IL149618A0 - Pharmaceutical compositions comprising thiazolidinedione and process for preparation thereof - Google Patents

Pharmaceutical compositions comprising thiazolidinedione and process for preparation thereof

Info

Publication number
IL149618A0
IL149618A0 IL14961800A IL14961800A IL149618A0 IL 149618 A0 IL149618 A0 IL 149618A0 IL 14961800 A IL14961800 A IL 14961800A IL 14961800 A IL14961800 A IL 14961800A IL 149618 A0 IL149618 A0 IL 149618A0
Authority
IL
Israel
Prior art keywords
thiazolidinedione
preparation
pharmaceutical compositions
pharmaceutical
compositions
Prior art date
Application number
IL14961800A
Other languages
English (en)
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27447849&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL149618(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9927120.7A external-priority patent/GB9927120D0/en
Priority claimed from GBGB9927119.9A external-priority patent/GB9927119D0/en
Priority claimed from GB0013236A external-priority patent/GB0013236D0/en
Priority claimed from GB0013240A external-priority patent/GB0013240D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of IL149618A0 publication Critical patent/IL149618A0/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1635Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
IL14961800A 1999-11-16 2000-11-16 Pharmaceutical compositions comprising thiazolidinedione and process for preparation thereof IL149618A0 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9927120.7A GB9927120D0 (en) 1999-11-16 1999-11-16 Novel composition and use
GBGB9927119.9A GB9927119D0 (en) 1999-11-16 1999-11-16 Novel composition and use
GB0013236A GB0013236D0 (en) 2000-05-31 2000-05-31 Novel composition and use
GB0013240A GB0013240D0 (en) 2000-05-31 2000-05-31 Novel composition and use
PCT/GB2000/004368 WO2001035941A2 (fr) 1999-11-16 2000-11-16 Nouvelle composition et utilisation

Publications (1)

Publication Number Publication Date
IL149618A0 true IL149618A0 (en) 2002-12-01

Family

ID=27447849

Family Applications (3)

Application Number Title Priority Date Filing Date
IL14961800A IL149618A0 (en) 1999-11-16 2000-11-16 Pharmaceutical compositions comprising thiazolidinedione and process for preparation thereof
IL149618A IL149618A (en) 1999-11-16 2002-05-13 Pharmaceutical compositions comprising thiazolidinedione and process for preparation thereof
IL190220A IL190220A0 (en) 1999-11-16 2008-03-17 Novel composition and use

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL149618A IL149618A (en) 1999-11-16 2002-05-13 Pharmaceutical compositions comprising thiazolidinedione and process for preparation thereof
IL190220A IL190220A0 (en) 1999-11-16 2008-03-17 Novel composition and use

Country Status (40)

Country Link
US (1) US8236345B2 (fr)
EP (3) EP1913945A3 (fr)
JP (2) JP4865975B2 (fr)
KR (1) KR100760063B1 (fr)
CN (1) CN1222290C (fr)
AP (1) AP1389A (fr)
AR (2) AR030920A1 (fr)
AT (1) ATE292466T1 (fr)
AU (3) AU775654B2 (fr)
BG (1) BG65616B1 (fr)
BR (1) BR0015605A (fr)
CA (1) CA2388846A1 (fr)
CO (1) CO5300392A1 (fr)
CZ (1) CZ302500B6 (fr)
DE (1) DE60019329T2 (fr)
DK (1) DK1231918T3 (fr)
DZ (1) DZ3251A1 (fr)
EA (1) EA004878B1 (fr)
ES (1) ES2240199T3 (fr)
HK (1) HK1049788B (fr)
HR (1) HRP20020416B1 (fr)
HU (1) HU229960B1 (fr)
IL (3) IL149618A0 (fr)
MA (1) MA25567A1 (fr)
ME (1) ME00318B (fr)
MX (1) MXPA02005005A (fr)
MY (1) MY125516A (fr)
NO (1) NO329926B1 (fr)
NZ (1) NZ518946A (fr)
OA (1) OA12513A (fr)
PE (1) PE20011011A1 (fr)
PL (1) PL200943B1 (fr)
PT (1) PT1231918E (fr)
RS (1) RS51343B (fr)
SI (1) SI1231918T1 (fr)
SK (1) SK286985B6 (fr)
TW (1) TWI240626B (fr)
UA (1) UA73150C2 (fr)
UY (1) UY26439A1 (fr)
WO (1) WO2001035941A2 (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2407713A1 (fr) * 2000-05-01 2001-11-08 Aeropharm Technology, Inc. Formulation de noyaux
JP2004536842A (ja) * 2001-07-10 2004-12-09 エアロファーム テクノロジー インコーポレイテッド トログリタゾンおよびビグアナイドを含むコア製剤
GB0203296D0 (en) * 2002-02-12 2002-03-27 Glaxo Group Ltd Novel composition
WO2003105809A1 (fr) * 2002-06-17 2003-12-24 Themis Laboratories Private Limited Comprimes multicouche contenant des thiazolidinediones et des biguanides et procedes de production desdits comprimes
WO2004006921A1 (fr) * 2002-07-11 2004-01-22 Takeda Pharmaceutical Company Limited Procede de production d'une preparation recouverte
US8637512B2 (en) * 2002-07-29 2014-01-28 Glaxo Group Limited Formulations and method of treatment
KR20120034211A (ko) * 2002-09-20 2012-04-10 안드렉스 랩스 엘엘씨 약제학적 정제
US8084058B2 (en) 2002-09-20 2011-12-27 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US9060941B2 (en) 2002-09-20 2015-06-23 Actavis, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7785627B2 (en) 2002-09-20 2010-08-31 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
US7959946B2 (en) 2002-09-20 2011-06-14 Watson Pharmaceuticals, Inc. Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
UA80991C2 (en) * 2002-10-07 2007-11-26 Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes
US7976853B2 (en) 2003-01-29 2011-07-12 Takeda Pharmaceutical Company Limited Process for producing coated preparation
FR2858556B1 (fr) * 2003-08-06 2006-03-10 Galenix Innovations Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation
JP4739189B2 (ja) * 2004-04-14 2011-08-03 武田薬品工業株式会社 固形製剤
JPWO2006011397A1 (ja) * 2004-07-27 2008-05-01 興和株式会社 糖尿病の予防または治療のための薬剤
CA2607419C (fr) 2005-04-26 2014-06-17 Dainippon Sumitomo Pharma Co., Ltd. Preparation granulaire contenant un derive de biguanide
AU2006328328B2 (en) * 2005-12-22 2012-08-30 Takeda Pharmaceutical Company Limited Solid preparation containing an insulin sensitizer
FR2896159B1 (fr) 2006-01-13 2008-09-12 Merck Sante Soc Par Actions Si Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline.
WO2008078390A1 (fr) 2006-12-26 2008-07-03 Fujitsu Limited Dispositif de compression et de restauration de données
MY147596A (en) 2007-02-01 2012-12-31 Takeda Pharmaceutical Solid preparation comprising alogliptin and pioglitazone
JP5467870B2 (ja) 2007-02-09 2014-04-09 アルファファーム ピーティーワイ リミテッド 異なる物理的形態の2種以上の有効医薬成分を含有する投薬形態
TR200803177A2 (tr) * 2008-05-06 2009-11-23 Bi̇li̇m İlaç Sanayi̇ Ti̇caret A.Ş. Antihiperglisemik etkili metformîn - pioglitazon formülasyonu.
US8846315B2 (en) 2008-08-12 2014-09-30 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
PE20110565A1 (es) 2008-08-12 2011-09-02 Zinfandel Pharmaceuticals Inc Metodo de identificacion de factores de riesgo de la enfermedad
FR2951945B1 (fr) * 2009-11-05 2013-08-09 Sanofi Aventis Composition pharmaceutique
ES2689107T3 (es) * 2009-11-13 2018-11-08 Astrazeneca Ab Formulaciones de tabletas bicapa
EP2441442A1 (fr) 2010-10-08 2012-04-18 LEK Pharmaceuticals d.d. Composition pharmaceutique comprenant un thiazolidinedione
US8796338B2 (en) 2011-01-07 2014-08-05 Elcelyx Therapeutics, Inc Biguanide compositions and methods of treating metabolic disorders
US9572784B2 (en) 2011-01-07 2017-02-21 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
US11974971B2 (en) 2011-01-07 2024-05-07 Anji Pharmaceuticals Inc. Compositions and methods for treating metabolic disorders
US9211263B2 (en) 2012-01-06 2015-12-15 Elcelyx Therapeutics, Inc. Compositions and methods of treating metabolic disorders
US9480663B2 (en) 2011-01-07 2016-11-01 Elcelyx Therapeutics, Inc. Biguanide compositions and methods of treating metabolic disorders
US11759441B2 (en) 2011-01-07 2023-09-19 Anji Pharmaceuticals Inc. Biguanide compositions and methods of treating metabolic disorders
PT2661266T (pt) 2011-01-07 2020-11-30 Anji Pharma Us Llc Terapias com base em ligandos do recetor quimiossensorial
EA201391017A1 (ru) 2011-01-10 2014-04-30 Зинфандел Фармасьютикалз, Инк. Способы и готовые лекарственные формы для лечения болезни альцгеймера
MX2014008190A (es) 2012-01-06 2015-02-04 Elcelyx Therapeutics Inc Composiciones de biguanida y métodos para tratar transtornos metabólicos.
SG10201901922VA (en) 2012-01-06 2019-04-29 Elcelyx Therapeutics Inc Compositions and methods for treating metabolic disorders
CN108451923B (zh) * 2018-05-31 2025-05-06 常州兰陵制药有限公司 盐酸二甲双胍速释胶囊及其制备方法
JP2023528565A (ja) 2020-04-01 2023-07-05 ハンジョウ ジョンメイ フアドン ファーマシューティカル シーオー.,エルティーディー. Glp-1受容体アゴニストの結晶形aおよびその調製法
EP4141008A4 (fr) 2020-04-01 2024-04-17 Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. Sel d'acide pharmaceutiquement acceptable de base libre d'agoniste du récepteur glp-1, et son procédé de préparation

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4613596Y1 (fr) * 1969-06-02 1971-05-14
DE2347531A1 (de) * 1973-09-21 1975-04-30 Hoechst Ag Arzneizubereitungen zur oralen diabetes-behandlung
ATE186724T1 (de) * 1987-09-04 1999-12-15 Beecham Group Plc Substituierte thiazolidindionderivate
US4999226A (en) 1988-06-01 1991-03-12 Merrell Dow Pharmaceuticals Inc. Pharmaceutical compositions for piperidinoalkanol-ibuprofen combination
JPH0553521A (ja) 1991-08-28 1993-03-05 Mitsubishi Electric Corp オートトラツキング型crtデイスプレイモニタ
GB9218830D0 (en) * 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
IT1255522B (it) 1992-09-24 1995-11-09 Ubaldo Conte Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita'
US6183778B1 (en) 1993-09-21 2001-02-06 Jagotec Ag Pharmaceutical tablet capable of liberating one or more drugs at different release rates
TW438587B (en) 1995-06-20 2001-06-07 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
DE19539361A1 (de) 1995-10-23 1997-04-24 Basf Ag Verfahren zur Herstellung von mehrschichtigen, festen Arzneiformen zur oralen oder rektalen Verabreichung
GB9612496D0 (en) 1996-06-14 1996-08-14 De La Rue Thomas & Co Ltd Security device
TW522014B (en) 1997-02-07 2003-03-01 Sepracor Inc Lactose-free, non-hygroscopic and anhydrous pharmaceutical unit dosage form containing descarboethoxyloratadine
US20020004515A1 (en) 1997-06-18 2002-01-10 Smith Stephen Alistair Treatment of diabetes with thiazolidinedione and metformin
EP1787646A3 (fr) * 1997-06-18 2007-10-03 Smithkline Beecham Plc Nouveau procédé de traitement
GB9715295D0 (en) * 1997-07-18 1997-09-24 Smithkline Beecham Plc Novel method of treatment
EP1063973B1 (fr) 1998-03-19 2016-11-16 Bristol-Myers Squibb Company Systeme d'apport a liberation lente biphasique destine a des medicaments a solubilite elevee et procede associe
US6099859A (en) 1998-03-20 2000-08-08 Andrx Pharmaceuticals, Inc. Controlled release oral tablet having a unitary core
US6117451A (en) * 1998-08-25 2000-09-12 Pharmalogix, Inc. Direct compression metformin hydrochloride tablets
US20040102486A1 (en) 1998-11-12 2004-05-27 Smithkline Beecham Corporation Novel method of treatment
AR023700A1 (es) 1998-11-12 2002-09-04 Smithkline Beecham Plc Un procedimiento para preparar una composicion farmaceutica que comprende un sensibilizador de insulina
GB9824893D0 (en) 1998-11-12 1999-01-06 Smithkline Beckman Corp Novel method of treatment
US20040081697A1 (en) 1998-11-12 2004-04-29 Smithkline Beecham P.L.C. Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
CZ20011629A3 (cs) 1998-11-12 2001-12-12 Smithkline Beecham Plc Farmaceutický prostředek pro upravené uvolňování senzitizéru inzulínu a jiných antidiabetických přípravků
AU1403501A (en) 1999-11-16 2001-05-30 Smithkline Beecham Plc Novel composition and use
US6296874B1 (en) 2000-05-01 2001-10-02 Aeropharm Technology Incorporated Core formulation comprising troglitazone and abiguanide
US6451342B2 (en) 2000-05-01 2002-09-17 Aeropharm Technology Incorporated Core formulation comprised of troglitazone and a biguanide
US6461639B2 (en) 2000-05-01 2002-10-08 Aeropharm Technology, Inc. Core formulation
US6780432B1 (en) 2000-05-01 2004-08-24 Aeropharm Technology, Inc. Core formulation
US6403121B1 (en) 2000-05-01 2002-06-11 Aeropharm Technology Incorporated Core formulation
US6524621B2 (en) 2000-05-01 2003-02-25 Aeropharm Technology Inc. Core formulation
GB0318824D0 (en) 2003-08-11 2003-09-10 Glaxo Group Ltd Novel composition

Also Published As

Publication number Publication date
AP2002002505A0 (en) 2002-06-30
HK1049788A1 (en) 2003-05-30
AU2004226955A1 (en) 2004-12-02
AU2004226955B2 (en) 2008-08-28
SI1231918T1 (en) 2005-08-31
NO20022334D0 (no) 2002-05-15
AU775654B2 (en) 2004-08-12
PT1231918E (pt) 2005-08-31
EP1520581A1 (fr) 2005-04-06
DZ3251A1 (fr) 2001-05-25
UA73150C2 (uk) 2005-06-15
SK286985B6 (sk) 2009-08-06
AU2008207375A1 (en) 2008-09-11
CN1414852A (zh) 2003-04-30
AR030920A1 (es) 2003-09-03
WO2001035941A3 (fr) 2002-05-23
MY125516A (en) 2006-08-30
JP5282130B2 (ja) 2013-09-04
CO5300392A1 (es) 2003-07-31
DE60019329T2 (de) 2006-03-09
CN1222290C (zh) 2005-10-12
US8236345B2 (en) 2012-08-07
HRP20020416B1 (hr) 2011-04-30
DE60019329D1 (de) 2005-05-12
AR057970A2 (es) 2007-12-26
OA12513A (en) 2006-05-29
PL200943B1 (pl) 2009-02-27
IL190220A0 (en) 2008-11-03
YU38802A (sh) 2005-03-15
BG106747A (en) 2003-01-31
HK1049788B (en) 2005-11-04
MA25567A1 (fr) 2002-10-01
NO20022334L (no) 2002-07-09
JP4865975B2 (ja) 2012-02-01
EP1913945A3 (fr) 2008-04-30
SK6792002A3 (en) 2002-09-10
RS51343B (sr) 2011-02-28
PL355331A1 (en) 2004-04-19
NO329926B1 (no) 2011-01-24
US20070275054A1 (en) 2007-11-29
MEP34008A (en) 2011-02-10
HUP0204122A3 (en) 2006-01-30
UY26439A1 (es) 2001-07-31
JP2011252007A (ja) 2011-12-15
BG65616B1 (bg) 2009-03-31
DK1231918T3 (da) 2005-08-01
ME00318B (fr) 2011-05-10
KR20030019300A (ko) 2003-03-06
CA2388846A1 (fr) 2001-05-25
JP2003514012A (ja) 2003-04-15
EP1231918A2 (fr) 2002-08-21
WO2001035941A2 (fr) 2001-05-25
HUP0204122A2 (hu) 2003-03-28
EA004878B1 (ru) 2004-08-26
ES2240199T3 (es) 2005-10-16
MXPA02005005A (es) 2003-10-14
AP1389A (en) 2005-04-14
EA200200571A1 (ru) 2002-12-26
PE20011011A1 (es) 2001-10-28
KR100760063B1 (ko) 2007-09-18
WO2001035941A8 (fr) 2002-08-29
EP1231918B1 (fr) 2005-04-06
IL149618A (en) 2008-07-08
TWI240626B (en) 2005-10-01
AU1404001A (en) 2001-05-30
NZ518946A (en) 2003-10-31
HU229960B1 (hu) 2015-03-30
ATE292466T1 (de) 2005-04-15
BR0015605A (pt) 2002-07-09
EP1913945A2 (fr) 2008-04-23
CZ302500B6 (cs) 2011-06-22
HRP20020416A2 (en) 2004-08-31

Similar Documents

Publication Publication Date Title
HUP0301325A3 (en) Stabilized pharmaceutically effective composition and pharmaceutical composition comprising the same and process for preparation the composition
HUP0203316A3 (en) Amino-triazolopyridine derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0300618A3 (en) Adamantana derivatives, process for their preparation, their use and pharmaceutical compositions containing them
HUP0302499A3 (en) Pharmaceutical compositions of estrogen-cyclodextrin complexes and process for their preparation
HUP0301315A3 (en) Benzothiazole derivatives, process for their preparation, their use and pharmaceutical compositions containing them
HUP0203902A3 (en) Substituted oxazolidinones, process for their preparation and pharmaceutical compositions containing them and their use
HUP0204245A3 (en) Novel n-azabicyclo-amide derivatives, process for their preparation, pharmaceutical compositions containing them and their use
HUP0203378A3 (en) Pharmaceutical compounds and pharmaceutical compositions containing them
HUP0102711A3 (en) Epothilone derivatives and pharmaceutical compositions containing them and process for preparation the same
HUP0105021A3 (en) Compositions having improved delivery of actives and process for their preparation
HUP0104762A3 (en) Pharmaceutical moxifloxacin compositions and process for their preparation
IL150346A (en) Benzazole derivatives, their preparation and pharmaceutical compositions containing them
HUP0202731A3 (en) O-anisamide derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0302130A3 (en) Combination pharmaceutical compositions and process for their preparation
HUP0201516A3 (en) 13-methyl-erythromycin derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0105108A3 (en) Amide compounds, process for their preparation and pharmaceutical compositions containing them
HUP0201753A3 (en) Pyridopyranoazepine derivatives, process for their preparation and pharmaceutical compositions containing them
HUP9803040A3 (en) Thiazole derivatives, process for the preparation thereof, use thereof and pharmaceutical compositions containing them
HUP0201402A3 (en) Bis-sulfonamides, process for their preparation and pharmaceutical compositions containing them
AP2000002010A0 (en) Novel pharmaceutical compositions for treating and saving and the methods for the preparation thereof
AP2000001829A0 (en) Substituted thiazolidinedione derivative process for its preparation and its pharmaceutical use
HUP0203184A3 (en) Isoxazolecarboxamide derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0105481A3 (en) Pharmaceutical compositions containing clarithromycin and process for their preparation and their use
HUP0202654A3 (en) Pharmaceutical compositions of fibrinolytic agent and process for preparation thereof
HUP0200929A3 (en) Thiazolidinedione derivative and its use as antidiabetic and process for preparation thereof