IL123523A - Pharmaceutical preparations with neuroprotective activity containing 2 amino-4 (4-fluorobenzylamino) -1 ethoxy-carbonylbenzene - Google Patents

Pharmaceutical preparations with neuroprotective activity containing 2 amino-4 (4-fluorobenzylamino) -1 ethoxy-carbonylbenzene

Info

Publication number: IL123523A
Authority: IL; Israel
Prior art keywords: treatment; production; medicaments; formula; compounds
Prior art date: 1995-10-26

Application number

IL12352396A

Other languages

English (en)

Hebrew (he)

Other versions

IL123523A0 (en

Original Assignee

Asta Medica Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-26

Filing date

1996-10-15

Publication date

2001-12-23

1996-10-15 Application filed by Asta Medica Ag filed Critical Asta Medica Ag

1998-10-30 Publication of IL123523A0 publication Critical patent/IL123523A0/xx

2001-12-23 Publication of IL123523A publication Critical patent/IL123523A/en

Links

230000000324 neuroprotective effect Effects 0.000 title description 9
FPUVTTKHCADVJT-UHFFFAOYSA-N ethyl 2-amino-4-[(4-fluorophenyl)methylamino]benzoate Chemical compound NC1=C(C=CC(=C1)NCC1=CC=C(C=C1)F)C(=O)OCC FPUVTTKHCADVJT-UHFFFAOYSA-N 0.000 title description 2
239000008194 pharmaceutical composition Substances 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims abstract description 30
238000011282 treatment Methods 0.000 claims abstract description 21
239000003814 drug Substances 0.000 claims abstract description 20
230000036770 blood supply Effects 0.000 claims abstract description 17
238000004519 manufacturing process Methods 0.000 claims abstract description 14
230000002490 cerebral effect Effects 0.000 claims abstract description 12
230000001684 chronic effect Effects 0.000 claims abstract description 9
238000011321 prophylaxis Methods 0.000 claims abstract description 8
150000003839 salts Chemical class 0.000 claims abstract description 4
208000015122 neurodegenerative disease Diseases 0.000 claims description 8
208000014644 Brain disease Diseases 0.000 claims description 4
208000032274 Encephalopathy Diseases 0.000 claims description 4
208000014674 injury Diseases 0.000 claims description 4
241001484259 Lacuna Species 0.000 claims description 3
206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 3
208000030507 AIDS Diseases 0.000 claims description 2
206010001497 Agitation Diseases 0.000 claims description 2
208000024827 Alzheimer disease Diseases 0.000 claims description 2
241000589968 Borrelia Species 0.000 claims description 2
208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims description 2
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208000016604 Lyme disease Diseases 0.000 claims description 2
206010029240 Neuritis Diseases 0.000 claims description 2
208000018737 Parkinson disease Diseases 0.000 claims description 2
206010036105 Polyneuropathy Diseases 0.000 claims description 2
241000710799 Rubella virus Species 0.000 claims description 2
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230000035987 intoxication Effects 0.000 claims description 2
231100000566 intoxication Toxicity 0.000 claims description 2
201000006417 multiple sclerosis Diseases 0.000 claims description 2
230000001537 neural effect Effects 0.000 claims description 2
230000004770 neurodegeneration Effects 0.000 claims description 2
244000052769 pathogen Species 0.000 claims description 2
210000001428 peripheral nervous system Anatomy 0.000 claims description 2
230000007824 polyneuropathy Effects 0.000 claims description 2
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241001529453 unidentified herpesvirus Species 0.000 claims description 2
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230000000694 effects Effects 0.000 description 12
238000012360 testing method Methods 0.000 description 11
230000009471 action Effects 0.000 description 10
239000001961 anticonvulsive agent Substances 0.000 description 10
208000006011 Stroke Diseases 0.000 description 8
210000004556 brain Anatomy 0.000 description 7
241001132374 Asta Species 0.000 description 6
CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 6
230000001154 acute effect Effects 0.000 description 6
238000002474 experimental method Methods 0.000 description 6
238000006243 chemical reaction Methods 0.000 description 5
230000006378 damage Effects 0.000 description 5
238000011835 investigation Methods 0.000 description 5
JUUFBMODXQKSTD-UHFFFAOYSA-N N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester Chemical compound N1=C(N)C(NC(=O)OCC)=CC=C1NCC1=CC=C(F)C=C1 JUUFBMODXQKSTD-UHFFFAOYSA-N 0.000 description 4
CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 description 4
230000000202 analgesic effect Effects 0.000 description 4
AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 4
229960003529 diazepam Drugs 0.000 description 4
229960002036 phenytoin Drugs 0.000 description 4
238000002360 preparation method Methods 0.000 description 4
239000000126 substance Substances 0.000 description 4
238000002560 therapeutic procedure Methods 0.000 description 4
230000002411 adverse Effects 0.000 description 3
210000004027 cell Anatomy 0.000 description 3
239000003795 chemical substances by application Substances 0.000 description 3
230000005764 inhibitory process Effects 0.000 description 3
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206010002091 Anaesthesia Diseases 0.000 description 2
206010010904 Convulsion Diseases 0.000 description 2
206010061216 Infarction Diseases 0.000 description 2
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 description 2
206010039897 Sedation Diseases 0.000 description 2
108010052164 Sodium Channels Proteins 0.000 description 2
102000018674 Sodium Channels Human genes 0.000 description 2
208000027418 Wounds and injury Diseases 0.000 description 2
238000010521 absorption reaction Methods 0.000 description 2
208000029650 alcohol withdrawal Diseases 0.000 description 2
238000001949 anaesthesia Methods 0.000 description 2
230000037005 anaesthesia Effects 0.000 description 2
239000005557 antagonist Substances 0.000 description 2
230000002082 anti-convulsion Effects 0.000 description 2
230000001754 anti-pyretic effect Effects 0.000 description 2
239000002221 antipyretic Substances 0.000 description 2
DGBIGWXXNGSACT-UHFFFAOYSA-N clonazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1Cl DGBIGWXXNGSACT-UHFFFAOYSA-N 0.000 description 2
229960003120 clonazepam Drugs 0.000 description 2
230000036461 convulsion Effects 0.000 description 2
230000001120 cytoprotective effect Effects 0.000 description 2
238000011161 development Methods 0.000 description 2
PCOBBVZJEWWZFR-UHFFFAOYSA-N ezogabine Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1NCC1=CC=C(F)C=C1 PCOBBVZJEWWZFR-UHFFFAOYSA-N 0.000 description 2
238000011686 genetic mapping animal model Methods 0.000 description 2
230000007574 infarction Effects 0.000 description 2
230000003340 mental effect Effects 0.000 description 2
239000003158 myorelaxant agent Substances 0.000 description 2
DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 2
229960002695 phenobarbital Drugs 0.000 description 2
230000036280 sedation Effects 0.000 description 2
239000003826 tablet Substances 0.000 description 2
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
206010003591 Ataxia Diseases 0.000 description 1
229940127291 Calcium channel antagonist Drugs 0.000 description 1
206010008111 Cerebral haemorrhage Diseases 0.000 description 1
238000012404 In vitro experiment Methods 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 description 1
108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 description 1
208000028017 Psychotic disease Diseases 0.000 description 1
241000700159 Rattus Species 0.000 description 1
241000220317 Rosa Species 0.000 description 1
208000007536 Thrombosis Diseases 0.000 description 1
206010053648 Vascular occlusion Diseases 0.000 description 1
229960001138 acetylsalicylic acid Drugs 0.000 description 1
230000003109 amnesic effect Effects 0.000 description 1
239000000730 antalgic agent Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
210000004204 blood vessel Anatomy 0.000 description 1
230000037396 body weight Effects 0.000 description 1
239000002775 capsule Substances 0.000 description 1
210000001715 carotid artery Anatomy 0.000 description 1
230000020411 cell activation Effects 0.000 description 1
230000005779 cell damage Effects 0.000 description 1
208000037887 cell injury Diseases 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
230000006735 deficit Effects 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
230000003292 diminished effect Effects 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
208000035475 disorder Diseases 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
206010015037 epilepsy Diseases 0.000 description 1
230000001037 epileptic effect Effects 0.000 description 1
SGAMYRYSJXOTHR-UHFFFAOYSA-N ethyl n-[2-amino-3-[(4-fluorophenyl)methylamino]phenyl]carbamate Chemical compound CCOC(=O)NC1=CC=CC(NCC=2C=CC(F)=CC=2)=C1N SGAMYRYSJXOTHR-UHFFFAOYSA-N 0.000 description 1
238000009472 formulation Methods 0.000 description 1
230000003371 gabaergic effect Effects 0.000 description 1
239000008187 granular material Substances 0.000 description 1
230000006872 improvement Effects 0.000 description 1
238000000034 method Methods 0.000 description 1
239000000203 mixture Substances 0.000 description 1
210000005036 nerve Anatomy 0.000 description 1
230000004112 neuroprotection Effects 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
239000006187 pill Substances 0.000 description 1
230000008092 positive effect Effects 0.000 description 1
230000008569 process Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000035939 shock Effects 0.000 description 1
239000003195 sodium channel blocking agent Substances 0.000 description 1
239000000243 solution Substances 0.000 description 1
230000005236 sound signal Effects 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
239000000725 suspension Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
238000012353 t test Methods 0.000 description 1
238000012549 training Methods 0.000 description 1
208000021331 vascular occlusion disease Diseases 0.000 description 1
230000000304 vasodilatating effect Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Psychology (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Virology (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Diabetes (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL12352396A 1995-10-26 1996-10-15 Pharmaceutical preparations with neuroprotective activity containing 2 amino-4 (4-fluorobenzylamino) -1 ethoxy-carbonylbenzene IL123523A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19539861A DE19539861A1 (de)	1995-10-26	1995-10-26	Verwendung von 4-Amino-4-(4-fluorbenzylamino)-1-ethoxy-carbonylaminobenzen zur Prophylaxe und Behandlung der Folgen der akuten und chronischen zerebralen Minderdurchblutung sowie neurodegenerativer Erkrankungen
PCT/DE1996/001951 WO1997015300A2 (de)	1995-10-26	1996-10-15	Verwendung von 4-amino-4-(4-fluorbenzylamino)-1-ethoxycarbonylaminobenzen zur prophylaxe und behandlung der folgen der akuten und chronischen zerebralen minderdurchblutung sowie neurodegenerativer erkrankungen

Publications (2)

Publication Number	Publication Date
IL123523A0 IL123523A0 (en)	1998-10-30
IL123523A true IL123523A (en)	2001-12-23

Family

ID=7775835

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12352396A IL123523A (en)	1995-10-26	1996-10-15	Pharmaceutical preparations with neuroprotective activity containing 2 amino-4 (4-fluorobenzylamino) -1 ethoxy-carbonylbenzene

Country Status (26)

Country	Link
US (2)	US5852053A (es)
EP (1)	EP0857065B1 (es)
JP (2)	JP4567101B2 (es)
KR (1)	KR100423823B1 (es)
AR (1)	AR004108A1 (es)
AT (1)	ATE178487T1 (es)
AU (1)	AU706735B2 (es)
BR (1)	BR9610899A (es)
CA (1)	CA2188841C (es)
CZ (1)	CZ291456B6 (es)
DE (2)	DE19539861A1 (es)
DK (1)	DK0857065T3 (es)
ES (1)	ES2131973T3 (es)
GR (1)	GR3030336T3 (es)
HU (1)	HU228014B1 (es)
ID (1)	ID16489A (es)
IL (1)	IL123523A (es)
NO (1)	NO316493B1 (es)
NZ (1)	NZ326754A (es)
PL (1)	PL185714B1 (es)
RU (1)	RU2201227C2 (es)
SK (1)	SK283222B6 (es)
TW (1)	TW457084B (es)
UA (1)	UA51681C2 (es)
WO (1)	WO1997015300A2 (es)
ZA (1)	ZA968991B (es)

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DE19539861A1 (de) *	1995-10-26	1997-04-30	Asta Medica Ag	Verwendung von 4-Amino-4-(4-fluorbenzylamino)-1-ethoxy-carbonylaminobenzen zur Prophylaxe und Behandlung der Folgen der akuten und chronischen zerebralen Minderdurchblutung sowie neurodegenerativer Erkrankungen
GB9915414D0 (en) *	1999-07-01	1999-09-01	Glaxo Group Ltd	Medical use
US6472165B1 (en) *	1999-08-03	2002-10-29	Arzneimittelwerk Dresden Gmbh	Modulatory binding site in potassium channels for screening and finding new active ingredients
US6117900A (en) *	1999-09-27	2000-09-12	Asta Medica Aktiengesellschaft	Use of retigabine for the treatment of neuropathic pain
TWI287984B (en)	2000-10-17	2007-10-11	Wyeth Corp	Pharmaceutical composition for modulating bladder function
US6589986B2 (en) *	2000-12-20	2003-07-08	Wyeth	Methods of treating anxiety disorders
AR033095A1 (es) *	2001-04-04	2003-12-03	Wyeth Corp	Metodos para el tratamiento de motilidad gastrica hiperactiva
US7205307B2 (en) *	2002-02-14	2007-04-17	Icagen, Inc.	Pyrimidines as novel openers of potassium ion channels
KR20050089862A (ko) *	2002-12-27	2005-09-08	하. 룬트벡 아크티에 셀스카브	중추신경계 장애의 치료에 유용한 1,2,4-트리아미노벤젠유도체
MXPA05006463A (es) *	2002-12-27	2005-08-26	Lundbeck & Co As H	Derivados de 1,2,4-triaminobenceno, utiles para tratar transtornos del sistema nervioso central.
EP1631546A1 (en) *	2003-04-25	2006-03-08	H. Lundbeck A/S	Sustituted indoline and indole derivatives
US20050089559A1 (en) *	2003-10-23	2005-04-28	Istvan Szelenyi	Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
TWI357901B (en)	2004-03-12	2012-02-11	Lundbeck & Co As H	Substituted morpholine and thiomorpholine derivati
EP1861394A1 (en)	2005-03-03	2007-12-05	H.Lundbeck A/S	Substituted pyridine derivatives
US7960436B2 (en) *	2006-06-05	2011-06-14	Valeant Pharmaceuticals International	Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
US20080045534A1 (en) *	2006-08-18	2008-02-21	Valeant Pharmaceuticals North America	Derivatives of 1,3-diamino benzene as potassium channel modulators
US8993593B2 (en) *	2006-08-23	2015-03-31	Valeant Pharmaceuticals International	N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
BRPI0716715B1 (pt) *	2006-08-23	2021-07-06	Xenon Pharmaceuticals, Inc	Derivados de 4-(n-azacicloalquil) anilidas como moduladores de canal de potássio, seus usos, produto, composição, comprimido e cápsula
US8722929B2 (en) *	2006-10-10	2014-05-13	Valeant Pharmaceuticals International	N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
CA2670966A1 (en) *	2006-11-28	2008-06-05	Valeant Pharmaceuticals International	1,4 diamino bicyclic retigabine analogues as potassium channel modulators
US8367684B2 (en) *	2007-06-13	2013-02-05	Valeant Pharmaceuticals International	Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
US8563566B2 (en)	2007-08-01	2013-10-22	Valeant Pharmaceuticals International	Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) *	2007-08-13	2010-08-31	Valeant Pharmaceuticals International	Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
US20100120906A1 (en) *	2008-07-18	2010-05-13	Valeant Pharmaceuticals International	Modified release formulation and methods of use
US20100323015A1 (en) *	2008-07-18	2010-12-23	Biljana Nadjsombati	Modified release formulation and methods of use
US20100323016A1 (en) *	2008-07-18	2010-12-23	Biljana Nadjsombati	Modified release formulation and methods of use
WO2013011518A1 (en)	2011-07-21	2013-01-24	Arch Pharmalabs Limited	Process for the preparation of retigabine of the formula i and pharmaceutically acceptable salts thereof
CN103073455B (zh) *	2011-10-25	2015-08-19	中国科学院上海药物研究所	一类新型的kcnq钾通道激动剂、其制备方法和用途
CA2881464C (en)	2012-08-07	2021-12-21	Children's Medical Center Corporation	Potassium channel openers for treating neurodegenerative diseases
CN105017085B (zh)	2014-04-28	2018-06-29	中国科学院上海药物研究所	一类kcnq钾通道激动剂、其制备方法和用途
TWI886158B (zh)	2019-10-10	2025-06-11	加拿大商再諾製藥公司	選擇性鉀通道調節劑之固態晶型
WO2021092439A1 (en)	2019-11-08	2021-05-14	Xenon Pharmaceuticals Inc.	Methods of treating depressive disorders
IL304920A (en)	2021-02-09	2023-10-01	Xenon Pharmaceuticals Inc	A voltage-gated potassium channel opener for use in the treatment of anhedonia

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Publication number	Priority date	Publication date	Assignee	Title
JP2817334B2 (ja) *	1990-03-29	1998-10-30	株式会社ツムラ	神経細胞保護剤
DE4200259A1 (de) *	1992-01-08	1993-07-15	Asta Medica Ag	Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung
DE4327516A1 (de) *	1993-08-17	1995-02-23	Asta Medica Ag	Primäre und sekundäre neuroprotektive Wirkung bei neurodegenerativen Erkrankungen von Flupirtin
TW280819B (es) *	1993-11-17	1996-07-11	Sumitomo Pharma
DE19539861A1 (de) *	1995-10-26	1997-04-30	Asta Medica Ag	Verwendung von 4-Amino-4-(4-fluorbenzylamino)-1-ethoxy-carbonylaminobenzen zur Prophylaxe und Behandlung der Folgen der akuten und chronischen zerebralen Minderdurchblutung sowie neurodegenerativer Erkrankungen

1995
- 1995-10-26 DE DE19539861A patent/DE19539861A1/de not_active Withdrawn
1996
- 1996-10-15 RU RU98109951/14A patent/RU2201227C2/ru not_active IP Right Cessation
- 1996-10-15 PL PL96325956A patent/PL185714B1/pl not_active IP Right Cessation
- 1996-10-15 HU HU9900508A patent/HU228014B1/hu not_active IP Right Cessation
- 1996-10-15 WO PCT/DE1996/001951 patent/WO1997015300A2/de not_active Ceased
- 1996-10-15 DE DE59601624T patent/DE59601624D1/de not_active Expired - Lifetime
- 1996-10-15 ES ES96945354T patent/ES2131973T3/es not_active Expired - Lifetime
- 1996-10-15 BR BR9610899A patent/BR9610899A/pt not_active Application Discontinuation
- 1996-10-15 UA UA98052705A patent/UA51681C2/uk unknown
- 1996-10-15 KR KR10-1998-0702958A patent/KR100423823B1/ko not_active Expired - Fee Related
- 1996-10-15 IL IL12352396A patent/IL123523A/en not_active IP Right Cessation
- 1996-10-15 EP EP96945354A patent/EP0857065B1/de not_active Expired - Lifetime
- 1996-10-15 JP JP51618597A patent/JP4567101B2/ja not_active Expired - Fee Related
- 1996-10-15 CZ CZ19981225A patent/CZ291456B6/cs not_active IP Right Cessation
- 1996-10-15 DK DK96945354T patent/DK0857065T3/da active
- 1996-10-15 AU AU15400/97A patent/AU706735B2/en not_active Ceased
- 1996-10-15 SK SK520-98A patent/SK283222B6/sk not_active IP Right Cessation
- 1996-10-15 NZ NZ326754A patent/NZ326754A/xx not_active IP Right Cessation
- 1996-10-15 AT AT96945354T patent/ATE178487T1/de active
- 1996-10-21 TW TW085112851A patent/TW457084B/zh active
- 1996-10-24 ID IDP963059A patent/ID16489A/id unknown
- 1996-10-25 CA CA002188841A patent/CA2188841C/en not_active Expired - Fee Related
- 1996-10-25 AR ARP960104912A patent/AR004108A1/es not_active Application Discontinuation
- 1996-10-25 ZA ZA968991A patent/ZA968991B/xx unknown
- 1996-10-28 US US08/736,166 patent/US5852053A/en not_active Expired - Lifetime
1997
- 1997-09-25 US US08/937,420 patent/US5849789A/en not_active Expired - Lifetime
1998
- 1998-04-02 NO NO981503A patent/NO316493B1/no not_active IP Right Cessation
1999
- 1999-05-27 GR GR990401425T patent/GR3030336T3/el unknown
2008
- 2008-07-15 JP JP2008183440A patent/JP2009007366A/ja active Pending

Also Published As

Publication number	Publication date
HU228014B1 (en)	2012-08-28
US5852053A (en)	1998-12-22
IL123523A0 (en)	1998-10-30
EP0857065A2 (de)	1998-08-12
BR9610899A (pt)	1999-07-13
RU2201227C2 (ru)	2003-03-27
JP4567101B2 (ja)	2010-10-20
UA51681C2 (uk)	2002-12-16
TW457084B (en)	2001-10-01
AU1540097A (en)	1997-05-15
KR100423823B1 (ko)	2004-08-25
AR004108A1 (es)	1998-09-30
KR19990067021A (ko)	1999-08-16
SK52098A3 (en)	1998-09-09
DE19539861A1 (de)	1997-04-30
CZ122598A3 (cs)	1998-09-16
EP0857065B1 (de)	1999-04-07
SK283222B6 (sk)	2003-03-04
ES2131973T3 (es)	1999-08-01
PL325956A1 (en)	1998-08-17
NO316493B1 (no)	2004-02-02
US5849789A (en)	1998-12-15
DE59601624D1 (de)	1999-05-12
AU706735B2 (en)	1999-06-24
NO981503L (no)	1998-04-02
WO1997015300A3 (de)	1997-07-03
DK0857065T3 (da)	1999-10-18
CA2188841C (en)	2006-05-23
CA2188841A1 (en)	1997-04-27
NZ326754A (en)	2000-03-27
WO1997015300A2 (de)	1997-05-01
JP2009007366A (ja)	2009-01-15
HUP9900508A2 (hu)	1999-06-28
HUP9900508A3 (en)	1999-11-29
GR3030336T3 (en)	1999-09-30
ATE178487T1 (de)	1999-04-15
MX9803172A (es)	1998-09-30
JPH11515007A (ja)	1999-12-21
NO981503D0 (no)	1998-04-02
ID16489A (id)	1997-10-02
PL185714B1 (pl)	2003-07-31
CZ291456B6 (cs)	2003-03-12
ZA968991B (en)	1997-06-10

Legal Events

Date	Code	Title
2002-05-23	FF	Patent granted
2002-06-30	KB	Patent renewed
2002-08-14	HP	Change in proprietorship
2003-01-12	KB	Patent renewed
2006-12-07	KB	Patent renewed
2015-05-31	MM9K	Patent not in force due to non-payment of renewal fees

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WO1997018803A1 (en)	1997-05-29	The use of aliphatic carboxylic acid derivatives in ophthalmic disorders
JP2009535410A (ja)	2009-10-01	ピロロキノリンキノンおよびその使用
JP2001517202A (ja)	2001-10-02	痛み処置方法
CA2457982C (en)	2009-11-03	Use of nefiracetam for treating neurodegeneration
US6872751B2 (en)	2005-03-29	Composition and method for augmenting or restoring the production of fetal protein in patient in need thereof
AU784418B2 (en)	2006-03-30	Method for treating neurodegeneration
IE790157L (en)	1979-08-17	Therapeutic agents
EP1645270B1 (en)	2010-04-28	Control of pain with ANANDAMIDE
MXPA98003172A (es)	1998-11-16	Utilizacion de 2-amino-4-(4-fluorbencilamino)-1-etoxicarbonilaminobenceno para la profilaxis y eltratamiento de las consecuencias del deficit agudo y cronico de la irrigacion sanguinea cerebral,como tambien de enfermedades neurodegenerativas
WO1998004262A1 (de)	1998-02-05	Prophylaxe und behandlung der folgen der zerebralen minderdurchblutung sowie neurodegenerativen erkrankungen
WO1998046596A1 (en)	1998-10-22	Method for providing neuro-protective effects