IL126202A0 - Processes and intermediates for preparing 4'-trifluoromethylbiphenyl-2-carboxylic acid [2-(2H-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl]-amide - Google Patents

Processes and intermediates for preparing 4'-trifluoromethylbiphenyl-2-carboxylic acid [2-(2H-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl]-amide

Info

Publication number: IL126202A0
Authority: IL; Israel
Prior art keywords: trifluoromethylbiphenyl; isoquinolin; triazol; ylmethyl; tetrahydro
Prior art date: 1996-04-30

Application number

IL12620297A

Other languages

English (en)

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-30

Filing date

1997-03-13

Publication date

1999-05-09

1997-03-13 Application filed by Pfizer filed Critical Pfizer

1999-05-09 Publication of IL126202A0 publication Critical patent/IL126202A0/xx

Links

239000000543 intermediate Substances 0.000 title 1
WNDIAFXQKOHFLV-UHFFFAOYSA-N n-[2-(1h-1,2,4-triazol-5-ylmethyl)-3,4-dihydro-1h-isoquinolin-6-yl]-2-[4-(trifluoromethyl)phenyl]benzamide Chemical compound C1=CC(C(F)(F)F)=CC=C1C1=CC=CC=C1C(=O)NC1=CC=C(CN(CC2=NNC=N2)CC2)C2=C1 WNDIAFXQKOHFLV-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

IL12620297A 1996-04-30 1997-03-13 Processes and intermediates for preparing 4'-trifluoromethylbiphenyl-2-carboxylic acid [2-(2H-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl]-amide IL126202A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1649596P	1996-04-30	1996-04-30
PCT/IB1997/000254 WO1997041111A1 (fr)	1996-04-30	1997-03-13	Procedes et intermediaires pour la preparation de [2-(2h-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolein-6-yl]-amide d'acide 4'-trifluoromethylbiphenyl-2-carboxylique

Publications (1)

Publication Number	Publication Date
IL126202A0 true IL126202A0 (en)	1999-05-09

Family

ID=21777423

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12620297A IL126202A0 (en)	1996-04-30	1997-03-13	Processes and intermediates for preparing 4'-trifluoromethylbiphenyl-2-carboxylic acid [2-(2H-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl]-amide

Country Status (23)

Country	Link
US (1)	US5998623A (fr)
EP (1)	EP0902785B1 (fr)
JP (1)	JPH11507959A (fr)
KR (1)	KR20000065152A (fr)
CN (1)	CN1216988A (fr)
AR (1)	AR006876A1 (fr)
AT (1)	ATE223400T1 (fr)
AU (1)	AU711279B2 (fr)
BR (1)	BR9709137A (fr)
CA (1)	CA2252621C (fr)
CZ (1)	CZ346498A3 (fr)
DE (1)	DE69715188T2 (fr)
DK (1)	DK0902785T3 (fr)
ES (1)	ES2180935T3 (fr)
HU (1)	HUP9902157A3 (fr)
ID (1)	ID17294A (fr)
IL (1)	IL126202A0 (fr)
PL (1)	PL329739A1 (fr)
PT (1)	PT902785E (fr)
TR (1)	TR199802163T2 (fr)
WO (1)	WO1997041111A1 (fr)
YU (1)	YU16297A (fr)
ZA (1)	ZA973696B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6197798B1 (en)	1998-07-21	2001-03-06	Novartis Ag	Amino-benzocycloalkane derivatives
CO5271688A1 (es) *	1999-11-10	2003-04-30	Pfizer Prod Inc	Uso de inhibidor de secrecion de apoliproteinas b y/o de proteina de transferencia de trigliceridos microsmales
CA2324801A1 (fr) *	1999-11-10	2001-05-10	Andrew Gordon Swick	Utilisation d'inhibiteurs de secretion d'apo b et/ou de mtp et d'agents contre l'obesite
CA2324800A1 (fr) *	1999-11-10	2001-05-10	Mary Anne Hickman	Utilisation d'inhibiteurs de secretion d'apo b et/ou de mtp
IL139450A0 (en) *	1999-11-10	2001-11-25	Pfizer Prod Inc	Methods of administering apo b-secretion/mtp inhibitors
US6878707B2 (en) *	2000-01-18	2005-04-12	Novartis Ag	Carboxamides useful as inhibitors of microsomal triglyceride transfer protein and of apolipoprotein b secretion
AU2001277727A1 (en) *	2000-08-10	2002-02-25	Tanabe Seiyaku Co., Ltd.	Benzoylaminoisoindoline compounds, processes for the preparation of the same andintermediates for the synthesis thereof
AU2001277728A1 (en) *	2000-08-10	2002-02-25	Tanabe Seiyaku Co., Ltd.	Biphenylcarboxamidoisoindoline compounds, processes for the preparation of the same and intermediates for the synthesis thereof
NZ549721A (en)	2004-03-05	2010-08-27	Univ Pennsylvania	Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side-effects
WO2008075949A1 (fr) *	2006-12-20	2008-06-26	Friesland Brands B.V.	Modulation de l'expression génique d'une protéine microsomale de transfert des triglycérides (mtp ou mttp) au moyen de microorganismes alimentaires ingérés/de qualité alimentaire
EP4188372A1 (fr)	2020-07-29	2023-06-07	Amryt Pharmaceuticals Inc.	Lomitapide destiné à être utilisé dans des méthodes de traitement de l'hyperlipidémie et de l'hypercholestérolémie chez des patients pédiatriques

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5595872A (en) *	1992-03-06	1997-01-21	Bristol-Myers Squibb Company	Nucleic acids encoding microsomal trigyceride transfer protein
ZA931601B (en) *	1992-03-06	1993-10-05	Squibb & Sons Inc	Microsomal triglyceride transfer protein
IL110172A (en) *	1993-07-22	2001-10-31	Lilly Co Eli	Bicyclic compounds and pharmaceutical compositions containing them
DK0832069T3 (da) *	1995-06-07	2003-04-22	Pfizer	Biphenyl-2-carboxylsyre-tetrahydroisoquinolin-6-ylamidderivater, deres fremstilling og deres anvendelse som inhibitorer af sekretion af mikrosomalt triglyceridoverførselsprotein og/eller apolipoprotein B (Apo B)
WO1996040640A1 (fr) *	1995-06-07	1996-12-19	Pfizer Inc.	DERIVES DE BIPHENYL-2-ACIDE CARBOXYLIQUE-TETRAHYDRO-ISOQUINOLEINE-6-YL AMIDES, PREPARATION DE CES AMIDES ET UTILISATION EN TANT QU'INHIBITEURS DE LA PROTEINE DE TRANSFERT DE TRIGLYCERIDE MICROSOMAL ET/OU DE LA SECRETION D'APOLIPOPROTEINES B (Apo B)

1997
- 1997-03-13 PT PT97905354T patent/PT902785E/pt unknown
- 1997-03-13 DE DE69715188T patent/DE69715188T2/de not_active Expired - Fee Related
- 1997-03-13 WO PCT/IB1997/000254 patent/WO1997041111A1/fr not_active Ceased
- 1997-03-13 CN CN97194209A patent/CN1216988A/zh active Pending
- 1997-03-13 HU HU9902157A patent/HUP9902157A3/hu unknown
- 1997-03-13 AU AU22266/97A patent/AU711279B2/en not_active Ceased
- 1997-03-13 PL PL97329739A patent/PL329739A1/xx unknown
- 1997-03-13 KR KR1019980708760A patent/KR20000065152A/ko not_active Ceased
- 1997-03-13 BR BR9709137A patent/BR9709137A/pt not_active Application Discontinuation
- 1997-03-13 US US09/147,197 patent/US5998623A/en not_active Expired - Fee Related
- 1997-03-13 ES ES97905354T patent/ES2180935T3/es not_active Expired - Lifetime
- 1997-03-13 AT AT97905354T patent/ATE223400T1/de not_active IP Right Cessation
- 1997-03-13 TR TR1998/02163T patent/TR199802163T2/xx unknown
- 1997-03-13 CZ CZ983464A patent/CZ346498A3/cs unknown
- 1997-03-13 EP EP97905354A patent/EP0902785B1/fr not_active Expired - Lifetime
- 1997-03-13 DK DK97905354T patent/DK0902785T3/da active
- 1997-03-13 CA CA002252621A patent/CA2252621C/fr not_active Expired - Fee Related
- 1997-03-13 IL IL12620297A patent/IL126202A0/xx unknown
- 1997-03-13 JP JP9538686A patent/JPH11507959A/ja active Pending
- 1997-04-25 AR ARP970101731A patent/AR006876A1/es unknown
- 1997-04-28 ID IDP971403A patent/ID17294A/id unknown
- 1997-04-29 ZA ZA973696A patent/ZA973696B/xx unknown
- 1997-04-29 YU YU16297A patent/YU16297A/sh unknown

Also Published As

Publication number	Publication date
DE69715188D1 (de)	2002-10-10
CA2252621A1 (fr)	1997-11-06
AU2226697A (en)	1997-11-19
WO1997041111A1 (fr)	1997-11-06
DK0902785T3 (da)	2002-10-07
AU711279B2 (en)	1999-10-07
HUP9902157A2 (hu)	2000-04-28
HUP9902157A3 (en)	2000-07-28
CA2252621C (fr)	2002-09-03
CN1216988A (zh)	1999-05-19
JPH11507959A (ja)	1999-07-13
BR9709137A (pt)	1999-08-03
TR199802163T2 (xx)	1999-02-22
YU16297A (sh)	1999-09-27
ATE223400T1 (de)	2002-09-15
KR20000065152A (ko)	2000-11-06
DE69715188T2 (de)	2003-01-02
ZA973696B (en)	1998-10-29
ID17294A (id)	1997-12-18
AR006876A1 (es)	1999-09-29
US5998623A (en)	1999-12-07
EP0902785B1 (fr)	2002-09-04
PT902785E (pt)	2002-12-31
EP0902785A1 (fr)	1999-03-24
CZ346498A3 (cs)	1999-09-15
ES2180935T3 (es)	2003-02-16
PL329739A1 (en)	1999-04-12

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