IL179013A - Medicaments comprising glycopyrrolate and (r)-5[ 2 -(5,6-diethyl-indan 2-ylamino)-1- hydroxy-ethyl]- 8-hydroxy-1h-quinoline-2-one for the treatment of chronic obstructive pulmonary disease - Google Patents

Medicaments comprising glycopyrrolate and (r)-5[ 2 -(5,6-diethyl-indan 2-ylamino)-1- hydroxy-ethyl]- 8-hydroxy-1h-quinoline-2-one for the treatment of chronic obstructive pulmonary disease

Info

Publication number: IL179013A
Authority: IL; Israel
Prior art keywords: hydroxy; medicament according; ethyl; medicament; glycopyrrolate
Prior art date: 2004-05-18

Application number

IL179013A

Other languages

English (en)

Other versions

IL179013A0 (en

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-18

Filing date

2006-11-02

Publication date

2012-02-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32607514&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL179013(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-11-02 Application filed by Novartis Ag filed Critical Novartis Ag

2007-05-15 Publication of IL179013A0 publication Critical patent/IL179013A0/en

2012-02-29 Publication of IL179013A publication Critical patent/IL179013A/en

Links

238000011282 treatment Methods 0.000 title claims abstract description 21
VPNYRYCIDCJBOM-UHFFFAOYSA-M Glycopyrronium bromide Chemical compound [Br-].C1[N+](C)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 VPNYRYCIDCJBOM-UHFFFAOYSA-M 0.000 title claims abstract description 16
229940015042 glycopyrrolate Drugs 0.000 title claims abstract description 16
239000003814 drug Substances 0.000 title claims description 47
208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 title claims description 8
QZZUEBNBZAPZLX-QFIPXVFZSA-N indacaterol Chemical compound N1C(=O)C=CC2=C1C(O)=CC=C2[C@@H](O)CNC1CC(C=C(C(=C2)CC)CC)=C2C1 QZZUEBNBZAPZLX-QFIPXVFZSA-N 0.000 title claims description 3
239000000203 mixture Substances 0.000 claims abstract description 38
150000003839 salts Chemical group 0.000 claims abstract description 12
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 10
239000003937 drug carrier Substances 0.000 claims abstract description 9
239000012453 solvate Chemical group 0.000 claims abstract description 9
239000000843 powder Substances 0.000 claims description 36
-1 cyclo-pentyl-hydroxyphenylacetyl Chemical group 0.000 claims description 18
238000002648 combination therapy Methods 0.000 claims description 5
VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims description 2
LUKZNWIVRBCLON-GXOBDPJESA-N Ciclesonide Chemical compound C1([C@H]2O[C@@]3([C@H](O2)C[C@@H]2[C@@]3(C[C@H](O)[C@@H]3[C@@]4(C)C=CC(=O)C=C4CC[C@H]32)C)C(=O)COC(=O)C(C)C)CCCCC1 LUKZNWIVRBCLON-GXOBDPJESA-N 0.000 claims description 2
229940124599 anti-inflammatory drug Drugs 0.000 claims description 2
229960004436 budesonide Drugs 0.000 claims description 2
229960003728 ciclesonide Drugs 0.000 claims description 2
239000002552 dosage form Substances 0.000 claims description 2
WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims description 2
229960000289 fluticasone propionate Drugs 0.000 claims description 2
IREJFXIHXRZFER-PCBAQXHCSA-N indacaterol maleate Chemical compound OC(=O)\C=C/C(O)=O.N1C(=O)C=CC2=C1C(O)=CC=C2[C@@H](O)CNC1CC(C=C(C(=C2)CC)CC)=C2C1 IREJFXIHXRZFER-PCBAQXHCSA-N 0.000 claims description 2
229960002744 mometasone furoate Drugs 0.000 claims description 2
WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 claims description 2
238000002360 preparation method Methods 0.000 claims description 2
239000002260 anti-inflammatory agent Substances 0.000 claims 1
150000001875 compounds Chemical class 0.000 abstract description 51
230000002757 inflammatory effect Effects 0.000 abstract description 13
208000027771 Obstructive airways disease Diseases 0.000 abstract description 11
208000027866 inflammatory disease Diseases 0.000 abstract description 8
239000000443 aerosol Substances 0.000 description 24
208000006673 asthma Diseases 0.000 description 19
239000002245 particle Substances 0.000 description 16
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 16
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 15
125000004432 carbon atom Chemical group C* 0.000 description 15
239000003380 propellant Substances 0.000 description 15
239000004480 active ingredient Substances 0.000 description 14
239000002775 capsule Substances 0.000 description 12
125000005843 halogen group Chemical group 0.000 description 12
239000006185 dispersion Substances 0.000 description 11
125000002887 hydroxy group Chemical group [H]O* 0.000 description 11
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 10
239000001257 hydrogen Substances 0.000 description 10
229910052739 hydrogen Inorganic materials 0.000 description 10
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 10
238000000034 method Methods 0.000 description 10
229960001375 lactose Drugs 0.000 description 9
239000008101 lactose Substances 0.000 description 9
125000000623 heterocyclic group Chemical group 0.000 description 8
239000005557 antagonist Substances 0.000 description 7
229910052757 nitrogen Inorganic materials 0.000 description 7
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 6
201000010099 disease Diseases 0.000 description 6
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
150000002430 hydrocarbons Chemical group 0.000 description 6
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229910052736 halogen Inorganic materials 0.000 description 5
150000002367 halogens Chemical group 0.000 description 5
235000019359 magnesium stearate Nutrition 0.000 description 5
239000004094 surface-active agent Substances 0.000 description 5
125000005330 8 membered heterocyclic group Chemical group 0.000 description 4
WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 4
239000000556 agonist Substances 0.000 description 4
NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 4
239000004067 bulking agent Substances 0.000 description 4
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 4
230000000694 effects Effects 0.000 description 4
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150000002431 hydrogen Chemical group 0.000 description 4
229960001021 lactose monohydrate Drugs 0.000 description 4
229940071648 metered dose inhaler Drugs 0.000 description 4
238000002156 mixing Methods 0.000 description 4
230000000414 obstructive effect Effects 0.000 description 4
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 4
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 4
229960002052 salbutamol Drugs 0.000 description 4
125000001424 substituent group Chemical group 0.000 description 4
YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 description 3
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 3
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 3
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 3
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 3
229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 description 3
ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 3
206010047924 Wheezing Diseases 0.000 description 3
230000009471 action Effects 0.000 description 3
230000001154 acute effect Effects 0.000 description 3
125000000217 alkyl group Chemical group 0.000 description 3
230000003110 anti-inflammatory effect Effects 0.000 description 3
239000000739 antihistaminic agent Substances 0.000 description 3
125000003118 aryl group Chemical group 0.000 description 3
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 3
102000014974 beta2-adrenergic receptor activity proteins Human genes 0.000 description 3
108040006828 beta2-adrenergic receptor activity proteins Proteins 0.000 description 3
150000003842 bromide salts Chemical class 0.000 description 3
230000003182 bronchodilatating effect Effects 0.000 description 3
239000000460 chlorine Substances 0.000 description 3
229910052801 chlorine Inorganic materials 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 3
125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 3
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 3
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
239000003112 inhibitor Substances 0.000 description 3
239000000314 lubricant Substances 0.000 description 3
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 3
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125000004430 oxygen atom Chemical group O* 0.000 description 3
239000002587 phosphodiesterase IV inhibitor Substances 0.000 description 3
150000003431 steroids Chemical class 0.000 description 3
238000002560 therapeutic procedure Methods 0.000 description 3
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 description 2
YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Chemical compound C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 description 2
DCYGAPKNVCQNOE-UHFFFAOYSA-N 2,2,2-triphenylacetic acid Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(C(=O)O)C1=CC=CC=C1 DCYGAPKNVCQNOE-UHFFFAOYSA-N 0.000 description 2
QTWVYUJFBIVOHT-SZMVWBNQSA-N 4-hydroxy-7-[(1r)-1-hydroxy-2-[[(1s,2s)-2-phenylmethoxycyclopentyl]amino]ethyl]-3h-1,3-benzothiazol-2-one Chemical compound O([C@H]1CCC[C@@H]1NC[C@H](O)C=1C=2SC(=O)NC=2C(O)=CC=1)CC1=CC=CC=C1 QTWVYUJFBIVOHT-SZMVWBNQSA-N 0.000 description 2
FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
125000001054 5 membered carbocyclic group Chemical group 0.000 description 2
IHOXNOQMRZISPV-YJYMSZOUSA-N 5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-methoxyphenyl)propan-2-yl]azaniumyl]ethyl]-2-oxo-1h-quinolin-8-olate Chemical compound C1=CC(OC)=CC=C1C[C@@H](C)NC[C@H](O)C1=CC=C(O)C2=C1C=CC(=O)N2 IHOXNOQMRZISPV-YJYMSZOUSA-N 0.000 description 2
125000004008 6 membered carbocyclic group Chemical group 0.000 description 2
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KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 2
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VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
229930195725 Mannitol Natural products 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
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125000004665 trialkylsilyl group Chemical group 0.000 description 1
150000003852 triazoles Chemical class 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
229960005486 vaccine Drugs 0.000 description 1
229960004764 zafirlukast Drugs 0.000 description 1
XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/402—1-aryl substituted, e.g. piretanide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system

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Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Compositions Of Oxide Ceramics (AREA)
Steroid Compounds (AREA)

IL179013A 2004-05-18 2006-11-02 Medicaments comprising glycopyrrolate and (r)-5[ 2 -(5,6-diethyl-indan 2-ylamino)-1- hydroxy-ethyl]- 8-hydroxy-1h-quinoline-2-one for the treatment of chronic obstructive pulmonary disease IL179013A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0411056.5A GB0411056D0 (en)	2004-05-18	2004-05-18	Organic compounds
PCT/EP2005/005354 WO2005110402A1 (en)	2004-05-18	2005-05-17	Combinations of glycopyrrolate and beta2 adrenoceptor agonists

Publications (2)

Publication Number	Publication Date
IL179013A0 IL179013A0 (en)	2007-05-15
IL179013A true IL179013A (en)	2012-02-29

Family

ID=32607514

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL179013A IL179013A (en)	2004-05-18	2006-11-02	Medicaments comprising glycopyrrolate and (r)-5[ 2 -(5,6-diethyl-indan 2-ylamino)-1- hydroxy-ethyl]- 8-hydroxy-1h-quinoline-2-one for the treatment of chronic obstructive pulmonary disease

Country Status (33)

Country	Link
US (6)	US20080267886A1 (2)
EP (3)	EP3603634B1 (2)
JP (2)	JP5567252B2 (2)
KR (2)	KR101360556B1 (2)
CN (1)	CN1953745A (2)
AT (1)	ATE521348T1 (2)
AU (1)	AU2005244439C1 (2)
BE (1)	BE2020C517I2 (2)
BR (1)	BRPI0511327B8 (2)
CA (1)	CA2563302C (2)
CY (4)	CY1112086T1 (2)
DK (2)	DK2228064T3 (2)
EC (1)	ECSP066950A (2)
ES (2)	ES2370647T3 (2)
FR (1)	FR20C1018I2 (2)
GB (1)	GB0411056D0 (2)
HU (3)	HUE048936T2 (2)
IL (1)	IL179013A (2)
LT (3)	LT2228064T (2)
LU (1)	LUC00155I2 (2)
MA (1)	MA28598B1 (2)
MX (1)	MXPA06013382A (2)
NO (2)	NO334760B1 (2)
NZ (1)	NZ550369A (2)
PL (2)	PL1755590T3 (2)
PT (2)	PT2228064T (2)
RU (1)	RU2388465C2 (2)
SE (1)	SE1755590T5 (2)
SG (1)	SG153836A1 (2)
SI (2)	SI1755590T1 (2)
TN (1)	TNSN06377A1 (2)
WO (1)	WO2005110402A1 (2)
ZA (1)	ZA200608123B (2)

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Also Published As

Publication number	Publication date
CA2563302C (en)	2012-08-28
LTPA2014015I1 (lt)	2014-04-25
TNSN06377A1 (en)	2008-02-22
SG153836A1 (en)	2009-07-29
HUE048936T2 (hu)	2020-09-28
LTC1755590I2 (lt)	2018-05-10
CY2014014I1 (el)	2015-11-04
ES2775979T3 (es)	2020-07-28
AU2005244439A1 (en)	2005-11-24
KR101360556B1 (ko)	2014-02-21
EP2228064B1 (en)	2019-12-11
RU2006144810A (ru)	2008-06-27
LTC2228064I2 (lt)	2022-05-10
PL2228064T3 (pl)	2020-06-01
JP5567252B2 (ja)	2014-08-06
US20180071276A1 (en)	2018-03-15
MA28598B1 (fr)	2007-05-02
AU2005244439B2 (en)	2009-07-30
EP3603634A1 (en)	2020-02-05
HUS2000014I1 (hu)	2020-07-28
ZA200608123B (en)	2008-07-30
ATE521348T1 (de)	2011-09-15
DK1755590T3 (da)	2011-12-12
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Legal Events

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2015-04-30	KB	Patent renewed
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Publication	Publication Date	Title
CA2563302C (en)	2012-08-28	Combinations of glycopyrrolate and beta2 adrenoceptor agonists
US20080279948A1 (en)	2008-11-13	Treatment of Asthma and Copd Using Triple-Combination Therapy
US20080317862A1 (en)	2008-12-25	Organic Compounds Comprising a Glycopyrrolium Salt
US20080286363A1 (en)	2008-11-20	Pharmaceutical Compositions for the Treatment of Inflammatory and Obstructive Airways Diseases
US20080274189A1 (en)	2008-11-06	Organic Compounds Comprising a Glycopyrr Onium Salt
HK40015531A (en)	2020-09-04	Pharmaceutical composition containing glycopyrrolate and a beta2 adrenoceptor agonist
EP1938822A1 (en)	2008-07-02	Combination therapy for the treatment of airways disease
TWI392493B (zh)	2013-04-11	格隆溴銨(GLYCOPYRROLATE)及β2腎上腺素受體激動劑之組合
HK40015531B (en)	2025-03-21	Pharmaceutical composition containing glycopyrrolate and a beta2 adrenoceptor agonist
HK1105579B (en)	2012-03-02	Combinations of glycopyrrolate and beta2 adrenoceptor agonists