IL87834A - 2-substituted spiro(1,3-oxathiolane-4(and-5),3')quinuclidines and pharmaceutical compositions containing them - Google Patents

2-substituted spiro(1,3-oxathiolane-4(and-5),3')quinuclidines and pharmaceutical compositions containing them

Info

Publication number: IL87834A
Authority: IL; Israel
Prior art keywords: hydrogen; group; sec; oxathiolane; quinuclidines
Prior art date: 1987-10-28

Application number

IL87834A

Other languages

English (en)

Other versions

IL87834A0 (en

Inventor

Fisher Abraham

Karton Ishai

Original Assignee

Israel Inst Biolog Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-28

Filing date

1988-09-22

Publication date

1992-05-25

1988-09-22 Application filed by Israel Inst Biolog Res filed Critical Israel Inst Biolog Res

1989-03-31 Publication of IL87834A0 publication Critical patent/IL87834A0/xx

1992-05-25 Publication of IL87834A publication Critical patent/IL87834A/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
150000008584 quinuclidines Chemical class 0.000 title 1
125000003003 spiro group Chemical class 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
150000002431 hydrogen Chemical class 0.000 abstract 3
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000000304 alkynyl group Chemical group 0.000 abstract 2
125000004103 aminoalkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000001713 cholinergic effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
229910052805 deuterium Inorganic materials 0.000 abstract 1
239000000032 diagnostic agent Substances 0.000 abstract 1
229940039227 diagnostic agent Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
229910052722 tritium Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D497/20—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Compositions Of Macromolecular Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

IL87834A 1987-10-28 1988-09-22 2-substituted spiro(1,3-oxathiolane-4(and-5),3')quinuclidines and pharmaceutical compositions containing them IL87834A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US11447387A	1987-10-28	1987-10-28
US07/189,210 US4876260A (en)	1987-10-28	1988-05-02	Oxathiolanes

Publications (2)

Publication Number	Publication Date
IL87834A0 IL87834A0 (en)	1989-03-31
IL87834A true IL87834A (en)	1992-05-25

Family

ID=26812231

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL87834A IL87834A (en)	1987-10-28	1988-09-22	2-substituted spiro(1,3-oxathiolane-4(and-5),3')quinuclidines and pharmaceutical compositions containing them

Country Status (13)

Country	Link
US (1)	US4876260A (fr)
EP (1)	EP0314444B1 (fr)
JP (1)	JP2753280B2 (fr)
KR (1)	KR910007979B1 (fr)
AT (1)	ATE138663T1 (fr)
AU (1)	AU608903B2 (fr)
CA (1)	CA1315791C (fr)
DE (1)	DE3855325T2 (fr)
DK (1)	DK175064B1 (fr)
ES (1)	ES2087854T3 (fr)
IL (1)	IL87834A (fr)
NO (1)	NO167806C (fr)
NZ (1)	NZ226415A (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5534520A (en) *	1990-04-10	1996-07-09	Fisher; Abraham	Spiro compounds containing five-membered rings
US5852029A (en) *	1990-04-10	1998-12-22	Israel Institute For Biological Research	Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
JP2683783B2 (ja) *	1992-07-10	1997-12-03	雪印乳業株式会社	シェーグレン症候群治療剤
DE4343838C2 (de) *	1993-12-22	1998-07-09	Lohmann Therapie Syst Lts	Deuteriertes Arzneimittel in transdermaler Applikation und Verfahren zu seiner Herstellung
US6290986B1 (en)	1996-10-24	2001-09-18	Pharmaceutical Applications Associates, Llc	Method and composition for transdermal administration of pharmacologic agents
US6572880B2 (en)	1996-10-24	2003-06-03	Pharmaceutical Applications Associates Llc	Methods and transdermal compositions for pain relief
US6479074B2 (en)	1996-10-24	2002-11-12	Pharmaceutical Applications Associates Llc	Methods and transdermal compositions for pain relief
WO1998054189A1 (fr)	1997-05-30	1998-12-03	Neurosearch A/S	Derives de spiro-quinuclidine, leur preparation et utilisation
US20040209849A1 (en) *	1998-11-27	2004-10-21	Sanochemia Pharmazeutika Aktiengesellschaft	Use of effectors of the central cholinergic nervous system for treatment of delirium
JP4447685B2 (ja) *	1999-01-14	2010-04-07	第一三共株式会社	皮膚乾燥症治療剤
US6433168B1 (en)	1999-07-26	2002-08-13	Sumika Fine Chemicals Co., Ltd.	Highly pure phenothiazine compound, production method thereof, production method of intermediate therefor, and hydrate and novel crystal as starting materials for the intermediate
EP2320661B8 (fr)	2001-11-29	2015-09-02	Godo Kaisha IP Bridge 1	Procédé de retrait de distorsion de codage
AU2003223093B2 (en) *	2002-05-03	2010-02-04	Israel Institute For Biological Research	Methods and compositions for treatment of central and peripheral nervous system disorders and novel compounds useful therefor
CN101472924A (zh) *	2006-06-20	2009-07-01	惠氏公司	Kv1.5钾通道抑制剂
US8143400B2 (en) *	2008-01-10	2012-03-27	Apotex Pharmachem Inc.	Process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine hydrochloride
MA32929B1 (fr) *	2008-11-23	2012-01-02	Pfizer	Lactames en tant qu'inhibiteurs de bêta-sécrétase
US9034891B2 (en)	2009-01-26	2015-05-19	Israel Institute For Biological Research	Bicyclic heterocyclic spiro compounds
KR20150116466A (ko)	2009-01-26	2015-10-15	이스라엘 인스티튜트 포 바이올로지컬 리서치	이환형 헤테로사이클릭 스피로 화합물
CN101798311A (zh) *	2010-04-07	2010-08-11	天津炜杰凯华科技有限公司	顺式西维美林的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2146962A1 (en) *	1971-07-28	1973-03-09	Yoshitomi Pharmaceutical	Aza-spirodecanones - useful in treating gastric disorders
IL48453A (en) *	1975-11-11	1980-06-30	Purdue Frederick Co	Substituted 6-oxa-1-azatricyclo-(6.2.2.0 )dodecan-5-ones and 1,4-ethano-5-oxo octa (or decahydro)quinoline,their preparation and pharmaceutical compositions containing them
IL48452A (en) *	1975-11-11	1979-07-25	Purdue Frederick Co	Spiro (1,3-dioxolane-4,3') quinuclidines,their preparationand pharmaceutical compositions comprising them
US4855290A (en) *	1985-05-10	1989-08-08	State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research	Derivatives of quinuclidine
ZA868369B (en) *	1986-01-10	1987-11-25	Israel State	Derivatives of quinuclidine
IL87234A (en) *	1987-08-13	1992-02-16	Israel Inst Biolog Res	Optical isomers of 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine,their preparation and pharmaceutical compositions containing them

1988
- 1988-05-02 US US07/189,210 patent/US4876260A/en not_active Expired - Lifetime
- 1988-09-22 IL IL87834A patent/IL87834A/xx active Protection Beyond IP Right Term
- 1988-09-30 NZ NZ226415A patent/NZ226415A/xx unknown
- 1988-10-12 AU AU23671/88A patent/AU608903B2/en not_active Expired
- 1988-10-26 EP EP88310040A patent/EP0314444B1/fr not_active Expired - Lifetime
- 1988-10-26 AT AT88310040T patent/ATE138663T1/de not_active IP Right Cessation
- 1988-10-26 DE DE3855325T patent/DE3855325T2/de not_active Expired - Lifetime
- 1988-10-26 ES ES88310040T patent/ES2087854T3/es not_active Expired - Lifetime
- 1988-10-27 DK DK198805986A patent/DK175064B1/da not_active IP Right Cessation
- 1988-10-27 CA CA000581526A patent/CA1315791C/fr not_active Expired - Lifetime
- 1988-10-27 NO NO884790A patent/NO167806C/no not_active IP Right Cessation
- 1988-10-28 JP JP63271085A patent/JP2753280B2/ja not_active Expired - Lifetime
- 1988-10-28 KR KR1019880014136A patent/KR910007979B1/ko not_active Expired

Also Published As

Publication number	Publication date
IL87834A0 (en)	1989-03-31
JP2753280B2 (ja)	1998-05-18
NO884790L (no)	1989-05-02
EP0314444B1 (fr)	1996-05-29
ES2087854T3 (es)	1996-08-01
NZ226415A (en)	1990-05-28
AU2367188A (en)	1989-05-04
CA1315791C (fr)	1993-04-06
JPH0262883A (ja)	1990-03-02
ATE138663T1 (de)	1996-06-15
KR910007979B1 (ko)	1991-10-05
KR890006641A (ko)	1989-06-15
DE3855325T2 (de)	1996-10-10
DK598688A (da)	1989-04-29
US4876260A (en)	1989-10-24
NO167806B (no)	1991-09-02
NO884790D0 (no)	1988-10-27
NO167806C (no)	1991-12-11
DK598688D0 (da)	1988-10-27
AU608903B2 (en)	1991-04-18
DK175064B1 (da)	2004-05-17
EP0314444A2 (fr)	1989-05-03
DE3855325D1 (de)	1996-07-04
EP0314444A3 (en)	1990-11-07

Legal Events

Date	Code	Title
1999-03-12	KB	Patent renewed
2002-12-01	KB	Patent renewed
2006-12-07	KB	Patent renewed
2009-05-03	EXTN	Extension order renewed

Publication	Publication Date	Title
IL87834A (en)	1992-05-25	2-substituted spiro(1,3-oxathiolane-4(and-5),3')quinuclidines and pharmaceutical compositions containing them
GB2236751B (en)	1993-04-28	Heterocyclic compounds
PH21696A (en)	1988-01-13	1,8-naphthyridine derivatives,pharmaceutical composition containing the same and method of use therof
BG60262B2 (en)	1994-03-31	Process for the preparation of substituted bicyclic compounds
JO1184B1 (en)	1983-11-30	Therapeutic agents
ES8705443A1 (es)	1987-05-01	Procedimiento para la obtencion de poli-hidro piridazo diacepinas, triacepinas o diazocinas
HUT40101A (en)	1986-11-28	Process for producing quinolin-carboxylic acid derivatives and pharmaceutical compositions containing them as active agents
DK43683D0 (da)	1983-02-03	Aromatiske forbindelser med antihistamin-aktivitet, fremgangsmade til deres fremstilling samt deres anvendelse
EP0404737A3 (fr)	1992-03-11	Dérivés R(-)3-quinuclidinol
HU199766B (en)	1990-03-28	Process for producing new bicyclic compounds of 5-lipoxygenaze inhibiting activity and pharmaceutical compositions containing them
MY103502A (en)	1993-06-30	Novel compounds
PH21976A (en)	1988-05-02	New 5,11-dihydro-6h-pyrido-(2,3-b)(1,4) benzodiazepin-6-ones substituted in the 11-position and pharmaceutical compositions containing these compounds
HUT75647A (en)	1997-05-28	Imidazolidinone derivatives and pharmaceutical compositions containing them, which are suitable for treament of senile dementia
ES8305359A1 (es)	1983-04-01	Un procedimiento para la preparacion de benzamitas sustituidas.
IL93051A0 (en)	1990-11-05	((5-oxo-2-pyrrolidinyl)methyl)cyclohexaneacetamides,their preparation and pharmaceutical compositions containing them
JPS5754169A (fr)	1982-03-31
NZ217276A (en)	1988-10-28	Bicyclic heterocyclic compounds and pharmaceutical compositions
ES8401059A1 (es)	1983-12-16	Procedimiento para la preparacion de fenoleteres biciclicos.
IL82946A (en)	1991-04-15	1-t-butyl-6-methylergoline-8-methanol derivatives,their preparation and pharmaceutical compositions containing them
GEP19970835B (en)	1997-02-10	Process for obtaining 3-(methyltio, methylsulphinyl or methylsulphonyl)-4-quinolone
HUT51614A (en)	1990-05-28	Process for producing cardio-protective and suitable for treating ischemic illnesses pharmaceutical compositions containing nitriferous heterocyclic compounds as active agent as well as for producing the active agents
JO1825B1 (en)	1995-07-05	Therapeutic agents