IL79926A - Extracellular human superoxide dismutase, dna fragment encoding it, recombinant method for making it and vectors and cells for use in the method, method for recovering the dismutase and pharmaceutical compositions comprising it - Google Patents

Extracellular human superoxide dismutase, dna fragment encoding it, recombinant method for making it and vectors and cells for use in the method, method for recovering the dismutase and pharmaceutical compositions comprising it

Info

Publication number: IL79926A
Authority: IL; Israel
Prior art keywords: sod; cell; heparin; dna; origin
Prior art date: 1985-09-03

Application number

IL7992686A

Other languages

English (en)

Other versions

IL79926A0 (en

Inventor

Stefan Marklund

Thomas Edlund

Original Assignee

Symbicom Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-09-03

Filing date

1986-09-02

Publication date

1994-10-07

1986-09-02 Application filed by Symbicom Ab filed Critical Symbicom Ab

1986-12-31 Publication of IL79926A0 publication Critical patent/IL79926A0/xx

1994-10-07 Publication of IL79926A publication Critical patent/IL79926A/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/446—Superoxide dismutase (1.15)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Genetics & Genomics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Hematology (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
Physics & Mathematics (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)

IL7992686A 1985-09-03 1986-09-02 Extracellular human superoxide dismutase, dna fragment encoding it, recombinant method for making it and vectors and cells for use in the method, method for recovering the dismutase and pharmaceutical compositions comprising it IL79926A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK402785A DK402785D0 (da)	1985-09-03	1985-09-03	Fremgangsmaade til fremstilling af et enzym

Publications (2)

Publication Number	Publication Date
IL79926A0 IL79926A0 (en)	1986-12-31
IL79926A true IL79926A (en)	1994-10-07

Family

ID=8129425

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL7992686A IL79926A (en)	1985-09-03	1986-09-02	Extracellular human superoxide dismutase, dna fragment encoding it, recombinant method for making it and vectors and cells for use in the method, method for recovering the dismutase and pharmaceutical compositions comprising it

Country Status (18)

Country	Link
US (1)	US5130245A (de)
EP (1)	EP0236385B1 (de)
JP (2)	JP2643934B2 (de)
KR (1)	KR920008738B1 (de)
CN (1)	CN1030718C (de)
AT (1)	ATE69466T1 (de)
AU (1)	AU598756B2 (de)
CA (1)	CA1340329C (de)
DE (1)	DE3682505D1 (de)
DK (2)	DK402785D0 (de)
FI (1)	FI100252B (de)
HU (1)	HU215937B (de)
IE (1)	IE59078B1 (de)
IL (1)	IL79926A (de)
NO (1)	NO301132B1 (de)
SU (1)	SU1779263A3 (de)
WO (1)	WO1987001387A1 (de)
ZA (1)	ZA871267B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0213628A3 (de) *	1985-09-03	1988-09-21	Yeda Research And Development Company, Ltd.	Expression von Superoxiddismutase in eukaryotischen Zellen
US6610520B1 (en)	1985-11-22	2003-08-26	Bio-Technology General Corp.	Gene encoding human manganese superoxide dismutase and recombinant polypeptide encoded thereby
JPS63132820A (ja) *	1986-11-22	1988-06-04	Minoru Nakano	口腔用組成物
DE3854872D1 (de) *	1987-03-14	1996-02-22	Boehringer Ingelheim Int	Humane Mangan-Superoxiddismutase (hMn-SOD)
US5260204A (en) *	1987-03-14	1993-11-09	Boehringer Ingelheim International Gmbh	Human manganese superoxide dismutase (hMn-SOD)
EP0284105B1 (de) *	1987-03-27	1995-11-15	Bio-Technology General Corporation	Menschliches Mangansuperoxiddismutase und Behandlungsverfahren
DK310788A (da) *	1987-06-09	1988-12-10	Int Cardiovascular Med Inc	Praeparat indeholdende superoxid-dismutase, dets fremstilling og anvendelse til behandling af global iskaemi
JPH01238537A (ja) *	1988-03-18	1989-09-22	Toyo Jozo Co Ltd	肝障害治療剤
JPH01246225A (ja) *	1988-03-28	1989-10-02	Toyo Jozo Co Ltd	膵炎治療剤
JPH0262829A (ja) *	1988-05-18	1990-03-02	Nippon Kayaku Co Ltd	虚血に基づく傷害の予防及び治療剤
DK455789D0 (da) *	1989-09-15	1989-09-15	Symbicom Ab	Polypeptid
DE4038563A1 (de) *	1990-12-04	1992-06-11	Gruenenthal Gmbh	Verwendung von superoxiddismutasen zur prophylaxe und/oder behandlung von organversagen bei risikopatienten mit polytrauma
DE4239877C1 (de) *	1992-11-27	1994-03-17	Boehringer Ingelheim Int	Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung
EP0627486A1 (de) *	1993-06-04	1994-12-07	N.V. Innogenetics S.A.	Extra zellulare Superoxyd-Dismutase, Verfahren zur deren Herstellung und diese enthaltende Zusammensetzungen
DK75393D0 (da) *	1993-06-24	1993-06-24	Symbicom Ab	Production of protein
US6127356A (en)	1993-10-15	2000-10-03	Duke University	Oxidant scavengers
US5994339A (en) *	1993-10-15	1999-11-30	University Of Alabama At Birmingham Research Foundation	Oxidant scavengers
US5747026A (en) *	1993-10-15	1998-05-05	University Of Alabama At Birmingham Research Foundation	Antioxidants
DE4336641C2 (de) *	1993-10-22	1995-09-07	Deutsches Rheuma Forschungszen	Verwendung von Superoxid-Dismutase (SOD) zur Behandlung retroviraler Erkrankungen
WO1996009053A1 (en) *	1994-09-20	1996-03-28	Duke University	Oxidoreductase activity of manganic porphyrins
PT789584E (pt) *	1994-11-04	2002-03-28	Polymun Scient Immunbio Forsch	Aplicacao de superoxido-dismutase (sod) em liposomas
MY128323A (en) *	1996-09-30	2007-01-31	Otsuka Pharma Co Ltd	Thiazole derivatives for inhibition of cytokine production and of cell adhesion
US6171856B1 (en)	1997-07-30	2001-01-09	Board Of Regents, The University Of Texas System	Methods and compositions relating to no-mediated cytotoxicity
AU8671798A (en) *	1997-07-30	1999-02-22	Betagene, Inc.	Methods and compositions relating to no-mediated cytotoxicity
WO1999023097A1 (en)	1997-11-03	1999-05-14	Duke University	Substituted porphyrins
ES2257858T3 (es)	1998-04-24	2006-08-01	Duke University	Porfirinas sustituidas.
ATE312103T1 (de)	1999-01-25	2005-12-15	Nat Jewish Med & Res Center	Substituierte porphyrine und deren therapeutische verwendungen
DE60233317D1 (de) *	2001-01-19	2009-09-24	Nat Jewish Med & Res Center	Medikament zum schutz in der radiotherapie
FI20010898A0 (fi) *	2001-04-30	2001-04-30	Ylae Herttuala Seppo	Ekstrasellulaarinen superoksididismutaasi (EC-SOD) geeniterapia restenoosoin ehkäisemiseksi
EP1439842A4 (de) *	2001-06-01	2009-09-02	Nat Jewish Med & Res Center	Oxidantienfänger zur behandlung von diabetes oder zur verwendung bei der transplantation oder induktion von immuntoleranz
KR20050000416A (ko) *	2002-04-30	2005-01-03	핏 바이오테크 오와이제이 피엘씨	의료 장치
US7485721B2 (en) *	2002-06-07	2009-02-03	Duke University	Substituted porphyrins
US7740839B2 (en) *	2003-10-31	2010-06-22	Tae-Yoon Kim	EC SOD and cell transducing EC SOD and use thereof
CN100345973C (zh) *	2004-11-18	2007-10-31	中国农业大学	超氧化物歧化酶基因的表达方法及其专用载体
CN102105146A (zh)	2008-05-23	2011-06-22	国立犹太保健医院	用于治疗与暴露于烷化物质有关的损伤的方法
US20100098768A1 (en) *	2008-10-16	2010-04-22	Clarkson University	Method of neuroprotection from oxidant injury using metal oxide nanoparticles
CN102660580A (zh) *	2012-05-18	2012-09-12	深圳市北科生物科技有限公司	Sod基因修饰间充质干细胞的构建方法及其应用
MX363474B (es) *	2013-03-15	2019-03-25	Baxter Int	Inmovilizacion de un agente activo en un sustrato.
ES2660595T3 (es)	2013-06-07	2018-03-23	Baxter International Inc.	Inmovilización de un agente activo sobre un sustrato empleando compuestos que incluyen grupos trihidroxifenilo
CN104342409B (zh) *	2014-06-17	2018-05-25	吉林金梓源生物科技股份有限公司	重组人参超氧化物歧化酶的制备方法
CN104342408B (zh) *	2014-06-18	2018-05-25	吉林金梓源生物科技股份有限公司	重组蛹虫草超氧化物歧化酶的制备方法
AU2020225319B2 (en) *	2019-02-19	2025-05-29	Medizinische Universität Wien	New recombinant diamine oxidase and its use for the treatment of diseases characterized by excess histamine
CN115786287A (zh) *	2022-08-24	2023-03-14	江苏恰瑞生物科技有限公司	一种重组sod蛋白及其培育方法

Family Cites Families (10)

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Publication number	Priority date	Publication date	Assignee	Title
DK145950C (da) *	1979-05-17	1983-09-26	Forenede Bryggerier As	Fremgangsmaade til isolering af cu,zn-superoxid-dismutase fra vandige oploesninger indeholdende dette enzym sammen med ledsagende proteiner
US4530901A (en) *	1980-01-08	1985-07-23	Biogen N.V.	Recombinant DNA molecules and their use in producing human interferon-like polypeptides
JPS56102787A (en) *	1980-01-18	1981-08-17	Mamoru Sugiura	Preparation of human placenta superoxide dismutase
JPS5729285A (en) *	1980-07-30	1982-02-17	Takeda Chem Ind Ltd	Superoxide dismutase and its preparation
JPS57155991A (en) *	1981-03-23	1982-09-27	Green Cross Corp:The	Preparation of superoxide dismutase derived from human placenta
DE3377363D1 (en) *	1982-03-31	1988-08-18	Ajinomoto Kk	Gene coding for interleukin-2 polypeptide, recombinant dna carrying said gene, cell lines possessing the recombinant dna,and method for producing interleukin-2 using said cells
IT1150598B (it) *	1982-12-14	1986-12-17	Ines Bianchi	Procedimento per la purificazione della superossidodismutasi mediante cromatografia di affinita'
ATE155527T1 (de) *	1983-10-03	1997-08-15	Chiron Corp	Superoxiddismutase und deren expression in mikroorganismen
JPS61111690A (ja) *	1984-11-06	1986-05-29	Ube Ind Ltd	組換えｄｎａおよびその用途
JPS61139390A (ja) *	1984-12-13	1986-06-26	Nippon Kayaku Co Ltd	ひとｓｏｄをコ−ドする新規ｄｎａおよびそれを有する微生物

1985
- 1985-09-03 DK DK402785A patent/DK402785D0/da unknown
1986
- 1986-09-02 CN CN86106774A patent/CN1030718C/zh not_active Expired - Fee Related
- 1986-09-02 EP EP86905243A patent/EP0236385B1/de not_active Expired - Lifetime
- 1986-09-02 JP JP61505070A patent/JP2643934B2/ja not_active Expired - Lifetime
- 1986-09-02 AT AT86905243T patent/ATE69466T1/de not_active IP Right Cessation
- 1986-09-02 KR KR1019870700381A patent/KR920008738B1/ko not_active Expired
- 1986-09-02 AU AU63708/86A patent/AU598756B2/en not_active Ceased
- 1986-09-02 IE IE234286A patent/IE59078B1/en not_active IP Right Cessation
- 1986-09-02 DE DE8686905243T patent/DE3682505D1/de not_active Expired - Fee Related
- 1986-09-02 WO PCT/DK1986/000098 patent/WO1987001387A1/en not_active Ceased
- 1986-09-02 IL IL7992686A patent/IL79926A/en not_active IP Right Cessation
- 1986-09-02 HU HU864441A patent/HU215937B/hu not_active IP Right Cessation
- 1986-09-03 CA CA000517419A patent/CA1340329C/en not_active Expired - Fee Related
1987
- 1987-02-20 ZA ZA871267A patent/ZA871267B/xx unknown
- 1987-04-28 FI FI871853A patent/FI100252B/fi not_active IP Right Cessation
- 1987-04-30 NO NO871816A patent/NO301132B1/no unknown
- 1987-04-30 SU SU874202612A patent/SU1779263A3/ru active
- 1987-05-01 DK DK224587A patent/DK224587D0/da not_active Application Discontinuation
1990
- 1990-08-27 US US07/576,114 patent/US5130245A/en not_active Expired - Lifetime
1996
- 1996-04-23 JP JP8101552A patent/JP2688190B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI871853A0 (fi)	1987-04-28
IE862342L (en)	1987-03-03
EP0236385A1 (de)	1987-09-16
IL79926A0 (en)	1986-12-31
HU215937B (hu)	1999-03-29
DE3682505D1 (de)	1991-12-19
JP2643934B2 (ja)	1997-08-25
IE59078B1 (en)	1994-01-12
SU1779263A3 (ru)	1992-11-30
JP2688190B2 (ja)	1997-12-08
CA1340329C (en)	1999-01-26
DK224587A (da)	1987-05-01
EP0236385B1 (de)	1991-11-13
AU6370886A (en)	1987-03-24
CN86106774A (zh)	1987-07-15
FI100252B (fi)	1997-10-31
FI871853L (fi)	1987-04-28
ZA871267B (en)	1987-10-28
CN1030718C (zh)	1996-01-17
WO1987001387A1 (en)	1987-03-12
AU598756B2 (en)	1990-07-05
JPH08317793A (ja)	1996-12-03
JPS63501473A (ja)	1988-06-09
HUT46059A (en)	1988-09-28
KR880700066A (ko)	1988-02-15
US5130245A (en)	1992-07-14
DK224587D0 (da)	1987-05-01
ATE69466T1 (de)	1991-11-15
NO871816L (no)	1987-07-02
NO301132B1 (no)	1997-09-15
KR920008738B1 (ko)	1992-10-08
NO871816D0 (no)	1987-04-30
DK402785D0 (da)	1985-09-03

Legal Events

Date	Code	Title	Description
1996-11-14	KB	Patent renewed
2001-06-14	RH	Patent void

Publication	Publication Date	Title
US5130245A (en)	1992-07-14	Superoxide dismutase
US5248603A (en)	1993-09-28	Superoxide dismutase
EP0593435B1 (de)	1996-12-11	Polypeptid
Tibell et al.	1987	Expression of human extracellular superoxide dismutase in Chinese hamster ovary cells and characterization of the product.
US5728381A (en)	1998-03-17	Glycosylation variants of iduronate 2-sulfatase
US5658567A (en)	1997-08-19	Recombinant α-galactosidase A therapy for Fabry disease
CA1340597C (en)	1999-06-22	Expression vectors containing pl promoter, and engineered restriction site for convenient replacement of ribosomal binding site, plasmids containing the vectors, hosts containing the plasmids and related methods
EP0460072B1 (de)	1998-02-04	Menschlicher elastase-inhibitor
NZ219393A (en)	1991-06-25	Extracellular superoxide dismutase and its production by genetic engineering
KR20260006590A (ko)	2026-01-13	시알릴화된 인간 인자 h 단백질 및 이의 치료적 용도
EP3512940B1 (de)	2024-10-30	Verfahren zur plasminogenreinigung ausgehend von menschlichem plasma
WO2002064621A2 (en)	2002-08-22	Histidine proline rich glycoprotein (hprg) as an anti-angiogenic and anti-tumor agent
PT84387B (pt)	1991-02-08	Processo para a preparacao de superoxido-dismutase e de vectores e linhas de celulas que a segregam
JP4588279B2 (ja)	2010-11-24	エンド−β−ガラクトシダーゼをコードするＤＮＡ
JPWO1990010694A1 (ja)	1991-02-07	新規スーパーオキサイドディスムターゼ
JPH09121858A (ja)	1997-05-13	免疫的寛容誘導剤
AU2002247129A1 (en)	2002-08-28	Histidine proline rich glycoprotein (HPRG) as an anti-angiogenic and anti-tumor agent