IL92101A - Amidine derivatives and pharmaceutical compositions containing the same - Google Patents

Amidine derivatives and pharmaceutical compositions containing the same

Info

Publication number
IL92101A
IL92101A IL9210189A IL9210189A IL92101A IL 92101 A IL92101 A IL 92101A IL 9210189 A IL9210189 A IL 9210189A IL 9210189 A IL9210189 A IL 9210189A IL 92101 A IL92101 A IL 92101A
Authority
IL
Israel
Prior art keywords
compounds
compound
formula
pentamidine
groups
Prior art date
Application number
IL9210189A
Other languages
English (en)
Original Assignee
Tidwell Richard R
Geratz Dieter
Hall James Edwin
Kyle Dennis E
Grogl Max
Ohemeng Kwasi A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/262,535 external-priority patent/US4933347A/en
Priority claimed from US07/262,324 external-priority patent/US4963589A/en
Priority claimed from US07/334,730 external-priority patent/US5202320A/en
Application filed by Tidwell Richard R, Geratz Dieter, Hall James Edwin, Kyle Dennis E, Grogl Max, Ohemeng Kwasi A filed Critical Tidwell Richard R
Publication of IL92101A publication Critical patent/IL92101A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL9210189A 1988-10-25 1989-10-24 Amidine derivatives and pharmaceutical compositions containing the same IL92101A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/262,535 US4933347A (en) 1988-10-25 1988-10-25 Diamidines and bis(imidazolines) for the treatment of and prophylaxis against pneumocystis carinii pneumonia
US07/262,324 US4963589A (en) 1988-10-25 1988-10-25 Methods for treating Giardia lamblia
US33459089A 1989-04-06 1989-04-06
US07/334,730 US5202320A (en) 1989-04-06 1989-04-06 Method for treating leishmaniasis

Publications (1)

Publication Number Publication Date
IL92101A true IL92101A (en) 1995-11-27

Family

ID=27500733

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9210189A IL92101A (en) 1988-10-25 1989-10-24 Amidine derivatives and pharmaceutical compositions containing the same

Country Status (13)

Country Link
EP (1) EP0366066B1 (da)
JP (1) JP2887397B2 (da)
AR (1) AR248011A1 (da)
AT (1) ATE119147T1 (da)
AU (1) AU626033B2 (da)
BR (1) BR8905441A (da)
CA (1) CA2001359C (da)
CH (1) CH679857A5 (da)
DE (1) DE68921413T2 (da)
DK (1) DK526689A (da)
FI (1) FI895039A7 (da)
IL (1) IL92101A (da)
NO (1) NO894222L (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5488160A (en) * 1991-06-11 1996-01-30 Ciba-Geigy Corporation Amidino compounds, their manufacture and method of treatment
EP0518819B1 (en) * 1991-06-11 1995-08-02 Ciba-Geigy Ag Amidino compounds, their manufacture and use as medicament
EP0518818A3 (en) * 1991-06-11 1993-04-28 Ciba-Geigy Ag Arylethers, their manufacture and use as medicament
US5246965A (en) * 1991-06-11 1993-09-21 Ciba-Geigy Arylethers, their manufacture and methods of treatment
US5451700A (en) * 1991-06-11 1995-09-19 Ciba-Geigy Corporation Amidino compounds, their manufacture and methods of treatment
PL173781B1 (pl) * 1992-02-05 1998-04-30 Boehringer Ingelheim Kg Sposób wytwarzania nowych pochodnych amidyny
US5428051A (en) * 1992-10-13 1995-06-27 University Of North Carolina Methods of combating pneumocystis carinii pneumonia and compounds useful therefor
US5629348A (en) * 1994-11-14 1997-05-13 Nzym, Inc. Methods and compositions for treating septoria infections
US5637621A (en) * 1994-11-14 1997-06-10 Nzym, Inc. Methods and compositions for treating Botrytis infections
WO1996015104A2 (en) * 1994-11-14 1996-05-23 Nzym, Inc. Methods and compositions for treating phytopathogenic fungi infections
US5723495A (en) 1995-11-16 1998-03-03 The University Of North Carolina At Chapel Hill Benzamidoxime prodrugs as antipneumocystic agents
US6635668B1 (en) * 1998-07-22 2003-10-21 The University Of North Carolina At Chapel Hill Imidazoline receptor binding compounds
ES2198139T3 (es) * 1998-08-20 2004-01-16 The University Of North Carolina At Chapel Hill Compuestos de dibenzotiofeno y procedimientos de uso de los mismos.
DE19853944A1 (de) * 1998-11-24 2000-05-25 Bourdichon Alain Jacques Verwendung von Diminazen-di-aceturat zur Behandlung von Malaria
CA2559208A1 (en) * 2004-03-17 2005-09-29 Mpex Pharmaceuticals, Inc. Use and administration of bacterial efflux pump inhibitors
RU2620016C1 (ru) * 2016-03-28 2017-05-22 Федеральное государственное бюджетное учреждение "Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации Способ профилактики пневмоцистной пневмонииии у реципиентов сердца в раннем послеоперационном периоде после трансплантации сердца

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2277861A (en) * 1937-12-10 1942-03-31 May & Baker Ltd Process for the preparation of diamidine derivatives
FR925999A (fr) * 1945-03-22 1947-09-18 May & Baker Ltd Procédé de préparation d'amidines

Also Published As

Publication number Publication date
JPH02243666A (ja) 1990-09-27
AR248011A1 (es) 1995-05-31
EP0366066B1 (en) 1995-03-01
DE68921413T2 (de) 1995-06-29
CA2001359C (en) 1997-05-06
DE68921413D1 (de) 1995-04-06
EP0366066A1 (en) 1990-05-02
FI895039A0 (fi) 1989-10-24
JP2887397B2 (ja) 1999-04-26
CH679857A5 (da) 1992-04-30
DK526689A (da) 1990-04-26
CA2001359A1 (en) 1990-04-25
DK526689D0 (da) 1989-10-24
AU626033B2 (en) 1992-07-23
NO894222D0 (no) 1989-10-24
BR8905441A (pt) 1990-10-23
FI895039A7 (fi) 1990-04-26
NO894222L (no) 1990-04-26
ATE119147T1 (de) 1995-03-15
AU4366789A (en) 1990-05-03

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees