IL71538A - Process for the preparation of benzothiazepine derivatives - Google Patents

Process for the preparation of benzothiazepine derivatives

Info

Publication number: IL71538A
Authority: IL; Israel
Prior art keywords: general formula; advantageously; hydrocarbon solvent; aliphatic; water
Prior art date: 1984-04-13

Application number

IL71538A

Other languages

English (en)

Other versions

IL71538A0 (en

Inventor

Simonovitch Chaim

Hoffmann Teodor

Sasson Sabar

Original Assignee

Abic Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-04-13

Filing date

1984-04-13

Publication date

1987-07-31

1984-04-13 Application filed by Abic Ltd filed Critical Abic Ltd

1984-04-13 Priority to IL71538A priority Critical patent/IL71538A/xx

1984-07-31 Publication of IL71538A0 publication Critical patent/IL71538A0/xx

1985-04-01 Priority to US06/718,100 priority patent/US4566995A/en

1985-04-03 Priority to CA000478259A priority patent/CA1223585A/en

1985-04-05 Priority to EP85104182A priority patent/EP0158303B1/en

1985-04-05 Priority to DE8585104182T priority patent/DE3583407D1/de

1985-04-05 Priority to AT85104182T priority patent/ATE65083T1/de

1985-04-12 Priority to ES542902A priority patent/ES542902A0/es

1985-04-12 Priority to JP60079156A priority patent/JPH06768B2/ja

1987-07-31 Publication of IL71538A publication Critical patent/IL71538A/xx

Links

238000000034 method Methods 0.000 title abstract 5
238000002360 preparation method Methods 0.000 title abstract 2
229940085242 benzothiazepine derivative selective calcium channel blockers with direct cardiac effects Drugs 0.000 title 1
150000007657 benzothiazepines Chemical class 0.000 title 1
239000002904 solvent Substances 0.000 abstract 4
239000004215 Carbon black (E152) Substances 0.000 abstract 3
125000001931 aliphatic group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
229930195733 hydrocarbon Natural products 0.000 abstract 3
150000002430 hydrocarbons Chemical class 0.000 abstract 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
RQPZNWPYLFFXCP-UHFFFAOYSA-L barium dihydroxide Chemical compound [OH-].[OH-].[Ba+2] RQPZNWPYLFFXCP-UHFFFAOYSA-L 0.000 abstract 2
229910001863 barium hydroxide Inorganic materials 0.000 abstract 2
AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 abstract 2
229910001861 calcium hydroxide Inorganic materials 0.000 abstract 2
239000000920 calcium hydroxide Substances 0.000 abstract 2
-1 quaternary ammonium halide Chemical class 0.000 abstract 2
FHGWEHGZBUBQKL-UHFFFAOYSA-N 1,2-benzothiazepine Chemical class S1N=CC=CC2=CC=CC=C12 FHGWEHGZBUBQKL-UHFFFAOYSA-N 0.000 abstract 1
WQMAANNAZKNUDL-UHFFFAOYSA-N 2-dimethylaminoethyl chloride Chemical compound CN(C)CCCl WQMAANNAZKNUDL-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000002051 biphasic effect Effects 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
238000010992 reflux Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL71538A 1984-04-13 1984-04-13 Process for the preparation of benzothiazepine derivatives IL71538A (en)

Priority Applications (8)

Application Number	Priority Date	Filing Date	Title
IL71538A IL71538A (en)	1984-04-13	1984-04-13	Process for the preparation of benzothiazepine derivatives
US06/718,100 US4566995A (en)	1984-04-13	1985-04-01	Process for the preparation of benzothiazepine derivatives
CA000478259A CA1223585A (en)	1984-04-13	1985-04-03	Process for the preparation of benzothiazepine derivatives
EP85104182A EP0158303B1 (en)	1984-04-13	1985-04-05	A process for the preparation of benzothiazepin derivatives
DE8585104182T DE3583407D1 (de)	1984-04-13	1985-04-05	Verfahren zur herstellung von benzothiazepin-derivaten.
AT85104182T ATE65083T1 (de)	1984-04-13	1985-04-05	Verfahren zur herstellung von benzothiazepinderivaten.
ES542902A ES542902A0 (es)	1984-04-13	1985-04-12	Procedimiento para la obtencion de derivados de benzotiace- pina
JP60079156A JPH06768B2 (ja)	1984-04-13	1985-04-12	ベンゾチアゼピン誘導体の製造方法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IL71538A IL71538A (en)	1984-04-13	1984-04-13	Process for the preparation of benzothiazepine derivatives

Publications (2)

Publication Number	Publication Date
IL71538A0 IL71538A0 (en)	1984-07-31
IL71538A true IL71538A (en)	1987-07-31

Family

ID=11054990

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL71538A IL71538A (en)	1984-04-13	1984-04-13	Process for the preparation of benzothiazepine derivatives

Country Status (8)

Country	Link
US (1)	US4566995A (es)
EP (1)	EP0158303B1 (es)
JP (1)	JPH06768B2 (es)
AT (1)	ATE65083T1 (es)
CA (1)	CA1223585A (es)
DE (1)	DE3583407D1 (es)
ES (1)	ES542902A0 (es)
IL (1)	IL71538A (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4652561A (en) *	1986-02-26	1987-03-24	Hoffmann-La Roche Inc.	Naphtho[1,2-b]-1,4-thiazepinones
IL81954A0 (en) *	1986-03-24	1987-10-20	Hoffmann La Roche	Naphthothiazocinones,their manufacture and pharmaceutical compositions containing them
US4808580A (en) *	1987-12-17	1989-02-28	Hoffmann-La Roche Inc.	Naphtho[1,2-b][1,4]thiazepin-4(5H)-ones and use thereof in treatment of ischemia and blood pressure lowering
IT1244878B (it) *	1990-12-11	1994-09-12	Lusochimica Spa	Processo per la preparazione del (+)-cis-3-(acetossi)-5-!2-( dimetilammino)etil!-2,3-diidro-2-(4-metossifenil)-1,5-benzotiazepin- 4-(5h)-one cloridrato
TW438787B (en) *	1997-02-27	2001-06-07	Tanabe Seiyaku Co	Process for preparing optically active trans-3-substituted glycidic acid ester
US7887410B2 (en)	2001-10-02	2011-02-15	Universal Entertainment Corporation	Gaming machine
US8025563B2 (en)	2001-10-02	2011-09-27	Universal Entertainment Corporation	Gaming machine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1236467A (en) *	1967-10-28	1971-06-23	Tanabe Seiyaku Co	Benzothiazepine derivatives
US3562257A (en) *	1967-10-28	1971-02-09	Tanabe Seiyaku Co	Benzothiazepine derivatives
JPS5829779A (ja) *	1981-08-17	1983-02-22	Nippon Iyakuhin Kogyo Kk	Ｎ−アミノアルキル−１，５−ベンゾチアゼピン誘導体の製造法
JPS5899471A (ja) *	1981-12-07	1983-06-13	Tanabe Seiyaku Co Ltd	ベンゾチアゼピン誘導体の新規製造法
SE449611B (sv) *	1982-07-09	1987-05-11	Tanabe Seiyaku Co	Sett att framstella 1,5-bensotiazepinderivat
US4552695A (en) *	1983-04-21	1985-11-12	Shionogi & Co., Ltd.	Process for production of diltiazem hydrochloride
GB8316032D0 (en) *	1983-06-11	1983-07-13	Tanabe Seiyaku Co	Benzothiazepine derivatives

1984
- 1984-04-13 IL IL71538A patent/IL71538A/xx not_active IP Right Cessation
1985
- 1985-04-01 US US06/718,100 patent/US4566995A/en not_active Expired - Lifetime
- 1985-04-03 CA CA000478259A patent/CA1223585A/en not_active Expired
- 1985-04-05 DE DE8585104182T patent/DE3583407D1/de not_active Expired - Fee Related
- 1985-04-05 EP EP85104182A patent/EP0158303B1/en not_active Expired - Lifetime
- 1985-04-05 AT AT85104182T patent/ATE65083T1/de not_active IP Right Cessation
- 1985-04-12 ES ES542902A patent/ES542902A0/es active Granted
- 1985-04-12 JP JP60079156A patent/JPH06768B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPS61118377A (ja)	1986-06-05
IL71538A0 (en)	1984-07-31
EP0158303A3 (en)	1986-05-21
ES8603704A1 (es)	1986-01-01
CA1223585A (en)	1987-06-30
ATE65083T1 (de)	1991-07-15
JPH06768B2 (ja)	1994-01-05
ES542902A0 (es)	1986-01-01
EP0158303A2 (en)	1985-10-16
EP0158303B1 (en)	1991-07-10
DE3583407D1 (de)	1991-08-14
US4566995A (en)	1986-01-28

Legal Events

Date	Code	Title
1998-09-24	KB	Patent renewed
2002-05-23	KB	Patent renewed
2004-06-20	EXP	Patent expired

Publication	Publication Date	Title
AU553419B2 (en)	1986-07-17	New deiphosphonic acid derivatives
IE832713L (en)	1984-05-22	Indole derivatives.
ES8604545A1 (es)	1986-02-01	Procedimiento para preparar nuevos derivados de acidos feni-laceticos
DE3279103D1 (en)	1988-11-17	New cephem compounds, processes for preparation thereof and pharmaceutical composition containing them
HUT65750A (en)	1994-07-28	Process for preparing aryl-piperazinyl-heterocyclic compounds
IE802347L (en)	1981-05-19	7-acylamino-3-vinylcephalosporanic acid derivatives
IE861820L (en)	1987-01-10	2-hydroxy-2-phenylethylaminotetralines
DE3473763D1 (en)	1988-10-06	Novel 4'-demethyl-4-epipodophyllotoxin derivatives, a process for their preparation and their use as medicaments
DE69230265D1 (de)	1999-12-09	Galakturonsäure-Derivate, Verfahren zur ihrer Herstellung und ihre Verwendung
IL71538A0 (en)	1984-07-31	Process for the preparation of benzothiazepine derivatives
AU3131684A (en)	1985-02-07	New compounds derived from diphenyl-methylene-ethylamine
ES8802152A1 (es)	1988-04-01	Procedimiento para preparar un derivado de 1,3-oxazolidina-2-ona.
DE3363550D1 (en)	1986-06-19	New nitro aliphatic compounds, process for preparation thereof and use thereof
CA2049655A1 (en)	1992-03-18	Pharmaceutical composition for inhibiting platelet aggregation
MX9705836A (es)	1998-02-28	Sales de zinc del acido citraconamico y compuestos de hule que contienen estas sales.
GR852530B (es)	1986-02-19
ES8603434A1 (es)	1985-12-16	Un procedimiento para la produccion del 1, 2, 4-triazolilpropanol
KR860001815A (ko)	1986-03-22	옥타하이드로-옥사졸로[4,5-g]퀴놀린의 제조방법
ES8103079A1 (es)	1981-02-16	Un procedimiento para preparar derivados de fenotiazina
AU551839B2 (en)	1986-05-15	Imidazolylcarboxylic acids and derivative
DE3262166D1 (en)	1985-03-14	A new p-chlorophenoxyacetic acid derivative, its method of preparation and pharmaceutical composition
IE801537L (en)	1981-02-01	Phenylacetic acid derivatives.
DE3480542D1 (en)	1989-12-28	Cephem compounds
ES484086A1 (es)	1980-05-16	Procedimiento para la preparacion de compuestos de isopropi-lamina