IL87001A - ניטרילאז נקי מחיידקי קלבסיילה, רצף דץנץאץ המקדד אותו ותאים המבטאים אותו - Google Patents

ניטרילאז נקי מחיידקי קלבסיילה, רצף דץנץאץ המקדד אותו ותאים המבטאים אותו

Info

Publication number: IL87001A
Authority: IL; Israel
Prior art keywords: nitrilase; bromoxynil; dna; plasmid; ala
Prior art date: 1987-07-08

Application number

IL8700188A

Other languages

English (en)

Other versions

IL87001A0 (en

Inventor

David M Stalker

Original Assignee

Rhone Poulenc Agrochimie

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-08

Filing date

1988-07-06

Publication date

1994-08-26

1988-07-06 Application filed by Rhone Poulenc Agrochimie filed Critical Rhone Poulenc Agrochimie

1988-12-30 Publication of IL87001A0 publication Critical patent/IL87001A0/xx

1994-08-26 Publication of IL87001A publication Critical patent/IL87001A/he

Links

108010033272 Nitrilase Proteins 0.000 title claims description 115
108091028043 Nucleic acid sequence Proteins 0.000 title claims description 12
241000588748 Klebsiella Species 0.000 title claims description 6
239000013612 plasmid Substances 0.000 claims description 85
108090000623 proteins and genes Proteins 0.000 claims description 81
UPMXNNIRAGDFEH-UHFFFAOYSA-N 3,5-dibromo-4-hydroxybenzonitrile Chemical compound OC1=C(Br)C=C(C#N)C=C1Br UPMXNNIRAGDFEH-UHFFFAOYSA-N 0.000 claims description 70
239000005489 Bromoxynil Substances 0.000 claims description 70
108020004414 DNA Proteins 0.000 claims description 38
230000000694 effects Effects 0.000 claims description 31
241000588724 Escherichia coli Species 0.000 claims description 23
241000588744 Klebsiella pneumoniae subsp. ozaenae Species 0.000 claims description 21
230000001105 regulatory effect Effects 0.000 claims description 17
102000004169 proteins and genes Human genes 0.000 claims description 15
230000001580 bacterial effect Effects 0.000 claims description 14
150000001413 amino acids Chemical class 0.000 claims description 12
230000002103 transcriptional effect Effects 0.000 claims description 12
238000013518 transcription Methods 0.000 claims description 11
230000035897 transcription Effects 0.000 claims description 11
230000000977 initiatory effect Effects 0.000 claims description 8
239000000758 substrate Substances 0.000 claims description 8
108700026244 Open Reading Frames Proteins 0.000 claims description 7
230000014621 translational initiation Effects 0.000 claims description 7
238000006467 substitution reaction Methods 0.000 claims description 6
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238000004519 manufacturing process Methods 0.000 claims description 3
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230000002934 lysing effect Effects 0.000 claims description 2
108010083942 mannopine synthase Proteins 0.000 claims description 2
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IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 28
JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 description 24
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RLMISHABBKUNFO-WHFBIAKZSA-N Ala-Ala-Gly Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(O)=O RLMISHABBKUNFO-WHFBIAKZSA-N 0.000 description 21
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FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 18
BYXHQQCXAJARLQ-ZLUOBGJFSA-N Ala-Ala-Ala Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(O)=O BYXHQQCXAJARLQ-ZLUOBGJFSA-N 0.000 description 17
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IOQWIOPSKJOEKI-SRVKXCTJSA-N Lys-Ser-Leu Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O IOQWIOPSKJOEKI-SRVKXCTJSA-N 0.000 description 4
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NRXQIUSYPAHGNM-UHFFFAOYSA-N ioxynil Chemical compound OC1=C(I)C=C(C#N)C=C1I NRXQIUSYPAHGNM-UHFFFAOYSA-N 0.000 description 4
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COEXAQSTZUWMRI-STQMWFEESA-N (2s)-1-[2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]pyrrolidine-2-carboxylic acid Chemical compound C([C@H](N)C(=O)NCC(=O)N1[C@@H](CCC1)C(O)=O)C1=CC=C(O)C=C1 COEXAQSTZUWMRI-STQMWFEESA-N 0.000 description 3
YLTKNGYYPIWKHZ-ACZMJKKPSA-N Ala-Ala-Glu Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(O)=O)CCC(O)=O YLTKNGYYPIWKHZ-ACZMJKKPSA-N 0.000 description 3
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230000007480 spreading Effects 0.000 description 1
238000003892 spreading Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
235000013619 trace mineral Nutrition 0.000 description 1
239000011573 trace mineral Substances 0.000 description 1
238000000844 transformation Methods 0.000 description 1
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108010020532 tyrosyl-proline Proteins 0.000 description 1
238000005199 ultracentrifugation Methods 0.000 description 1
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230000001018 virulence Effects 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8274—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for herbicide resistance
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)

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Molecular Biology (AREA)
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Microbiology (AREA)
Biochemistry (AREA)
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Biophysics (AREA)
Plant Pathology (AREA)
Cell Biology (AREA)
Medicinal Chemistry (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

IL8700188A 1987-07-08 1988-07-06 ניטרילאז נקי מחיידקי קלבסיילה, רצף דץנץאץ המקדד אותו ותאים המבטאים אותו IL87001A (he)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/071,146 US4810648A (en)	1986-01-08	1987-07-08	Haloarylnitrile degrading gene, its use, and cells containing the gene

Publications (2)

Publication Number	Publication Date
IL87001A0 IL87001A0 (en)	1988-12-30
IL87001A true IL87001A (he)	1994-08-26

Family

ID=22099529

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL8700188A IL87001A (he)	1987-07-08	1988-07-06	ניטרילאז נקי מחיידקי קלבסיילה, רצף דץנץאץ המקדד אותו ותאים המבטאים אותו

Country Status (15)

Country	Link
US (1)	US4810648A (he)
EP (1)	EP0373173A1 (he)
KR (1)	KR890701735A (he)
CN (1)	CN1031252A (he)
AU (1)	AU2071988A (he)
BR (1)	BR8807609A (he)
CA (1)	CA1339683C (he)
DD (2)	DD285922A5 (he)
DK (1)	DK2890A (he)
ES (1)	ES2010763A6 (he)
GR (1)	GR880100421A (he)
IL (1)	IL87001A (he)
PL (1)	PL273589A1 (he)
WO (1)	WO1989000193A1 (he)
ZA (1)	ZA884894B (he)

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1987
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1988
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- 1988-07-04 WO PCT/EP1988/000588 patent/WO1989000193A1/en not_active Ceased
- 1988-07-04 EP EP88905798A patent/EP0373173A1/en not_active Withdrawn
- 1988-07-04 BR BR888807609A patent/BR8807609A/pt unknown
- 1988-07-04 KR KR1019890700419A patent/KR890701735A/ko not_active Withdrawn
- 1988-07-04 AU AU20719/88A patent/AU2071988A/en not_active Abandoned
- 1988-07-06 IL IL8700188A patent/IL87001A/he not_active IP Right Cessation
- 1988-07-07 ES ES8802134A patent/ES2010763A6/es not_active Expired
- 1988-07-07 CA CA000571422A patent/CA1339683C/en not_active Expired - Fee Related
- 1988-07-07 ZA ZA884894A patent/ZA884894B/xx unknown
- 1988-07-07 PL PL27358988A patent/PL273589A1/xx unknown
- 1988-07-08 CN CN88104173A patent/CN1031252A/zh active Pending
- 1988-07-08 DD DD88317745A patent/DD285922A5/de not_active IP Right Cessation
- 1988-07-08 DD DD88330727A patent/DD284048A5/de not_active IP Right Cessation
1990
- 1990-01-05 DK DK002890A patent/DK2890A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR890701735A (ko)	1989-12-21
DK2890D0 (da)	1990-01-05
IL87001A0 (en)	1988-12-30
AU2071988A (en)	1989-01-30
DK2890A (da)	1990-03-02
GR880100421A (el)	1989-04-12
ZA884894B (en)	1990-04-25
WO1989000193A1 (en)	1989-01-12
DD285922A5 (de)	1991-01-10
US4810648A (en)	1989-03-07
BR8807609A (pt)	1990-05-29
EP0373173A1 (en)	1990-06-20
ES2010763A6 (es)	1989-12-01
CN1031252A (zh)	1989-02-22
CA1339683C (en)	1998-02-24
DD284048A5 (de)	1990-10-31
PL273589A1 (en)	1989-04-03

Legal Events

Date	Code	Title
1998-12-27	KB	Patent renewed
1999-04-11	HC	Change of name of proprietor(s)
2002-09-12	KB	Patent renewed
2007-05-21	MM9K	Patent not in force due to non-payment of renewal fees

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