IL160142A0 - Methods and compounds for the targeting of protein to exosomes - Google Patents

Methods and compounds for the targeting of protein to exosomes

Info

Publication number
IL160142A0
IL160142A0 IL16014202A IL16014202A IL160142A0 IL 160142 A0 IL160142 A0 IL 160142A0 IL 16014202 A IL16014202 A IL 16014202A IL 16014202 A IL16014202 A IL 16014202A IL 160142 A0 IL160142 A0 IL 160142A0
Authority
IL
Israel
Prior art keywords
methods
relates
membrane vesicles
well
exosomes
Prior art date
Application number
IL16014202A
Other languages
English (en)
Original Assignee
Anosys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anosys Inc filed Critical Anosys Inc
Publication of IL160142A0 publication Critical patent/IL160142A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/41—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a Myc-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL16014202A 2001-08-17 2002-08-14 Methods and compounds for the targeting of protein to exosomes IL160142A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31315901P 2001-08-17 2001-08-17
US34399101P 2001-12-26 2001-12-26
PCT/EP2002/009108 WO2003016522A2 (fr) 2001-08-17 2002-08-14 Procedes et composes pour le ciblage de proteines vers des exosomes

Publications (1)

Publication Number Publication Date
IL160142A0 true IL160142A0 (en) 2004-06-20

Family

ID=26978714

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16014202A IL160142A0 (en) 2001-08-17 2002-08-14 Methods and compounds for the targeting of protein to exosomes

Country Status (9)

Country Link
US (1) US7704964B2 (fr)
EP (1) EP1417229B1 (fr)
JP (1) JP4662708B2 (fr)
CN (1) CN100590131C (fr)
AT (1) ATE512982T1 (fr)
AU (1) AU2002331244B2 (fr)
CA (1) CA2454756C (fr)
IL (1) IL160142A0 (fr)
WO (1) WO2003016522A2 (fr)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL160142A0 (en) 2001-08-17 2004-06-20 Anosys Inc Methods and compounds for the targeting of protein to exosomes
AU2003237870A1 (en) * 2002-06-07 2003-12-22 The Brigham & Women's Hospital, Inc. Method and composition for inhibing or slowing blood coagulation
JP4939926B2 (ja) * 2003-02-14 2012-05-30 アノシス・インコーポレーテッド 抗体を生成し抗体レパートリーをスクリーニングするための方法とコンパウンド
US7771956B2 (en) * 2003-06-30 2010-08-10 Brigham & Women's Hospital, Inc. Method for detecting the presence of a phospholipid
WO2005037229A2 (fr) * 2003-10-17 2005-04-28 Emory University Procedes et compositions conçus pour moduler l'adherence des gametes
AU2006243905B2 (en) * 2005-05-13 2011-09-01 The Feinstein Institute For Medical Research Milk fat globule epidermal growth factor-factor VIII and sepsis
CN1322115C (zh) * 2005-07-06 2007-06-20 清华大学 载有外源配体分子的胞外体及其制备方法与应用
DK3517151T3 (da) * 2006-03-09 2021-07-12 Aethlon Medical Inc Ekstrakorporal fjernelse af mikrovesikulære partikler
US9085778B2 (en) 2006-05-03 2015-07-21 VL27, Inc. Exosome transfer of nucleic acids to cells
CN101641010A (zh) * 2007-01-26 2010-02-03 路易斯维尔大学研究基金会公司 用作疫苗的外来体组分的修饰
JP2010540466A (ja) 2007-09-24 2010-12-24 ザ ユニバーシティ オブ クイーンズランド 分子送達ベシクル
FR2928926B1 (fr) 2008-03-18 2015-08-21 Centre Nat Rech Scient Polynucleotides et polypeptides chimeriques permettant la secretion d'un polypeptide d'interet en association avec des exosomes et leur utilisation pour la production de compositions immunogenes
US7888035B2 (en) * 2008-10-30 2011-02-15 Caris Mpi, Inc. Methods for assessing RNA patterns
WO2010056337A2 (fr) 2008-11-12 2010-05-20 Caris Mpi, Inc. Procédés et systèmes d'utilisation d'exosomes pour déterminer des phénotypes
US20130053426A1 (en) * 2009-04-17 2013-02-28 Yiqi Seow Composition For Delivery Of Genetic Material
FR2950350B1 (fr) * 2009-09-24 2013-12-13 Centre Nat Rech Scient Nouveaux polynucleotides et polypeptides chimeriques permettant la secretion d'un polypeptide d'interet en association avec des exosomes et leurs utilisations
WO2011097480A1 (fr) 2010-02-05 2011-08-11 University Of Louisville Research Foundation, Inc. Compositions exosomales et procédés pour le traitement de maladies
EP2542696B1 (fr) 2010-03-01 2016-09-28 Caris Life Sciences Switzerland Holdings GmbH Biomarqueurs pour théranostique
JP2013526852A (ja) 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス 疾患に対する循環バイオマーカー
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
EP2603520A4 (fr) 2010-08-10 2014-02-19 Ecole Polytech Agents thérapeutiques se liant aux érythrocytes
WO2012135844A2 (fr) 2011-04-01 2012-10-04 Cornell University Exosomes circulants en tant qu'indicateurs de diagnostic/pronostic et cibles thérapeutiques de mélanome et d'autres cancers
ITRM20110403A1 (it) 2011-07-28 2013-01-29 Ospedale Pediatrico Bambino Gesu Microvescicole isolate da cellule mesenchimali come agenti immunosoppressori.
KR20130032646A (ko) * 2011-09-23 2013-04-02 삼성전자주식회사 막단백질 및 광발생 단백질이 결합된 융합단백질을 포함하는 재조합 엑소좀을 이용한 엑소좀 수득율을 측정하는 방법
GB201121070D0 (en) 2011-12-07 2012-01-18 Isis Innovation composition for delivery of biotherapeutics
CA2910802A1 (fr) 2013-04-12 2014-10-16 Samir El Andaloussi Vesicules d'administration therapeutiques
WO2014168721A2 (fr) 2013-04-12 2014-10-16 Tufts Medical Center Procédés et systèmes pour mettre au point et/ou caractériser des agents ligands lipidés solubles
GB201313249D0 (en) * 2013-07-25 2013-09-11 Isis Innovation Method
US10877033B2 (en) 2013-06-18 2020-12-29 Oxford University Innovation Limited Method of detecting the presence or absence of autoantibodies
EP2862874B1 (fr) * 2013-10-15 2018-12-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Procédé de production d'anticorps polyclonaux à l'aide d'une composition antigénique comprenant des vésicules de membrane contenant des protéines
EP3057662A4 (fr) * 2013-10-17 2017-03-29 Children's Hospital Los Angeles Thérapie par exosomes dépendant d'un anticorps
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
SG11201606761RA (en) 2014-02-21 2016-09-29 Ecole Polytecnique Federale De Lausanne Epfl Epfl Tto Glycotargeting therapeutics
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
TW201627318A (zh) * 2014-10-22 2016-08-01 臺北醫學大學 膽固醇酯轉運蛋白抗原肽及其融合蛋白以及其組合物及應用
US10702581B2 (en) 2015-05-04 2020-07-07 Ilias Biologics Inc. Compositions containing protein loaded exosome and methods for preparing and delivering the same
KR20160130937A (ko) * 2015-05-04 2016-11-15 한국과학기술원 목적 단백질을 포함하는 엑소솜의 제조 방법 및 상기 제조 방법에 의해 제조된 엑소솜을 이용하여 목적 단백질을 세포질로 전달시키는 방법
EP3307890A1 (fr) 2015-06-10 2018-04-18 Board of Regents, The University of Texas System Utilisation d'exosomes pour le traitement de maladies
US9840542B2 (en) 2015-09-11 2017-12-12 Nomadogen Biotechnologies Inc. Methods and compositions for the packaging of nucleic acids into microglial exosomes for the targeted expression of polypeptides in neural cells
WO2017118764A1 (fr) * 2016-01-07 2017-07-13 Thomas Brocker Nouvelles approches pour la visualisation in vivo et in vitro de cellules mourantes
EP3405208B1 (fr) 2016-01-22 2020-04-29 Tufts Medical Center, Inc. Composés et procédés pour le traitement de l'inflammation
AU2017226956A1 (en) 2016-03-03 2018-10-11 Institut Gustave Roussy PTPS-based vaccines against cancer
WO2017173367A2 (fr) 2016-03-31 2017-10-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Vésicules extracellulaires, leurs procédés de préparation, et méthodes de réduction de l'absorption hépatique des vésicules extracellulaires
US20190112351A1 (en) * 2016-04-04 2019-04-18 National Institutes Of Biomedical Innovation, Health And Nutrition Exosome-targeted dna vaccine
AU2017335084B2 (en) * 2016-09-30 2023-06-29 Ilias Biologics Inc. Compositions containing protein loaded exosome and methods for preparing and delivering the same
US10487143B2 (en) * 2016-10-05 2019-11-26 Duke University Vaccines against HER3 antigens and methods of using the same
CN108324735B (zh) * 2017-01-20 2024-02-09 李莉 用于疾病治疗的胞外体制剂及其应用
CN107185612B (zh) * 2017-03-17 2020-12-01 庶安永龄(厦门)健康产业有限公司 一种应用于外泌体捕获的微流体芯片及其制备方法
US11672849B2 (en) * 2017-05-10 2023-06-13 University Of Louisville Research Foundation, Inc. Method of inhibiting lung or breast cancer growth with engineered embryonic stem-cell derived exosomes compositions
WO2018232176A1 (fr) 2017-06-16 2018-12-20 The University Of Chicago Compositions et procédés d'induction d'une tolérance immunitaire
WO2019027847A1 (fr) * 2017-07-29 2019-02-07 University Of Southern California Vésicules extracellulaires synthétiques pour nouvelles thérapies
CA3071553A1 (fr) * 2017-08-04 2019-02-07 Ohio State Innovation Foundation Procede de production d'exosomes therapeutiques a partir de nanoelectroporation et autre transfection de cellule non endocytique
WO2019067464A1 (fr) * 2017-09-27 2019-04-04 The Board Of Trustees Of The Leland Stanford Junior University Agents thérapeutiques spécifiquement administrés par des exosomes pour le traitement du cancer
CN111655271B (zh) 2017-12-28 2025-09-23 隆萨销售股份公司 用于免疫肿瘤学和抗炎疗法的外来体
WO2019199941A1 (fr) * 2018-04-10 2019-10-17 Northwestern University Vésicules extracellulaires comprenant des protéines membranaires de ciblage à base d'un domaine d'affinité
EP3790577A4 (fr) 2018-05-09 2022-04-27 The University of Chicago Compositions et procédés d'induction d'une tolérance immunitaire
JP7659499B2 (ja) * 2018-10-25 2025-04-09 ネクセル カンパニー，リミテッド 線維症を治療又は予防するための組成物及び方法
WO2021045501A1 (fr) * 2019-09-02 2021-03-11 경북대학교 산학협력단 Composition pour la prévention ou le traitement du cancer, contenant, en tant que principe actif, des vésicules extracellulaires exprimant l'il-2 en surface
CN112824530A (zh) * 2019-11-20 2021-05-21 中国科学院深圳先进技术研究院 一种hek293f悬浮细胞高效电转染方法
EP4093408A4 (fr) * 2020-01-22 2024-04-24 AgeX Therapeutics, Inc. Exosomes thérapeutiques et leur procédé de production
JP2023512562A (ja) 2020-02-05 2023-03-27 ダイアデム バイオセラピューティクス インコーポレイテッド 人工シナプス
JP7628320B2 (ja) * 2020-03-30 2025-02-10 達也 沢村 変性ｈｄｌの定量方法、及びそれに用いる分析用試薬
MX2024006801A (es) 2021-12-06 2024-08-09 Ciloa Polipeptidos quimericos de adiponectina, vesicula extracelular que los comprende y usos de los mismos.
CN116082517B (zh) * 2022-05-26 2025-08-22 成都地奥制药集团有限公司 融合蛋白及其用途
CN116162597B (zh) * 2022-12-12 2025-12-19 中国科学技术大学 装载有Wnt蛋白的工程化细胞外囊泡及其应用
CN116769717B (zh) * 2023-04-18 2024-06-11 河南中医药大学第一附属医院 一种靶向外泌体及其制备方法和应用
CN116676265B (zh) * 2023-04-18 2024-05-24 河南中医药大学第一附属医院 一种酸敏融合肽靶向外泌体及其制备方法和应用
EP4537820A1 (fr) 2023-10-13 2025-04-16 Institut Gustave-Roussy Composé et combinaisons comprenant ledit composé pour améliorer une réponse immunitaire

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455031A (en) 1990-11-01 1995-10-03 Cancer Research Fund Of Contra Costa Polypeptide with 46 Kdalton HMFG differentiation antigen binding specificity, composition, kit and diagnostic method
US5972337A (en) * 1990-11-01 1999-10-26 Cancer Research Fund Of Contra Costa 46 kilodalton human milk fat globule (HMFG) antigen, fragments and fusion protein
IT1264516B1 (it) 1993-05-31 1996-09-24 Biotop Sas Di Rita Cassarin Cellule dendritiche immortalizzate
WO1997005900A1 (fr) 1995-08-03 1997-02-20 Rijksuniversiteit Te Leiden Vesicules presentant des antigenes obtenues a partir de cellules
US5834015A (en) 1996-09-11 1998-11-10 Albany Medical College Protein-lipid vesicles and autogenous vaccine comprising the same
FR2766205B1 (fr) 1997-07-16 2002-08-30 Inst Nat Sante Rech Med Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede
FR2785543B1 (fr) 1998-11-05 2003-02-28 Inst Nat Sante Rech Med Exosomes modifies et utilisations
EP1004664A1 (fr) * 1998-11-24 2000-05-31 Institut National De La Sante Et De La Recherche Medicale (Inserm) Compositions et procédés utilisant la lactadhérine ou des dérivés de celle-ci
FR2788780B1 (fr) 1999-01-27 2001-03-30 Ap Cells Inc Procede de preparation de vesicules membranaires
US20040241176A1 (en) 2000-04-27 2004-12-02 Ap Cells. Inc. Method of producing membrane vesicles
US6410271B1 (en) 2000-06-23 2002-06-25 Genetastix Corporation Generation of highly diverse library of expression vectors via homologous recombination in yeast
CA2431212A1 (fr) 2000-12-27 2002-07-25 Richard T. Wyatt Proteoliposomes immunogenes et applications de ceux-ci
IL160142A0 (en) 2001-08-17 2004-06-20 Anosys Inc Methods and compounds for the targeting of protein to exosomes
EP1483372A2 (fr) 2002-03-14 2004-12-08 Anosys, Inc. Vesicules derivees de lymphocytes t, production et utilisations

Also Published As

Publication number Publication date
WO2003016522A2 (fr) 2003-02-27
AU2002331244B2 (en) 2007-02-15
US20040197314A1 (en) 2004-10-07
WO2003016522A3 (fr) 2003-08-28
JP4662708B2 (ja) 2011-03-30
EP1417229B1 (fr) 2011-06-15
CA2454756A1 (fr) 2003-02-27
CA2454756C (fr) 2014-02-18
US7704964B2 (en) 2010-04-27
EP1417229A2 (fr) 2004-05-12
CN100590131C (zh) 2010-02-17
JP2005503791A (ja) 2005-02-10
CN1543476A (zh) 2004-11-03
ATE512982T1 (de) 2011-07-15
HK1062444A1 (en) 2004-11-05

Similar Documents

Publication Publication Date Title
IL160142A0 (en) Methods and compounds for the targeting of protein to exosomes
MXPA02012106A (es) Polipeptidos y acidos nucleicos relacionados con b7 empleados para inmunomodulacion.
WO2002099119A3 (fr) Acides nucleiques et polypeptides associes a b7 utiles pour l'immunomodulation
EP1304382A3 (fr) Production de peptides dans des végétaux par fusions de protéines d'enveloppes virales
MY162624A (en) Antibodies directed to her-3 and uses thereof
NZ591415A (en) Haemophilus influenzae type B
WO2007064917A3 (fr) Procedes de preparation de formes recombinees de la proteine beta-amyloide humaine et utilisation desdites proteines
ATE112801T1 (de) Menschliche lactoferrin-cdna-sequenz.
EP1487966A4 (fr) Secretion de proteines a plusieurs liaisons disulfure chez des bacteries et leur utilisation
WO1995019435A3 (fr) Proteines de la region v du recepteur d'antigene des lymphocytes t et leurs procedes de preparation
WO2001085782A3 (fr) Recepteur de la famille tnf
WO2001079446A3 (fr) Matieres et procedes relatifs au metabolisme lipidique
ATE337336T1 (de) Nukleinsäuren, die für stichodactylidae chromoproteine kodieren
WO1999019470A3 (fr) Proteines de fusion de la gfp et de l'annexine
WO2002068459A3 (fr) Proteines fluorescentes anti-agregantes et leurs methodes d'utilisation
WO2000059942A3 (fr) COMPOSITIONS hOB-BP2h, LEURS TECHNIQUES ET LEURS UTILISATIONS
ATE295890T1 (de) Vektor zur expression von n-terminal verlängerten proteinen in hefezellen
WO2000012710A8 (fr) Acides nucleiques codant pour des proteines de liaison a l'ataxine-2, produits y relatifs et procedes utilisant ces acides nucleiques et ces proteines
GB0116460D0 (en) Biological products
WO2000018909A3 (fr) Acides nucleiques et proteines provenant de cenarchaeum symbiosum
WO2002094992A3 (fr) Evolution dirigee de proteine dans des cellules de mammifere
WO1999024835A3 (fr) Immuno-essai pour propeptide de procollagene iii a terminal c
AU6310100A (en) Single-chain polypeptides comprising troponin i n-terminal fragments and troponin
WO2002002771A3 (fr) Nouveau gene hsparc-11 et procedes de fabrication et d'utilisation de ce dernier
EP1892251A3 (fr) Acides nucléiques et polypeptides apparentés à B7 utiles pour effectuer une immunomodulation