|
GB9718972D0
(en)
|
1996-09-25 |
1997-11-12 |
Zeneca Ltd |
Chemical compounds
|
|
AU733551B2
(en)
|
1996-09-25 |
2001-05-17 |
Astrazeneca Ab |
Qinoline derivatives inhibiting the effect of growth factors such as VEGF
|
|
CO4950519A1
(es)
*
|
1997-02-13 |
2000-09-01 |
Novartis Ag |
Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
|
|
ATE368665T1
(de)
|
1997-08-22 |
2007-08-15 |
Astrazeneca Ab |
Oxindolylchinazolinderivate als angiogenesehemmer
|
|
EP1107964B8
(de)
*
|
1998-08-11 |
2010-04-07 |
Novartis AG |
Isochinoline derivate mit angiogenesis-hemmender wirkung
|
|
ATE371453T1
(de)
*
|
1998-08-13 |
2007-09-15 |
Novartis Pharma Gmbh |
Verfahren zur behandlung von okularen neovaskularen erkrankungen
|
|
JP4673977B2
(ja)
|
1999-03-30 |
2011-04-20 |
ノバルティス アーゲー |
炎症性疾患治療用フタラジン誘導体
|
|
AR025068A1
(es)
*
|
1999-08-10 |
2002-11-06 |
Bayer Corp |
Pirazinas sustituidas y piridazinas fusionadas, composicion farmaceutica que las comprenden, uso de dichos compuestos para la manufactura de un medicamentocon actividad inhibidora de angiogenesis
|
|
US6271233B1
(en)
|
1999-08-10 |
2001-08-07 |
Ciba Vision Corporation |
Method for treating ocular neovascular diseases
|
|
CO5200835A1
(es)
*
|
1999-09-28 |
2002-09-27 |
Bayer Corp |
Piridinas y piridacinas sustituidas con actividad de inhibicion de angiogenesis
|
|
US6689883B1
(en)
|
1999-09-28 |
2004-02-10 |
Bayer Pharmaceuticals Corporation |
Substituted pyridines and pyridazines with angiogenesis inhibiting activity
|
|
CN100376567C
(zh)
|
1999-11-05 |
2008-03-26 |
阿斯特拉曾尼卡有限公司 |
作为vegf抑制剂的喹唑啉衍生物
|
|
DE19963607B4
(de)
*
|
1999-12-23 |
2005-12-15 |
Schering Ag |
Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen
|
|
PT1254138E
(pt)
*
|
2000-02-09 |
2005-09-30 |
Novartis Ag |
Derivados de piridina que inibem a angiogenese e/ou o receptor de tirosina cinase do vegf
|
|
US7087608B2
(en)
|
2000-03-03 |
2006-08-08 |
Robert Charles Atkins |
Use of PDGF receptor tyrosine kinase inhibitors for the treatment of diabetic nephropathy
|
|
US7160889B2
(en)
|
2000-04-07 |
2007-01-09 |
Astrazeneca Ab |
Quinazoline compounds
|
|
US7977333B2
(en)
|
2000-04-20 |
2011-07-12 |
Bayer Healthcare Llc |
Substituted pyridines and pyridazines with angiogenesis inhibiting activity
|
|
EP1166798A1
(de)
*
|
2000-06-23 |
2002-01-02 |
Schering Aktiengesellschaft |
Zusammensetzungen die interferieren mit VEGF/VEGF und Angiopoietin/Tie Rezeptor-Funktionen
|
|
EP1166799A1
(de)
*
|
2000-06-28 |
2002-01-02 |
Schering Aktiengesellschaft |
Zusammensetzungen die interferieren mit VEGF/VEGF und Angiopoietin/Tie Rezeptor-Funktionen
|
|
HUP0302779A3
(en)
*
|
2000-06-23 |
2005-12-28 |
Schering Ag |
Combinations and compositions which interfere with vegf/vegf and angiopoietin/tie receptor function and their use (ii)
|
|
CA2416525A1
(en)
*
|
2000-08-09 |
2002-02-14 |
Astrazeneca Ab |
Indole, azaindole and indazole derivatives having vegf inhibiting activity
|
|
US6903101B1
(en)
*
|
2000-08-10 |
2005-06-07 |
Bayer Pharmaceuticals Corporation |
Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity
|
|
EP1415987B1
(de)
|
2000-10-20 |
2007-02-28 |
Eisai R&D Management Co., Ltd. |
Stickstoff-enthaltende aromatische ringverbindungen zur behandlung von tumorerkrankungen
|
|
AU9578901A
(en)
*
|
2000-10-30 |
2002-05-15 |
Kudos Pharm Ltd |
Phthalazinone derivatives
|
|
AU2002223684A1
(en)
*
|
2000-11-22 |
2002-06-03 |
Novartis Pharma Gmbh |
Combination comprising an agent decreasing vegf activity and an agent decreasing egf activity
|
|
US7814641B2
(en)
*
|
2001-01-09 |
2010-10-19 |
Black & Decker Inc. |
Method of forming a power tool
|
|
US7096566B2
(en)
*
|
2001-01-09 |
2006-08-29 |
Black & Decker Inc. |
Method for making an encapsulated coil structure
|
|
LT2762140T
(lt)
|
2001-02-19 |
2017-06-26 |
Novartis Ag |
Solidinių smegenų navikų gydymas rapamicino dariniu
|
|
GB0111078D0
(en)
|
2001-05-04 |
2001-06-27 |
Novartis Ag |
Organic compounds
|
|
BR0209647A
(pt)
|
2001-05-16 |
2004-07-27 |
Novartis Ag |
Combinação que compreende n-{5-[4-(4-metil-piperazino-metil)-benzoilamido]-2-metil fenil}-4-(3-piridil)-2-pirimidina-amina e um agente quimioterapêutico
|
|
TWI315982B
(en)
|
2001-07-19 |
2009-10-21 |
Novartis Ag |
Combinations comprising epothilones and pharmaceutical uses thereof
|
|
US20030073692A1
(en)
|
2001-08-07 |
2003-04-17 |
Pharmacia & Upjohn S.P.A. |
Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them
|
|
EP1427420B1
(de)
*
|
2001-09-12 |
2006-06-14 |
Novartis AG |
Die verwendung von einer 4-pyridylmethylphtalazine enthaltenden kombination zur behandlung von tumoren
|
|
SI1427420T1
(sl)
*
|
2001-09-12 |
2006-12-31 |
Novartis Ag |
Uporaba kombinacije, ki vsebuje 4-piridilmetilftalazine za zdravljenje raka
|
|
RU2320344C2
(ru)
*
|
2001-09-12 |
2008-03-27 |
Новартис Аг |
Применение 4-пиридилметилфталазинов для лечения рака
|
|
AU2002338807A1
(en)
*
|
2001-09-27 |
2003-04-14 |
Novartis Ag |
Use of c-kit inhibitors for the treatment of myeloma
|
|
DE60224299T2
(de)
*
|
2001-10-25 |
2008-12-11 |
Novartis Ag |
Kombinationsmedikationen mit einem selektiven cyclooxygenase-2-inhibitor
|
|
US20050019424A1
(en)
*
|
2001-12-21 |
2005-01-27 |
Adams Paul E. |
Anti-angiogenesis combination therapies comprising pyridazine or pyridine derivatives
|
|
WO2003057690A1
(en)
*
|
2001-12-27 |
2003-07-17 |
Theravance, Inc. |
Indolinone derivatives useful as protein kinase inhibitors
|
|
US20030171375A1
(en)
*
|
2002-02-13 |
2003-09-11 |
Brazzell Romulus Kimbro |
Method for treating ocular neovascular diseases
|
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
|
WO2003092696A1
(en)
*
|
2002-04-30 |
2003-11-13 |
Novartis Ag |
Method for decreasing capillary permeability in the retina
|
|
CA2483594C
(en)
|
2002-05-16 |
2011-02-15 |
Novartis Ag |
Use of edg receptor binding agents in cancer
|
|
JP2005531622A
(ja)
*
|
2002-06-28 |
2005-10-20 |
ノバルティス アクチエンゲゼルシャフト |
血管沈静化合物とアルキル化剤を含む腫瘍処置用の組合せ剤
|
|
WO2004015082A2
(en)
*
|
2002-08-09 |
2004-02-19 |
Theravance, Inc. |
Oncokinase fusion polypeptides associated with hyperproliferative and related disorders, nucleic acids encoding the same and methods for detecting and identifying the same
|
|
JP2006502195A
(ja)
*
|
2002-09-24 |
2006-01-19 |
ノバルティス アクチエンゲゼルシャフト |
骨髄異形成症候群の処置用医薬の製造のための4−ピリジルメチル−フタラジン誘導体の使用
|
|
GB0223341D0
(en)
*
|
2002-10-08 |
2002-11-13 |
Groningen Acad Ziekenhuis |
Organic compounds
|
|
WO2004033042A1
(en)
*
|
2002-10-10 |
2004-04-22 |
Novartis Ag |
Treatment of amm
|
|
US7268137B2
(en)
*
|
2002-11-07 |
2007-09-11 |
Campochiaro Peter A |
Ocular therapy
|
|
AU2003288034A1
(en)
*
|
2002-11-12 |
2004-06-03 |
Novartis Ag |
Treatment of mesothelioma
|
|
US7094785B1
(en)
|
2002-12-18 |
2006-08-22 |
Cornell Research Foundation, Inc. |
Method of treating polycythemia vera
|
|
US20060252763A1
(en)
*
|
2002-12-20 |
2006-11-09 |
William Kaelin |
Treatment of von hippel lindau disease
|
|
EP1641458A2
(de)
*
|
2002-12-27 |
2006-04-05 |
Schering Aktiengesellschaft |
Pharmazeutische zusammensetzungen aus phthalazine vegf hemmern und benzamide hdac hemmern
|
|
WO2004078723A1
(ja)
|
2003-03-07 |
2004-09-16 |
Santen Pharmaceutical Co. Ltd. |
4-ピリジルアルキルチオ基を置換基として有する新規化合物
|
|
US20050043233A1
(en)
|
2003-04-29 |
2005-02-24 |
Boehringer Ingelheim International Gmbh |
Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
|
|
US20040242886A1
(en)
*
|
2003-04-30 |
2004-12-02 |
Sandeep Gupta |
Monocyclic diazodioxide based Bcl-2 protein antagonists related applications
|
|
AU2004251146A1
(en)
|
2003-05-19 |
2005-01-06 |
Irm, Llc |
Immunosuppressant compounds and compositions
|
|
MY150088A
(en)
|
2003-05-19 |
2013-11-29 |
Irm Llc |
Immunosuppressant compounds and compositions
|
|
NZ544797A
(en)
|
2003-07-18 |
2011-04-29 |
Amgen Fremont Inc |
Specific antibodies that bind HGF and neutralise binding of HGF to met
|
|
WO2005044788A1
(ja)
|
2003-11-11 |
2005-05-19 |
Eisai Co., Ltd. |
ウレア誘導体およびその製造方法
|
|
PT1686997E
(pt)
|
2003-11-18 |
2009-07-17 |
Novartis Ag |
Inibidores da forma mutante de kit
|
|
JP2007513967A
(ja)
*
|
2003-12-11 |
2007-05-31 |
セラヴァンス, インコーポレーテッド |
変異レセプターチロシンキナーゼが駆動する細胞増殖性疾患の処置において使用するための組成物
|
|
ATE512950T1
(de)
|
2004-02-17 |
2011-07-15 |
Santen Pharmaceutical Co Ltd |
Neue cyclische verbindung mit 4- pyridylalkylthiogruppe mit darin eingeführtem (un)substituiertem amino
|
|
EP1568368A1
(de)
*
|
2004-02-26 |
2005-08-31 |
Schering Aktiengesellschaft |
Pharmazeutische Kombination enthaltend einen CDK Inhibitoren und einen VEGF Rezeptor Inhibitoren
|
|
FR2868780B1
(fr)
*
|
2004-04-13 |
2008-10-17 |
Sanofi Synthelabo |
Derives de la 1-amino-phthalazine, leur preparation et leur application en therapeutique
|
|
GB0512324D0
(en)
|
2005-06-16 |
2005-07-27 |
Novartis Ag |
Organic compounds
|
|
CA2571421A1
(en)
|
2004-06-24 |
2006-01-05 |
Nicholas Valiante |
Compounds for immunopotentiation
|
|
EP1797877A4
(de)
|
2004-09-13 |
2010-12-15 |
Eisai Co Ltd |
Gemeinsame verwendung einer verbindung auf sulfonamid-basis mit einem angiogenese-hemmer
|
|
US8772269B2
(en)
|
2004-09-13 |
2014-07-08 |
Eisai R&D Management Co., Ltd. |
Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
|
|
PE20060664A1
(es)
*
|
2004-09-15 |
2006-08-04 |
Novartis Ag |
Amidas biciclicas como inhibidores de cinasa
|
|
ATE428421T1
(de)
|
2004-09-17 |
2009-05-15 |
Eisai R&D Man Co Ltd |
Medizinische zusammensetzung mit verbesserter stabilität und reduzierten gelierungseigenschaften
|
|
ES2325344B1
(es)
*
|
2004-11-02 |
2010-06-09 |
Univ Madrid Autonoma |
Inhibidores de angiogenesis multifuncionales y multivalentes.
|
|
US7652009B2
(en)
|
2004-11-30 |
2010-01-26 |
Amgem Inc. |
Substituted heterocycles and methods of use
|
|
ES2351613T3
(es)
|
2005-03-03 |
2011-02-08 |
Santen Pharmaceutical Co., Ltd. |
Nuevo compuesto cíclico que tiene un grupo quinolilalquiltio.
|
|
US20060216288A1
(en)
*
|
2005-03-22 |
2006-09-28 |
Amgen Inc |
Combinations for the treatment of cancer
|
|
ES2548729T3
(es)
|
2005-03-31 |
2015-10-20 |
Santen Pharmaceutical Co., Ltd. |
Nuevo compuesto cíclico que tiene grupo pirimidinilalquiltio
|
|
GT200600147A
(es)
*
|
2005-04-13 |
2006-11-24 |
|
Uso de inhibidores de receptor de factor de crecimiento endotelial vascular para el tratamiento de canceres gastrointestinal, genitourinario, linfoide y pulmonar
|
|
CN103638028A
(zh)
|
2005-05-02 |
2014-03-19 |
诺瓦提斯公司 |
嘧啶基氨基苯甲酰胺衍生物用于治疗全身性肥大细胞增多症的应用
|
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
|
EP1731154A1
(de)
*
|
2005-06-07 |
2006-12-13 |
Schering Aktiengesellschaft |
Pharmazeutische Formulierungen mit sofortiger Freisetzung und hohem Wirkstoffanteil von micronisiertem (4-Chlorophenyl)¬4-(4-pyridylmethyl)phthalazin-1-yl| und dessen Salzen
|
|
EP1731153A1
(de)
*
|
2005-06-07 |
2006-12-13 |
Schering Aktiengesellschaft |
Pharmazeutische Formulierungen mit sofortiger Freisetzung und hohem Wirkstoffanteil von nicht micronisiertem (4-Chlorophenyl)¬4-(4-pyridylmethyl)phthalazin-1-yl| und dessen Salzen
|
|
EP1925676A4
(de)
|
2005-08-02 |
2010-11-10 |
Eisai R&D Man Co Ltd |
Testverfahren für die wirkung eines vaskularisierungsinhibitors
|
|
GB0517205D0
(en)
*
|
2005-08-22 |
2005-09-28 |
Novartis Ag |
Organic compounds
|
|
CN101277939A
(zh)
|
2005-09-09 |
2008-10-01 |
布里斯托尔-迈尔斯斯奎布公司 |
无环ikur抑制剂
|
|
CA2623034A1
(en)
|
2005-09-27 |
2007-04-05 |
Novartis Ag |
Carboxyamine compounds and their use in the treatment of hdac dependent diseases
|
|
UA96139C2
(uk)
|
2005-11-08 |
2011-10-10 |
Дженентек, Інк. |
Антитіло до нейропіліну-1 (nrp1)
|
|
EP2275103B1
(de)
|
2005-11-21 |
2014-04-23 |
Novartis AG |
mTOR-Inhibitoren in der Behandlung endokriner Tumore
|
|
US7989461B2
(en)
|
2005-12-23 |
2011-08-02 |
Amgen Inc. |
Substituted quinazolinamine compounds for the treatment of cancer
|
|
US20080108664A1
(en)
*
|
2005-12-23 |
2008-05-08 |
Liu Belle B |
Solid-state form of AMG 706 and pharmaceutical compositions thereof
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
|
AR059066A1
(es)
|
2006-01-27 |
2008-03-12 |
Amgen Inc |
Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf)
|
|
ATE489380T1
(de)
|
2006-02-10 |
2010-12-15 |
Amgen Inc |
Hydratformen von amg706
|
|
PE20070978A1
(es)
*
|
2006-02-14 |
2007-11-15 |
Novartis Ag |
COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
|
|
JP2009532503A
(ja)
|
2006-04-05 |
2009-09-10 |
ノバルティス アクチエンゲゼルシャフト |
癌を処置するための治療剤の組合せ
|
|
TW200808739A
(en)
*
|
2006-04-06 |
2008-02-16 |
Novartis Vaccines & Diagnostic |
Quinazolines for PDK1 inhibition
|
|
US8777120B2
(en)
*
|
2006-04-15 |
2014-07-15 |
International Business Machines Corporation |
Hydronic radiant flooring heating system
|
|
PE20080251A1
(es)
|
2006-05-04 |
2008-04-25 |
Boehringer Ingelheim Int |
Usos de inhibidores de dpp iv
|
|
US20090317489A1
(en)
|
2006-05-09 |
2009-12-24 |
Hanspeter Nick |
Combination Comprising an Iron Chelator and an Anti-Neoplastic Agent and Use Thereof
|
|
MX2008013990A
(es)
|
2006-05-09 |
2009-01-29 |
Pfizer Prod Inc |
Derivados de cicloalquilamino acidos.
|
|
WO2007136103A1
(ja)
|
2006-05-18 |
2007-11-29 |
Eisai R & D Management Co., Ltd. |
甲状腺癌に対する抗腫瘍剤
|
|
GB0610925D0
(en)
*
|
2006-06-02 |
2006-07-12 |
Novartis Ag |
Use of vascular endothelial growth factor receptor inhibitors for the treatment of cancer
|
|
GB0612721D0
(en)
|
2006-06-27 |
2006-08-09 |
Novartis Ag |
Organic compounds
|
|
PE20080403A1
(es)
|
2006-07-14 |
2008-04-25 |
Amgen Inc |
Derivados heterociclicos fusionados y metodos de uso
|
|
US8217177B2
(en)
|
2006-07-14 |
2012-07-10 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
|
BRPI0714665A2
(pt)
|
2006-08-04 |
2012-03-13 |
Takeda Pharmaceutical Company Limited |
Composto, pró-droga, agente farmacêutico, e, método para a profilaxia ou tratamento do câncer
|
|
KR101472600B1
(ko)
|
2006-08-28 |
2014-12-15 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
미분화형 위암에 대한 항종양제
|
|
KR20090073121A
(ko)
|
2006-09-29 |
2009-07-02 |
노파르티스 아게 |
Pi3k 지질 키나제 억제제로서의 피라졸로피리미딘
|
|
WO2008044045A1
(en)
|
2006-10-12 |
2008-04-17 |
Astex Therapeutics Limited |
Pharmaceutical combinations
|
|
WO2008044041A1
(en)
|
2006-10-12 |
2008-04-17 |
Astex Therapeutics Limited |
Pharmaceutical combinations
|
|
WO2008079291A2
(en)
|
2006-12-20 |
2008-07-03 |
Amgen Inc. |
Substituted heterocycles and methods of use
|
|
WO2008086014A2
(en)
|
2007-01-09 |
2008-07-17 |
Amgen Inc. |
Bis-aryl amide derivatives useful for the treatment of cancer
|
|
JP5216341B2
(ja)
|
2007-01-29 |
2013-06-19 |
参天製薬株式会社 |
血管新生阻害活性を有する新規オキサジアゾール誘導体およびチアジアゾール誘導体
|
|
EP2119707B1
(de)
|
2007-01-29 |
2015-01-14 |
Eisai R&D Management Co., Ltd. |
Zusammensetzung zur behandlung von nicht differenzierten formen von magenkrebsen
|
|
EP2491923A3
(de)
|
2007-02-15 |
2012-12-26 |
Novartis AG |
Kombinationen therapeutischer Wirkstoffe zur Krebsbehandlung
|
|
US8314087B2
(en)
|
2007-02-16 |
2012-11-20 |
Amgen Inc. |
Nitrogen-containing heterocyclyl ketones and methods of use
|
|
CL2008001626A1
(es)
|
2007-06-05 |
2009-06-05 |
Takeda Pharmaceuticals Co |
Compuestos derivados de heterociclos fusionados, agente farmaceutico que los comprende y su uso en la profilaxis y tratamiento del cancer.
|
|
US20090023727A1
(en)
*
|
2007-07-05 |
2009-01-22 |
Muhammad Hashim Javaid |
Phthalazinone derivatives
|
|
RS56743B1
(sr)
|
2007-08-21 |
2018-03-30 |
Amgen Inc |
Humani c-fms antigen vezujući proteini
|
|
JP5270553B2
(ja)
|
2007-08-23 |
2013-08-21 |
武田薬品工業株式会社 |
複素環化合物およびその用途
|
|
CN101116664B
(zh)
*
|
2007-08-28 |
2010-05-19 |
山东省科学院生物研究所 |
化合物1-(4-氯苯胺基)-4-(4-甲基吡啶基)-2,3-二氮杂萘的应用
|
|
CN101848895B
(zh)
|
2007-11-09 |
2013-10-23 |
卫材R&D管理有限公司 |
血管新生抑制物质和抗肿瘤性铂络合物的组合使用
|
|
KR20100093129A
(ko)
|
2007-12-20 |
2010-08-24 |
노파르티스 아게 |
Pi 3 키나제 억제제로서 사용되는 티아졸 유도체
|
|
PT2260020E
(pt)
|
2008-03-26 |
2014-10-28 |
Novartis Ag |
Inibidores das desacetilases b baseados no hidroxamato
|
|
UY32030A
(es)
|
2008-08-06 |
2010-03-26 |
Boehringer Ingelheim Int |
"tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
|
|
MX370599B
(es)
|
2008-08-15 |
2019-12-18 |
Boehringer Ingelheim Int |
Derivados de purina para su uso en el tratamiento de enfermedades relacionadas con fab.
|
|
ES2704986T3
(es)
|
2008-10-16 |
2019-03-21 |
Celator Pharmaceuticals Inc |
Combinaciones de una camptotecina liposomal soluble en agua con cetuximab o bevacizumab
|
|
US8697874B2
(en)
|
2008-12-01 |
2014-04-15 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compound and use thereof
|
|
JO3101B1
(ar)
|
2008-12-02 |
2017-09-20 |
Takeda Pharmaceuticals Co |
مشتقات بنزوثيازول كعوامل مضادة للسرطان
|
|
EP2379499B1
(de)
|
2008-12-18 |
2014-04-09 |
Novartis AG |
Hydrochlorid Salz der 1-(4-(1-((E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)-ethyl)-2-ethyl-benzyl)-azetidin-3-carbonsäure
|
|
RS53041B
(sr)
|
2008-12-18 |
2014-04-30 |
Novartis Ag |
Hemifumaratna so 1-[4-[1-(4-cikloheksil-3-trifluorometil-benziloksiimino)-etil]-2-etil-benzil]-azetidin-3-karboksilne kiseline
|
|
AU2009327405A1
(en)
|
2008-12-18 |
2011-06-30 |
Novartis Ag |
New polymorphic form of 1- (4- { l- [ (E) -4-cyclohexyl--3-trifluoromethyl-benzyloxyimino] -ethyl) -2-ethyl-benzy l) -azetidine-3-carboxylic
|
|
EA022310B1
(ru)
|
2008-12-23 |
2015-12-30 |
Бёрингер Ингельхайм Интернациональ Гмбх |
Солевые формы органического соединения
|
|
AR074990A1
(es)
|
2009-01-07 |
2011-03-02 |
Boehringer Ingelheim Int |
Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
|
|
PL2391366T3
(pl)
|
2009-01-29 |
2013-04-30 |
Novartis Ag |
Podstawione benzimidazole do leczenia gwiaździaków
|
|
TWI466672B
(zh)
|
2009-01-29 |
2015-01-01 |
Boehringer Ingelheim Int |
小兒科病人糖尿病之治療
|
|
NZ619520A
(en)
|
2009-02-13 |
2015-06-26 |
Boehringer Ingelheim Int |
Antidiabetic medications comprising a dpp-4 inhibitor (linagliptin) optionally in combination with other antidiabetics
|
|
WO2010108503A1
(en)
|
2009-03-24 |
2010-09-30 |
Life & Brain Gmbh |
Promotion of neuronal integration in neural stem cell grafts
|
|
WO2010120386A1
(en)
|
2009-04-17 |
2010-10-21 |
Nektar Therapeutics |
Oligomer-protein tyrosine kinase inhibitor conjugates
|
|
MA33451B1
(fr)
|
2009-06-26 |
2012-07-03 |
Novartis Ag |
Dérivés d'imidazolidin-2-one 1,3-disubstitués en tant qu'inhibiteurs de cyp 17
|
|
US8293753B2
(en)
|
2009-07-02 |
2012-10-23 |
Novartis Ag |
Substituted 2-carboxamide cycloamino ureas
|
|
US8389526B2
(en)
|
2009-08-07 |
2013-03-05 |
Novartis Ag |
3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
|
|
EA201200260A1
(ru)
|
2009-08-12 |
2012-09-28 |
Новартис Аг |
Гетероциклические гидразоны и их применение для лечения рака и воспаления
|
|
MY162604A
(en)
|
2009-08-17 |
2017-06-30 |
Intellikine Llc |
Heterocyclic compounds and uses thereof
|
|
BR112012003592B8
(pt)
|
2009-08-19 |
2021-05-25 |
Eisai R&D Man Co Ltd |
composição farmacêutica contendo derivado de quinolina
|
|
MX2012002179A
(es)
|
2009-08-20 |
2012-03-16 |
Novartis Ag |
Compuestos heterociclicos de oxima.
|
|
AU2010288534A1
(en)
|
2009-08-26 |
2012-03-15 |
Novartis Ag |
Tetra-substituted heteroaryl compounds and their use as MDM2 and/or MDM4 modulators
|
|
AU2010294209A1
(en)
|
2009-09-10 |
2012-03-29 |
Irm Llc |
Ether derivatives of bicyclic heteroaryls
|
|
EA030999B1
(ru)
|
2009-10-02 |
2018-10-31 |
Бёрингер Ингельхайм Интернациональ Гмбх |
Применение фармацевтической композиции, включающей ингибитор дпп-4 и гидрохлорид метформина
|
|
MY156209A
(en)
|
2009-11-04 |
2016-01-29 |
Novartis Ag |
Heterocyclic sulfonamide derivatives useful mek inhibitors
|
|
WO2011064211A1
(en)
|
2009-11-25 |
2011-06-03 |
Novartis Ag |
Benzene-fused 6-membered oxygen-containing heterocyclic derivatives of bicyclic heteroaryls
|
|
NZ599298A
(en)
|
2009-11-27 |
2014-11-28 |
Boehringer Ingelheim Int |
Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
|
|
JP5456908B2
(ja)
|
2009-12-08 |
2014-04-02 |
ノバルティス アーゲー |
ヘテロ環式スルホンアミド誘導体
|
|
AU2012265844A1
(en)
|
2009-12-08 |
2013-05-02 |
Novartis Ag |
Heterocyclic sulfonamide derivatives
|
|
CU24130B1
(es)
|
2009-12-22 |
2015-09-29 |
Novartis Ag |
Isoquinolinonas y quinazolinonas sustituidas
|
|
US8440693B2
(en)
|
2009-12-22 |
2013-05-14 |
Novartis Ag |
Substituted isoquinolinones and quinazolinones
|
|
EP2547339A1
(de)
|
2010-03-18 |
2013-01-23 |
Boehringer Ingelheim International GmbH |
Kombination eines gpr119-agonisten und des dpp-iv-hemmers linagliptin zur verwendung bei der behandlung von diabetes und zugehöriger erkrankungen
|
|
WO2011138421A1
(en)
|
2010-05-05 |
2011-11-10 |
Boehringer Ingelheim International Gmbh |
Combination therapy
|
|
EP2582681A1
(de)
|
2010-06-17 |
2013-04-24 |
Novartis AG |
Piperidinylsubstituierte 1,3-dihydro-benzoimidazol-2-ylidenaminderivate
|
|
CN102947274A
(zh)
|
2010-06-17 |
2013-02-27 |
诺瓦提斯公司 |
联苯基取代的1,3-二氢-苯并咪唑-2-亚基胺衍生物
|
|
WO2011161217A2
(en)
|
2010-06-23 |
2011-12-29 |
Palacký University in Olomouc |
Targeting of vegfr2
|
|
NZ603319A
(en)
|
2010-06-24 |
2015-04-24 |
Boehringer Ingelheim Int |
Diabetes therapy
|
|
CA2802644C
(en)
|
2010-06-25 |
2017-02-21 |
Eisai R & D Management Co., Ltd. |
Antitumor agent using compounds having kinase inhibitory effect in combination
|
|
WO2012006503A1
(en)
|
2010-07-09 |
2012-01-12 |
Genentech, Inc. |
Anti-neuropilin antibodies and methods of use
|
|
AR082418A1
(es)
|
2010-08-02 |
2012-12-05 |
Novartis Ag |
Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
|
|
JP2013537210A
(ja)
|
2010-09-16 |
2013-09-30 |
ノバルティス アーゲー |
17α−ヒドロキシラーゼ/C17,20−リアーゼ阻害剤
|
|
AR083878A1
(es)
|
2010-11-15 |
2013-03-27 |
Boehringer Ingelheim Int |
Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
|
|
CA2817564A1
(en)
|
2010-11-18 |
2012-05-24 |
Ronald K. Blackman |
Preselection of subjects for therapeutic treatment based on hypoxic status
|
|
EP2640384A1
(de)
|
2010-11-18 |
2013-09-25 |
Synta Pharmaceuticals Corp. |
Vorauswahl von personen für eine therapeutische behandlung mit sauerstoffempfindlichen mitteln auf der basis des hypoxischen status
|
|
CA2825605C
(en)
|
2011-01-31 |
2019-05-07 |
Novartis Ag |
Heterocyclic derivatives
|
|
JP2014505088A
(ja)
|
2011-02-10 |
2014-02-27 |
ノバルティス アーゲー |
C−METチロシンキナーゼ阻害剤としての[1,2,4]トリアゾロ[4,3−b]ピリダジン化合物
|
|
EP2678016B1
(de)
|
2011-02-23 |
2016-08-10 |
Intellikine, LLC |
Heterocyclische verbindungen und ihre verwendung
|
|
CN103492390A
(zh)
|
2011-03-08 |
2014-01-01 |
诺瓦提斯公司 |
氟苯基双环杂芳基化合物
|
|
DK2937349T3
(en)
|
2011-03-23 |
2017-02-20 |
Amgen Inc |
CONDENSED TRICYCLIC DUAL INHIBITORS OF CDK 4/6 AND FLT3
|
|
EP2700403B1
(de)
|
2011-04-18 |
2015-11-25 |
Eisai R&D Management Co., Ltd. |
Therapeutikum für tumor
|
|
EA023064B1
(ru)
|
2011-04-28 |
2016-04-29 |
Новартис Аг |
ИНГИБИТОРЫ 17α-ГИДРОКСИЛАЗЫ/C-ЛИАЗЫ
|
|
WO2012166899A2
(en)
|
2011-06-03 |
2012-12-06 |
Eisai R&D Management Co., Ltd. |
Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
|
|
KR101391745B1
(ko)
*
|
2011-06-16 |
2014-05-07 |
카톨리에케 유니버시타이트 로이벤 케이.유. 로이벤 알 앤 디 |
1,3-다이옥소인덴 유도체, 이의 약학적으로 허용되는 염 또는 이의 광학 이성질체, 이의 제조방법 및 이를 유효성분으로 함유하는 항바이러스용 약학적 조성물
|
|
EP2721007B1
(de)
|
2011-06-20 |
2015-04-29 |
Novartis AG |
Cyclohexyl-isochinolinon-verbindungen
|
|
US8859535B2
(en)
|
2011-06-20 |
2014-10-14 |
Novartis Ag |
Hydroxy substituted isoquinolinone derivatives
|
|
CA2841552C
(en)
|
2011-07-15 |
2020-06-23 |
Boehringer Ingelheim International Gmbh |
Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
|
|
US9745288B2
(en)
|
2011-08-16 |
2017-08-29 |
Indiana University Research And Technology Corporation |
Compounds and methods for treating cancer by inhibiting the urokinase receptor
|
|
EP2758043A4
(de)
|
2011-08-17 |
2016-02-24 |
Dennis M Brown |
Zusammensetzungen und verfahren zur erhöhung des therapeutischen nutzens von suboptimal verabreichten chemischen verbindungen einschliesslich substituierter hexitole wie dibromodulcitol
|
|
UY34329A
(es)
|
2011-09-15 |
2013-04-30 |
Novartis Ag |
Compuestos de triazolopiridina
|
|
PH12014500912A1
(en)
|
2011-10-28 |
2014-06-09 |
Novartis Ag |
Novel purine derivatives and their use in the treatment of disease
|
|
US8969341B2
(en)
|
2011-11-29 |
2015-03-03 |
Novartis Ag |
Pyrazolopyrrolidine compounds
|
|
CN104125953A
(zh)
|
2011-12-23 |
2014-10-29 |
诺华股份有限公司 |
用于抑制bcl2与结合配偶体相互作用的化合物
|
|
AU2012355615A1
(en)
|
2011-12-23 |
2014-07-10 |
Novartis Ag |
Compounds for inhibiting the interaction of BCL2 with binding partners
|
|
US9126979B2
(en)
|
2011-12-23 |
2015-09-08 |
Novartis Ag |
Compounds for inhibiting the interaction of BCL2 with binding partners
|
|
CN104136429A
(zh)
|
2011-12-23 |
2014-11-05 |
诺华股份有限公司 |
用于抑制bcl2与结合配偶体相互作用的化合物
|
|
CN104125955A
(zh)
|
2011-12-23 |
2014-10-29 |
诺华股份有限公司 |
用于抑制bcl2与结合配偶体相互作用的化合物
|
|
US20130172244A1
(en)
|
2011-12-29 |
2013-07-04 |
Thomas Klein |
Subcutaneous therapeutic use of dpp-4 inhibitor
|
|
JO3357B1
(ar)
|
2012-01-26 |
2019-03-13 |
Novartis Ag |
مركبات إيميدازوبيروليدينون
|
|
AR090263A1
(es)
|
2012-03-08 |
2014-10-29 |
Hoffmann La Roche |
Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
|
|
CN110507654A
(zh)
|
2012-04-03 |
2019-11-29 |
诺华有限公司 |
有酪氨酸激酶抑制剂的组合产品和其应用
|
|
EP3685839A1
(de)
|
2012-05-14 |
2020-07-29 |
Boehringer Ingelheim International GmbH |
Linagliptin zur verwendung in der behandlung von albuminuria und nierenbedingten erkrankungen
|
|
US20130303554A1
(en)
|
2012-05-14 |
2013-11-14 |
Boehringer Ingelheim International Gmbh |
Use of a dpp-4 inhibitor in sirs and/or sepsis
|
|
SG11201406550QA
(en)
|
2012-05-16 |
2014-11-27 |
Novartis Ag |
Dosage regimen for a pi-3 kinase inhibitor
|
|
JP6374862B2
(ja)
|
2012-05-24 |
2018-08-15 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
自己免疫性糖尿病、特に、ladaの治療に使用するためのdpp−4阻害剤としてのキサンチン誘導体
|
|
JP6171003B2
(ja)
|
2012-05-24 |
2017-07-26 |
ノバルティス アーゲー |
ピロロピロリジノン化合物
|
|
WO2013174767A1
(en)
|
2012-05-24 |
2013-11-28 |
Boehringer Ingelheim International Gmbh |
A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
|
|
SG10201610869TA
(en)
|
2012-06-26 |
2017-02-27 |
Del Mar Pharmaceuticals |
Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalacti
|
|
EP2890696A1
(de)
|
2012-08-29 |
2015-07-08 |
Amgen, Inc. |
Quinazolinonverbindungen und derivate davon
|
|
PT3882244T
(pt)
|
2012-12-14 |
2025-04-04 |
Univ Leuven Kath |
Composto, sal farmaceuticamente aceitável ou isómero ótico do mesmo, método para a sua preparação e composição farmacêutica para prevenção ou tratamento de doenças virais que contenha o mesmo como ingrediente ativo
|
|
AU2013364953A1
(en)
|
2012-12-21 |
2015-04-30 |
Eisai R&D Management Co., Ltd. |
Amorphous form of quinoline derivative, and method for producing same
|
|
US9556180B2
(en)
|
2013-01-22 |
2017-01-31 |
Novartis Ag |
Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the P53/MDM2 interaction
|
|
US9403827B2
(en)
|
2013-01-22 |
2016-08-02 |
Novartis Ag |
Substituted purinone compounds
|
|
WO2014124860A1
(en)
|
2013-02-14 |
2014-08-21 |
Boehringer Ingelheim International Gmbh |
Specific pde4b-inhibitors for the treatment of diabetes mellitus
|
|
KR20210099201A
(ko)
|
2013-03-15 |
2021-08-11 |
베링거 인겔하임 인터내셔날 게엠베하 |
심장보호 및 신장보호 항당뇨병 치료요법에서의 리나글립틴의 사용
|
|
EP2968340A4
(de)
|
2013-03-15 |
2016-08-10 |
Intellikine Llc |
Kombination von kinaseinhibitoren und verwendungen davon
|
|
WO2014155268A2
(en)
|
2013-03-25 |
2014-10-02 |
Novartis Ag |
Fgf-r tyrosine kinase activity inhibitors - use in diseases associated with lack of or reduced snf5 activity
|
|
EP2983674A4
(de)
|
2013-04-08 |
2017-05-10 |
Dennis M. Brown |
Therapeutischer nutzen suboptimal verabreichter chemischer verbindungen
|
|
CN105264380B
(zh)
|
2013-05-14 |
2017-09-05 |
卫材R&D管理有限公司 |
用于预测和评价子宫内膜癌受试者对乐伐替尼化合物响应性的生物标志
|
|
US9227969B2
(en)
|
2013-08-14 |
2016-01-05 |
Novartis Ag |
Compounds and compositions as inhibitors of MEK
|
|
WO2015022663A1
(en)
|
2013-08-14 |
2015-02-19 |
Novartis Ag |
Compounds and compositions as inhibitors of mek
|
|
WO2015022664A1
(en)
|
2013-08-14 |
2015-02-19 |
Novartis Ag |
Compounds and compositions as inhibitors of mek
|
|
WO2015084804A1
(en)
|
2013-12-03 |
2015-06-11 |
Novartis Ag |
Combination of mdm2 inhibitor and braf inhibitor and their use
|
|
KR20160095035A
(ko)
|
2013-12-06 |
2016-08-10 |
노파르티스 아게 |
알파-이소형 선택성 포스파티딜이노시톨 3-키나제 억제제를 위한 투여 요법
|
|
KR20170036037A
(ko)
|
2014-07-31 |
2017-03-31 |
노파르티스 아게 |
조합 요법
|
|
CA2957005C
(en)
|
2014-08-28 |
2021-10-12 |
Eisai R&D Management Co., Ltd. |
High-purity quinoline derivative and method for manufacturing same
|
|
EP3233918A1
(de)
|
2014-12-19 |
2017-10-25 |
Novartis AG |
Kombinationstherapien
|
|
AU2016205311B2
(en)
|
2015-01-08 |
2022-02-17 |
The Board Of Trustees Of The Leland Stanford Junior University |
Factors and cells that provide for induction of bone, bone marrow, and cartilage
|
|
WO2016123796A1
(en)
*
|
2015-02-06 |
2016-08-11 |
Abbvie Inc. |
Substituted phthalazines
|
|
SG11201706630UA
(en)
|
2015-02-25 |
2017-09-28 |
Eisai R&D Man Co Ltd |
Method for suppressing bitterness of quinoline derivative
|
|
WO2016140717A1
(en)
|
2015-03-04 |
2016-09-09 |
Merck Sharp & Dohme Corp. |
Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer
|
|
JO3746B1
(ar)
|
2015-03-10 |
2021-01-31 |
Aduro Biotech Inc |
تركيبات وطرق لتنشيط الإشارات المعتمدة على "منبه أو تحفيز جين انترفيرون"
|
|
BR112017027227B1
(pt)
|
2015-06-16 |
2023-12-12 |
Eisai R&D Management Co., Ltd |
Agente anti-câncer
|
|
JP6553726B2
(ja)
|
2015-08-20 |
2019-07-31 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
腫瘍治療剤
|
|
KR20180073674A
(ko)
|
2015-11-02 |
2018-07-02 |
노파르티스 아게 |
포스파티딜이노시톨 3-키나제 억제제에 대한 투여 요법
|
|
WO2017211979A1
(en)
|
2016-06-10 |
2017-12-14 |
Boehringer Ingelheim International Gmbh |
Combinations of linagliptin and metformin
|
|
EP3507367A4
(de)
|
2016-07-05 |
2020-03-25 |
Aduro BioTech, Inc. |
Cyclisches dinukleotidverbindungen mit eingeschlossenen nukleinsäuren und verwendungen davon
|
|
WO2018060833A1
(en)
|
2016-09-27 |
2018-04-05 |
Novartis Ag |
Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
|
|
CA3048217A1
(en)
|
2016-12-22 |
2018-06-28 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
|
US12303505B2
(en)
|
2017-02-08 |
2025-05-20 |
Eisai R&D Management Co., Ltd. |
Tumor-treating pharmaceutical composition
|
|
UY37695A
(es)
|
2017-04-28 |
2018-11-30 |
Novartis Ag |
Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
|
|
BR112019023064A2
(pt)
|
2017-05-16 |
2020-06-09 |
Eisai R&D Man Co Ltd |
tratamento de carcinoma hepatocelular
|
|
ES2905676T3
(es)
|
2017-05-22 |
2022-04-11 |
Amgen Inc |
Inhibidores de KRAS G12C y métodos para su uso
|
|
CN111051306B
(zh)
|
2017-09-08 |
2023-01-03 |
美国安进公司 |
Kras g12c的抑制剂及其使用方法
|
|
CA3079076A1
(en)
|
2017-10-18 |
2019-04-25 |
Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus |
Methods and compounds for improved immune cell therapy
|
|
AU2017444054B2
(en)
|
2017-12-21 |
2021-10-07 |
Hefei Institutes Of Physical Science, Chinese Academy Of Sciences |
Class of pyrimidine derivative kinase inhibitors
|
|
MX2020010836A
(es)
|
2018-05-04 |
2021-01-08 |
Amgen Inc |
Inhibidores de kras g12c y métodos para su uso.
|
|
ES2995514T3
(en)
|
2018-05-04 |
2025-02-10 |
Amgen Inc |
Kras g12c inhibitors and methods of using the same
|
|
EP3790886B1
(de)
|
2018-05-10 |
2024-06-26 |
Amgen Inc. |
Kras g12c-inhibitoren zur behandlung von krebs
|
|
AU2019278998B2
(en)
|
2018-06-01 |
2023-11-09 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
|
MX2020012204A
(es)
|
2018-06-11 |
2021-03-31 |
Amgen Inc |
Inhibidores de kras g12c para tratar el cáncer.
|
|
CA3100390A1
(en)
|
2018-06-12 |
2020-03-12 |
Amgen Inc. |
Kras g12c inhibitors encompassing piperazine ring and use thereof in the treatment of cancer
|
|
BR112020026164A2
(pt)
|
2018-07-17 |
2021-03-23 |
Boehringer Ingelheim International Gmbh |
terapia antidiabética cardioprotetora e nefroprotetora
|
|
BR112020024793A2
(pt)
|
2018-07-17 |
2021-03-02 |
Boehringer Ingelheim International Gmbh |
terapia antidiabética cardiossegura
|
|
JP7516029B2
(ja)
|
2018-11-16 |
2024-07-16 |
アムジエン・インコーポレーテツド |
Kras g12c阻害剤化合物の重要な中間体の改良合成法
|
|
CA3117222A1
(en)
|
2018-11-19 |
2020-05-28 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
|
JP7377679B2
(ja)
|
2018-11-19 |
2023-11-10 |
アムジエン・インコーポレーテツド |
がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法
|
|
WO2020132651A1
(en)
|
2018-12-20 |
2020-06-25 |
Amgen Inc. |
Kif18a inhibitors
|
|
MX2021007157A
(es)
|
2018-12-20 |
2021-08-16 |
Amgen Inc |
Heteroarilamidas utiles como inhibidores de kif18a.
|
|
PE20211475A1
(es)
|
2018-12-20 |
2021-08-05 |
Amgen Inc |
Inhibidores de kif18a
|
|
CA3123227A1
(en)
|
2018-12-20 |
2020-06-25 |
Amgen Inc. |
Heteroaryl amides useful as kif18a inhibitors
|
|
JP2022522777A
(ja)
|
2019-03-01 |
2022-04-20 |
レボリューション メディシンズ インコーポレイテッド |
二環式ヘテロアリール化合物及びその使用
|
|
EP3930845A1
(de)
|
2019-03-01 |
2022-01-05 |
Revolution Medicines, Inc. |
Bicyclische heterocyclyl-verbindungen und ihre verwendung
|
|
EP3738593A1
(de)
|
2019-05-14 |
2020-11-18 |
Amgen, Inc |
Dosierung von kras-inhibitor zur behandlung von krebserkrankungen
|
|
US12590094B2
(en)
*
|
2019-05-14 |
2026-03-31 |
University Of Florida Research Foundation, Incorporated |
Compounds for the treatment of neurodegenerative and metabolic disorders
|
|
CN114144414B
(zh)
|
2019-05-21 |
2025-11-07 |
美国安进公司 |
固态形式
|
|
WO2021026101A1
(en)
|
2019-08-02 |
2021-02-11 |
Amgen Inc. |
Kif18a inhibitors
|
|
CN114302880B
(zh)
|
2019-08-02 |
2025-07-15 |
美国安进公司 |
Kif18a抑制剂
|
|
CA3147272A1
(en)
|
2019-08-02 |
2021-02-11 |
Amgen Inc. |
Kif18a inhibitors
|
|
US12540129B2
(en)
|
2019-08-02 |
2026-02-03 |
Amgen Inc. |
KIF18A inhibitors
|
|
MX2022004656A
(es)
|
2019-10-24 |
2022-05-25 |
Amgen Inc |
Derivados de piridopirimidina utiles como inhibidores de kras g12c y kras g12d en el tratamiento del cancer.
|
|
PE20221277A1
(es)
|
2019-11-04 |
2022-09-05 |
Revolution Medicines Inc |
Inhibidores de ras
|
|
CN114867735A
(zh)
|
2019-11-04 |
2022-08-05 |
锐新医药公司 |
Ras抑制剂
|
|
CN114786777A
(zh)
|
2019-11-04 |
2022-07-22 |
锐新医药公司 |
Ras抑制剂
|
|
PE20230249A1
(es)
|
2019-11-08 |
2023-02-07 |
Revolution Medicines Inc |
Compuestos de heteroarilo biciclicos y usos de estos
|
|
CA3158188A1
(en)
|
2019-11-14 |
2021-05-20 |
Amgen Inc. |
Improved synthesis of kras g12c inhibitor compound
|
|
US20220395553A1
(en)
|
2019-11-14 |
2022-12-15 |
Cohbar, Inc. |
Cxcr4 antagonist peptides
|
|
TW202132271A
(zh)
|
2019-11-14 |
2021-09-01 |
美商安進公司 |
Kras g12c抑制劑化合物之改善的合成
|
|
EP4065231A1
(de)
|
2019-11-27 |
2022-10-05 |
Revolution Medicines, Inc. |
Kovalente ras-inhibitoren und verwendungen davon
|
|
CA3163703A1
(en)
|
2020-01-07 |
2021-07-15 |
Steve Kelsey |
Shp2 inhibitor dosing and methods of treating cancer
|
|
KR102894005B1
(ko)
|
2020-04-20 |
2025-12-03 |
노파르티스 아게 |
항바이러스 1,3-다이-옥소-인덴 화합물
|
|
CN115916763B
(zh)
|
2020-04-20 |
2025-06-03 |
诺华股份有限公司 |
抗病毒素1,3-二氧代茚化合物
|
|
KR20230042600A
(ko)
|
2020-06-18 |
2023-03-28 |
레볼루션 메디슨즈, 인크. |
Ras 억제제에 대한 획득된 저항성을 지연, 예방, 및 치료하는 방법
|
|
CA3187757A1
(en)
|
2020-09-03 |
2022-03-24 |
Ethan AHLER |
Use of sos1 inhibitors to treat malignancies with shp2 mutations
|
|
AU2021345111B2
(en)
|
2020-09-15 |
2025-11-27 |
Revolution Medicines, Inc. |
Indole derivatives as Ras inhibitors in the treatment of cancer
|
|
EP4267250A1
(de)
|
2020-12-22 |
2023-11-01 |
Qilu Regor Therapeutics Inc. |
Sos1-inhibitoren und verwendungen davon
|
|
WO2022165173A1
(en)
*
|
2021-01-28 |
2022-08-04 |
The Scripps Research Institute |
Compounds and use thereof for treatment of neurodegenerative, degenerative and metabolic disorders
|
|
EP4334324A1
(de)
|
2021-05-05 |
2024-03-13 |
Revolution Medicines, Inc. |
Kovalente ras-inhibitoren und verwendungen davon
|
|
CR20230558A
(es)
|
2021-05-05 |
2024-01-24 |
Revolution Medicines Inc |
Inhibidores de ras para el tratamiento del cáncer
|
|
AR125782A1
(es)
|
2021-05-05 |
2023-08-16 |
Revolution Medicines Inc |
Inhibidores de ras
|
|
EP4358963A4
(de)
*
|
2021-06-21 |
2025-04-02 |
Mirati Therapeutics, Inc. |
Sos1-inhibitoren
|
|
AR127308A1
(es)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
Inhibidores ras
|
|
WO2023114954A1
(en)
|
2021-12-17 |
2023-06-22 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
|
KR20230098078A
(ko)
*
|
2021-12-24 |
2023-07-03 |
제일약품주식회사 |
신규한 바이사이클릭 헤테로사이클릴 화합물 및 이의 용도
|
|
EP4227307A1
(de)
|
2022-02-11 |
2023-08-16 |
Genzyme Corporation |
Pyrazolopyrazinverbindungen als shp2-inhibitoren
|
|
IL314883A
(en)
|
2022-03-07 |
2024-10-01 |
Amgen Inc |
Process for preparing 4-methyl-2-propan-2-yl-pyridine-3-carbonitrile
|
|
WO2023172940A1
(en)
|
2022-03-08 |
2023-09-14 |
Revolution Medicines, Inc. |
Methods for treating immune refractory lung cancer
|
|
AU2023285116A1
(en)
|
2022-06-10 |
2024-12-19 |
Revolution Medicines, Inc. |
Macrocyclic ras inhibitors
|
|
EP4601644A1
(de)
|
2022-10-14 |
2025-08-20 |
Black Diamond Therapeutics, Inc. |
Verfahren zur behandlung von krebs mit isochinolin- oder 6-azachinolinderivaten
|
|
AU2024241633A1
(en)
|
2023-03-30 |
2025-11-06 |
Revolution Medicines, Inc. |
Compositions for inducing ras gtp hydrolysis and uses thereof
|
|
WO2024211663A1
(en)
|
2023-04-07 |
2024-10-10 |
Revolution Medicines, Inc. |
Condensed macrocyclic compounds as ras inhibitors
|
|
EP4688790A1
(de)
|
2023-04-07 |
2026-02-11 |
Revolution Medicines, Inc. |
Makrocyclische ras-inhibitoren
|
|
AU2024252105A1
(en)
|
2023-04-14 |
2025-10-16 |
Revolution Medicines, Inc. |
Crystalline forms of ras inhibitors, compositions containing the same, and methods of use thereof
|
|
WO2024216016A1
(en)
|
2023-04-14 |
2024-10-17 |
Revolution Medicines, Inc. |
Crystalline forms of a ras inhibitor
|
|
CN121712509A
(zh)
|
2023-05-04 |
2026-03-20 |
锐新医药公司 |
用于ras相关疾病或病症的组合疗法
|
|
US20250049810A1
(en)
|
2023-08-07 |
2025-02-13 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
IL327306A
(en)
|
2023-10-12 |
2026-05-01 |
Revolution Medicines Inc |
Macrocyclic RAS inhibitors
|
|
WO2025137507A1
(en)
|
2023-12-22 |
2025-06-26 |
Regor Pharmaceuticals, Inc. |
Sos1 inhibitors and uses thereof
|
|
WO2025171296A1
(en)
|
2024-02-09 |
2025-08-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025240847A1
(en)
|
2024-05-17 |
2025-11-20 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025255438A1
(en)
|
2024-06-07 |
2025-12-11 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
WO2025265060A1
(en)
|
2024-06-21 |
2025-12-26 |
Revolution Medicines, Inc. |
Therapeutic compositions and methods for managing treatment-related effects
|
|
WO2026006747A1
(en)
|
2024-06-28 |
2026-01-02 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2026015825A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Use of ras inhibitor for treating pancreatic cancer
|
|
WO2026015790A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015796A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015801A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026050446A1
(en)
|
2024-08-29 |
2026-03-05 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2026072904A2
(en)
|
2024-09-26 |
2026-04-02 |
Revolution Medicines, Inc. |
Compositions and methods for treating lung cancer
|
|
WO2026090116A2
(en)
|
2024-10-21 |
2026-04-30 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2026090245A1
(en)
|
2024-10-22 |
2026-04-30 |
Revolution Medicines, Inc. |
Use of ras inhibitors for treating cancer
|
|
US20260108528A1
(en)
|
2024-10-22 |
2026-04-23 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|