ZA973696B - Processes and intermediates for preparing 4'-trifluoro-methylbiphenyl-2-carboxylic acid [2-(2H-[1,2,4]triazol-3-ylmethyl)-1-2-3-4-tetrahydro-isoquinolin-6-yl]-amide - Google Patents

Processes and intermediates for preparing 4'-trifluoro-methylbiphenyl-2-carboxylic acid [2-(2H-[1,2,4]triazol-3-ylmethyl)-1-2-3-4-tetrahydro-isoquinolin-6-yl]-amide

Info

Publication number
ZA973696B
ZA973696B ZA973696A ZA973696A ZA973696B ZA 973696 B ZA973696 B ZA 973696B ZA 973696 A ZA973696 A ZA 973696A ZA 973696 A ZA973696 A ZA 973696A ZA 973696 B ZA973696 B ZA 973696B
Authority
ZA
South Africa
Prior art keywords
methylbiphenyl
isoquinolin
triazol
ylmethyl
trifluoro
Prior art date
Application number
ZA973696A
Other languages
English (en)
Inventor
Frank J Urban
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA973696B publication Critical patent/ZA973696B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
ZA973696A 1996-04-30 1997-04-29 Processes and intermediates for preparing 4'-trifluoro-methylbiphenyl-2-carboxylic acid [2-(2H-[1,2,4]triazol-3-ylmethyl)-1-2-3-4-tetrahydro-isoquinolin-6-yl]-amide ZA973696B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1649596P 1996-04-30 1996-04-30

Publications (1)

Publication Number Publication Date
ZA973696B true ZA973696B (en) 1998-10-29

Family

ID=21777423

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA973696A ZA973696B (en) 1996-04-30 1997-04-29 Processes and intermediates for preparing 4'-trifluoro-methylbiphenyl-2-carboxylic acid [2-(2H-[1,2,4]triazol-3-ylmethyl)-1-2-3-4-tetrahydro-isoquinolin-6-yl]-amide

Country Status (23)

Country Link
US (1) US5998623A (fr)
EP (1) EP0902785B1 (fr)
JP (1) JPH11507959A (fr)
KR (1) KR20000065152A (fr)
CN (1) CN1216988A (fr)
AR (1) AR006876A1 (fr)
AT (1) ATE223400T1 (fr)
AU (1) AU711279B2 (fr)
BR (1) BR9709137A (fr)
CA (1) CA2252621C (fr)
CZ (1) CZ346498A3 (fr)
DE (1) DE69715188T2 (fr)
DK (1) DK0902785T3 (fr)
ES (1) ES2180935T3 (fr)
HU (1) HUP9902157A3 (fr)
ID (1) ID17294A (fr)
IL (1) IL126202A0 (fr)
PL (1) PL329739A1 (fr)
PT (1) PT902785E (fr)
TR (1) TR199802163T2 (fr)
WO (1) WO1997041111A1 (fr)
YU (1) YU16297A (fr)
ZA (1) ZA973696B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197798B1 (en) 1998-07-21 2001-03-06 Novartis Ag Amino-benzocycloalkane derivatives
CA2324801A1 (fr) * 1999-11-10 2001-05-10 Andrew Gordon Swick Utilisation d'inhibiteurs de secretion d'apo b et/ou de mtp et d'agents contre l'obesite
IL139450A0 (en) * 1999-11-10 2001-11-25 Pfizer Prod Inc Methods of administering apo b-secretion/mtp inhibitors
IL139449A0 (en) * 1999-11-10 2001-11-25 Pfizer Prod Inc Use of apo b secretion/mtp inhibitors
CA2324800A1 (fr) * 1999-11-10 2001-05-10 Mary Anne Hickman Utilisation d'inhibiteurs de secretion d'apo b et/ou de mtp
ES2240420T3 (es) * 2000-01-18 2005-10-16 Novartis Ag Carboxamidas utiles como inhibidores de la proteina de transferencia de trigliceridos microsomicos y de la secrecion de apolipoproteina b.
WO2002014276A1 (fr) * 2000-08-10 2002-02-21 Tanabe Seiyaku Co., Ltd. Composes a base de benzoylaminoisoindoline, leurs procedes de preparation et produits intermediaires utilises dans leur synthese
WO2002014277A1 (fr) * 2000-08-10 2002-02-21 Tanabe Seiyaku Co., Ltd. Composes de biphenylcarboxamidoisoindoline, procedes de preparation de ceux-ci et produits intermediaires destines a la synthese de ceux-ci
KR101494067B1 (ko) 2004-03-05 2015-02-16 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 부작용을 최소화하면서 과지질혈증 및 과콜레스테롤혈증과 연관된 질환 또는 질병의 치료 방법
WO2008075949A1 (fr) * 2006-12-20 2008-06-26 Friesland Brands B.V. Modulation de l'expression génique d'une protéine microsomale de transfert des triglycérides (mtp ou mttp) au moyen de microorganismes alimentaires ingérés/de qualité alimentaire
CA3186856A1 (fr) 2020-07-29 2022-02-03 Ruth NALLEN Lomitapide destine a etre utilise dans des methodes de traitement de l'hyperlipidemie et de l'hypercholesterolemie chez des patients pediatriques

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU218419B (hu) * 1992-03-06 2000-08-28 E.R. Squibb And Sons, Inc. Mikroszomális triglicerid transzfer protein (MTP) nagy molekulatömegű alegységének rekombináns úton történő előállítására és a protein és inhibitorainak kimutatására szolgáló eljárások
US5595872A (en) * 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
IL110172A (en) * 1993-07-22 2001-10-31 Lilly Co Eli Bicyclic compounds and pharmaceutical compositions containing them
WO1996040640A1 (fr) * 1995-06-07 1996-12-19 Pfizer Inc. DERIVES DE BIPHENYL-2-ACIDE CARBOXYLIQUE-TETRAHYDRO-ISOQUINOLEINE-6-YL AMIDES, PREPARATION DE CES AMIDES ET UTILISATION EN TANT QU'INHIBITEURS DE LA PROTEINE DE TRANSFERT DE TRIGLYCERIDE MICROSOMAL ET/OU DE LA SECRETION D'APOLIPOPROTEINES B (Apo B)
DK0832069T3 (da) * 1995-06-07 2003-04-22 Pfizer Biphenyl-2-carboxylsyre-tetrahydroisoquinolin-6-ylamidderivater, deres fremstilling og deres anvendelse som inhibitorer af sekretion af mikrosomalt triglyceridoverførselsprotein og/eller apolipoprotein B (Apo B)

Also Published As

Publication number Publication date
AU2226697A (en) 1997-11-19
DE69715188D1 (de) 2002-10-10
DE69715188T2 (de) 2003-01-02
JPH11507959A (ja) 1999-07-13
KR20000065152A (ko) 2000-11-06
CZ346498A3 (cs) 1999-09-15
IL126202A0 (en) 1999-05-09
EP0902785B1 (fr) 2002-09-04
CA2252621C (fr) 2002-09-03
AR006876A1 (es) 1999-09-29
ES2180935T3 (es) 2003-02-16
PL329739A1 (en) 1999-04-12
YU16297A (sh) 1999-09-27
US5998623A (en) 1999-12-07
ID17294A (id) 1997-12-18
CA2252621A1 (fr) 1997-11-06
EP0902785A1 (fr) 1999-03-24
HUP9902157A2 (hu) 2000-04-28
HUP9902157A3 (en) 2000-07-28
PT902785E (pt) 2002-12-31
TR199802163T2 (xx) 1999-02-22
CN1216988A (zh) 1999-05-19
DK0902785T3 (da) 2002-10-07
WO1997041111A1 (fr) 1997-11-06
BR9709137A (pt) 1999-08-03
AU711279B2 (en) 1999-10-07
ATE223400T1 (de) 2002-09-15

Similar Documents

Publication Publication Date Title
HUP0004388A3 (en) Process for the preparation of oxazolidinones, intermediates and preparation thereof
EG23861A (en) Intermediates and process for preparing olanzapine
SG118060A1 (en) Process for preparation of pyrazoloÄ4,3-dÜpyrimidin-7-ones and intermediates thereof
DE69713352D1 (en) Substituierte [2-(1-piperazinyl)ethoxy]methyl-derivate
ZA973696B (en) Processes and intermediates for preparing 4'-trifluoro-methylbiphenyl-2-carboxylic acid [2-(2H-[1,2,4]triazol-3-ylmethyl)-1-2-3-4-tetrahydro-isoquinolin-6-yl]-amide
IL121730A0 (en) Process for the preparation of 2'-fluoro-5-methyl-beta-L-arabino-furanosyluridine
HUP9901176A3 (en) Process for the preparation of 2,2'-bipyrrolyl-pyrromethene (prodigiosins) derivatives and their intermediates
HUP0002159A3 (en) Process for preparing intermediates of pesticidally active compounds, the novel intermediates using in this process and preparation thereof
IL126989A (en) Process for making 4,6-dihydroxypyrimidine
HUP0001813A3 (en) Process for preparing eprosartan and intermediates
EP0692476A3 (fr) Procédé amélioré pour la préparation de N,N'-carbonyldiazoles, spécialement de N,N'-carbonyldiimidazole
HUP0003019A3 (en) Process for preparing 4-substituted-1h-indole-3-glyoxamides and their intermediates
HUP0001444A3 (en) Process for preparing carboxamido-4-azasteroids and their intermediates
HU9801775D0 (en) Bereznai's bnsc-wc system
HUP0003325A3 (en) Method for producing n-alkyl-n'-nitroguanidines
HUP9903524A3 (en) Process for the preparation of 1,2,4-triazol derivatives, intermediates and preparation of the latters
IL120285A (en) Process for the preparation of 1,5-benzothiazepine derivatives, process for the preparation of the intermediate thereof and an intermediate thereof
MD956F1 (en) N-carboxyaryl-N',N'-dimethylthiouûreas preparation process
AU4765599A (en) Lafora's disease gene
HU9701022D0 (en) Process for the preparation of [(5,6-dicarboxy-3-pyridil)methyl]ammonium halides
PL313636A1 (en) Method of obtaining 3,3',5,5'-tetraisopropylo-4,4-diphenylquinone
PL323962A1 (en) Method of obtaining n,n'-4h-byrane-bis-acrylamide
GB9403651D0 (en) Carrying case for tutu's
ZA98943B (en) Method of purifying 1,3,5-triisopropylbenzene
HUP9903878A3 (en) Process for the preparation of pyridazine-3-on derivatives, intermediates and preparation of the latter