IL79926A - Extracellular human superoxide dismutase, dna fragment encoding it, recombinant method for making it and vectors and cells for use in the method, method for recovering the dismutase and pharmaceutical compositions comprising it - Google Patents

Extracellular human superoxide dismutase, dna fragment encoding it, recombinant method for making it and vectors and cells for use in the method, method for recovering the dismutase and pharmaceutical compositions comprising it

Info

Publication number
IL79926A
IL79926A IL7992686A IL7992686A IL79926A IL 79926 A IL79926 A IL 79926A IL 7992686 A IL7992686 A IL 7992686A IL 7992686 A IL7992686 A IL 7992686A IL 79926 A IL79926 A IL 79926A
Authority
IL
Israel
Prior art keywords
sod
cell
heparin
dna
origin
Prior art date
Application number
IL7992686A
Other languages
English (en)
Other versions
IL79926A0 (en
Inventor
Stefan Marklund
Thomas Edlund
Original Assignee
Symbicom Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symbicom Ab filed Critical Symbicom Ab
Publication of IL79926A0 publication Critical patent/IL79926A0/xx
Publication of IL79926A publication Critical patent/IL79926A/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Physics & Mathematics (AREA)
IL7992686A 1985-09-03 1986-09-02 Extracellular human superoxide dismutase, dna fragment encoding it, recombinant method for making it and vectors and cells for use in the method, method for recovering the dismutase and pharmaceutical compositions comprising it IL79926A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK402785A DK402785D0 (da) 1985-09-03 1985-09-03 Fremgangsmaade til fremstilling af et enzym

Publications (2)

Publication Number Publication Date
IL79926A0 IL79926A0 (en) 1986-12-31
IL79926A true IL79926A (en) 1994-10-07

Family

ID=8129425

Family Applications (1)

Application Number Title Priority Date Filing Date
IL7992686A IL79926A (en) 1985-09-03 1986-09-02 Extracellular human superoxide dismutase, dna fragment encoding it, recombinant method for making it and vectors and cells for use in the method, method for recovering the dismutase and pharmaceutical compositions comprising it

Country Status (18)

Country Link
US (1) US5130245A (fr)
EP (1) EP0236385B1 (fr)
JP (2) JP2643934B2 (fr)
KR (1) KR920008738B1 (fr)
CN (1) CN1030718C (fr)
AT (1) ATE69466T1 (fr)
AU (1) AU598756B2 (fr)
CA (1) CA1340329C (fr)
DE (1) DE3682505D1 (fr)
DK (2) DK402785D0 (fr)
FI (1) FI100252B (fr)
HU (1) HU215937B (fr)
IE (1) IE59078B1 (fr)
IL (1) IL79926A (fr)
NO (1) NO301132B1 (fr)
SU (1) SU1779263A3 (fr)
WO (1) WO1987001387A1 (fr)
ZA (1) ZA871267B (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0213628A3 (fr) * 1985-09-03 1988-09-21 Yeda Research And Development Company, Ltd. Expression de superoxyde-dismutase dans des cellules eucaryotes
US6610520B1 (en) 1985-11-22 2003-08-26 Bio-Technology General Corp. Gene encoding human manganese superoxide dismutase and recombinant polypeptide encoded thereby
JPS63132820A (ja) * 1986-11-22 1988-06-04 Minoru Nakano 口腔用組成物
ES2083357T3 (es) * 1987-03-14 1996-04-16 Boehringer Ingelheim Int Manganeso-superoxido-dismutasa humana (hmn-sod).
US5260204A (en) * 1987-03-14 1993-11-09 Boehringer Ingelheim International Gmbh Human manganese superoxide dismutase (hMn-SOD)
DE3854678T2 (de) * 1987-03-27 1996-06-13 Bio Technology General Corp Menschliches Mangansuperoxiddismutase und Behandlungsverfahren.
DK310788A (da) * 1987-06-09 1988-12-10 Int Cardiovascular Med Inc Praeparat indeholdende superoxid-dismutase, dets fremstilling og anvendelse til behandling af global iskaemi
JPH01238537A (ja) * 1988-03-18 1989-09-22 Toyo Jozo Co Ltd 肝障害治療剤
JPH01246225A (ja) * 1988-03-28 1989-10-02 Toyo Jozo Co Ltd 膵炎治療剤
JPH0262829A (ja) * 1988-05-18 1990-03-02 Nippon Kayaku Co Ltd 虚血に基づく傷害の予防及び治療剤
DK455789D0 (da) * 1989-09-15 1989-09-15 Symbicom Ab Polypeptid
DE4038563A1 (de) * 1990-12-04 1992-06-11 Gruenenthal Gmbh Verwendung von superoxiddismutasen zur prophylaxe und/oder behandlung von organversagen bei risikopatienten mit polytrauma
DE4239877C1 (de) * 1992-11-27 1994-03-17 Boehringer Ingelheim Int Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung
EP0627486A1 (fr) * 1993-06-04 1994-12-07 N.V. Innogenetics S.A. Superoxyde dismutase extra cellulaire, procédé pour sa préparation et compositions la contenant
DK75393D0 (da) * 1993-06-24 1993-06-24 Symbicom Ab Production of protein
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
US5994339A (en) * 1993-10-15 1999-11-30 University Of Alabama At Birmingham Research Foundation Oxidant scavengers
US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
DE4336641C2 (de) * 1993-10-22 1995-09-07 Deutsches Rheuma Forschungszen Verwendung von Superoxid-Dismutase (SOD) zur Behandlung retroviraler Erkrankungen
WO1996009053A1 (fr) * 1994-09-20 1996-03-28 Duke University Activite d'oxydoreductase de porphyrines manganiques
NZ296098A (en) 1994-11-04 2001-05-25 Polymun Scient Immunbio Forsch Super oxide dismutase in liposome and it's use in therapy
MY128323A (en) * 1996-09-30 2007-01-31 Otsuka Pharma Co Ltd Thiazole derivatives for inhibition of cytokine production and of cell adhesion
US6171856B1 (en) 1997-07-30 2001-01-09 Board Of Regents, The University Of Texas System Methods and compositions relating to no-mediated cytotoxicity
AU8671798A (en) * 1997-07-30 1999-02-22 Betagene, Inc. Methods and compositions relating to no-mediated cytotoxicity
JP2001521939A (ja) 1997-11-03 2001-11-13 デューク・ユニバーシティー 置換されたポルフィリン類
DE69928655T2 (de) 1998-04-24 2006-08-24 Duke University Substituierte porphyrine
EP1155019B1 (fr) 1999-01-25 2005-12-07 National Jewish Medical and Research Center Porphyrines substituees et leur utilisation therapeutique
JP2004520380A (ja) * 2001-01-19 2004-07-08 ナショナル・ジュウィッシュ・メディカル・アンド・リサーチ・センター 癌治療本出願は、２００１年１月１９日に出願の仮出願番号第６０／２６２，３９０号の優先権を主張し、その全ての内容は、参照により本願明細書に援用したものとする。
FI20010898A0 (fi) * 2001-04-30 2001-04-30 Ylae Herttuala Seppo Ekstrasellulaarinen superoksididismutaasi (EC-SOD) geeniterapia restenoosoin ehkäisemiseksi
JP2005508864A (ja) * 2001-06-01 2005-04-07 ナショナル・ジュウィッシュ・メディカル・アンド・リサーチ・センター 糖尿病の治療、または移植術における使用、または免疫寛容の誘導のためのオキシダントスカベンジャー
EP1499344A1 (fr) * 2002-04-30 2005-01-26 FIT Biotech Oyj Plc Dispositif medical
EP1513537A4 (fr) * 2002-06-07 2006-09-06 Univ Duke Porphyrines substituees
WO2005042583A1 (fr) * 2003-10-31 2005-05-12 Bio Clue & Solution Co., Ltd. Superoxyde dismutase ec (sod), ec sod de traduction de cellule et utilisation de celle-ci
CN100345973C (zh) * 2004-11-18 2007-10-31 中国农业大学 超氧化物歧化酶基因的表达方法及其专用载体
US11382895B2 (en) 2008-05-23 2022-07-12 National Jewish Health Methods for treating injury associated with exposure to an alkylating species
US20100098768A1 (en) * 2008-10-16 2010-04-22 Clarkson University Method of neuroprotection from oxidant injury using metal oxide nanoparticles
CN102660580A (zh) * 2012-05-18 2012-09-12 深圳市北科生物科技有限公司 Sod基因修饰间充质干细胞的构建方法及其应用
EP2968676B1 (fr) * 2013-03-15 2017-05-03 Baxter International Inc Immobilisation de principe actif sur un substrat
ES2660595T3 (es) 2013-06-07 2018-03-23 Baxter International Inc. Inmovilización de un agente activo sobre un sustrato empleando compuestos que incluyen grupos trihidroxifenilo
CN104342409B (zh) * 2014-06-17 2018-05-25 吉林金梓源生物科技股份有限公司 重组人参超氧化物歧化酶的制备方法
CN104342408B (zh) * 2014-06-18 2018-05-25 吉林金梓源生物科技股份有限公司 重组蛹虫草超氧化物歧化酶的制备方法
EA202192305A1 (ru) * 2019-02-19 2021-12-08 Медицинише Универзитэт Вин Новая рекомбинантная диаминоксидаза и её применение для лечения заболеваний, характеризующихся избытком гистамина
CN115786287A (zh) * 2022-08-24 2023-03-14 江苏恰瑞生物科技有限公司 一种重组sod蛋白及其培育方法

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Publication number Priority date Publication date Assignee Title
DK145950C (da) * 1979-05-17 1983-09-26 Forenede Bryggerier As Fremgangsmaade til isolering af cu,zn-superoxid-dismutase fra vandige oploesninger indeholdende dette enzym sammen med ledsagende proteiner
US4530901A (en) * 1980-01-08 1985-07-23 Biogen N.V. Recombinant DNA molecules and their use in producing human interferon-like polypeptides
JPS56102787A (en) * 1980-01-18 1981-08-17 Mamoru Sugiura Preparation of human placenta superoxide dismutase
JPS5729285A (en) * 1980-07-30 1982-02-17 Takeda Chem Ind Ltd Superoxide dismutase and its preparation
JPS57155991A (en) * 1981-03-23 1982-09-27 Green Cross Corp:The Preparation of superoxide dismutase derived from human placenta
EP0091539B2 (fr) * 1982-03-31 1996-11-27 Ajinomoto Co., Inc. Gène codant pour interleukin-2 polypeptide, ADN recombinant portant ledit gène, lignées cellulaires possédant le recombinant ADN et procédé pour la préparation d'interleukin-2 utilisant lesdites cellules
IT1150598B (it) * 1982-12-14 1986-12-17 Ines Bianchi Procedimento per la purificazione della superossidodismutasi mediante cromatografia di affinita'
DE3486452T2 (de) * 1983-10-03 1997-11-06 Chiron Corp., Emeryville, Calif. Superoxiddismutase und deren Expression in Mikroorganismen
JPS61111690A (ja) * 1984-11-06 1986-05-29 Ube Ind Ltd 組換えｄｎａおよびその用途
JPS61139390A (ja) * 1984-12-13 1986-06-26 Nippon Kayaku Co Ltd ひとｓｏｄをコ−ドする新規ｄｎａおよびそれを有する微生物

Also Published As

Publication number Publication date
AU6370886A (en) 1987-03-24
NO871816D0 (no) 1987-04-30
DK224587D0 (da) 1987-05-01
FI871853L (fi) 1987-04-28
KR920008738B1 (ko) 1992-10-08
SU1779263A3 (ru) 1992-11-30
IL79926A0 (en) 1986-12-31
WO1987001387A1 (fr) 1987-03-12
EP0236385A1 (fr) 1987-09-16
AU598756B2 (en) 1990-07-05
NO871816L (no) 1987-07-02
KR880700066A (ko) 1988-02-15
CN86106774A (zh) 1987-07-15
FI100252B (fi) 1997-10-31
DK402785D0 (da) 1985-09-03
EP0236385B1 (fr) 1991-11-13
ZA871267B (en) 1987-10-28
NO301132B1 (no) 1997-09-15
IE862342L (en) 1987-03-03
JPS63501473A (ja) 1988-06-09
JP2688190B2 (ja) 1997-12-08
HUT46059A (en) 1988-09-28
HU215937B (hu) 1999-03-29
JPH08317793A (ja) 1996-12-03
JP2643934B2 (ja) 1997-08-25
ATE69466T1 (de) 1991-11-15
DK224587A (da) 1987-05-01
CN1030718C (zh) 1996-01-17
IE59078B1 (en) 1994-01-12
CA1340329C (fr) 1999-01-26
FI871853A0 (fi) 1987-04-28
US5130245A (en) 1992-07-14
DE3682505D1 (de) 1991-12-19

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