IL80319A - 4,5-dihydro-3-(substituted 1,2,4-oxadiazolyl)-imidazo-(1,5-a)pyrrolo(2,1-c)-quinoxaline derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

4,5-dihydro-3-(substituted 1,2,4-oxadiazolyl)-imidazo-(1,5-a)pyrrolo(2,1-c)-quinoxaline derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL80319A
IL80319A IL80319A IL8031986A IL80319A IL 80319 A IL80319 A IL 80319A IL 80319 A IL80319 A IL 80319A IL 8031986 A IL8031986 A IL 8031986A IL 80319 A IL80319 A IL 80319A
Authority
IL
Israel
Prior art keywords
sub
pyrrolo
imidazo
oxadiazolyl
dihydro
Prior art date
Application number
IL80319A
Other languages
English (en)
Original Assignee
Ferrosan As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrosan As filed Critical Ferrosan As
Publication of IL80319A publication Critical patent/IL80319A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Lubricants (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL80319A 1985-10-17 1986-10-15 4,5-dihydro-3-(substituted 1,2,4-oxadiazolyl)-imidazo-(1,5-a)pyrrolo(2,1-c)-quinoxaline derivatives,their preparation and pharmaceutical compositions containing them IL80319A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK476885A DK476885D0 (da) 1985-10-17 1985-10-17 Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf

Publications (1)

Publication Number Publication Date
IL80319A true IL80319A (en) 1990-03-19

Family

ID=8136485

Family Applications (1)

Application Number Title Priority Date Filing Date
IL80319A IL80319A (en) 1985-10-17 1986-10-15 4,5-dihydro-3-(substituted 1,2,4-oxadiazolyl)-imidazo-(1,5-a)pyrrolo(2,1-c)-quinoxaline derivatives,their preparation and pharmaceutical compositions containing them

Country Status (18)

Country Link
US (5) US4870073A (fr)
EP (2) EP0220845A1 (fr)
JP (2) JPS62155278A (fr)
KR (1) KR940010034B1 (fr)
AT (1) ATE48844T1 (fr)
AU (2) AU591937B2 (fr)
CA (2) CA1275411C (fr)
DE (1) DE3667665D1 (fr)
DK (1) DK476885D0 (fr)
ES (1) ES2014234B3 (fr)
FI (2) FI864124A7 (fr)
GR (1) GR3000367T3 (fr)
IE (1) IE59642B1 (fr)
IL (1) IL80319A (fr)
NO (2) NO163776C (fr)
NZ (2) NZ217958A (fr)
PH (1) PH22556A (fr)
PT (2) PT83572B (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK476885D0 (da) * 1985-10-17 1985-10-17 Ferrosan As Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
ATE44381T1 (de) * 1985-10-17 1989-07-15 Ferrosan As Heterocyclische verbindungen und ihre herstellung und verwendung.
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
DK155524C (da) * 1987-03-18 1989-09-11 Ferrosan As Kondenserede imidazolderivater og farmaceutiske praeparater indeholdende disse
DK160876C (da) * 1987-12-08 1991-10-14 Novo Nordisk As Imidazoquinoxalinforbindelser, fremgangsmaade til deres fremstilling, anvendelse af forbindelserne og farmaceutiske praeparater, hvori forbindelserne indgaar
IL90315A0 (en) * 1988-06-01 1989-12-15 Ferrosan As Imidazoquinoxaline compounds,their preparation and pharmaceutical compositions containing them
DK161148C (da) * 1988-06-14 1991-11-18 Novo Nordisk As Imidazoquinoxalinforbindelser, fremgangsmaade til fremstilling deraf samt farmaceutiske praeprater indeholdende forbindelserne
GB8823475D0 (en) * 1988-10-06 1988-11-16 Merck Sharp & Dohme Chemical compounds
DK626288D0 (da) * 1988-11-10 1988-11-10 Ferrosan As Kemisk proces til fremstilling af imidazoquinoxaliner og mellemprodukter til brug i processen
ES2052172T3 (es) * 1989-03-23 1994-07-01 Pfizer Agentes antialergicos basados en diazepina.
DK443589D0 (da) * 1989-09-08 1989-09-08 Ferrosan As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK588389D0 (da) * 1989-11-22 1989-11-22 Ferrosan As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK588489D0 (da) * 1989-11-22 1989-11-22 Ferrosan As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK151890D0 (da) * 1990-06-22 1990-06-22 Ferrosan As Heterocykliske forbindelser deres fremstilling og brug
US5371080A (en) * 1990-06-22 1994-12-06 Novo Nordisk A/S Imidazoquinazoline compounds and their use
US5276028A (en) * 1990-06-22 1994-01-04 Nordisk A/S Imidazoquinoxaline compounds
DK41191D0 (da) * 1991-03-07 1991-03-07 Novo Nordisk As Heterocycliske forbindelser, deres fremstilling og anvendelse
KR100207360B1 (ko) * 1991-06-14 1999-07-15 돈 더블유. 슈미츠 이미다조[1,5,-a]퀸옥살린
US5561227A (en) * 1991-07-23 1996-10-01 Schering Corporation Process for the stereospecific synthesis of azetidinones
JP2525125B2 (ja) * 1991-07-23 1996-08-14 シェリング・コーポレーション 血清コレステロ―ル低下薬として有用な置換β−ラクタム化合物およびそれらの製法
AU4035893A (en) * 1991-12-17 1993-07-19 Upjohn Company, The 3-substituted imidazo (1,5-a) and imidazo (1,5-a)-triazolo (1,5-c) quinoxalines and quinazolines with cns activity
US5244906A (en) * 1992-01-23 1993-09-14 Dowelanco Insect control with substituted oxadiazole and thiadiazole compounds
WO1993016082A1 (fr) * 1992-02-13 1993-08-19 The Upjohn Company Benzoxazines 4-oxo et 4h-imidazo(5,1-c)(1,4) utiles comme agents de liaison de recepteurs de benzodiazepine
GB9212486D0 (en) * 1992-06-12 1992-07-22 Erba Carlo Spa Derivatives of substituted imidazo benzoxazin-1-one and process for their preparation
CA2143246C (fr) * 1994-03-16 2000-08-22 Thierry Godel Imidazodiazepines
GB2328940B (en) * 1997-09-05 1999-12-08 Dong Kook Pharm Co Ltd A process for preparing benzodiazepine derivatives
EP1978966A4 (fr) 2006-01-23 2010-11-10 Amira Pharmaceuticals Inc Inhibiteurs tricycliques de la 5-lipoxygenase
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
KR101589314B1 (ko) 2007-08-20 2016-01-28 에보텍 인터내셔널 게엠베하 수면 장애의 치료
AR077463A1 (es) 2009-07-09 2011-08-31 Irm Llc Derivados de imidazo[1, 2 - a]pirazina y su uso en medicamentos para el tratamiento de enfermedades parasitarias
CN108473495B (zh) 2015-11-20 2022-04-12 福马治疗有限公司 作为泛素-特异性蛋白酶1抑制剂的嘌呤酮
CN110691597A (zh) 2017-04-24 2020-01-14 诺华股份有限公司 2-氨基-1-(2-(4-氟苯基)-3-(4-氟苯基氨基)-8,8-二甲基-5,6-二氢咪唑并[1,2-a]吡嗪-7(8H)-基)乙酮及其组合的治疗方案

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4118386A (en) * 1977-04-04 1978-10-03 Hoffmann-La Roche Inc. Synthesis of imidazo[1,5-a]diazepine-3-carboxylates
US4668678A (en) * 1980-05-09 1987-05-26 Usv Pharmaceutical Corporation Triazoloquinoxalin-1,4-diones
CA1184175A (fr) * 1981-02-27 1985-03-19 Walter Hunkeler Imidazodiazepines
US4440929A (en) * 1981-07-16 1984-04-03 Usv Pharmaceutical Corporation Imidazoquinoxaline compounds
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
IL74070A (en) * 1984-01-19 1988-12-30 Hoffmann La Roche Imidazodiazepine derivatives,their manufacture and pharmaceutical compositions containing them
US4771051A (en) * 1985-05-17 1988-09-13 A/S Ferrosan 3-substituted-4,5-dihydro-5-oxo imidazoquinazolines, their preparation, and their use in treating benzodiazepin receptor-related ailments
DK476885D0 (da) * 1985-10-17 1985-10-17 Ferrosan As Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
ATE44381T1 (de) * 1985-10-17 1989-07-15 Ferrosan As Heterocyclische verbindungen und ihre herstellung und verwendung.
FR2598147B1 (fr) * 1986-04-30 1988-08-26 Pasteur Institut Immunogene isole de mollusques, son procede de preparation, reactifs de diagnostic des bilharzioses humaines, vaccins contre les schistosomiases et compositions immunisantes comprenant ledit immunogene.

Also Published As

Publication number Publication date
NZ217958A (en) 1989-02-24
IE862733L (en) 1987-04-17
FI864125A7 (fi) 1987-04-18
AU6417886A (en) 1987-04-30
US4795749A (en) 1989-01-03
NO163776B (no) 1990-04-09
PH22556A (en) 1988-10-17
GR3000367T3 (en) 1991-06-07
EP0220845A1 (fr) 1987-05-06
ES2014234B3 (es) 1990-07-01
US4886797A (en) 1989-12-12
FI864124A0 (fi) 1986-10-13
ATE48844T1 (de) 1990-01-15
DK476885D0 (da) 1985-10-17
DE3667665D1 (de) 1990-01-25
KR940010034B1 (ko) 1994-10-21
FI82050C (fi) 1991-01-10
EP0225013B1 (fr) 1989-12-20
FI82050B (fi) 1990-09-28
NO163776C (no) 1990-07-18
AU591937B2 (en) 1989-12-21
NO864062D0 (no) 1986-10-13
FI864125A0 (fi) 1986-10-13
CA1293723C (fr) 1991-12-31
AU6417986A (en) 1987-04-30
IE59642B1 (en) 1994-03-09
JPS62155278A (ja) 1987-07-10
NO864062L (no) 1987-04-21
NO864061L (no) 1987-04-21
JPS62161785A (ja) 1987-07-17
US4870073A (en) 1989-09-26
NO864061D0 (no) 1986-10-13
EP0225013A1 (fr) 1987-06-10
CA1275411C (fr) 1990-10-23
US4774245A (en) 1988-09-27
JPH0753731B2 (ja) 1995-06-07
NZ217957A (en) 1989-02-24
FI864124A7 (fi) 1987-04-18
US4880799A (en) 1989-11-14
PT83572B (pt) 1988-10-14
KR870004032A (ko) 1987-05-07
PT83571B (en) 1988-03-09
PT83571A (en) 1986-11-01
PT83572A (en) 1986-11-01

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Legal Events

Date Code Title Description
KB Patent renewed
RH Patent void