996-08-09 RS YU46196A patent/RS49521B/sr unknown
- 1996-08-09 CO CO96042164A patent/CO4750830A1/es unknown
- 1996-08-09 HR HR960372A patent/HRP960372B1/xx not_active IP Right Cessation
1997
- 1997-12-30 IS IS4643A patent/IS1945B/is unknown
1998
- 1998-02-10 NO NO19980574A patent/NO310458B1/no unknown
- 1998-02-10 OA OA9800021A patent/OA10664A/en unknown
- 1998-02-27 BG BG102289A patent/BG63678B1/bg unknown

Also Published As

Publication number	Publication date
JPH10510552A (ja)	1998-10-13
CZ39098A3 (cs)	1999-02-17
ATE215072T1 (de)	2002-04-15
TNSN96104A1 (fr)	2005-03-15
GT199600051A (es)	1997-12-26
IS1945B (is)	2004-08-13
PL185603B1 (pl)	2003-06-30
HRP960372B1 (en)	2003-04-30
ZA966760B (en)	1998-02-09
HUP9802862A3 (en)	1999-05-28
PE4898A1 (es)	1998-03-16
RS49521B (sr)	2006-10-27
NZ309134A (en)	1999-09-29
YU46196A (sh)	1999-07-28
EP0843661A1 (en)	1998-05-27
DE69620191D1 (de)	2002-05-02
KR100291882B1 (ko)	2001-10-26
NO310458B1 (no)	2001-07-09
IL122649A0 (en)	1998-08-16
EP0843661B1 (en)	2002-03-27
NO980574L (no)	1998-02-10
WO1997007098A1 (en)	1997-02-27
BG102289A (en)	1998-09-30
ES2170857T3 (es)	2002-08-16
AR004676A1 (es)	1999-03-10
UA59341C2 (uk)	2003-09-15
HUP9802862A2 (hu)	1999-04-28
PT843661E (pt)	2002-07-31
CA2228752A1 (en)	1997-02-27
SK284209B6 (en)	2004-11-03
PL325050A1 (en)	1998-07-06
BR9610766A (pt)	1999-07-13
DZ2083A1 (fr)	2002-10-23
AP9600856A0 (en)	1996-10-31
TW495502B (en)	2002-07-21
SA96170171B1 (ar)	2006-05-20
NO980574D0 (no)	1998-02-10
SK16698A3 (en)	1999-06-11
AU710984B2 (en)	1999-10-07
TR199800208T1 (cs)	1998-05-21
DE69620191T2 (de)	2002-07-18
RO120134B1 (ro)	2005-09-30
CN1198739A (zh)	1998-11-11
CN1615861A (zh)	2005-05-18
CA2228752C (en)	2002-12-10
AU5908496A (en)	1997-03-12
AP755A (en)	1999-08-02
MA23957A1 (fr)	1997-04-01
DK0843661T3 (da)	2002-07-22
CZ296236B6 (cs)	2006-02-15
BG63678B1 (bg)	2002-09-30
KR19990036321A (ko)	1999-05-25
MX9801149A (es)	1998-05-31
OA10664A (en)	2000-11-06
IS4643A (is)	1997-12-30
US6008233A (en)	1999-12-28
JP3099072B2 (ja)	2000-10-16
RU2140910C1 (ru)	1999-11-10
CO4750830A1 (es)	1999-03-31
HRP960372A2 (en)	1998-04-30

Legal Events

Date	Code	Title
2002-02-10	KB	Patent renewed
2002-08-14	KB	Patent renewed
2011-02-28	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
GB9407386D0 (en)	1994-06-08	Pharmaceutical formulation
GB9402203D0 (en)	1994-03-30	Pharmaceutical formulation
IL112521A0 (en)	1995-05-26	Pharmaceutical formulation
EP0841936A4 (en)	2001-09-26	CONJUGATION-STABILIZED THERAPEUTIC AGENT COMPOSITIONS, ADDITIONAL FORMULATIONS AND DIAGNOSTICS
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