IL64314A - 2-oxoazetidine derivatives,their production and antimicrobial and beta-lactamase inhibitory compositions containing them - Google Patents

2-oxoazetidine derivatives,their production and antimicrobial and beta-lactamase inhibitory compositions containing them

Info

Publication number: IL64314A
Authority: IL; Israel
Prior art keywords: antimicrobial; beta; production; amino group; compositions containing
Prior art date: 1980-12-05

Application number

IL64314A

Other languages

English (en)

Other versions

IL64314A0 (en

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-12-05

Filing date

1981-11-19

Publication date

1988-06-30

1980-12-05 Priority claimed from PCT/JP1980/000296 external-priority patent/WO1982001872A1/fr

1981-04-30 Priority claimed from PCT/JP1981/000102 external-priority patent/WO1982003858A1/fr

1981-08-25 Priority claimed from PCT/JP1981/000192 external-priority patent/WO1983000690A1/fr

1981-11-19 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1982-02-28 Publication of IL64314A0 publication Critical patent/IL64314A0/xx

1988-06-30 Publication of IL64314A publication Critical patent/IL64314A/xx

Links

108090000204 Dipeptidase 1 Proteins 0.000 title abstract 2
230000000845 anti-microbial effect Effects 0.000 title abstract 2
102000006635 beta-lactamase Human genes 0.000 title abstract 2
230000002401 inhibitory effect Effects 0.000 title abstract 2
MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical class O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 title 1
239000000203 mixture Substances 0.000 title 1
125000003277 amino group Chemical group 0.000 abstract 4
CDFGMYLBUSYTKQ-UHFFFAOYSA-N 2-oxoazetidine-1-sulfonic acid Chemical class OS(=O)(=O)N1CCC1=O CDFGMYLBUSYTKQ-UHFFFAOYSA-N 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL64314A 1980-12-05 1981-11-19 2-oxoazetidine derivatives,their production and antimicrobial and beta-lactamase inhibitory compositions containing them IL64314A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
PCT/JP1980/000296 WO1982001872A1 (fr)	1980-12-05	1980-12-05	Derives azetidine et leur procede de preparation
PCT/JP1981/000102 WO1982003858A1 (fr)	1981-04-30	1981-04-30	Derives d'azetidine et procede de preparation
PCT/JP1981/000192 WO1983000690A1 (fr)	1981-08-25	1981-08-25	Derives d'azetidine et leur procede de preparation

Publications (2)

Publication Number	Publication Date
IL64314A0 IL64314A0 (en)	1982-02-28
IL64314A true IL64314A (en)	1988-06-30

Family

ID=27303167

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL64314A IL64314A (en)	1980-12-05	1981-11-19	2-oxoazetidine derivatives,their production and antimicrobial and beta-lactamase inhibitory compositions containing them

Country Status (26)

Country	Link
US (1)	US4822790A (fr)
EP (1)	EP0053815B1 (fr)
JP (1)	JPS57131759A (fr)
KR (1)	KR880001564B1 (fr)
AT (3)	ATE13178T1 (fr)
AU (1)	AU551463B2 (fr)
CH (1)	CH656122A5 (fr)
DE (2)	DE3170437D1 (fr)
DK (1)	DK534381A (fr)
ES (2)	ES507716A0 (fr)
FI (1)	FI79528C (fr)
FR (1)	FR2495612A1 (fr)
GB (1)	GB2091723B (fr)
HU (1)	HU189545B (fr)
IE (1)	IE53451B1 (fr)
IL (1)	IL64314A (fr)
IT (1)	IT1146726B (fr)
LU (1)	LU83820A1 (fr)
MX (1)	MX7096E (fr)
NL (1)	NL8105468A (fr)
NO (1)	NO160297C (fr)
NZ (1)	NZ199168A (fr)
PT (1)	PT74087B (fr)
SE (1)	SE8107273L (fr)
SU (2)	SU1662348A3 (fr)
WO (1)	WO1982002042A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ199828A (en) *	1981-03-30	1985-11-08	Squibb & Sons Inc	4-substituted mercapto-2-oxo-1-azetidine-sulphonic acid derivatives and pharmaceutical compositions
US4734496A (en) *	1981-05-29	1988-03-29	E. R. Squibb & Sons, Inc.	4-amino derivatives of 2-oxo-1-azetidinesulfonic acid salts
JPS588060A (ja) *	1981-06-29	1983-01-18	イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド	アリ−ルチオアゼチジノンスルホン酸塩類
IT1157292B (it) *	1981-07-16	1987-02-11	Squibb & Sons Inc	Derivati 4-sostituiti dei sali dell'acido 2-osso-1-azetidinsolfonico e procedimento per la loro preparazione
DE3274981D1 (en) *	1981-10-05	1987-02-12	Squibb & Sons Inc	4-ether derivatives of 2-azetidinone-1-sulfonic acids
AU564150B2 (en) *	1982-04-30	1987-08-06	Takeda Chemical Industries Ltd.	1-sulfo-2-azetidinone derivatives
JPS58210060A (ja) *	1982-05-31	1983-12-07	Takeda Chem Ind Ltd	２−オキソアゼチジン誘導体、その製造法および用途
JPS5916888A (ja) *	1982-07-20	1984-01-28	Takeda Chem Ind Ltd	１−スルホ−２−アゼチジノン誘導体およびその製造法
US4681937A (en) *	1982-09-27	1987-07-21	E. R. Squibb & Sons, Inc.	3-acylamino-2-oxo-1-azetidinyl esters of phosphonic acids, phosphoric acid and phosphoric acid esters
JPS59101485A (ja) *	1982-11-29	1984-06-12	Otsuka Chem Co Ltd	アセチジノン誘導体
DE3342929A1 (de) *	1983-11-26	1985-06-05	Bayer Ag, 5090 Leverkusen	Ss-lactamantibiotika, verfahren zu deren herstellung sowie ihre verwendung als arzneimittel
US4883869A (en) *	1984-12-20	1989-11-28	The Upjohn Company	Novel beta-lactams containing amino acid substituents
US5006650A (en) *	1987-02-11	1991-04-09	The Upjohn Company	Novel N-1 substituted beta-lactams as antibiotics
WO1988006587A1 (fr) *	1987-02-27	1988-09-07	The Upjohn Company	beta LACTAMES ANTIBIOTIQUES CONTENANT UN ACIDE PYRIDONE CARBOXYLIQUE OU UN ACIDE DERIVE
CA1317298C (fr) *	1987-03-03	1993-05-04	Upjohn Company (The)	.beta.-lactames antibiotiques activees par des groupes sulfonylaminocar bonyles
US5015737A (en) *	1987-07-22	1991-05-14	The Upjohn Company	Therapeutically useful beta-lactams
EP0950046B1 (fr) *	1996-09-23	2002-04-10	Naeja Pharmaceutical Inc.	Derives d'azetidine-2-one disubstituee en 3,4 regulateurs de cysteine proteinase
HRP970146A2 (en) *	1997-03-13	1998-10-31	Mice Kovacevic	Epoxi-azetidines, preparation and use

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6046955B2 (ja) *	1977-12-30	1985-10-18	武田薬品工業株式会社	抗生物質ｇ−６３０２
JPS5549394A (en) *	1978-10-03	1980-04-09	Takeda Chem Ind Ltd	Antibiotic substance sb-72310
US4260627A (en) *	1978-10-24	1981-04-07	Merck & Co., Inc.	1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
DE3069587D1 (en) *	1979-06-08	1984-12-13	Takeda Chemical Industries Ltd	1-sulpho-2-oxoazetidine derivatives, their production and pharmaceutical compositions thereof
CA1242188A (fr) *	1979-06-08	1988-09-20	Takeda Pharmaceutical Company Limited	Derives de 3-methoxy-2-oxoazetidine et leur preparation
NZ196202A (en) *	1980-02-07	1984-07-31	Squibb & Sons Inc	Beta-lactam antibiotics (of azetidine-sulphonic acid type)
NZ199828A (en) *	1981-03-30	1985-11-08	Squibb & Sons Inc	4-substituted mercapto-2-oxo-1-azetidine-sulphonic acid derivatives and pharmaceutical compositions
JPS588060A (ja) *	1981-06-29	1983-01-18	イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド	アリ−ルチオアゼチジノンスルホン酸塩類
IT1157292B (it) *	1981-07-16	1987-02-11	Squibb & Sons Inc	Derivati 4-sostituiti dei sali dell'acido 2-osso-1-azetidinsolfonico e procedimento per la loro preparazione
FR2515182B1 (fr) *	1981-10-23	1986-05-09	Roussel Uclaf	Nouveaux produits derives de l'acide 3-amino 2-oxo azetidine 1-sulfamique, leur procede de preparation, leur application comme medicaments et les produits intermediaires necessaires a leur preparation

1980
- 1980-12-05 MX MX819801U patent/MX7096E/es unknown
1981
- 1981-11-19 IL IL64314A patent/IL64314A/xx unknown
- 1981-11-26 HU HU813576A patent/HU189545B/hu not_active IP Right Cessation
- 1981-12-02 NO NO814113A patent/NO160297C/no unknown
- 1981-12-02 FI FI813851A patent/FI79528C/fi not_active IP Right Cessation
- 1981-12-02 DK DK534381A patent/DK534381A/da not_active Application Discontinuation
- 1981-12-03 SU SU813364650A patent/SU1662348A3/ru active
- 1981-12-03 US US06/326,939 patent/US4822790A/en not_active Expired - Fee Related
- 1981-12-04 CH CH7786/81A patent/CH656122A5/de not_active IP Right Cessation
- 1981-12-04 ES ES507716A patent/ES507716A0/es active Granted
- 1981-12-04 FR FR8122774A patent/FR2495612A1/fr active Granted
- 1981-12-04 EP EP81110154A patent/EP0053815B1/fr not_active Expired
- 1981-12-04 DE DE8181110154T patent/DE3170437D1/de not_active Expired
- 1981-12-04 IT IT68585/81A patent/IT1146726B/it active
- 1981-12-04 NL NL8105468A patent/NL8105468A/nl not_active Application Discontinuation
- 1981-12-04 JP JP56196078A patent/JPS57131759A/ja active Pending
- 1981-12-04 LU LU83820A patent/LU83820A1/fr unknown
- 1981-12-04 DE DE19813148020 patent/DE3148020A1/de not_active Withdrawn
- 1981-12-04 AT AT81110154T patent/ATE13178T1/de not_active IP Right Cessation
- 1981-12-04 AT AT0520781A patent/AT379800B/de not_active IP Right Cessation
- 1981-12-04 SE SE8107273A patent/SE8107273L/xx unknown
- 1981-12-04 PT PT74087A patent/PT74087B/pt unknown
- 1981-12-04 GB GB8136617A patent/GB2091723B/en not_active Expired
- 1981-12-04 NZ NZ199168A patent/NZ199168A/en unknown
- 1981-12-04 IE IE2859/81A patent/IE53451B1/en unknown
- 1981-12-05 KR KR1019810004759A patent/KR880001564B1/ko not_active Expired
- 1981-12-05 WO PCT/JP1981/000368 patent/WO1982002042A1/fr not_active Ceased
- 1981-12-07 AU AU78313/81A patent/AU551463B2/en not_active Ceased
1982
- 1982-06-25 ES ES513420A patent/ES513420A0/es active Granted
1983
- 1983-02-02 SU SU833547568A patent/SU1531852A3/ru active
1984
- 1984-05-23 AT AT0170384A patent/AT380471B/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
SU1662348A3 (ru)	1991-07-07
IE53451B1 (en)	1988-11-23
IL64314A0 (en)	1982-02-28
NZ199168A (en)	1985-08-30
ATA170384A (de)	1985-10-15
PT74087A (en)	1982-01-01
MX7096E (es)	1987-06-19
SE8107273L (sv)	1982-06-06
NO160297B (no)	1988-12-27
DE3148020A1 (de)	1982-10-21
HU189545B (en)	1986-07-28
EP0053815B1 (fr)	1985-05-08
PT74087B (en)	1983-05-23
FI79528C (fi)	1990-01-10
FR2495612B1 (fr)	1984-06-01
ES8305325A1 (es)	1983-04-01
IT8168585A0 (it)	1981-12-04
FR2495612A1 (fr)	1982-06-11
NO814113L (no)	1982-06-07
KR830007549A (ko)	1983-10-21
ATE13178T1 (de)	1985-05-15
FI813851L (fi)	1982-06-06
AT380471B (de)	1986-05-26
SU1531852A3 (ru)	1989-12-23
ATA520781A (de)	1985-07-15
NO160297C (no)	1989-04-05
JPS57131759A (en)	1982-08-14
AU551463B2 (en)	1986-05-01
ES513420A0 (es)	1983-04-01
IE812859L (en)	1982-06-05
EP0053815A1 (fr)	1982-06-16
FI79528B (fi)	1989-09-29
DK534381A (da)	1982-06-06
AU7831381A (en)	1982-06-10
GB2091723A (en)	1982-08-04
AT379800B (de)	1986-02-25
GB2091723B (en)	1985-06-12
US4822790A (en)	1989-04-18
ES8301915A1 (es)	1982-12-16
DE3170437D1 (en)	1985-06-13
IT1146726B (it)	1986-11-19
NL8105468A (nl)	1982-07-01
LU83820A1 (fr)	1982-05-07
KR880001564B1 (ko)	1988-08-22
WO1982002042A1 (fr)	1982-06-24
ES507716A0 (es)	1982-12-16
CH656122A5 (de)	1986-06-13

Publication	Publication Date	Title
FR2495612B1 (fr)	1984-06-01
HUT59676A (en)	1992-06-29	Process for producing piperazinyl-alkyl-carbonyl derivatives of condensed heterocyclic compounds and pharmaceutical compositions containing them
TW368501B (en)	1999-09-01	7-(2-aminoethyl)-benzothiazolones
ATE146476T1 (de)	1997-01-15	Cephalosporinverbindungen und verfahren zu ihrer herstellung
FI895139A0 (fi)	1989-10-30	Pyrrolidinderivat.
ES8303327A1 (es)	1983-02-01	Un metodo para preparar derivados de 1-sulfo-2-oxoazetidina .