IL148631A0 - Quinuclidine derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof - Google Patents

Quinuclidine derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof

Info

Publication number
IL148631A0
IL148631A0 IL14863100A IL14863100A IL148631A0 IL 148631 A0 IL148631 A0 IL 148631A0 IL 14863100 A IL14863100 A IL 14863100A IL 14863100 A IL14863100 A IL 14863100A IL 148631 A0 IL148631 A0 IL 148631A0
Authority
IL
Israel
Prior art keywords
optionally substituted
chain
substituted
denotes
preparation
Prior art date
Application number
IL14863100A
Other languages
English (en)
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of IL148631A0 publication Critical patent/IL148631A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL14863100A 1999-09-28 2000-09-27 Quinuclidine derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof IL148631A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP27390599 1999-09-28
JP2000179352 2000-06-15
PCT/JP2000/006665 WO2001023383A1 (en) 1999-09-28 2000-09-27 Quinuclidine compounds and drugs containing the same as the active ingredient

Publications (1)

Publication Number Publication Date
IL148631A0 true IL148631A0 (en) 2002-09-12

Family

ID=26550809

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14863100A IL148631A0 (en) 1999-09-28 2000-09-27 Quinuclidine derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof
IL148631A IL148631A (en) 1999-09-28 2002-03-12 History of quinocladin, pharmaceutical preparations containing them and processes for their preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL148631A IL148631A (en) 1999-09-28 2002-03-12 History of quinocladin, pharmaceutical preparations containing them and processes for their preparation

Country Status (20)

Country Link
US (1) US6599917B1 (de)
EP (1) EP1217001B1 (de)
JP (1) JP4206212B2 (de)
KR (1) KR100694687B1 (de)
CN (1) CN100334085C (de)
AT (1) ATE312100T1 (de)
AU (1) AU782114B2 (de)
BR (1) BR0014331A (de)
CA (1) CA2385995C (de)
DE (1) DE60024651T2 (de)
DK (1) DK1217001T3 (de)
ES (1) ES2252063T3 (de)
HU (1) HUP0203514A3 (de)
IL (2) IL148631A0 (de)
MX (1) MXPA02003167A (de)
NO (1) NO328218B1 (de)
NZ (1) NZ517788A (de)
RU (1) RU2266905C2 (de)
TW (1) TWI282794B (de)
WO (1) WO2001023383A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0010955D0 (en) * 2000-05-05 2000-06-28 Novartis Ag Organic compounds
US7112593B2 (en) * 2001-03-27 2006-09-26 Eisai Co., Ltd. N-aryl-substituted cyclic amine derivative and medicine containing the same as active ingredient
EP1256573A1 (de) 2001-05-09 2002-11-13 Eisai Co., Ltd. Verfahren zur Herstellung eines Stereoisomers von Pyrrolidinderivat
JP2005512974A (ja) * 2001-10-17 2005-05-12 ユ セ ベ ソシエテ アノニム キヌクリジン誘導体、その調製方法、及びｍ２及び／又はｍ３ムスカリン受容体阻害剤としてのその使用
US7361671B2 (en) * 2001-11-15 2008-04-22 The Institute For Pharmaceutical Discovery, Inc. Substituted heteroarylalkanoic acids
DE10225537A1 (de) * 2002-06-10 2003-12-18 Bayer Ag N-alkylierte Thiazoliumsalze und Verfahren zu deren Herstellung
GB0218876D0 (en) * 2002-08-13 2002-09-25 Merck Sharp & Dohme Therapeutic agents
MXPA05003317A (es) 2002-09-25 2005-07-05 Memory Pharm Corp Indazoles, benzotiazoles y benzoisotiazoles asi como preparacion y usos de los mismos.
DE10334724A1 (de) * 2003-07-30 2005-02-24 Bayer Healthcare Ag N-Biarylamide
BRPI0415179A (pt) * 2003-10-07 2006-11-28 Renovis Inc derivados de amida como ligandos de canal de ìon e composições farmacêuticas e métodos de empregar as mesmas
NZ550534A (en) 2004-03-25 2009-07-31 Memory Pharm Corp Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
JP2010519328A (ja) 2007-02-26 2010-06-03 ファイザー・プロダクツ・インク Ｈ−ｐｇｄｓの阻害剤としてのニコチンアミド誘導体およびプロスタグランジンｄ２が媒介する疾患の治療のためのそれらの使用
TW201111385A (en) 2009-08-27 2011-04-01 Biocryst Pharm Inc Heterocyclic compounds as janus kinase inhibitors
US8420661B2 (en) * 2010-04-13 2013-04-16 Hoffmann-La Roche Inc. Arylethynyl derivatives
AU2011258005A1 (en) 2010-05-28 2013-01-17 Biocryst Pharmaceuticals, Inc. Heterocyclic compounds as Janus kinase inhibitors
HK1203412A1 (en) 2011-12-28 2015-10-30 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
ES2643403T3 (es) 2011-12-28 2017-11-22 Global Blood Therapeutics, Inc. Compuestos de benzaldehído sustituidos y métodos para su uso en el aumento de la oxigenación tisular
WO2014060381A1 (de) 2012-10-18 2014-04-24 Bayer Cropscience Ag Heterocyclische verbindungen als schädlingsbekämpfungsmittel
CN104884449A (zh) 2012-10-31 2015-09-02 拜尔农作物科学股份公司 作为害虫防治剂的新的杂环化合物
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
CN105073728A (zh) 2013-03-15 2015-11-18 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
WO2014150258A1 (en) 2013-03-15 2014-09-25 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
MX379235B (es) 2013-03-15 2025-03-11 Global Blood Therapeutics Inc Compuestos y sus usos para modular la hemoglobina.
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
CN114181195A (zh) 2014-02-07 2022-03-15 全球血液疗法股份有限公司 一种化合物的结晶多晶型物
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
LT3303316T (lt) 2015-06-03 2020-05-11 F. Hoffmann-La Roche Ag Etinilo dariniai
SG11201804647TA (en) 2015-12-04 2018-06-28 Global Blood Therapeutics Inc Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
TWI663160B (zh) 2016-05-12 2019-06-21 全球血液治療公司 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
TW202332423A (zh) 2016-10-12 2023-08-16 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
JP7542538B2 (ja) 2018-09-18 2024-08-30 ニカング セラピューティクス， インコーポレイテッド Ｓｒｃホモロジー－２ホスファターゼ阻害剤としての縮合三環式環誘導体
US11014884B2 (en) 2018-10-01 2021-05-25 Global Blood Therapeutics, Inc. Modulators of hemoglobin

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2105655A1 (en) 1991-03-08 1992-09-09 Kent Neuenschwander Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors
US5135935A (en) 1991-05-17 1992-08-04 Merck & Co., Inc. Squalene synthetase inhibitors
GB9127279D0 (en) 1991-12-23 1992-02-19 Ici Plc Heterocyclic derivatives
JPH05310732A (ja) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
GB9207961D0 (en) 1992-04-10 1992-05-27 Ici Plc Heterocyclic derivatives
GB9218334D0 (en) 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
AU7394394A (en) * 1992-10-13 1995-12-05 Rhone-Poulenc Rorer Pharmaceuticals Inc. 3-hydroxyquinuclidin-3-ylphenylquinolines as squalene synthase inhibitors
GB9226573D0 (en) 1992-12-21 1993-02-17 Ici Plc Heterocyclic compounds
IL109451A0 (en) 1993-04-29 1994-07-31 Zeneca Ltd Heterocyclic derivatives
GB9412145D0 (en) 1994-06-17 1994-08-10 Zeneca Ltd Heterocycles
JPH08134067A (ja) 1994-11-11 1996-05-28 Yamanouchi Pharmaceut Co Ltd キヌクリジン誘導体
JPH08269056A (ja) 1995-03-29 1996-10-15 Chugai Pharmaceut Co Ltd スクアレンシンセターゼ阻害作用を有するキヌクリジン誘導体
US5712270A (en) * 1995-11-06 1998-01-27 American Home Products Corporation 2-arylamidothiazole derivatives with CNS activity
US6150352A (en) 1996-05-20 2000-11-21 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone

Also Published As

Publication number Publication date
EP1217001A1 (de) 2002-06-26
CN1377349A (zh) 2002-10-30
NO20021528D0 (no) 2002-03-26
DE60024651D1 (de) 2006-01-12
EP1217001B1 (de) 2005-12-07
IL148631A (en) 2010-04-29
EP1217001A4 (de) 2002-12-18
NZ517788A (en) 2003-11-28
KR100694687B1 (ko) 2007-03-13
DE60024651T2 (de) 2006-09-28
BR0014331A (pt) 2003-06-10
US6599917B1 (en) 2003-07-29
CN100334085C (zh) 2007-08-29
JP4206212B2 (ja) 2009-01-07
HUP0203514A3 (en) 2004-01-28
AU782114B2 (en) 2005-07-07
AU7446400A (en) 2001-04-30
ATE312100T1 (de) 2005-12-15
KR20020034197A (ko) 2002-05-08
WO2001023383A1 (en) 2001-04-05
TWI282794B (en) 2007-06-21
MXPA02003167A (es) 2003-10-06
ES2252063T3 (es) 2006-05-16
DK1217001T3 (da) 2006-03-20
CA2385995A1 (en) 2001-04-05
CA2385995C (en) 2009-06-16
RU2266905C2 (ru) 2005-12-27
HUP0203514A2 (hu) 2003-03-28
NO328218B1 (no) 2010-01-11
NO20021528L (no) 2002-05-28

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