IL88419A - Pharmaceutical formulations containing melphalan - Google Patents

Pharmaceutical formulations containing melphalan

Info

Publication number: IL88419A
Authority: IL; Israel
Prior art keywords: melphalan; pharmaceutical formulations; formulations containing; hydrochloride; containing melphalan
Prior art date: 1987-11-19

Application number

IL88419A

Other languages

English (en)

Other versions

IL88419A0 (en

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-11-19

Filing date

1988-11-18

Publication date

1993-03-15

1988-11-18 Application filed by Wellcome Found filed Critical Wellcome Found

1989-06-30 Publication of IL88419A0 publication Critical patent/IL88419A0/xx

1993-03-15 Publication of IL88419A publication Critical patent/IL88419A/xx

Links

SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 title abstract 3
229960001924 melphalan Drugs 0.000 title abstract 3
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
SGDBTWWWUNNDEQ-UHFFFAOYSA-N Merphalan Chemical compound OC(=O)C(N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-UHFFFAOYSA-N 0.000 abstract 1
OUUYBRCCFUEMLH-YDALLXLXSA-N [(1s)-2-[4-[bis(2-chloroethyl)amino]phenyl]-1-carboxyethyl]azanium;chloride Chemical compound Cl.OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 OUUYBRCCFUEMLH-YDALLXLXSA-N 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
229960002514 melphalan hydrochloride Drugs 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oil, Petroleum & Natural Gas (AREA)
Dermatology (AREA)
Inorganic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Catalysts (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)

IL88419A 1987-11-19 1988-11-18 Pharmaceutical formulations containing melphalan IL88419A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB878727157A GB8727157D0 (en)	1987-11-19	1987-11-19	Pharmaceutical formulations

Publications (2)

Publication Number	Publication Date
IL88419A0 IL88419A0 (en)	1989-06-30
IL88419A true IL88419A (en)	1993-03-15

Family

ID=10627252

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL88419A IL88419A (en)	1987-11-19	1988-11-18	Pharmaceutical formulations containing melphalan

Country Status (22)

Country	Link
US (1)	US4997651A (fr)
EP (1)	EP0317281B1 (fr)
JP (1)	JP2693191B2 (fr)
KR (1)	KR970002607B1 (fr)
AT (1)	ATE83922T1 (fr)
AU (1)	AU619781B2 (fr)
CA (1)	CA1341114C (fr)
DE (1)	DE3877151T2 (fr)
DK (1)	DK172794B1 (fr)
ES (1)	ES2052745T3 (fr)
FI (2)	FI90204C (fr)
GB (1)	GB8727157D0 (fr)
GR (1)	GR3007287T3 (fr)
HK (1)	HK108994A (fr)
HU (3)	HU203197B (fr)
IE (1)	IE63996B1 (fr)
IL (1)	IL88419A (fr)
LV (1)	LV10179B (fr)
NZ (2)	NZ239867A (fr)
PT (1)	PT89028B (fr)
SG (1)	SG73894G (fr)
ZA (1)	ZA888674B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5407672A (en) *	1993-04-08	1995-04-18	Cornell Research Foundation, Inc.	Enhancing the anti-tumor effect of melphalan with L-amino acid oxidase
US5695751A (en) *	1993-04-08	1997-12-09	Cornell Research Foundation, Inc.	Enhancing delivery of large neutral amino acid drugs
US6020004A (en) *	1997-04-17	2000-02-01	Amgen Inc.	Biodegradable microparticles for the sustained delivery of therapeutic drugs
US5980904A (en) *	1998-11-18	1999-11-09	Amway Corporation	Skin whitening composition containing bearberry extract and a reducing agent
GB2386066A (en) *	2002-02-28	2003-09-10	Norbrook Lab Ltd	Long-acting parasiticidal composition with improved bioavailability comprising a salicylanilide, a further anti-parasitic compound & a polymeric species
AU2003253681B2 (en) *	2002-06-24	2008-05-01	Research Development Foundation	Treatment of human multiple myeloma by Curcumin
EP1694335A4 (fr)	2003-08-26	2008-12-31	Res Dev Foundation	Inhibiteurs d'osteoclastogenese et leurs utilisations
US8501818B2 (en)	2005-03-14	2013-08-06	Ceptaris Therapeutics, Inc.	Stabilized compositions of alkylating agents and methods of using same
US8501817B2 (en)	2005-03-14	2013-08-06	Ceptaris Therapeutics, Inc.	Stabilized compositions of alkylating agents and methods of using same
US7872050B2 (en)	2005-03-14	2011-01-18	Yaupon Therapeutics Inc.	Stabilized compositions of volatile alkylating agents and methods of using thereof
AR066943A1 (es) *	2008-06-10	2009-09-23	Eriochem Sa	Una composicion farmaceutica de melfalano
US11020363B2 (en)	2009-05-29	2021-06-01	Cydex Pharmaceuticals, Inc.	Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same
KR101522918B1 (ko) *	2009-05-29	2015-05-27	사이덱스 파마슈티칼스, 인크.	사이클로덱스트린 유도체를 포함하는 주사용 멜팔란 조성물 및 이의 제조 및 사용 방법
AR077384A1 (es)	2010-07-05	2011-08-24	Eriochem Sa	Una formulacion farmaceutica inyectable de melfalano.
US8921596B2 (en) *	2010-11-04	2014-12-30	Emcure Pharmaceuticals, Ltd.	Process for the preparation of melphalan hydrochloride
SI3228319T1 (sl)	2011-04-28	2020-10-30	Oncopeptides Ab	Liofiliziran pripravek citotoksičnih dipeptidov
JP6284945B2 (ja) *	2012-10-26	2018-02-28	オンコペプティデスエービーＯｎｃｏｐｅｐｔｉｄｅｓＡＢ	メルファランフルフェナミドの凍結乾燥製剤
EP2970102B1 (fr)	2013-03-11	2019-05-08	Biophore India Pharmaceuticals Pvt. Ltd.	Procédé perfectionné pour la synthèse de melphalan et de son sel chlorhydrate
ITMI20130896A1 (it)	2013-05-31	2014-12-01	Farmabios Spa	Processo di purificazione di melphalan
US10576101B2 (en)	2015-03-06	2020-03-03	Leadiant Biosciences Sa	Roneparstat combined therapy of multiple myeloma
WO2017002030A1 (fr) *	2015-06-30	2017-01-05	Leiutis Pharmaceuticals Pvt Ltd	Formulations liquides stables de melphalan
JP7464995B2 (ja) *	2018-03-29	2024-04-10	プロジェクトファーマシューティクスゲーエムベーハー	液体薬学的製剤
US10682326B1 (en)	2019-06-03	2020-06-16	Shilpa Medicare Limited	Stable melphalan liquid injectable formulations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB750155A (en) *	1953-03-17	1956-06-13	Nat Res Dev	Substituted alanines
US3032585A (en) *	1954-12-03	1962-05-01	Nat Res Dev	Process for the production of p-bis-(2-chloroethyl)-aminophenylalanine
DE1292660B (de) *	1963-04-24	1969-04-17	Ural Polytechnitscheskij I Im	Verfahren zur Herstellung von p-(Bis-ª‰-chloraethyl-amino)-phenylalanin-hydrochlorid
US4029778A (en) *	1969-01-23	1977-06-14	Aktiebolaget Leo	Cortical steroid nitrogen mustard compositions and treatment therewith
RO57195A2 (fr) *	1970-11-30	1974-09-01
FR2285855A1 (fr) *	1974-09-25	1976-04-23	Kohjin Co	Composition therapeutique lyophilisee a base de sel de cyclocytidine et son procede de preparation
JPS59186924A (ja) *	1983-04-08	1984-10-23	Kureha Chem Ind Co Ltd	ヒト免疫グロブリン結合抗腫瘍剤
US4696814A (en) *	1985-08-21	1987-09-29	Warner-Lambert Company	Parenteral phenytoin compositions
JPS62192357A (ja) *	1986-02-19	1987-08-22	Kureha Chem Ind Co Ltd	Ｎ−フタロイル−ｐ−ニトロ−Ｌ−フエニルアラニンの製造方法

1987
- 1987-11-19 GB GB878727157A patent/GB8727157D0/en active Pending
1988
- 1988-11-16 EP EP88310805A patent/EP0317281B1/fr not_active Expired - Lifetime
- 1988-11-16 AT AT88310805T patent/ATE83922T1/de not_active IP Right Cessation
- 1988-11-16 ES ES88310805T patent/ES2052745T3/es not_active Expired - Lifetime
- 1988-11-16 DE DE8888310805T patent/DE3877151T2/de not_active Expired - Lifetime
- 1988-11-18 IE IE344788A patent/IE63996B1/en not_active IP Right Cessation
- 1988-11-18 US US07/273,227 patent/US4997651A/en not_active Expired - Lifetime
- 1988-11-18 DK DK198806466A patent/DK172794B1/da not_active IP Right Cessation
- 1988-11-18 AU AU25748/88A patent/AU619781B2/en not_active Expired
- 1988-11-18 PT PT89028A patent/PT89028B/pt not_active IP Right Cessation
- 1988-11-18 KR KR1019880015196A patent/KR970002607B1/ko not_active Expired - Lifetime
- 1988-11-18 CA CA000583540A patent/CA1341114C/fr not_active Expired - Fee Related
- 1988-11-18 NZ NZ239867A patent/NZ239867A/en unknown
- 1988-11-18 HU HU885953A patent/HU203197B/hu unknown
- 1988-11-18 HU HU91335A patent/HU207286B/hu unknown
- 1988-11-18 HU HU91336A patent/HU206671B/hu unknown
- 1988-11-18 IL IL88419A patent/IL88419A/xx not_active IP Right Cessation
- 1988-11-18 FI FI885358A patent/FI90204C/fi not_active IP Right Cessation
- 1988-11-18 NZ NZ227004A patent/NZ227004A/xx unknown
- 1988-11-18 ZA ZA888674A patent/ZA888674B/xx unknown
- 1988-11-18 JP JP63292228A patent/JP2693191B2/ja not_active Expired - Lifetime
1992
- 1992-10-15 FI FI924668A patent/FI102275B/fi not_active IP Right Cessation
1993
- 1993-03-09 GR GR930400510T patent/GR3007287T3/el unknown
- 1993-12-28 LV LVP-93-1379A patent/LV10179B/en unknown
1994
- 1994-06-03 SG SG73894A patent/SG73894G/en unknown
- 1994-10-06 HK HK108994A patent/HK108994A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
HUT48198A (en)	1989-05-29
GR3007287T3 (fr)	1993-07-30
DK646688A (da)	1989-05-20
FI102275B1 (fi)	1998-11-13
DK172794B1 (da)	1999-07-19
HU203197B (en)	1991-06-28
FI924668A0 (fi)	1992-10-15
DK646688D0 (da)	1988-11-18
DE3877151D1 (de)	1993-02-11
ATE83922T1 (de)	1993-01-15
US4997651A (en)	1991-03-05
EP0317281B1 (fr)	1992-12-30
DE3877151T2 (de)	1993-07-15
FI102275B (fi)	1998-11-13
AU619781B2 (en)	1992-02-06
KR970002607B1 (ko)	1997-03-06
LV10179B (en)	1995-06-20
HU206671B (en)	1992-12-28
AU2574888A (en)	1989-05-25
PT89028B (pt)	1993-02-26
ZA888674B (en)	1990-07-25
NZ239867A (en)	1992-11-25
IE883447L (en)	1989-05-19
EP0317281A3 (en)	1989-08-09
FI885358A0 (fi)	1988-11-18
JPH01153628A (ja)	1989-06-15
HU9100335D0 (en)	1991-08-28
CA1341114C (fr)	2000-10-10
ES2052745T3 (es)	1994-07-16
FI924668L (fi)	1992-10-15
JP2693191B2 (ja)	1997-12-24
HK108994A (en)	1994-10-14
PT89028A (pt)	1988-12-01
FI90204B (fi)	1993-09-30
GB8727157D0 (en)	1987-12-23
IL88419A0 (en)	1989-06-30
FI885358L (fi)	1989-05-20
HU207286B (en)	1993-03-29
HU910336D0 (en)	1991-08-28
EP0317281A2 (fr)	1989-05-24
SG73894G (en)	1994-11-25
FI90204C (fi)	1994-01-10
IE63996B1 (en)	1995-06-28
KR890007729A (ko)	1989-07-05
LV10179A (lv)	1994-10-20
NZ227004A (en)	1992-11-25

Legal Events

Date	Code	Title
1999-04-11	KB	Patent renewed
2003-02-12	KB	Patent renewed
2006-12-27	KB	Patent renewed
2009-07-20	EXP	Patent expired

Publication	Publication Date	Title
IL88419A0 (en)	1989-06-30	Pharmaceutical formulations containing melphalan
IL86782A (en)	1993-04-04	Amino acid derivatives, processes for the preparation thereof and pharmaceutical compositions comprising the same
NO890271L (no)	1989-01-20	Steroid-lotion.
GB2133983B (en)	1986-11-05	Method for preparing galenic formulations particularly for pharmaceutical, dietary, cosmetic and diagnostic uses
IL68456A0 (en)	1983-07-31	Pharmaceutical compositions comprising perfluorohydrocarbons as vehicles
PT80752A (en)	1985-08-01	Process for preparing solid medicament formulations containing dihydropyridines
AU536582B2 (en)	1984-05-10	Plenylpiperazine derivatives of 1,3,4-oxiadiazolylphends
HUT47096A (en)	1989-01-30	Process for producing 1,2-dithiol-3-thion derivatives and pharmaceutical compositions containing them as active components
GR75738B (fr)	1984-08-02
MY105860A (en)	1995-02-28	Pharmaceutical formulations.
DE3065087D1 (en)	1983-11-03	Piperidine derivatives of 3-hydroxy-thiophene-2-carboxylic acid esters, their preparation, and pharmaceutical preparations containing them
GB8800886D0 (en)	1988-02-17	Pharmaceutical veterinary & cosmetic compositions & uses