IL35545A - Streptokinase chemically bonded to a water soluble dextran support medium - Google Patents

Streptokinase chemically bonded to a water soluble dextran support medium

Info

Publication number: IL35545A
Authority: IL; Israel
Prior art keywords: streptokinase; dextran; weight; composition; support medium
Prior art date: 1969-12-02

Application number

IL35545A

Other languages

English (en)

Other versions

IL35545A0 (en

Original Assignee

Baxter Laboratories Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1969-12-02

Filing date

1970-10-27

Publication date

1974-06-30

1970-10-27 Application filed by Baxter Laboratories Inc filed Critical Baxter Laboratories Inc

1970-12-24 Publication of IL35545A0 publication Critical patent/IL35545A0/xx

1974-06-30 Publication of IL35545A publication Critical patent/IL35545A/en

Links

229960005202 streptokinase Drugs 0.000 title claims description 55
108010023197 Streptokinase Proteins 0.000 title claims description 54
229920002307 Dextran Polymers 0.000 title claims description 47
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims description 8
239000000203 mixture Substances 0.000 claims description 23
239000007795 chemical reaction product Substances 0.000 claims description 7
238000000034 method Methods 0.000 claims description 5
125000004430 oxygen atom Chemical group O* 0.000 claims description 5
ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 claims description 3
229910052736 halogen Inorganic materials 0.000 claims description 3
229910052739 hydrogen Inorganic materials 0.000 claims description 3
239000001257 hydrogen Chemical group 0.000 claims description 3
239000004215 Carbon black (E152) Substances 0.000 claims description 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
125000004429 atom Chemical group 0.000 claims description 2
125000004432 carbon atom Chemical group C* 0.000 claims description 2
150000001875 compounds Chemical class 0.000 claims description 2
229930195733 hydrocarbon Natural products 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims 3
QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 claims 1
150000001718 carbodiimides Chemical class 0.000 claims 1
125000004181 carboxyalkyl group Chemical group 0.000 claims 1
125000005843 halogen group Chemical group 0.000 claims 1
VUQUOGPMUUJORT-UHFFFAOYSA-N methyl 4-methylbenzenesulfonate Chemical compound COS(=O)(=O)C1=CC=C(C)C=C1 VUQUOGPMUUJORT-UHFFFAOYSA-N 0.000 claims 1
ADAMEOZKZQRNKP-UHFFFAOYSA-N n'-propylmethanediimine Chemical compound CCCN=C=N ADAMEOZKZQRNKP-UHFFFAOYSA-N 0.000 claims 1
239000000243 solution Substances 0.000 description 15
239000000463 material Substances 0.000 description 13
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
210000004369 blood Anatomy 0.000 description 11
239000008280 blood Substances 0.000 description 11
108090000790 Enzymes Proteins 0.000 description 9
102000004190 Enzymes Human genes 0.000 description 9
229940088598 enzyme Drugs 0.000 description 9
239000002609 medium Substances 0.000 description 9
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
208000007536 Thrombosis Diseases 0.000 description 6
230000000694 effects Effects 0.000 description 6
MGNCLNQXLYJVJD-UHFFFAOYSA-N cyanuric chloride Chemical compound ClC1=NC(Cl)=NC(Cl)=N1 MGNCLNQXLYJVJD-UHFFFAOYSA-N 0.000 description 5
-1 dextran azide Chemical class 0.000 description 5
239000000047 product Substances 0.000 description 5
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
239000002244 precipitate Substances 0.000 description 4
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 3
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
125000002843 carboxylic acid group Chemical group 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
239000002808 molecular sieve Substances 0.000 description 3
URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 3
206010020751 Hypersensitivity Diseases 0.000 description 2
229920005654 Sephadex Polymers 0.000 description 2
239000012507 Sephadex™ Substances 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
208000030961 allergic reaction Diseases 0.000 description 2
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
229910052921 ammonium sulfate Inorganic materials 0.000 description 2
235000011130 ammonium sulphate Nutrition 0.000 description 2
150000001540 azides Chemical class 0.000 description 2
235000019441 ethanol Nutrition 0.000 description 2
150000002367 halogens Chemical group 0.000 description 2
239000002245 particle Substances 0.000 description 2
210000002381 plasma Anatomy 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
159000000000 sodium salts Chemical class 0.000 description 2
238000003756 stirring Methods 0.000 description 2
239000000126 substance Substances 0.000 description 2
238000005406 washing Methods 0.000 description 2
JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 description 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
229940126062 Compound A Drugs 0.000 description 1
NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 1
241000282414 Homo sapiens Species 0.000 description 1
IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 description 1
108091000080 Phosphotransferase Proteins 0.000 description 1
230000004913 activation Effects 0.000 description 1
210000004204 blood vessel Anatomy 0.000 description 1
239000000872 buffer Substances 0.000 description 1
239000008366 buffered solution Substances 0.000 description 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
230000002939 deleterious effect Effects 0.000 description 1
239000006619 dextran medium Substances 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
229910000397 disodium phosphate Inorganic materials 0.000 description 1
235000019800 disodium phosphate Nutrition 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000012530 fluid Substances 0.000 description 1
230000002949 hemolytic effect Effects 0.000 description 1
125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
230000002779 inactivation Effects 0.000 description 1
239000002198 insoluble material Substances 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
238000006386 neutralization reaction Methods 0.000 description 1
238000012856 packing Methods 0.000 description 1
102000020233 phosphotransferase Human genes 0.000 description 1
229920002401 polyacrylamide Polymers 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
230000001698 pyrogenic effect Effects 0.000 description 1
230000036647 reaction Effects 0.000 description 1
238000010992 reflux Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000012047 saturated solution Substances 0.000 description 1
229920002379 silicone rubber Polymers 0.000 description 1
239000004945 silicone rubber Substances 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
239000012064 sodium phosphate buffer Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
238000005292 vacuum distillation Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- A61K38/166—Streptokinase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Epidemiology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Enzymes And Modification Thereof (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IL35545A 1969-12-02 1970-10-27 Streptokinase chemically bonded to a water soluble dextran support medium IL35545A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US88163269A	1969-12-02	1969-12-02

Publications (2)

Publication Number	Publication Date
IL35545A0 IL35545A0 (en)	1970-12-24
IL35545A true IL35545A (en)	1974-06-30

Family

ID=25378866

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL35545A IL35545A (en)	1969-12-02	1970-10-27	Streptokinase chemically bonded to a water soluble dextran support medium

Country Status (11)

Country	Link
US (1)	US3639213A (fr)
BE (1)	BE758425A (fr)
CA (1)	CA976101A (fr)
DE (1)	DE2059165A1 (fr)
DK (1)	DK131471B (fr)
FR (1)	FR2073443B1 (fr)
GB (1)	GB1325912A (fr)
IL (1)	IL35545A (fr)
IT (1)	IT1050704B (fr)
NL (1)	NL7017625A (fr)
ZA (1)	ZA707355B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4167446A (en) *	1973-03-15	1979-09-11	Bayer Aktiengesellschaft	Water soluble carrier-bound penicillinacylase
US3865615A (en) *	1973-05-07	1975-02-11	Air Prod & Chem	Non-thrombogenic plastics
GB1479268A (en) *	1973-07-05	1977-07-13	Beecham Group Ltd	Pharmaceutical compositions
US4179337A (en) *	1973-07-20	1979-12-18	Davis Frank F	Non-immunogenic polypeptides
US4273873A (en) *	1977-10-25	1981-06-16	Unitika Ltd.	Preparation of antithrombogenic polymeric materials
US4305926A (en) *	1979-09-13	1981-12-15	Johannes Everse	Immobilization of Streptokinase
DE3033029A1 (de) *	1979-09-28	1981-04-23	Vsesojuznyj kardiologi&ccaron;eskij nau&ccaron;nyj centr Akademii medicinskich Nauk SSSR,, Moskva	Urokinasederivate und verfahren zu deren herstellung
IT1209419B (it) *	1980-07-01	1989-07-16	Texcontor Ets	Composti ad attivita' mucolitica non assimilabili, processo per laloro preparazione e composizioni terapeutiche che li comprendono come principio attivo.
JPS5823847B2 (ja) *	1981-02-06	1983-05-18	株式会社林原生物化学研究所	抗ヒト蛋白質抗体の製造方法
JPH04503607A (ja) *	1989-02-24	1992-07-02	イムノセラピューティックス・インコーポレイテッド	固定化サイトカイン類
US5133968A (en) *	1990-08-20	1992-07-28	Kanebo, Ltd.	Modified protease, method of producing the same and cosmetic products containing the modified protease
US5230891A (en) *	1990-08-20	1993-07-27	Kanebo Limited	Modified protease, method of producing the same and cosmetic products containing the modified protease
US5595732A (en) *	1991-03-25	1997-01-21	Hoffmann-La Roche Inc.	Polyethylene-protein conjugates
AU4104093A (en) *	1992-04-20	1993-11-18	Rufeld, Inc.	Method and compositions for treatment of pyonecrotic processes
US5382657A (en) *	1992-08-26	1995-01-17	Hoffmann-La Roche Inc.	Peg-interferon conjugates
US20090130017A1 (en) *	2007-11-19	2009-05-21	Searete Llc	Targeted short-lived drug delivery
NZ589557A (en) *	2008-06-04	2012-08-31	Talecris Biotherapeutics Inc	Immobilised streptokinase, method and kit for preparing plasmin
ES2552337T3 (es)	2009-03-03	2015-11-27	Grifols Therapeutics Inc.	Procedimientos para la preparación de plasminógeno
US9791463B2 (en)	2013-03-15	2017-10-17	Lawrence Livermore National Security, Llc	Methods for the selective detection of alkyne-presenting molecules and related compositions and systems
CN104758945B (zh) *	2015-02-26	2018-10-16	宁波大学	一种pH响应的溶栓药物靶向纳米凝胶及其合成方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL287978A (fr) *	1962-10-17	1900-01-01
US3255094A (en) *	1963-01-10	1966-06-07	Baxter Laboratories Inc	Method for purification of streptokinase
GB1108533A (en) *	1965-03-20	1968-04-03	Kyowa Hakko Kogyo Kk	Water-insoluble enzymes
US3824150A (en) *	1967-07-14	1974-07-16	Nat Res Dev	Enzyme bound to polymeric sheet with a triazine bridging group

0
- BE BE758425D patent/BE758425A/fr unknown
1969
- 1969-12-02 US US881632A patent/US3639213A/en not_active Expired - Lifetime
1970
- 1970-10-26 CA CA096,534A patent/CA976101A/en not_active Expired
- 1970-10-27 IL IL35545A patent/IL35545A/en unknown
- 1970-10-29 ZA ZA707355*A patent/ZA707355B/xx unknown
- 1970-11-11 GB GB5356670A patent/GB1325912A/en not_active Expired
- 1970-11-19 FR FR7041485A patent/FR2073443B1/fr not_active Expired
- 1970-11-24 IT IT32143/70A patent/IT1050704B/it active
- 1970-12-02 DE DE19702059165 patent/DE2059165A1/de active Pending
- 1970-12-02 NL NL7017625A patent/NL7017625A/xx unknown
- 1970-12-02 DK DK613070AA patent/DK131471B/da unknown

Also Published As

Publication number	Publication date
DE2059165A1 (de)	1971-06-09
FR2073443A1 (fr)	1971-10-01
DK131471B (da)	1975-07-21
DK131471C (fr)	1975-12-08
BE758425A (fr)	1971-04-16
CA976101A (en)	1975-10-14
US3639213A (en)	1972-02-01
NL7017625A (fr)	1971-06-04
FR2073443B1 (fr)	1975-04-18
IL35545A0 (en)	1970-12-24
GB1325912A (en)	1973-08-08
IT1050704B (it)	1981-03-20
ZA707355B (en)	1971-07-28

Publication	Publication Date	Title
US3980772A (en)	1976-09-14	Methods of dissolving blood clots and the like with streptokinase chemically bonded to a carbohydrate matrix
IL35545A (en)	1974-06-30	Streptokinase chemically bonded to a water soluble dextran support medium
US4954622A (en)	1990-09-04	Pharmaceutical composition and method containing gamma inulin or derivative thereof
EP0073371B1 (fr)	1985-11-21	Globuline de sérum immunisant injectable par voie intraveineuse et son procédé de préparation
US4401592A (en)	1983-08-30	Pharmaceutical composition having antitumor activity
US4499073A (en)	1985-02-12	Intravenously injectable immune serum globulin
EP0491708A1 (fr)	1992-07-01	Separation d'aminoarginine, utilisee pour bloquer la formation d'oxyde nitrique dans le corps.
PL99599B1 (pl)	1978-07-31	Sposob otrzymywania tolerowanej srodzylnie gammaglobuliny
JPH02108624A (ja)	1990-04-20	抗ｈｉｖ作用を有するヘパリンフラグメント及びフラクション
JPH02500368A (ja)	1990-02-08	温血動物における腫瘍阻止方法
EP0253313A2 (fr)	1988-01-20	Procédé pour le traitement par la chaleur de gamma-globuline chimiquement non modifiée
JPS6322801A (ja)	1988-01-30	Ｅｄｔａ不含のヘパリン、ヘパリン分画ならびに断片、それらの製造法及びそれらを含有する医薬品組成物
JPH0579649B2 (fr)	1993-11-04
US4009267A (en)	1977-02-22	Cross-linked orgotein
US2446974A (en)	1948-08-10	Synthesis of a penicillin-protein reaction product
CA2195863C (fr)	2001-04-17	Remede contre l'endotoxinemie et des defaillances d'organes multiples induites par celle-ci
JP3769045B2 (ja)	2006-04-19	抗炎症剤
CZ289560B6 (cs)	2002-02-13	Způsob výroby přípravku obsahujícího hyaluronidázu
KR20020031404A (ko)	2002-05-01	혈장 대체 조성물
AU589233B2 (en)	1989-10-05	Immunotherapeutic treatment
JPS59167515A (ja)	1984-09-21	免疫機能増強剤
RU2032660C1 (ru)	1995-04-10	Способ получения комплексов на основе ациклических аминов, обладающих радиопротекторными свойствами
CA2180732A1 (fr)	1995-08-03	Medicaments anti-vih
RU2058788C1 (ru)	1996-04-27	Способ получения препарата инсулина для перорального применения
JPS60104018A (ja)	1985-06-08	Ν−メチルホルムアミド肝毒性の軽減剤