IL123595A - Hydrolysis-promoting taxane hydrophobic derivatives and pharmaceutical compositions containing them - Google Patents

Hydrolysis-promoting taxane hydrophobic derivatives and pharmaceutical compositions containing them

Info

Publication number: IL123595A
Authority: IL; Israel
Prior art keywords: taxane; hydrolysis; promoting; pharmaceutical compositions; compositions containing
Prior art date: 1995-09-12

Application number

IL12359596A

Other languages

English (en)

Other versions

IL123595A0 (en

Original Assignee

Liposome Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-12

Filing date

1996-09-12

Publication date

2000-10-31

1996-09-12 Application filed by Liposome Co Inc filed Critical Liposome Co Inc

1998-10-30 Publication of IL123595A0 publication Critical patent/IL123595A0/xx

2000-10-31 Publication of IL123595A publication Critical patent/IL123595A/xx

Links

229940123237 Taxane Drugs 0.000 title abstract 6
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title abstract 4
230000002209 hydrophobic effect Effects 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
239000004215 Carbon black (E152) Substances 0.000 abstract 2
229930195733 hydrocarbon Natural products 0.000 abstract 2
150000002430 hydrocarbons Chemical class 0.000 abstract 2
241001465754 Metazoa Species 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Epidemiology (AREA)
Dispersion Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Medicinal Preparation (AREA)

IL12359596A 1995-09-12 1996-09-12 Hydrolysis-promoting taxane hydrophobic derivatives and pharmaceutical compositions containing them IL123595A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US357595P	1995-09-12	1995-09-12
PCT/US1996/014631 WO1997010234A1 (en)	1995-09-12	1996-09-12	Hydrolysis-promoting taxane hydrophobic derivatives

Publications (2)

Publication Number	Publication Date
IL123595A0 IL123595A0 (en)	1998-10-30
IL123595A true IL123595A (en)	2000-10-31

Family

ID=21706522

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12359596A IL123595A (en)	1995-09-12	1996-09-12	Hydrolysis-promoting taxane hydrophobic derivatives and pharmaceutical compositions containing them

Country Status (21)

Country	Link
US (1)	US5703117A (cs)
EP (1)	EP0902783B1 (cs)
JP (1)	JP4192208B2 (cs)
KR (1)	KR100401220B1 (cs)
CN (1)	CN1100770C (cs)
AT (2)	ATE309235T1 (cs)
CA (1)	CA2231750C (cs)
CZ (1)	CZ288562B6 (cs)
DE (2)	DE69635428T2 (cs)
DK (2)	DK0902783T3 (cs)
ES (2)	ES2252347T3 (cs)
HU (1)	HU226325B1 (cs)
IL (1)	IL123595A (cs)
MX (1)	MX9801871A (cs)
NO (1)	NO319521B1 (cs)
NZ (1)	NZ318300A (cs)
PL (1)	PL187738B1 (cs)
PT (1)	PT902783E (cs)
SK (1)	SK283199B6 (cs)
TR (1)	TR199800443T1 (cs)
WO (1)	WO1997010234A1 (cs)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6107332A (en) *	1995-09-12	2000-08-22	The Liposome Company, Inc.	Hydrolysis-promoting hydrophobic taxane derivatives
US6667053B1 (en) *	1996-02-16	2003-12-23	Elan Pharmaceuticals, Inc.	D and L etherlipid stereoisomers and liposomes
US5912264A (en) *	1997-03-03	1999-06-15	Bristol-Myers Squibb Company	6-halo-or nitrate-substituted paclitaxels
US8853260B2 (en)	1997-06-27	2014-10-07	Abraxis Bioscience, Llc	Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
TR200002243T2 (tr) *	1997-11-10	2000-12-21	Memorial Sloan-Kettering Cancer Center	Arsenik trioksitin hazırlanması için işlem ve bunların kanser tedavisi için kullanımı.
SK17422000A3 (sk) *	1998-05-20	2001-09-11	The Liposome Company, Inc.	Kompozöcie ¬astöc
US6146659A (en) *	1998-07-01	2000-11-14	Neopharm, Inc.	Method of administering liposomal encapsulated taxane
US7314637B1 (en)	1999-06-29	2008-01-01	Neopharm, Inc.	Method of administering liposomal encapsulated taxane
JP2002534461A (ja) *	1999-01-12	2002-10-15	クアナムメディカルコーポレイション	水不溶性のパクリタキセル誘導体の投与のための組成物および方法
AU775373B2 (en)	1999-10-01	2004-07-29	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
CA2410632A1 (en)	2000-06-22	2001-12-27	David S. Garvey	Nitrosated and nitrosylated taxanes, compositions and methods of use
US6607689B1 (en) *	2000-08-29	2003-08-19	Micron Technology, Inc.	Layer thickness control for stereolithography utilizing variable liquid elevation and laser focal length
EP1304103B1 (en) *	2001-10-22	2008-12-31	Viroblock SA	New non-phospholipid lipid vesicles (npLV) and their use in cosmetic, therapeutic and prophylactic applications
US6710195B2 (en) *	2001-11-26	2004-03-23	Supergen, Inc.	Method for preparing and using polyoxyethylated castor oil in pharmaceutical compositions
EP1553924B1 (en) *	2002-06-26	2010-12-08	MediGene AG	Novel method of stabilizing diagnostic and therapeutic compounds in a cationic carrier system
BRPI0407096A (pt)	2003-02-03	2006-01-24	Neopharm Inc	Taxano encapsulado em lipossomo estável, estéril e filtrável e outros fármacos antineoplásicos
US20090130163A1 (en) *	2005-02-18	2009-05-21	Abraxis Bio Scoence, Inc.	Drugs With Improved Hydrophobicity For Incorporation in Medical Devices
AU2006235538A1 (en) *	2005-04-12	2006-10-19	Wisconsin Alumni Research Foundation	Micelle composition of polymer and passenger drug
TW200942233A (en) *	2008-04-10	2009-10-16	Abraxis Bioscience Llc	Compositions of hydrophobic taxane derivatives and uses thereof
MX2010011165A (es) *	2008-04-10	2011-02-22	Abraxis Bioscience Llc	Composiciones de derivados de taxano hidrofobos y sus usos.
EP2480207B1 (en)	2009-09-25	2016-11-09	Wisconsin Alumni Research Foundation	Micelle encapsulation of therapeutic agents
CN105503844A (zh) *	2015-12-11	2016-04-20	上海大学	C-13和c-7位结构改造的紫杉醇类化合物及其制备方法
CN111004195B (zh) *	2019-12-03	2022-01-28	沈阳药科大学	卡巴他赛弱碱性衍生物及其制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5059699A (en) *	1990-08-28	1991-10-22	Virginia Tech Intellectual Properties, Inc.	Water soluble derivatives of taxol
US5278324A (en) *	1990-08-28	1994-01-11	Virginia Tech Intellectual Properties, Inc.	Water soluble derivatives of taxol
CZ292993B6 (cs) *	1992-12-23	2004-01-14	Bristol-Myers Squibb Company	Způsob přípravy taxanu nesoucího oxazolinový postranní řetězec a taxan tímto způsobem připravený
IL108316A (en) *	1993-01-15	2006-10-31	Univ Florida State	C10 taxane derivatives and pharmaceutical compositions containing them
US5580899A (en) *	1995-01-09	1996-12-03	The Liposome Company, Inc.	Hydrophobic taxane derivatives

1996
- 1996-09-12 AT AT02008590T patent/ATE309235T1/de not_active IP Right Cessation
- 1996-09-12 US US08/712,684 patent/US5703117A/en not_active Expired - Fee Related
- 1996-09-12 AT AT96930847T patent/ATE216377T1/de not_active IP Right Cessation
- 1996-09-12 CZ CZ1998711A patent/CZ288562B6/cs not_active IP Right Cessation
- 1996-09-12 TR TR1998/00443T patent/TR199800443T1/xx unknown
- 1996-09-12 SK SK334-98A patent/SK283199B6/sk unknown
- 1996-09-12 DE DE69635428T patent/DE69635428T2/de not_active Expired - Fee Related
- 1996-09-12 DK DK96930847T patent/DK0902783T3/da active
- 1996-09-12 EP EP96930847A patent/EP0902783B1/en not_active Expired - Lifetime
- 1996-09-12 ES ES02008590T patent/ES2252347T3/es not_active Expired - Lifetime
- 1996-09-12 HU HU9901433A patent/HU226325B1/hu unknown
- 1996-09-12 PL PL96325477A patent/PL187738B1/pl not_active IP Right Cessation
- 1996-09-12 WO PCT/US1996/014631 patent/WO1997010234A1/en not_active Ceased
- 1996-09-12 DK DK02008590T patent/DK1229030T3/da active
- 1996-09-12 MX MX9801871A patent/MX9801871A/es not_active IP Right Cessation
- 1996-09-12 JP JP51210297A patent/JP4192208B2/ja not_active Expired - Fee Related
- 1996-09-12 CA CA002231750A patent/CA2231750C/en not_active Expired - Fee Related
- 1996-09-12 IL IL12359596A patent/IL123595A/xx not_active IP Right Cessation
- 1996-09-12 KR KR10-1998-0701653A patent/KR100401220B1/ko not_active Expired - Fee Related
- 1996-09-12 DE DE69620802T patent/DE69620802T2/de not_active Expired - Fee Related
- 1996-09-12 ES ES96930847T patent/ES2179208T3/es not_active Expired - Lifetime
- 1996-09-12 PT PT96930847T patent/PT902783E/pt unknown
- 1996-09-12 CN CN96198237A patent/CN1100770C/zh not_active Expired - Fee Related
- 1996-09-12 NZ NZ318300A patent/NZ318300A/xx unknown
1998
- 1998-03-11 NO NO19981071A patent/NO319521B1/no unknown

Also Published As

Publication number	Publication date
KR100401220B1 (ko)	2004-03-20
ES2179208T3 (es)	2003-01-16
DE69620802T2 (de)	2002-10-10
SK33498A3 (en)	1998-08-05
US5703117A (en)	1997-12-30
KR19990044409A (ko)	1999-06-25
JP2001519755A (ja)	2001-10-23
PL187738B1 (pl)	2004-09-30
HK1016169A1 (en)	1999-10-29
JP4192208B2 (ja)	2008-12-10
MX9801871A (es)	1998-05-31
AU6975696A (en)	1997-04-01
HUP9901433A3 (en)	2001-05-28
IL123595A0 (en)	1998-10-30
HU226325B1 (en)	2008-08-28
NO319521B1 (no)	2005-08-22
NO981071D0 (no)	1998-03-11
CA2231750C (en)	2006-07-11
HUP9901433A2 (hu)	2001-04-28
ATE216377T1 (de)	2002-05-15
EP0902783B1 (en)	2002-04-17
EP0902783A4 (cs)	1999-03-24
DK0902783T3 (da)	2002-07-22
CZ71198A3 (cs)	1998-07-15
DE69635428T2 (de)	2006-06-14
DE69620802D1 (de)	2002-05-23
CZ288562B6 (cs)	2001-07-11
CN1202166A (zh)	1998-12-16
ATE309235T1 (de)	2005-11-15
ES2252347T3 (es)	2006-05-16
CA2231750A1 (en)	1997-03-20
AU706290B2 (en)	1999-06-10
WO1997010234A1 (en)	1997-03-20
EP0902783A1 (en)	1999-03-24
CN1100770C (zh)	2003-02-05
DK1229030T3 (da)	2006-02-13
NO981071L (no)	1998-05-12
PL325477A1 (en)	1998-07-20
NZ318300A (en)	1999-08-30
TR199800443T1 (xx)	1998-06-22
DE69635428D1 (de)	2005-12-15
SK283199B6 (sk)	2003-03-04
PT902783E (pt)	2002-09-30

Legal Events

Date	Code	Title
2001-03-19	FF	Patent granted
2001-06-14	KB	Patent renewed
2002-12-01	KB	Patent renewed
2006-10-30	KB	Patent renewed
2011-04-28	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL123595A (en)	2000-10-31	Hydrolysis-promoting taxane hydrophobic derivatives and pharmaceutical compositions containing them
IL133585A0 (en)	2001-04-30	Soluble prodrugs of paclitaxel
CA2301057A1 (en)	2000-01-13	A method of administering liposomal encapsulated taxane
EP1033981A4 (en)	2001-10-04	FORMULATIONS AND METHODS FOR REDUCING THE TOXICITY OF ANTINEOPLASTIC AGENTS
SE9301951D0 (sv)	1993-06-08	Methods for administration of taxol
NL970006I2 (nl)	1997-10-01	Gebruik van indolon-derivaten voor het bereiden van geneesmiddelen ter behandeling van de ziekte vanParkinson.
AU1406895A (en)	1995-07-10	Inhalable contrast agent
NZ312715A (en)	2000-01-28	Novel camptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues
IL112664A0 (en)	1995-05-26	4-amino derivatives of mycophenolic acid, their preparation and pharmaceutical compositions containing them
ATE262515T1 (de)	2004-04-15	Discodermolide verbindungen und deren pharmazeutische zusammensetzungen zur krebstherapie
SE8404283L (sv)	1986-03-01	Anvendning av ett specifikt tumorassocierat antigen, nemligen sialosyllaktotetraos, for diagnostiska och terapeutiska forfaranden vid cancersjukdomar
GB1515241A (en)	1978-06-21	Beta-lactam antibiotics
FR2616330B1 (fr)	1990-12-21	Agent actif et medicament en contenant destines a prevenir ou a combattre le rejet de greffe d'organe chez l'homme
DE68927055D1 (de)	1996-10-02	2',5'-oligoadenylat-derivate zur verwendung als heilmittel
EP1229030A3 (en)	2002-09-25	Hydrolysis-promoting taxane hydrophobic derivates
JPS6485930A (en)	1989-03-30	Anticancer composition and therapy using monoclonal antibody and il-2 against gd3 ganglioside
IL112668A (en)	1999-08-17	4-Amino 6-substituted mycophenolic acid and derivatives thereof their preparation and pharmaceutical compositions containing them
GR3034062T3 (en)	2000-11-30	Utilization of efaroxan and derivatives thereof for the preparation of a medicament intended to the treatment of parkinson disease
DE69233773D1 (de)	2009-11-19	Verwendung von topotecan zur herstellung eines medikaments zur verwendung in der behandlung von ovarialkrebs
UA10301A (uk)	1996-12-25	Спосіб лікуваhhя раку шлуhку
HUT41778A (en)	1987-05-28	Process for producing ergoline derivatives
NZ335189A (en)	2000-10-27	Use of taxane hydrophobic derivatives for the treatment of cancer
MX9603483A (es)	1998-01-31	Acido micofenolico 6-sustituido y derivados.