IL74986A - Detecting target genetic material with desired base sequence or gene by using double labelled single-stranded polynucleotide sequences to form double-or multi-hybrid - Google Patents

Detecting target genetic material with desired base sequence or gene by using double labelled single-stranded polynucleotide sequences to form double-or multi-hybrid

Info

Publication number
IL74986A
IL74986A IL74986A IL7498685A IL74986A IL 74986 A IL74986 A IL 74986A IL 74986 A IL74986 A IL 74986A IL 7498685 A IL7498685 A IL 7498685A IL 74986 A IL74986 A IL 74986A
Authority
IL
Israel
Prior art keywords
double
genetic material
gene
base sequence
target genetic
Prior art date
Application number
IL74986A
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English (en)
Other versions
IL74986A0 (en
Original Assignee
Enzo Biochem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzo Biochem Inc filed Critical Enzo Biochem Inc
Publication of IL74986A0 publication Critical patent/IL74986A0/xx
Priority to IL91757A priority Critical patent/IL91757A0/xx
Publication of IL74986A publication Critical patent/IL74986A/xx

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/682—Signal amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6832—Enhancement of hybridisation reaction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/803—Physical recovery methods, e.g. chromatography, grinding

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL74986A 1984-04-27 1985-04-23 Detecting target genetic material with desired base sequence or gene by using double labelled single-stranded polynucleotide sequences to form double-or multi-hybrid IL74986A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL91757A IL91757A0 (en) 1984-04-27 1989-09-24 Hybridization method for the detection of genetic materials

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60502284A 1984-04-27 1984-04-27
US65381684A 1984-09-24 1984-09-24

Publications (2)

Publication Number Publication Date
IL74986A0 IL74986A0 (en) 1985-08-30
IL74986A true IL74986A (en) 1990-08-31

Family

ID=27084833

Family Applications (1)

Application Number Title Priority Date Filing Date
IL74986A IL74986A (en) 1984-04-27 1985-04-23 Detecting target genetic material with desired base sequence or gene by using double labelled single-stranded polynucleotide sequences to form double-or multi-hybrid

Country Status (11)

Country Link
US (1) US4894325A (fr)
EP (2) EP0526912B1 (fr)
JP (2) JP2560003B2 (fr)
AT (2) ATE91154T1 (fr)
AU (2) AU4148685A (fr)
CA (1) CA1260372A (fr)
DE (2) DE3587427T2 (fr)
DK (1) DK188385A (fr)
ES (1) ES8609473A1 (fr)
IL (1) IL74986A (fr)
NO (1) NO165269C (fr)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4948882A (en) * 1983-02-22 1990-08-14 Syngene, Inc. Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
FI71768C (fi) * 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
US6221581B1 (en) * 1984-04-27 2001-04-24 Enzo Diagnostics, Inc. Processes for detecting polynucleotides, determining genetic mutations or defects in genetic material, separating or isolating nucleic acid of interest from samples, and useful compositions of matter and multihybrid complex compositions
US4820630A (en) * 1984-11-23 1989-04-11 Digene Diagnostics, Incorporated Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels
CA1272443A (fr) * 1985-02-22 1990-08-07 Nanibhushan Dattagupta Essai de double hybridation en solution-phase pour deceler des sequences polynucleotidiques
GB8509367D0 (en) * 1985-04-12 1985-05-15 Amersham Int Plc Nucleic acid hybridisation
US5273882A (en) * 1985-06-13 1993-12-28 Amgen Method and kit for performing nucleic acid hybridization assays
ES8707343A1 (es) † 1985-06-13 1987-07-16 Amgen Un metodo para aislar una secuencia de acido nucleico objetivo seleccionada
JP3293820B2 (ja) * 1985-12-13 2002-06-17 エンゾ− バイオケム インコ−ポレイテツド 標的ポリヌクレオチドにハイブリツド形成するための新規な一工程方法とポリヌクレオチド化合物
US4882269A (en) * 1985-12-13 1989-11-21 Princeton University Amplified hybridization assay
FR2601455B1 (fr) * 1986-07-11 1989-08-04 Stallergenes Lab Nouveaux reactifs biologiques en phase solide et leur procede d'obtention
US5175270A (en) * 1986-09-10 1992-12-29 Polyprobe, Inc. Reagents for detecting and assaying nucleic acid sequences
AU8103687A (en) * 1986-10-14 1988-05-06 Beckman Instruments, Inc. Improved nucleic acid hybridization technique and kit therefor
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
ZA877772B (en) * 1986-10-23 1988-04-20 Amoco Corporation Target and background capture methods and apparatus for affinity assays
US5750338A (en) * 1986-10-23 1998-05-12 Amoco Corporation Target and background capture methods with amplification for affinity assays
IL85551A0 (en) * 1987-04-01 1988-08-31 Miles Inc Rapid hybridization assay and reagent system used therein
US5124246A (en) * 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5359100A (en) * 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
AU2735988A (en) * 1987-12-21 1989-07-13 Amoco Corporation Target and background capture methods with amplification for affinity assays
US5374524A (en) * 1988-05-10 1994-12-20 E. I. Du Pont De Nemours And Company Solution sandwich hybridization, capture and detection of amplified nucleic acids
EP0405592A3 (en) * 1989-06-30 1991-07-17 Sanyo Chemical Industries Ltd. A method for detection of nucleic acid and reagents for their detection
US5399676A (en) * 1989-10-23 1995-03-21 Gilead Sciences Oligonucleotides with inverted polarity
WO1991008307A1 (fr) * 1989-12-04 1991-06-13 Microprobe Corporation Capture amelioree d'acide nucleique cible faisant appel a des oligonucleotides attaches de façon covalente a des polymeres
US5264343A (en) * 1990-08-31 1993-11-23 Eleanor Roosevelt Institute Method for distinguishing normal and cancer cells
RU1794088C (ru) * 1991-03-18 1993-02-07 Институт Молекулярной Биологии Ан@ Ссср Способ определени нуклеотидной последовательности ДНК и устройство дл его осуществлени
WO1993013226A1 (fr) * 1991-12-23 1993-07-08 Chiron Corporation Sondes d'hav utilisees dans des methodes d'hybridation en sandwich en phase solution
US6300058B1 (en) 1992-01-29 2001-10-09 Hitachi Chemical Research Center, Inc. Method for measuring messenger RNA
CA2128891A1 (fr) * 1992-01-29 1993-08-05 Cylia Keller Polynucleotides immobilises sur support
US5329461A (en) * 1992-07-23 1994-07-12 Acrogen, Inc. Digital analyte detection system
WO1994002636A1 (fr) * 1992-07-28 1994-02-03 Hitachi Chemical Company Ltd. Systeme de detection de gene
US5580971A (en) * 1992-07-28 1996-12-03 Hitachi Chemical Company, Ltd. Fungal detection system based on rRNA probes
US7713528B1 (en) 1993-02-18 2010-05-11 Enzo Therapeutics, Inc. Method for in vivo delivery of active compounds using reagent conjugate
DE69434809T2 (de) * 1993-05-28 2007-03-29 The Mount Sinai School Of Medicine Of New York University Bc200 rna, daraus abgeleitete proben und entsprechende anwendungen
FR2707010B1 (fr) * 1993-06-25 1995-09-29 Bio Merieux
RU2041261C1 (ru) * 1993-08-11 1995-08-09 Институт молекулярной биологии им.В.А.Энгельгардта РАН Способ изготовления матрицы для детектирования мисматчей
FR2710075B1 (fr) * 1993-09-15 1995-10-27 Bio Merieux Réactif et procédé pour la détection d'une séquence nucléotidique avec amplification de signal.
US5681697A (en) * 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US5591578A (en) * 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
US5952172A (en) 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
CA2140081C (fr) 1994-01-13 2008-04-01 Dean L. Engelhardt Procede, construct et conjugue permettant de produire des copies multiples d'acides nucleiques
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5731153A (en) * 1996-08-26 1998-03-24 The Regents Of The University Of California Identification of random nucleic acid sequence aberrations using dual capture probes which hybridize to different chromosome regions
US5783387A (en) * 1995-02-06 1998-07-21 The Regents Of The University Of California Method for identifying and quantifying nucleic acid sequence aberrations
US5853974A (en) * 1995-06-07 1998-12-29 Chiron Corporation Enhancement of alkaline phosphatase with SDS in chemiluminescent substrates
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
US5780227A (en) * 1995-06-07 1998-07-14 Sheridan; Patrick J. Oligonucleotide probe conjugated to a purified hydrophilic alkaline phosphatase and uses thereof
US6096508A (en) * 1995-08-16 2000-08-01 Kirkegaard & Perry Laboratoies, Inc. Method of reducing background in biotin-based assays
US7282327B2 (en) 1996-01-23 2007-10-16 Affymetrix, Inc. Nucleic acid labeling compounds
US6965020B2 (en) 1996-01-23 2005-11-15 Affymetrix, Inc. Nucleic acid labeling compounds
EP0880598A4 (fr) 1996-01-23 2005-02-23 Affymetrix Inc Evaluation rapide de difference d'abondance d'acides nucleiques, avec un systeme d'oligonucleotides haute densite
US7291463B2 (en) 1996-01-23 2007-11-06 Affymetrix, Inc. Nucleic acid labeling compounds
US20010018514A1 (en) 1998-07-31 2001-08-30 Mcgall Glenn H. Nucleic acid labeling compounds
US7423143B2 (en) 1996-01-23 2008-09-09 Affymetrix. Inc. Nucleic acid labeling compounds
US6864059B2 (en) 1996-01-23 2005-03-08 Affymetrix, Inc. Biotin containing C-glycoside nucleic acid labeling compounds
JP3545158B2 (ja) * 1996-03-14 2004-07-21 シスメックス株式会社 遺伝子検出法
FR2746413B1 (fr) * 1996-03-19 1998-04-24 Bio Merieux Detection d'une sequence nucleotidique avec amplification de signal
US6444423B1 (en) 1996-06-07 2002-09-03 Molecular Dynamics, Inc. Nucleosides comprising polydentate ligands
WO1998004740A1 (fr) * 1996-07-29 1998-02-05 Nanosphere Llc Nanoparticules sur lesquelles sont attaches des oligonucleotides et utilisations desdites nanoparticules
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US5853993A (en) * 1996-10-21 1998-12-29 Hewlett-Packard Company Signal enhancement method and kit
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7393645B2 (en) * 1996-11-05 2008-07-01 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7014992B1 (en) * 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US7045285B1 (en) * 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
ES2271994T3 (es) * 1997-05-02 2007-04-16 Gen-Probe Incorporated Hibridacion en dos pasos y captura de un polinucleotido.
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US6013459A (en) * 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
BR9814271A (pt) * 1997-12-12 2001-03-20 Digene Corp Determinação de doenças relacionadas com o vìrus do papiloma humano
EP1049803A4 (fr) * 1997-12-15 2002-08-21 Nexstar Pharmaceuticals Inc Detection homogene de molecules cibles par interaction ligand acide nucleique et ligand balise
US20030219803A1 (en) * 1997-12-15 2003-11-27 Somalogic, Incorporated Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
US6686150B1 (en) 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
WO1999037819A2 (fr) 1998-01-27 1999-07-29 Clinical Micro Sensors, Inc. Amplification des acides nucleiques par detection electronique
US20050244954A1 (en) * 1998-06-23 2005-11-03 Blackburn Gary F Binding acceleration techniques for the detection of analytes
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6290839B1 (en) 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US6740518B1 (en) * 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
AU1241000A (en) * 1998-10-27 2000-05-15 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
JP3267576B2 (ja) * 1998-11-09 2002-03-18 三光純薬株式会社 プローブ高分子の形成方法
US6833267B1 (en) 1998-12-30 2004-12-21 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US7312087B2 (en) 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
ATE417127T1 (de) 1999-07-26 2008-12-15 Clinical Micro Sensors Inc Nukelinsäuresequenzbestimmung mittels elektronischem nachweis
US6428957B1 (en) 1999-11-08 2002-08-06 Agilent Technologies, Inc. Systems tools and methods of assaying biological materials using spatially-addressable arrays
AU2001241939A1 (en) * 2000-02-28 2001-09-12 Maxygen, Inc. Single-stranded nucleic acid template-mediated recombination and nucleic acid fragment isolation
ES2317893T3 (es) * 2000-03-31 2009-05-01 Sanko Junyaku Co., Ltd. Sondas para construir polimeros de sondas, procedimiento para construir un polimero de sondas y uso del mismo.
US6753143B2 (en) 2000-05-01 2004-06-22 Clinical Micro Sensors, Inc. Target analyte detection using asymmetrical self-assembled monolayers
US7601497B2 (en) * 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
US7439016B1 (en) * 2000-06-15 2008-10-21 Digene Corporation Detection of nucleic acids by type-specific hybrid capture method
JP4382265B2 (ja) * 2000-07-12 2009-12-09 日本電気株式会社 酸化シリコン膜の形成方法及びその形成装置
CA2440615A1 (fr) 2001-03-12 2002-09-19 Affymetrix, Inc. Composes de marquage d'acide nucleique
DE10164197A1 (de) * 2001-04-12 2003-07-17 Vladimir M Mirsky Steuerbare Verstärkung der Empfindlichkeit beim Hybridisierungsnachweis
US9261460B2 (en) 2002-03-12 2016-02-16 Enzo Life Sciences, Inc. Real-time nucleic acid detection processes and compositions
US9353405B2 (en) 2002-03-12 2016-05-31 Enzo Life Sciences, Inc. Optimized real time nucleic acid detection processes
US7166478B2 (en) * 2002-03-12 2007-01-23 Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses
US20040011650A1 (en) * 2002-07-22 2004-01-22 Frederic Zenhausern Method and apparatus for manipulating polarizable analytes via dielectrophoresis
US9303262B2 (en) * 2002-09-17 2016-04-05 Archemix Llc Methods for identifying aptamer regulators
DK1778867T3 (da) 2004-07-01 2010-08-02 Gen Probe Inc Fremgangsmåder og sammensætninger til detektering af nucleinsyrer i en biologisk prøve
EP1871913A2 (fr) * 2005-03-25 2008-01-02 Ambion, Inc. Methodes et compositions pour la depletion de transcrits d'arn abondants
CA2584230C (fr) 2005-05-06 2012-11-27 Gen-Probe Incorporated Procedes de capture d'acide nucleique cible
US20090162845A1 (en) * 2007-12-20 2009-06-25 Elazar Rabbani Affinity tag nucleic acid and protein compositions, and processes for using same
WO2009140374A2 (fr) 2008-05-13 2009-11-19 Gen-Probe Incorporated Oligomères de capture de cible inactivables pour hybridation et capture sélectives de séquences d'acides nucléiques cibles
TWI417389B (zh) * 2008-10-27 2013-12-01 Qiagen Gaithersburg Inc 於自動平台上之快速結果雜交捕捉法
WO2010068473A1 (fr) * 2008-11-25 2010-06-17 Gen-Probe Incorporated Compositions et procédés pour détecter des petits arn et utilisations de ceux-ci
EP2385979B1 (fr) * 2009-01-28 2017-08-16 QIAGEN Gaithersburg, Inc. Procédé de préparation d'un échantillon de grand volume spécifique à une séquence et dosage
AU2010242867B2 (en) * 2009-05-01 2016-05-12 Qiagen Gaithersburg, Inc. A non-target amplification method for detection of RNA splice-forms in a sample
US20110053143A1 (en) * 2009-09-03 2011-03-03 Qiagen Gaithersburg Inc. Methods and kits for determining viral load in clinical samples
JP5826752B2 (ja) * 2009-09-14 2015-12-02 キアジェン ゲイサーズバーグ インコーポレイテッド 細胞学用培地に固定された組織サンプルから核酸またはタンパク質を回収するための組成物および方法
EP2521778B1 (fr) 2010-01-04 2014-03-19 QIAGEN Gaithersburg, Inc. Procédés, compositions et kits de récupération des acides nucléiques ou des protéines dans des échantillons de tissus fixés
ES2615728T3 (es) * 2010-01-29 2017-06-08 Qiagen Gaithersburg, Inc. Métodos y composiciones para una purificación y un análisis múltiple específico de secuencia de ácidos nucleicos
CA2787781A1 (fr) 2010-01-29 2011-08-04 Qiagen Gaithersburg, Inc. Procede de determination de confirmation de la presence d'un hpv dans un echantillon
US9422593B2 (en) 2010-05-19 2016-08-23 Qiagen Gaithresburg, Inc Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
CA2799205A1 (fr) 2010-05-25 2011-12-01 Qiagen Gaithersburg, Inc. Analyse de capture hybride a resultats rapides et sondes associees tronquees de maniere strategique
AU2012220575B2 (en) 2011-02-24 2017-01-12 Qiagen Gaithersburg, Inc. Materials and methods for detection of HPV nucleic acid
KR102275006B1 (ko) 2013-03-11 2021-07-09 메소 스케일 테크놀러지즈, 엘엘시 다중화 어세이를 수행하기 위한 개선된 방법
EP3356547B1 (fr) * 2015-10-01 2020-11-18 Dynamic Biosensors GmbH Procédé pour détecter des interactions moléculaires au moyen d'un acide nucléique immobilisé

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5510590A (en) * 1978-05-04 1980-01-25 Wellcome Found Enzyme immunity quantity analysis
US4376165A (en) * 1978-06-22 1983-03-08 Miles Laboratories, Inc. Method of preparing an enzyme-labeled ligand for use in specific binding assays and the labeled conjugate produced thereby
GB2027031A (en) * 1978-08-02 1980-02-13 Hoffmann La Roche Diagnostic Reagent Comprising a Proteinaceous Material Bonded to a Latex
US4334017A (en) * 1979-04-16 1982-06-08 Massachusetts Institute Of Technology Method for detecting cancer in mammalian tissue
US4510244A (en) * 1980-04-17 1985-04-09 The Board Of Trustees Of The Leland Stanford Jr. University Cell labeling with antigen-coupled microspheres
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4358535A (en) * 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
CA1219824A (fr) * 1981-04-17 1987-03-31 David C. Ward Nucleotides modifies, leur preparation et leur emploi
CA1190838A (fr) * 1981-07-17 1985-07-23 Cavit Akin Procede de diagnostic d'hybridation
JPS5840099A (ja) * 1981-07-17 1983-03-08 アモコ・コ−ポレ−ション 光−放射ポリヌクレオチドの交雑診断方法
CA1180647A (fr) * 1981-07-17 1985-01-08 Cavit Akin Methode de diagnostic d'hybridation de polynucleotides par emission de lumiere
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
CA1223831A (fr) * 1982-06-23 1987-07-07 Dean Engelhardt Nucleotides modifies, methodes de preparation et d'utilisation et composes les contenant
US4554088A (en) * 1983-05-12 1985-11-19 Advanced Magnetics Inc. Magnetic particles for use in separations
CA1222680A (fr) * 1983-07-05 1987-06-09 Nanibhushan Dattagupta Dosages de sequences de nucleotides particulieres dans des echantillons d'adn
CA1256005A (fr) * 1983-09-26 1989-06-20 W. Peter Hansen Methode d'hybridation sandwich pour la detection d'acides nucleiques
GB8331071D0 (en) * 1983-11-22 1983-12-29 Karayiannis P Assay for dna/rna
US4724202A (en) * 1983-12-12 1988-02-09 Molecular Diagnostics, Inc. Use of non-hybridizable nucleic acids for the detection of nucleic acid hybridization
US4699876A (en) * 1984-01-27 1987-10-13 E. I. Du Pont De Nemours And Company Nonradiometric polynucleotide probes
FI71768C (fi) * 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
US4749647A (en) * 1984-06-22 1988-06-07 Genetic Systems Corporation Polymerization-induced separation assay using recognition pairs
US4755458A (en) * 1984-08-30 1988-07-05 Enzo Biochem, Inc. Composition and method for the detection of the presence of a polynucleotide sequence of interest
US4563417A (en) * 1984-08-31 1986-01-07 Miles Laboratories, Inc. Nucleic acid hybridization assay employing antibodies to intercalation complexes

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DK188385A (da) 1985-10-28
ES542602A0 (es) 1986-09-01
DE3587427D1 (de) 1993-08-05
EP0159719B1 (fr) 1993-06-30
US4894325A (en) 1990-01-16
DE3587427T2 (de) 1994-01-20
EP0526912A2 (fr) 1993-02-10
ES8609473A1 (es) 1986-09-01
JPS60237361A (ja) 1985-11-26
AU4598489A (en) 1990-03-29
DE3588250D1 (de) 2004-02-26
NO165269C (no) 1991-01-16
NO165269B (no) 1990-10-08
AU4148685A (en) 1986-01-30
EP0159719A3 (en) 1988-03-30
IL74986A0 (en) 1985-08-30
EP0159719A2 (fr) 1985-10-30
JP2560003B2 (ja) 1996-12-04
DK188385D0 (da) 1985-04-26
EP0526912A3 (fr) 1994-03-02
JP2735822B2 (ja) 1998-04-02
CA1260372A (fr) 1989-09-26
JPH08336400A (ja) 1996-12-24
ATE91154T1 (de) 1993-07-15
EP0526912B1 (fr) 2004-01-21
NO851689L (no) 1985-10-28
ATE258230T1 (de) 2004-02-15

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